EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

tocopheryl nicotinate
vitamin E nicotinate

Supplier Sponsors

Name:[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] pyridine-3-carboxylate
CAS Number: 43119-47-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:256-101-7
Nikkaji Web:J291.082I
Beilstein Number:0466142
XlogP3-AA:11.40 (est)
Molecular Weight:535.81201000
Formula:C35 H53 N O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:antioxidants, skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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US Patents:Search
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Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 649.02 °C. @ 760.00 mm Hg (est)
Flash Point: 655.00 °F. TCC ( 346.30 °C. ) (est)
logP (o/w): 11.327 (est)
Soluble in:
 water, 8.516e-009 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
skin conditioning
skin protecting agents
BOC Sciences
For experimental / research use only.
Santa Cruz Biotechnology
For experimental / research use only.
vitamin e nicotinate ≥98%
TRI-K Industries
Vitamin E Nicotinate
Odor: characteristic
Use: The ester of niacin and tocopherol, Vitamin E Nicotinate is a unique agent that gives the same warming effect on the skin as Nicotinate but without the irritation potential.
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intramuscular-mouse LD50 > 1000 mg/kg
Drugs in Japan Vol. 6, Pg. 508, 1982.

intraperitoneal-mouse LD50 > 10000 mg/kg
Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 18, Pg. 97, 1983.

intravenous-mouse LD50 > 1000 mg/kg
Drugs in Japan Vol. 6, Pg. 508, 1982.

oral-mouse LD50 > 20000 mg/kg
Drugs in Japan Vol. 6, Pg. 508, 1982.

intramuscular-rat LD50 > 1000 mg/kg
Drugs in Japan Vol. 6, Pg. 508, 1982.

intravenous-rat LD50 > 250 mg/kg
Drugs in Japan Vol. 6, Pg. 508, 1982.

oral-rat LD50 > 15000 mg/kg
Drugs in Japan Vol. 6, Pg. 508, 1982.

Dermal Toxicity:
subcutaneous-mouse LD50 > 20000 mg/kg
Drugs in Japan Vol. 6, Pg. 508, 1982.

subcutaneous-rat LD50 > 10000 mg/kg
Drugs in Japan Vol. 6, Pg. 508, 1982.

Inhalation Toxicity:
Not determined
Safety in Use Information:
antioxidants, skin conditioning
Recommendation for tocopheryl nicotinate usage levels up to:
 not for fragrance use.
Recommendation for tocopheryl nicotinate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :27990
National Institute of Allergy and Infectious Diseases:Data
[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] pyridine-3-carboxylate
 [(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] pyridine-3-carboxylate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:43119-47-7
Pubchem (cid):27990
Pubchem (sid):134991868
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C12981
HMDB (The Human Metabolome Database):Search
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
(2R-(2R*(4R*,8R*)))-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyl tridecyl)-2H-1-benzopyran-6-yl nicotinate
[2R-2R*(4R*,8R*)]-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol nicotinate
 juvela nicotinate
3-pyridinecarboxylic acid, (2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl ester
3-pyridinecarboxylic acid, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester, (2R-(2R*(4R*,8R*)))-
(2R-(2R*(4R*,8R*)))-3-pyridinecarboxylic acid, 3,4-dihydro-2,5,7,8tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl nicotinate
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl pyridine-3-carboxylate
[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] pyridine-3-carboxylate
DL-a-tocopherol nicotinate
(2R)-2-((4R,8R)-4,8,12-trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-yl pyridine-3-carboxylate
 vitamin E nicotinate
 vitamin E nicotinic acid ester


PubMed:Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan.
PubMed:Structural characteristic of terminal dicarboxylic moiety required for apoptogenic activity of alpha-tocopheryl esters.
PubMed:Allergic contact dermatitis due to DL-alpha-tocopheryl nicotinate.
PubMed:Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review.
PubMed:Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan.
PubMed:Enhancement by alpha-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-gamma through the upregulation of protein kinase C in rat vascular smooth muscle cells.
PubMed:Hemolytic anemia after methylene blue therapy for aniline-induced methemoglobinemia.
PubMed:A randomised, double masked, clinical trial of high dose vitamin A and vitamin E supplementation after photorefractive keratectomy.
PubMed:Hydrolysis of tocopheryl and retinyl esters by porcine carboxyl ester hydrolase is affected by their carboxylate moiety and bile acids.
PubMed:Reduction of tablet coloration at tableting for oily medicine (tocopheryl nicotinate).
PubMed:Application of calcium silicate for medicinal preparation. I. Solid preparation adsorbing an oily medicine to calcium silicate.
PubMed:Tissue alpha-tocopherol concentrations following supplementation with various forms of vitamin E in sheep.
PubMed:[The significance of lipoprotein(a) in assessment of risk for atherosclerosis].
PubMed:Protection against carbon tetrachloride-induced hepatotoxicity by pretreating rats with the hemisuccinate esters of tocopherol and cholesterol.
PubMed:Effects of dietary vitamin E on clinical course and plasma glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activities in hereditary hepatitis of LEC rats.
PubMed:Serum total cholesterol, high-density lipoprotein-cholesterol and triglyceride concentrations in lambs following supplementation with various forms of tocopherol.
PubMed:Vitamin E and cancer prevention: recent advances and future potentials.
PubMed:Bioavailability of vitamin E compounds in lambs.
PubMed:High-performance liquid chromatographic determination of alpha-tocopheryl nicotinate in cosmetic preparations.
PubMed:A prevention trial on cerebral infarction with dl-alpha-tocopheryl nicotinate--rationales for trial. The Alpha-Tocopheryl Nicotinate Prevention Study Group.
PubMed:Reduction of serum lipoprotein(a) levels in hyperlipidaemic patients with alpha-tocopheryl nicotinate.
PubMed:Effects of vitamin E administration on platelet function in diabetes mellitus.
PubMed:Effects of dietary vitamin E supplement on gracile axonal dystrophy (gad) mice.
PubMed:A nutritional evaluation of vitamin E status in very low birth weight infants with respect to changes in plasma and red blood cell tocopherol levels.
PubMed:Alpha tocopheryl succinate inhibits melanocyte-stimulating hormone (MSH)-sensitive adenylate cyclase activity in melanoma cells.
PubMed:Influence of vitamin E on platelet survival.
PubMed:Effect of vitamin E on IgE antibody formation in mice.
PubMed:Metabolism of the nicotinic acid moiety of d,l-alpha-tocopheryl nicotinate.
PubMed:[Clinical effect of dentifrice containing dl-alpha-Tocopheryl nicotinate].
PubMed:[A case with Bartter's syndrome associated with type II hyperlipidemia, increased fluidity of plasma VLDL and abnormal configuration of peripheral erythrocytes (author's transl)].
PubMed:[Effects of soysterol, pantethine and dl-alpha-tocopheryl nicotinate on hyperlipemia in rats (author's transl)].
PubMed:The effect of food on the absorption of alpha-tocopheryl nicotinate in beagle dogs and human volunteers.
PubMed:Cutaneous microcirculatory effects of various vasodilator agents on the conscious rabbit, with special regard to changes in the rhythmic property of vasomotion.
PubMed:Decreased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the blood and its unresponsiveness to tocophreyl nicotinate and indomethacin in patients with primary hepatocellular carcinoma.
PubMed:Antihypertensive action of d,l-alpha-tocopheryl nicotinate in rats.
PubMed:Inhibition of platelet aggregation by alpha-tocopherol and its nicotinate and acetate esters.
PubMed:Effects of dl-alpha-tocopheryl nicotinate on coronary circulation and development of coronary collateral vessels.
PubMed:Comparative double-blind trial of dl-alpha-tocopheryl nicotinate on vibration disease.
PubMed:A controlled, double-blind study of dl-alpha-tocopheryl nicotinate (Juvela-Nicotinate) for treatment of symptoms in hypertension and cerebral arteriosclerosis.
PubMed:Phagocytosis of alpha-tocopheryl nicotinate by the reticuloendothelial system: a microautoradiographic study.
PubMed:Anti-hypertensive action of DL-alpha-tocopharyl esters in rats.
PubMed:Comparison of alpha-tocopheryl nicotinate and acetate on skin microcirculation.
PubMed:Comparative studies of the effects of alpha-tocopheryl nicotinate and the combination alpha-tocopheryl acetate and nicotinic acid.
PubMed:Tissue uptake and metabolism of d,l-3,4- 3 H 2 -a-tocopheryl nicotinate and d,l-a-tocopheryl-1',2'- 3 H 2 -acetate following intravenous administration.
None found
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