EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

artemether
O-methyldihydroartemisinine

Supplier Sponsors

CAS Number: 71939-51-0Picture of molecule3D/inchi
FDA UNII: 111W6L37CC
Nikkaji Web:J841.010K
XlogP3-AA:3.10 (est)
Molecular Weight:298.37922000
Formula:C16 H26 O5
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 86.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 357.46 °C. @ 760.00 mm Hg (est)
Vapor Pressure:4.000000 mmHg @ 25.00 °C. (est)
Flash Point: 285.00 °F. TCC ( 140.50 °C. ) (est)
logP (o/w): 2.820 (est)
Soluble in:
 water, 12.13 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Alpha-Artemether > 95%
Odor: characteristic
Use: An isomer of Artemether. Artemether is an antimalarial for the treatment of multiple drug-resistant strains of Plasmodium falciparum malaria.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for artemether usage levels up to:
 not for fragrance use.
 
Recommendation for artemether flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :104888
National Institute of Allergy and Infectious Diseases:Data
Chemidplus:0071939510
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):104888
Pubchem (sid):135060909
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB15643
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
artemether and artemotil are dispensed dissolved in oil (groundnut, sesame seed) and given by i.m. injection into the anterior thigh.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
(+)-alpha-artemether
alpha-artemether
alpha-dihydroartemisinin methyl ether
3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10R,12R,12aR)-
3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10R,12R,12aR)-
ortho-methyl dihydroartemisinine
O-methyldihydroartemisinine
 

Articles:

PubMed:Pharmacokinetics of a novel sublingual spray formulation of the antimalarial drug artemether in African children with malaria.
PubMed:A comparative study on the impact of two artemisinin derivatives, artemether and artesunate, on the female reproductive system of Fasciola hepatica.
PubMed:Tailoring a Pediatric Formulation of Artemether-Lumefantrine for Treatment of Plasmodium falciparum Malaria.
PubMed:Integration of novel low-cost colorimetric, laser photometric, and visual fluorescent techniques for rapid identification of falsified medicines in resource-poor areas: application to artemether-lumefantrine.
PubMed:Artemether-lumefantrine: an option for malaria.
PubMed:Optimizing the programmatic deployment of the anti-malarials artemether-lumefantrine and dihydroartemisinin-piperaquine using pharmacological modelling.
PubMed:Comparison of bioavailability between the most available generic tablet formulation containing artemether and lumefantrine on the Tanzanian market and the innovator's product.
PubMed:Use of artemether-lumefantrine to treat malaria during pregnancy: what do we know and need to know?
PubMed:Population-wide malaria testing and treatment with rapid diagnostic tests and artemether-lumefantrine in southern Zambia: a community randomized step-wedge control trial design.
PubMed:Efficacy of artesunate-amodiaquine and artemether-lumefantrine fixed-dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria among children aged six to 59 months in Nimba County, Liberia: an open-label randomized non-inferiority trial.
PubMed:Efficacy of artemether-lumefantrine in area of high malaria endemicity in India and its correlation with blood concentration of lumefantrine.
PubMed:Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects.
PubMed:Monitoring of artemisinin, dihydroartemisinin, and artemether in environmental matrices using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS).
PubMed:Implementation of artemether-lumefantrine treatment policy for malaria at health facilities in Tanzania.
PubMed:The effect of food consumption on lumefantrine bioavailability in African children receiving artemether-lumefantrine crushed or dispersible tablets (Coartem) for acute uncomplicated Plasmodium falciparum malaria.
PubMed:Rational dispensing and use of artemether-lumefantrine during pregnancy in Dar es Salaam, Tanzania.
PubMed:Comparable lumefantrine oral bioavailability when co-administered with oil-fortified maize porridge or milk in healthy volunteers.
PubMed:Changes in the visceral functions of Plasmodium berghei-infected and -uninfected rats following administration of artemether.
PubMed:Adherence to and acceptability of artemether-lumefantrine as first-line anti-malarial treatment: evidence from a rural community in Tanzania.
PubMed:Evaluation of the developmental toxicity of artemether during different phases of rat pregnancy.
PubMed:Dispersible formulation of artemether/lumefantrine: specifically developed for infants and young children.
PubMed:First case of treatment failure of artemether-lumefantrine in a Japanese traveler with imported falciparum malaria.
PubMed:Pharmacokinetic interaction trial between co-artemether and mefloquine.
PubMed:The effect of grapefruit juice on the time-dependent decline of artemether plasma levels in healthy subjects.
PubMed:Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia.
PubMed:Pharmacokinetics and electrocardiographic pharmacodynamics of artemether-lumefantrine (Riamet) with concomitant administration of ketoconazole in healthy subjects.
PubMed:Effect of artesunate and artemether against Clonorchis sinensis and Opisthorchis viverrini in rodent models.
PubMed:Effect of artemether alone and in combination with grapefruit juice on hepatic drug-metabolising enzymes and biochemical aspects in experimental Schistosoma mansoni.
PubMed:Supervised versus unsupervised intake of six-dose artemether-lumefantrine for treatment of acute, uncomplicated Plasmodium falciparum malaria in Mbarara, Uganda: a randomised trial.
PubMed:Clinical pharmacokinetics and pharmacodynamics and pharmacodynamics of artemether-lumefantrine.
PubMed:Artemether + lumefantrine: new drug. An alternative to atovaquone + proguanil.
PubMed:Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda.
PubMed:Pharmacokinetic study of artemether-lumefantrine given once daily for the treatment of uncomplicated multidrug-resistant falciparum malaria.
PubMed:The content of African diets is adequate to achieve optimal efficacy with fixed-dose artemether-lumefantrine: a review of the evidence.
PubMed:Understanding the pharmacokinetics of Coartem.
PubMed:Factors affecting availability of essential medicines among community health workers in Ethiopia, Malawi, and Rwanda: solving the last mile puzzle.
PubMed:Experience With the Priority Review Voucher Program for Drug Development.
PubMed:Studies of the neurotoxicity of oral artemisinin derivatives in mice.
PubMed:A qualitative study of perceptions of a mass test and treat campaign in Southern Zambia and potential barriers to effectiveness.
PubMed:Management of imported malaria in Europe.
PubMed:Development of simplified HPLC methods for the detection of counterfeit antimalarials in resource-restraint environments.
PubMed:Malaria: severe, life-threatening.
PubMed:Awareness of anti-malarial policy and malaria treatment practices of patent medicine vendors in three Nigerian states.
PubMed:Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.
PubMed:Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria.
PubMed:How much fat is necessary to optimize lumefantrine oral bioavailability?
PubMed:[The treatment of falciparum malaria].
PubMed:Artemisinin-based combination therapies for uncomplicated malaria.
PubMed:First artemisinin-based antimalarial combination approved for U.S. market.
PubMed:Artemisinins and synthetic trioxolanes in the treatment of helminth infections.
PubMed:[Mechanism of action of antimalarials. Value of combined atovaquone/proguanil].
PubMed:Antiparasitic agents.
PubMed:Malaria: severe, life-threatening.
PubMed:Malaria: uncomplicated, caused by Plasmodium falciparum.
PubMed:Arteether toxicokinetics and pharmacokinetics in rats after 25 mg/kg/day single and multiple doses.
PubMed:FDA launches priority vouchers for neglected-disease drugs.
 
Notes:
quinghaosu derivative.
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