EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

harpagide
(1S-(1alpha,4aalpha,5alpha,7alpha,7aalpha))-1,4a,5,6,7,7a-hexahydro-4a,5,7-trihydroxy-7-methylcyclopenta(c)pyran-1-yl beta-D-glucopyranoside

Supplier Sponsors

CAS Number: 6926-08-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:230-050-0
FDA UNII: OF59XHX7SR
Nikkaji Web:J3.360.256A
MDL:MFCD00017306
XlogP3-AA:-3.30 (est)
Molecular Weight:364.34828000
Formula:C15 H24 O10
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 637.10 °C. @ 760.00 mm Hg (est)
Flash Point: 642.00 °F. TCC ( 339.10 °C. ) (est)
logP (o/w): -3.690 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Harpagide 98%
BOC Sciences
For experimental / research use only.
Harpagide >98%
Odor: characteristic
Use: Source from roots of Scrophularia ningpoensis Hemsl. Antibacterial, anti-inflammatory, and antiviral activities.
Carbosynth
For experimental / research use only.
Harpagide
ExtraSynthese
For experimental / research use only.
Harpagide (HPLC) ≥90%
Matrix Scientific
For experimental / research use only.
Harpagide
sds
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for harpagide usage levels up to:
 not for fragrance use.
 
Recommendation for harpagide flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :93045
National Institute of Allergy and Infectious Diseases:Data
(1S,4aS,5R,7S,7aR)-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-4a,5,7-triol
Chemidplus:0006926085
 
References:
 (1S,4aS,5R,7S,7aR)-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-4a,5,7-triol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):93045
Pubchem (sid):135051837
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 harpagophytum procumbens
Search Trop Picture
 
Synonyms:
beta-D-glucopyranoside
(1S-(1alpha,4aalpha,5alpha,7alpha,7aalpha))-1,4a,5,6,7,7a-hexahydro-4a,5,7-trihydroxy-7-methylcyclopenta(c)pyran-1-yl beta-D-glucopyranoside
(1S,4aS,5R,7S,7aR)-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-4a,5,7-triol
 

Articles:

PubMed:Iridoid glycosides isolated from Scrophularia dentata Royle ex Benth. and their anti-inflammatory activity.
PubMed:[Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens extract in beagle dog].
PubMed:Chiroptical properties of ajugol investigated by quantum chemical calculation using time-dependent density functional theory.
PubMed:Validated LC-MS method for simultaneous quantitation of catalpol and harpagide in rat plasma: application to a comparative pharmacokinetic study in normal and diabetic rats after oral administration of Zeng-Ye-Decoction.
PubMed:Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats.
PubMed:Verbascum xanthophoeniceum-derived phenylethanoid glycosides are potent inhibitors of inflammatory chemokines in dormant and interferon-gamma-stimulated human keratinocytes.
PubMed:A new flavonoid and other polar compounds from Galeopsis angustifolia Ehrh. ex Hoffm.
PubMed:Devil's Claw-a review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens.
PubMed:Phytochemical composition of polar fraction of Stachys germanica L. subsp. salviifolia (Ten.) Gams, a typical plant of Majella National Park.
PubMed:[Determination of harpagide and harpagoside in Scrophulariae Radix by HPLC-UV].
PubMed:Distribution of iridiod glucosides and anti-oxidant compounds in Spathodea campanulata parts.
PubMed:Antiinflammatory activities of Hungarian Stachys species and their iridoids.
PubMed:Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro.
PubMed:The interaction potential of herbal medicinal products: a luminescence-based screening platform assessing effects on cytochrome P450 and its use with devil's claw (Harpagophyti radix) preparations.
PubMed:[Simultaneous determination of five constituents in Scrophularia ningpoensis by HPLC].
PubMed:Anti-inflammatory effect of Ajuga bracteosa Wall Ex Benth. mediated through cyclooxygenase (COX) inhibition.
PubMed:A new iridoid glycoside from Scrophularia ningpoensis.
PubMed:Estimation of the relative antiinflammatory efficacies of six commercial preparations of Harpagophytum procumbens (Devil's Claw).
PubMed:The genome-wide expression profile of Scrophularia ningpoensis-treated thapsigargin-stimulated U-87MG cells.
PubMed:Study of chemical composition and antimicrobial activity of leaves and roots of Scrophularia ningpoensis.
PubMed:A novel ex vivo skin model for the assessment of the potential transcutaneous anti-inflammatory effect of topically applied Harpagophytum procumbens extract.
PubMed:[Determination of five compounds in Scrophularia ningpoensis by HPLC-UV-ELSD].
PubMed:Iridoid and aromatic glycosides from Scrophularia ningpoensis Hemsl. and their inhibition of [Ca2+](i) increase induced by KCl.
PubMed:Cytotoxic activities of Stachys species.
PubMed:Phytochemistry and molecular systematics of Triaenophora rupestris and Oreosolen wattii (Scrophulariaceae).
PubMed:Analysis of iridoids from Harpagophytum and eleutherosides from Eleutherococcus senticosus in horse urine.
PubMed:Effect of the major glycosides of Harpagophytum procumbens (Devil's Claw) on epidermal cyclooxygenase-2 (COX-2) in vitro.
PubMed:Dermal and transcutaneous delivery of the major glycoside constituents of Harpagophytum procumbens (Devil's Claw) in vitro.
PubMed:Optimization of solid-phase extraction for the liquid chromatography-mass spectrometry analysis of harpagoside, 8-para-coumaroyl harpagide, and harpagide in equine plasma and urine.
PubMed:Antinociceptive and anti-inflammatory effects of saponin and iridoid glycosides from Verbascum pterocalycinum var. mutense Hub.-Mor.
PubMed:Further flavonol and iridoid glycosides from Ajuga remota aerial parts.
PubMed:Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of Scrophularia cryptophila.
PubMed:Simultaneous determination of four active constituents in the roots of Scrophularia buergeriana by HPLC-DAD and LC-ESI-MS.
PubMed:Liquid chromatography/electrospray ionization mass spectrometric characterization of Harpagophytum in equine urine and plasma.
PubMed:Iridoid glycosides from Harpagophytum procumbens D.C. (devil's claw).
PubMed:Monoterpenoids from Stachys glutinosa L.
PubMed:A new phthalic acid ester from Ajuga bracteosa.
PubMed:Proton and sodium cation affinities of harpagide: a computational study.
PubMed:Rapid measurement and evaluation of the effect of drying conditions on harpagoside content in Harpagophytum procumbens (devil's claw) root.
PubMed:LC-DAD-MS/SPE-NMR hyphenation. A tool for the analysis of pharmaceutically used plant extracts: identification of isobaric iridoid glycoside regioisomers from Harpagophytum procumbens.
PubMed:A new iridoid diglycoside from Clerodendrum chinense.
PubMed:Iridoids as allelochemicals and DNA polymerase inhibitors.
PubMed:Iridoids from Scrophularia buergeriana attenuate glutamate-induced neurotoxicity in rat cortical cultures.
PubMed:Benzoxazinoids and iridoid glucosides from four Lamium species.
PubMed:Ionone, iridoid and phenylethanoid glycosides from Ajuga salicifolia.
PubMed:Scropolioside-D2 and harpagoside-B: two new iridoid glycosides from Scrophularia deserti and their antidiabetic and antiinflammatory activity.
PubMed:[Establishment of a TLC identification method for xuanshen(radix scrophulariae)].
PubMed:Four new neuroprotective iridoid glycosides from Scrophularia buergeriana roots.
PubMed:Chemistry of plants from Crete: stachyspinoside, a new flavonoid glycoside and iridoids from Stachys spinosa.
PubMed:Iridoids from Stachys grandidentata (Labiatae).
PubMed:Fast repairing of oxidized OH radical adducts of dAMP and dGMP by phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl.
PubMed:Inhibition of TNF-alpha synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap 69.
PubMed:Selective sequestration of iridoid glycosides from their host plants in Longitarsus flea beetles.
PubMed:Iridoid glucosides from Caryopteris mongholica.
PubMed:Iridoids from Caryopteris x clandonensis.
PubMed:Isoangoroside C, a phenylpropanoid glycoside from Scrophularia scorodonia roots.
PubMed:Effects of some iridoids from plant origin on arachidonic acid metabolism in cellular systems.
PubMed:Formation of nitrogen-containing metabolites from the main iridoids of Harpagophytum procumbens and H. zeyheri by human intestinal bacteria.
PubMed:Two new pyridine monoterpene alkaloids by chemical conversion of a commercial extract of harpagophytum procumbens
PubMed:Antiinflammatory effects of different extracts and harpagoside isolated from Scrophularia frutescens L.
PubMed:Karsoside and scropolioside D, two new iridoid glycosides from Scrophularia ilwensis.
PubMed:Vasoconstrictor activity of 8-O-acetylharpagide from Ajuga reptans.
PubMed:Iridoids and an Alkaloid from Oxera morieri1.
PubMed:A drug used in traditional medicine: Harpagophytum procumbens DC. IV. Effects on some isolated muscle preparations.
PubMed:A drug used in traditional medicine: Harpagophytum procumbens DC. II. Cardiovascular activity.
PubMed:A drug used in traditional medicine. Harpagophytum procumbens DC. I. Scanning electron microscope observations.
PubMed:[Biological analysis of Harpagophytum procumbens D.C. II. Pharmacological analysis of the effects of harpagoside, harpagide and harpagogenine on the isolated guinea-pig ileum (author's transl)].
 
Notes:
from s. african plant harpagophytum procumbens dc.
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy