EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

tamarixetin
flavone, 4'-methoxy-3,3',5,7-tetrahydroxy-

Supplier Sponsors

Name:3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one
CAS Number: 603-61-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:210-050-7
FDA UNII: 73WRA8Z8M8
Nikkaji Web:J839G
Beilstein Number:0324993
MDL:MFCD00017308
XlogP3:1.90 (est)
Molecular Weight:316.26604000
Formula:C16 H12 O7
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 601.80 °C. @ 760.00 mm Hg (est)
Flash Point: 444.00 °F. TCC ( 228.80 °C. ) (est)
logP (o/w): 2.420 (est)
Soluble in:
 water, 1122 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Chiosmethin 95%
BOC Sciences
For experimental / research use only.
Tamarixetin >97%
Odor: characteristic
Use: Tamarixetin is a natural flavonoid isolated from the herbs of Heracleum stenopterum. Tamarixetin can inhibit proliferation in a concentration- and time-dependent manner, inhance which induces apoptosis and blocked cell cycle progression at G2 -M phase. anticancer
Carbosynth
For experimental / research use only.
4'-O-Methyl quercetin
ExtraSynthese
For experimental / research use only.
Tamarixetin (HPLC) ≥99%
Santa Cruz Biotechnology
For experimental / research use only.
4'-O-Methyl Quercetin
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for tamarixetin usage levels up to:
 not for fragrance use.
 
Recommendation for tamarixetin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281699
National Institute of Allergy and Infectious Diseases:Data
3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one
Chemidplus:0000603612
 
References:
 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5281699
Pubchem (sid):134977089
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10188
HMDB (The Human Metabolome Database):HMDB02937
FooDB:FDB016383
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 cotton mexican cotton
Search Trop Picture
 ginkgo biloba
Search Trop Picture
 
Synonyms:
4H-1-benzopyran-4-one, 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)- (9CI)
 flavone, 4'-methoxy-3,3',5,7-tetrahydroxy-
4'-methoxy-3,3',5,7-tetrahydroxy-flavone
4'-methoxyquercetin
4'-methylquercetin
4'-O-methylquercetin
 quercetin, 4'-methyl ether
3-O-alpha-l-rhamnopyranosyl-1-2-beta-d-glucopyranoside
3-O-rhamnopyranosyl-1-2-glucopyranoside
 tamaraxetin
3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone
3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one
 

Articles:

PubMed:Quercetin bioavailability is associated with inadequate plasma vitamin C status and greater plasma endotoxin in adults.
PubMed:[Chemical constituents of leaves of Psidium guajava].
PubMed:The minor structural difference between the antioxidants quercetin and 4'O-methylquercetin has a major impact on their selective thiol toxicity.
PubMed:Anti-influenza sesquiterpene from the roots of Reynoutria japonica.
PubMed:Flavonoids from Lindera glauca Blume as low-density lipoprotein oxidation inhibitors.
PubMed:Dietary flavonoids modulate CYP2C to improve drug oral bioavailability and their qualitative/quantitative structure-activity relationship.
PubMed:Flavonoid inhibitory pharmacodynamics on platelet function in physiological environments.
PubMed:Indirect activation of the SV23 and SV24 splice variants of human constitutive androstane receptor: analysis with 3-hydroxyflavone and its analogues.
PubMed:Induction of G2 /M phase arrest and apoptosis by the flavonoid tamarixetin on human leukemia cells.
PubMed:Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2).
PubMed:Bioavailability of quercetin from its aglycone and its glucorhamnoside rutin in lactating dairy cows after intraduodenal administration.
PubMed:Dietary fat increases quercetin bioavailability in overweight adults.
PubMed:Evaluation of the inhibitory effects of quercetin-related flavonoids and tea catechins on the monoamine oxidase-A reaction in mouse brain mitochondria.
PubMed:On line characterization of 58 phenolic compounds in Citrus fruit juices from Spanish cultivars by high-performance liquid chromatography with photodiode-array detection coupled to electrospray ionization triple quadrupole mass spectrometry.
PubMed:Bioavailability of the flavonol quercetin in cows after intraruminal application of quercetin aglycone and rutin.
PubMed:Competition between ascorbate and glutathione for the oxidized form of methylated quercetin metabolites and analogues: tamarixetin, 4'O-methylquercetin, has the lowest thiol reactivity.
PubMed:Evaluation of flavonoids and enterolactone in overnight urine as intake biomarkers of fruits, vegetables and beverages in the Inter99 cohort study using the method of triads.
PubMed:Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica.
PubMed:The effective method for investigation meridian tropism theory in rats.
PubMed:Antioxidant flavonol glycosides from Elaeocarpus serratus and Filicium decipiens.
PubMed:Effects of O-methylated metabolites of quercetin on oxidative stress, thermotolerance, lifespan and bioavailability on Caenorhabditis elegans.
PubMed:Enriched cereal bars are more effective in increasing plasma quercetin compared with quercetin from powder-filled hard capsules.
PubMed:[Chemical constituents of Iris dichotoma].
PubMed:Flavonoid Glycosides from the Seeds of Litchi chinensis.
PubMed:[Studies on the chemical constituents from the aerial parts of Gladiolus gandavensis].
PubMed:Cholinesterase inhibitors from Cleistocalyx operculatus buds.
PubMed:Xanthine oxidase inhibitory activities of extracts and flavonoids of the leaves of Blumea balsamifera.
PubMed:Free fruit at workplace intervention increases total fruit intake: a validation study using 24 h dietary recall and urinary flavonoid excretion.
PubMed:[Chemical constituents of Laggera pterodonta].
PubMed:Plasma levels and distribution of flavonoids in rat brain after single and repeated doses of standardized Ginkgo biloba extract EGb 761®.
PubMed:Platelet-mediated metabolism of the common dietary flavonoid, quercetin.
PubMed:A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids.
PubMed:[Non-alkaloid constituents of Gelsemium elegans].
PubMed:Simultaneous determination of flavonoids and phenylethanoids in the flowers of Verbascum densiflorum and V. phlomoides by high-performance liquid chromatography.
PubMed:Flavonoids and isoflavonoids from Sophorae Flos improve glucose uptake in vitro.
PubMed:A new ferulic acid ester and other constituents from Tamarix nilotica leaves.
PubMed:Aphyllin, the first isoferulic acid glycoside and other phenolics from Tamarix aphylla flowers.
PubMed:Quantitative determination of flavonoids by column high-performance liquid chromatography with mass spectrometry and ultraviolet absorption detection in Artemisia afra and comparative studies with various species of Artemisia plants.
PubMed:Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways.
PubMed:Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans.
PubMed:Tissue distribution of quercetin in pigs after long-term dietary supplementation.
PubMed:[Studies on flavonoids from Blumea riparia].
PubMed:St. John's wort flavonoids and their metabolites show antidepressant activity and accumulate in brain after multiple oral doses.
PubMed:Activation of EpRE-mediated gene transcription by quercetin glucuronides depends on their deconjugation.
PubMed:Inhibitors of osteoclast differentiation from Cephalotaxus koreana.
PubMed:[Studies on flavonoids of Eupatorium odoratum L].
PubMed:Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted rats.
PubMed:Flavonoids in horse chestnut (Aesculus hippocastanum) seeds and powdered waste water byproducts.
PubMed:Dual regulation of the Bacillus subtilis regulon comprising the lmrAB and yxaGH operons and yxaF gene by two transcriptional repressors, LmrA and YxaF, in response to flavonoids.
PubMed:Flavonol galactoside caffeiate ester and homoisoflavones from Caesalpinia millettii HOOK. et ARN.
PubMed:Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study.
PubMed:Synthesis of 3-O-(beta-D-xylopyranosyl-(1-->2)-beta-D-glucopyranosyl)-3'-O-(beta-D-glucopyranosyl)tamarixetin, the putative structure of aescuflavoside A from the seeds of Aesculus chinensis.
PubMed:Red wine alcohol promotes quercetin absorption and directs its metabolism towards isorhamnetin and tamarixetin in rat intestine in vitro.
PubMed:Determination of St. John's wort flavonoid-metabolites in rat brain through high performance liquid chromatography coupled with fluorescence detection.
PubMed:Dietary flavonoids as intracellular substrates for an erythrocyte trans-plasma membrane oxidoreductase activity.
PubMed:Synthesis of tamarixetin and isorhamnetin 3-O-neohesperidoside.
PubMed:A new antipsychotic effective neolignan from Firmiana simplex.
PubMed:Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans.
PubMed:Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity.
PubMed:Inhibition of human cytochromes P450 by components of Ginkgo biloba.
PubMed:The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides.
PubMed:Urinary excretion of flavonoids reflects even small changes in the dietary intake of fruits and vegetables.
PubMed:Free radical scavenging abilities of flavonoids as mechanism of protection against mutagenicity induced by tert-butyl hydroperoxide or cumene hydroperoxide in Salmonella typhimurium TA102.
PubMed:Absorption and urinary excretion of quercetin, rutin, and alphaG-rutin, a water soluble flavonoid, in rats.
PubMed:Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy.
PubMed:Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans.
PubMed:Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteries.
PubMed:Flavonoids in human urine as biomarkers for intake of fruits and vegetables.
PubMed:Biologically active secondary metabolites from Ginkgo biloba.
PubMed:In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids.
PubMed:Antioxidant and antimicrobial activities of Tamarix ramosissima.
PubMed:The impact of different flavonoid classes on colonic CI- secretion in rats.
PubMed:Bioavailability and metabolism of the flavonol quercetin in the pig.
PubMed:Flavonol glycosides from Costus spicatus.
PubMed:Relaxant effects of quercetin methyl ether derivatives in isolated guinea pig trachea and their structure-activity relationships.
PubMed:Characterization of flavonoids as monofunctional or bifunctional inducers of quinone reductase in murine hepatoma cell lines.
PubMed:In vitro biotransformation of flavonoids by rat liver microsomes.
PubMed:Bioavailability of rutin and quercetin in rats.
PubMed:[Studies on the chemical constituents of Cynanchum thesioides].
PubMed:Methoxylated flavonols and flavanones from Eupatorium odoratum.
PubMed:Mutagenicity of plant flavonoids: structural requirements for mutagenic activity in Salmonella typhimurium.
 
Notes:
isolated from costsus spicatus. Isol. from Gossypium hirsutum (cotton) and other plants Tamarixetin is a flavanoid component of the Ginko Biloba extract. Exhibits antioxidant properties.
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