EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

eriodictyol
luteolin

Supplier Sponsors

Name:2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
CAS Number: 491-70-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:207-741-0
FDA UNII: KUX1ZNC9J2
Nikkaji Web:J1.554G
Beilstein Number:0292084
MDL:MFCD00017309
XlogP3:1.40 (est)
Molecular Weight:286.23990000
Formula:C15 H10 O6
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:yellow crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 329.00 to 330.00 °C. @ 760.00 mm Hg
Boiling Point: 616.00 to 617.00 °C. @ 760.00 mm Hg (est)
Flash Point: 463.00 °F. TCC ( 239.50 °C. ) (est)
logP (o/w): 2.695 (est)
Soluble in:
 alcohol
 water, 387.5 mg/L @ 25 °C (est)
 alkali
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Luteolin 98%
AuNutra® Industries
Luteolin P.E.
BOC Sciences
For experimental / research use only.
Luteolin >98%
Odor: characteristic
Use: Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor.
Coompo
For experimental / research use only.
Luteolin from Plants ≥96%
Odor: characteristic
Use: In basic research, luteolin is a PDE4 inhibitor, phosphodiesterase inhibitor, and an interleukin 6 inhibitor, affecting xylazine/ketamine-induced anesthesia in mice. Luteolin may inhibit skin cancer mechanisms in vitro and in vivo by various potential mechanisms. It also shows potent anti-inflammatory activities by inhibiting nuclear factor kappa B (NFkB) signaling in immune cells. Having multiple biological effects such as anti-inflammation, anti-allergy and anticancer, luteolin functions as either an antioxidant or a pro-oxidant biochemically. The biological effects of luteolin could be functionally related to each other. For instance, the anti-inflammatory activity may be linked to its anticancer property. Luteolin's anticancer property is associated with the induction of apoptosis, and inhibition of cell proliferation, metastasis and angiogenesis. Furthermore, luteolin sensitizes cancer cells to therapeutic-induced cytotoxicity through suppressing cell survival pathways such as phosphatidylinositol 3'-kinase (PI3K)/Akt, nuclear factor kappa B (NF-kappaB), and X-linked inhibitor of apoptosis protein (XIAP), and stimulating apoptosis pathways including those that induce the tumor suppressor p53. These observations suggest that luteolin could be an anticancer agent for various cancers. Furthermore, recent epidemiological studies have attributed a cancer prevention property to luteolin. In this review, we summarize the progress of recent research on luteolin, with a particular focus on its anticancer role and molecular mechanisms underlying this property of luteolin.
ExtraSynthese
For experimental / research use only.
Luteolin (HPLC) ≥99%
Glentham Life Sciences
Luteolin
P.L. Thomas
Luteolin
Qingdao Dacon Trading
Luteolin
Santa Cruz Biotechnology
For experimental / research use only.
Luteolin ≥98%
Shaanxi Y-Herb Biotechnology
Luteolin Monomer Powder Mignonette Reseda Odorata Skin Organic Peanut Shell Extract
Sigma-Aldrich
For experimental / research use only.
Eriodictyol analytical standard
Skyherb Technologies
Luteolin 98%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 180 mg/kg
Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 16(2), Pg. 11, 1981.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents
Recommendation for eriodictyol usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 25
 average usual ppmaverage maximum ppm
baked goods: 20.00000100.00000
beverages(nonalcoholic): 20.00000150.00000
beverages(alcoholic): 20.00000100.00000
breakfast cereal: 20.00000100.00000
cheese: --
chewing gum: 50.00000250.00000
condiments / relishes: --
confectionery froastings: 20.00000100.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: 20.00000100.00000
fruit ices: --
gelatins / puddings: 20.00000100.00000
granulated sugar: --
gravies: --
hard candy: 20.00000100.00000
imitation dairy: 20.00000100.00000
instant coffee / tea: 20.00000100.00000
jams / jellies: --
meat products: --
milk products: 20.00000100.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: 50.00000200.00000
snack foods: 20.00000100.00000
soft candy: --
soups: 20.00000100.00000
sugar substitutes: 20.00000100.00000
sweet sauces: 20.00000100.00000
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5280445
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
Chemidplus:0000491703
RTECS:LK9275210 for cas# 491-70-3
 
References:
 2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5280445
Pubchem (sid):134976637
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C01514
HMDB (The Human Metabolome Database):HMDB05800
FooDB:FDB013255
FDA Color Additive Status ListView
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 alfalfa
Search Trop Picture
 anise seed
Search Trop Picture
 apple heart wood
Search Trop Picture
 ashitaba
Search Trop Picture
 basil
Search Trop Picture
 basil leaf
Search Trop Picture
 basil plant
Search Trop Picture
 bean black bean plant
Search Trop Picture
 cacao plant
Search Trop Picture
 capsicum annuum
Search Trop Picture
 carrot plant
Search Trop Picture
 celery leaf
Search Trop Picture
 celery plant
Search Trop Picture
 celery seed
Search Trop Picture
 chamomile garden chamomile plant
Search Trop Picture
 chamomile sweet false chamomile flower
Search Trop Picture
 chamomillae requtita
Search Trop Picture
 cornmint shoot
Search Trop Picture
 cumin leaf
Search Trop Picture
 cumin seed
Search Trop Picture
 cynara scolymus
Search Trop Picture
 dandelion flower
Search Trop Picture
 fenugreek
Search Trop Picture
 fenugreek plant
Search Trop Picture
 fenugreek seed
Search Trop Picture
 flax plant
Search Trop Picture
 ginkgo biloba leaf
Search Trop Picture
 grape leaf
Search Trop Picture
 lemon flower
Search Trop Picture
 lemongrass leaf
Search Trop Picture
 lentil
Search Trop Picture
 lettuce plant
Search Trop Picture
 lotus indian lotus flower
Search Trop Picture
 olive leaf
Search Trop Picture
 oregano leaf
Search Trop Picture
 oregano plant
Search Trop Picture
 parsley plant
Search Trop Picture
 parsley tissue culture
Search Trop Picture
 peanut
Search Trop Picture
 peanut plant
Search Trop Picture
 pepper bell pepper fruit
Search Trop Picture
 peppermint leaf
Search Trop Picture
 pomegranate fruit
Search Trop Picture
 pomegranate leaf
Search Trop Picture
 pomegranate pericarp
Search Trop Picture
 pomegranate plant
Search Trop Picture
 potato flower
Search Trop Picture
 reseda luteola
Search Trop Picture
 rosemary leaf
Search Trop Picture
 rosemary plant
Search Trop Picture
 sage leaf
Search Trop Picture
 sage shoot
Search Trop Picture
 salsify plant
Search Trop Picture
 spearmint leaf
Search Trop Picture
 tarragon plant
Search Trop Picture
 tarragon shoot
Search Trop Picture
 thyme leaf
Search Trop Picture
 thyme plant
Search Trop Picture
 yarrow
Search Trop Picture
 yerba santa
Search Trop Picture
 
Synonyms:
 c.i. 75590
 ci 75590
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-benzopyrone
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
 eriodictyol
 luteolin
 natural yellow 2
3',4',5,7-tetrahydroxyflavanone
 

Articles:

PubMed:Identification of bisprenylated benzoic acid derivatives from yerba santa (Eriodictyon ssp.) using sensory-guided fractionation.
J-Stage:Inhibitory Effect of Eriodictyol on IgE/Ag-Induced Type I Hypersensitivity
PubMed:New bitter-masking compounds: hydroxylated benzoic acid amides of aromatic amines as structural analogues of homoeriodictyol.
PubMed:Bioactive Compounds from Culinary Herbs Inhibit a Molecular Target for Type 2 Diabetes Management, Dipeptidyl Peptidase IV.
PubMed:Feijoa sellowiana Berg fruit juice: anti-inflammatory effect and activity on superoxide anion generation.
PubMed:Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis.
PubMed:Hexanoyl-lysine as an oxidative-injured marker - application of development of functional food.
PubMed:Food ingredient extracts of Cyclopia subternata (Honeybush): variation in phenolic composition and antioxidant capacity.
PubMed:Screening natural antioxidants in peanut shell using DPPH-HPLC-DAD-TOF/MS methods.
PubMed:Flavonoid deactivation of excited state flavins: reaction monitoring by mass spectrometry.
PubMed:Analysis of hydrolyzable tannins and other phenolic compounds in emblic leafflower (Phyllanthus emblica L.) fruits by high performance liquid chromatography-electrospray ionization mass spectrometry.
PubMed:Effect of eriodictyol on glucose uptake and insulin resistance in vitro.
PubMed:Engineering the production of major catechins by Escherichia coli carrying metabolite genes of Camellia sinensis.
PubMed:Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines.
PubMed:Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity.
PubMed:Evaluation of flavonoids and enterolactone in overnight urine as intake biomarkers of fruits, vegetables and beverages in the Inter99 cohort study using the method of triads.
PubMed:Bioactive polyphenols in leaves, stems, and berries of Saskatoon (Amelanchier alnifolia Nutt.) cultivars.
PubMed:Transport mechanisms of flavanone aglycones across Caco-2 cell monolayers and artificial PAMPA membranes.
PubMed:Protective effect of Calamintha officinalis Moench leaves against alcohol-induced gastric mucosa injury in rats. Macroscopic, histologic and phytochemical analysis.
PubMed:Functional expression of geraniol 10-hydroxylase reveals its dual function in the biosynthesis of terpenoid and phenylpropanoid.
PubMed:Free fruit at workplace intervention increases total fruit intake: a validation study using 24 h dietary recall and urinary flavonoid excretion.
PubMed:Depsides and other polar constituents from Origanum dictamnus L. and their in vitro antimicrobial activity in clinical strains.
PubMed:Antioxidant activity and phenolic profile of pistachio (Pistacia vera L., variety Bronte) seeds and skins.
PubMed:Phenolic compounds in cherry ( Prunus avium ) heartwood with a view to their use in cooperage.
PubMed:Identification of bisprenylated benzoic acid derivatives from yerba santa (Eriodictyon ssp.) using sensory-guided fractionation.
PubMed:Effect of pre-drying treatments and storage on color and phenolic composition of green honeybush (Cyclopia subternata) herbal tea.
PubMed:Identification of compounds in adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seed hull extracts that inhibit lipopolysaccharide-induced inflammation in RAW 264.7 macrophages.
PubMed:Effects of phenolic compounds on the browning of cooked barley.
PubMed:Bioavailability of C-linked dihydrochalcone and flavanone glucosides in humans following ingestion of unfermented and fermented rooibos teas.
PubMed:Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract.
PubMed:Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C-glycoside.
PubMed:Analysis of flavonoids in propolis and Ginkgo biloba by micellar electrokinetic capillary chromatography.
PubMed:Dietary flavonoid sources in Australian adults.
PubMed:Characterization of phenolic compounds in rooibos tea.
PubMed:Evaluation of natural antioxidants of Leuzea carthamoides as a result of a screening study of 88 plant extracts from the European Asteraceae and Cichoriaceae.
PubMed:Alterations of flavonoid biosynthesis in young grapevine (Vitis vinifera L.) leaves, flowers, and berries induced by the dioxygenase inhibitor prohexadione-Ca.
PubMed:Transepithelial transport of flavanone in intestinal Caco-2 cell monolayers.
PubMed:Antimicrobial activity of flavonoids extracted from bergamot (Citrus bergamia Risso) peel, a byproduct of the essential oil industry.
PubMed:Identification and quantification of flavonoids of Mexican oregano (Lippia graveolens) by LC-DAD-ESI/MS analysis.
PubMed:Kinetic model for the antiradical activity of the isolated p-catechol group in flavanone type structures using the free stable radical 2,2-diphenyl-1-picrylhydrazyl as the antiradical probe.
PubMed:New bitter-masking compounds: hydroxylated benzoic acid amides of aromatic amines as structural analogues of homoeriodictyol.
PubMed:Pistachio skin phenolics are destroyed by bleaching resulting in reduced antioxidative capacities.
PubMed:Polar constituents from the aerial parts of Origanum vulgare L. Ssp. hirtum growing wild in Greece.
PubMed:Characterization of flavonoids and pectins from bergamot (Citrus bergamia Risso) peel, a major byproduct of essential oil extraction.
PubMed:Evaluation of bitter masking flavanones from Herba Santa (Eriodictyon californicum (H. and A.) Torr., Hydrophyllaceae).
PubMed:Isolation and structure elucidation of phenolic antioxidants from Tamarind (Tamarindus indica L.) seeds and pericarp.
PubMed:The pig caecum model: a suitable tool to study the intestinal metabolism of flavonoids.
PubMed:Screening of free radical scavenging compounds in water extracts of Mentha samples using a postcolumn derivatization method.
PubMed:Bioguided isolation and identification of the nonvolatile antioxidant compounds from fennel (Foeniculum vulgare Mill.) waste.
PubMed:Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells.
PubMed:Inhibitory effect of some flavonoids on tumor necrosis factor-alpha production in lipopolysaccharide-stimulated mouse macrophage cell line J774.1.
PubMed:Effect of the rootstock and interstock grafted in lemon tree (Citrus limon (L.) Burm.) on the flavonoid content of lemon juice.
PubMed:Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha.
PubMed:Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of heteropolyflavan-3-ols and glucosylated heteropolyflavans in sorghum [Sorghum bicolor (L.) Moench].
PubMed:In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids.
PubMed:Identification and antioxidant activity of flavonoid metabolites in plasma and urine of eriocitrin-treated rats.
PubMed:Japanese intake of flavonoids and isoflavonoids from foods.
 
Notes:
Widespread flavanone found esp. in citrus fruits (lemon, tangerine, orange, grapefruit and pummelo) and peppermint. Glycosides also widely distributed Flavone v. widespread in plant world; found esp. in celery, peppermint, rosemary, thyme and Queen Anne's Lace leaves (wild carrot). Potential nutriceutical
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy