EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

fraxidin
2H-1-benzopyran-2-one, 8-hydroxy-6,7-dimethoxy-

Supplier Sponsors

Name:8-hydroxy-6,7-dimethoxychromen-2-one
CAS Number: 525-21-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:208-370-7
FDA UNII: Search
Nikkaji Web:J11.697A
MDL:MFCD00017492
XlogP3-AA:1.50 (est)
Molecular Weight:222.19670000
Formula:C11 H10 O5
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 424.00 to 425.00 °C. @ 760.00 mm Hg (est)
Flash Point: 340.00 °F. TCC ( 171.00 °C. ) (est)
logP (o/w): 0.793 (est)
Soluble in:
 water, 1.462e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Fraxidin >98%
Odor: characteristic
Use: Fraxidin is natural coumarin found in the herbs of Sarcandra glabra.
Coompo
For experimental / research use only.
Fraxidin from Plants ≥96%
ExtraSynthese
For experimental / research use only.
Fraxidin (HPLC) ≥95%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for fraxidin usage levels up to:
 not for fragrance use.
 
Recommendation for fraxidin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3083616
National Institute of Allergy and Infectious Diseases:Data
8-hydroxy-6,7-dimethoxychromen-2-one
Chemidplus:0000525213
 
References:
 8-hydroxy-6,7-dimethoxychromen-2-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):3083616
Pubchem (sid):135230532
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C17479
HMDB (The Human Metabolome Database):Search
FooDB:FDB012577
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 chloranthvs holostegius
Search Trop Picture
 durian
Search Trop Picture
 watermelon seed
Search Trop Picture
 
Synonyms:
2H-1-benzopyran-2-one, 8-hydroxy-6,7-dimethoxy-
8-hydroxy-6,7-dimethoxy-2-benzopyrone
8-hydroxy-6,7-dimethoxychromen-2-one
 

Articles:

PubMed:Development of a highly visual, simple, and rapid test for the discovery of novel insulin mimetics in living vertebrates.
PubMed:Chemical constituents of Allophylus longipes.
PubMed:Constituents of the root of Anemone tomentosa.
PubMed:Inhibitory effects of coumarins from the stem barks of Fraxinus rhynchophylla on adipocyte differentiation in 3T3-L1 cells.
PubMed:Erymildbraedin A and B, two novel cytotoxic dimethylpyrano-isoflavones from the stem bark of Erythrina mildbraedii: evaluation of their activity toward endocrine cancer cells.
PubMed:[Studies on chemical constituents and antibacterial activity from n-butanol extract of Sarcandra glabra].
PubMed:Development of a rapid and validated method for investigating the metabolism of scoparone in rat using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry.
PubMed:Secondary metabolites from the wood bark of Durio zibethinus and Durio kutejensis.
PubMed:Metabolic fate of fraxin administered orally to rats.
PubMed:Natural compounds,fraxin and chemicals structurally related to fraxin protect cells from oxidative stress.
PubMed:Cytotoxic constituents of the twigs of Simarouba glauca collected from a plot in Southern Florida.
PubMed:Four new coumarin derivatives from Artemisia keiskeana.
PubMed:Antihyperglycemic activity of Teramnus labialis (Fabaceae).
PubMed:In vitro inducible nitric oxide synthesis inhibitory active constituents from Fraxinus rhynchophylla.
PubMed:Inhibition of the formation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid from arachidonic acid in polymorphonuclear leukocytes by various coumarins.
 
Notes:
None found
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