EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes


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CAS Number: 486-66-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:207-635-4
Nikkaji Web:J6.014C
Beilstein Number:231523
XlogP3-AA:2.50 (est)
Molecular Weight:254.24150000
Formula:C15 H10 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Pubchem Patents:Search
Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 323.00 °C. @ 760.00 mm Hg
Boiling Point: 512.00 to 513.00 °C. @ 760.00 mm Hg (est)
Flash Point: 394.00 °F. TCC ( 201.20 °C. ) (est)
logP (o/w): 2.632 (est)
Soluble in:
 water, 568.4 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
Alfa Biotechnology
For experimental / research use only.
Daidzein 98%
BOC Sciences
For experimental / research use only.
Daidzein >98%
Odor: characteristic
Use: Daidzein belongs to the group of isoflavones.Daidzein can be converted to its end metabolite S-equol in some humans based on the presence of certain intestinal bacteria. Based on several decades of research,
For experimental / research use only.
Daidzein from Plants ≥96%
Odor: characteristic
Use: Isoflavone daidzein transactivates all three PPAR isoforms, a, d, and ? and influences target cells. Similar to another isoflavone genistein, daidzein at concentrations between 1 and 100 uM activates PPARs in a dose dependent way in KS483 mesenchymal progenitor cells, breast cancer MCF-7 cells, T47D cells and MDA-MD-231 cells. Studies have shown that both ERs and PPARs influence each other and therefore induce differential effects in a dose-dependent way. The final biological effects of daidzein are determined by the balance among these pleiotrophic actions. Daidzein has both estrogenic and anti-estrogenic effects. Soy supplements are often consumed by women for alleviating menopausal symptoms or for the perceived protective effects against breast cancer, particularly after a well documented low incidence rates of breast cancer and high soy food intake among Asian women. But taking soy supplements carries serious risks of harm, especially in people who already have cancer and are taking drugs to treat the cancer. Experimental evidence in cells and in animals show that even low concentration stimulates breast tumor growth in in vitro and in vivo, and interfere with the antitumor effect of the cancer drug, tamoxifen. daidzein was demonstrated to induce human MCF-7 breast cancer cell line apoptosis through the mitochondrial caspase-dependent cell death pathway. However, epidemiological studies suggest that consuming soy isoflavones reduces the risks of certain types of cancer including breast and endometrial. Scientific studies of daidzein's antioxidant abilities have given contradictory results: some studies have shown antioxidant properties in laboratory experiments on cells, but in other experiments daidzein has caused oxidative stress on cells. Weak pro-estrogen and anti-estrogen activity which may be helpful in postmenopausal women.
For experimental / research use only.
Daidzein (HPLC) ≥95%
Glentham Life Sciences
Nacalai USA
For experimental / research use only.
Santa Cruz Biotechnology
For experimental / research use only.
Daidzein >98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Daidzein ≥98%, synthetic
For experimental / research use only.
Daidzein >98.0%(HPLC)(T)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 > 2000 mg/kg
Pharmaceutical Chemistry Journal Vol. 13, Pg. 51, 1979.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
natural substances and extractives
Recommendation for daidzein usage levels up to:
 not for fragrance use.
Recommendation for daidzein flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Preparatory work to support the risk assessment for peri- and postmenopausal women taking food supplements containing isolated isoflavones
View page or View pdf

Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281708
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
RTECS:DJ3100040 for cas# 486-66-8
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5281708
Pubchem (sid):135023643
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
Golm Metabolome Database:Search
KEGG (GenomeNet):C10208
HMDB (The Human Metabolome Database):HMDB03312
Export Tariff Code:2932.99.7000
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 bean adzuki bean seed
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 bean black bean fruit
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 bean black bean seed
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 bean butter bean seed
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 bean fava bean seed
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 bean mung bean seed
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 bean mung bean sprout
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 bean scarlet runner bean
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 bean scarlet runner bean plant
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 chickpea seed
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 chickpea sprout
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 lentil seed
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 pea black-eyed pea seed
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 pea black-eyed pea sprout
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 pea pigeon pea
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 pea seed
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 soybean cotyledon
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 soybean embryo
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 soybean hypocotyl
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 soybean leaf
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 soybean plant
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 soybean root
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 soybean seed
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 soybean seed coat
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 soybean shoot
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 soybean testa
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PubMed:Assessment of dietary phytoestrogen intake via plant-derived foods in China.
PubMed:Large inter-individual variation in isoflavone plasma concentration limits use of isoflavone intake data for risk assessment.
PubMed:β-Glucosidase activity and bioconversion of isoflavones during fermentation of soymilk.
PubMed:Identification and quantification of the main isoflavones and other phytochemicals in soy based nutraceutical products by liquid chromatography-orbitrap high resolution mass spectrometry.
PubMed:Soy and isoflavone intake associated with reduced risk of ovarian cancer in southern Chinese women.
PubMed:The Active Role of Leguminous Plant Components in Type 2 Diabetes.
PubMed:Daidzein suppresses tumor necrosis factor-α induced migration and invasion by inhibiting hedgehog/Gli1 signaling in human breast cancer cells.
PubMed:Essential Structural Requirements and Additive Effects for Flavonoids to Scavenge Methylglyoxal.
PubMed:Cooperative effects of soy isoflavones and carotenoids on osteoclast formation.
PubMed:Soy Sauce Residue Oil Extracted by a Novel Continuous Phase Transition Extraction under Low Temperature and Its Refining Process.
PubMed:Soy food frequency questionnaire does not correlate with baseline isoflavone levels in patients with bladder cancer.
PubMed:A diet formula of Puerariae radix, Lycium barbarum, Crataegus pinnatifida, and Polygonati rhizoma alleviates insulin resistance and hepatic steatosis in CD-1 mice and HepG2 cells.
PubMed:Oxidative metabolism enhances the cytotoxic and genotoxic properties of the soy isoflavone daidzein.
PubMed:R(-)-O-desmethylangolensin is the main enantiomeric form of daidzein metabolite produced by human in vitro and in vivo.
PubMed:Malonyl isoflavone glucosides are chiefly hydrolyzed and absorbed in the colon.
PubMed:Soybean-derived glyceollins induce apoptosis through ROS generation.
PubMed:Quantitative trait loci for seed isoflavone contents in 'MD96-5722' by 'Spencer' recombinant inbred lines of soybean.
PubMed:Isoflavones profiling of soybean [Glycine max (L.) Merrill] germplasms and their correlations with metabolic pathways.
PubMed:Isoflavonoids in the Amaryllidaceae family.
PubMed:Glyceollin transport, metabolism, and effects on p-glycoprotein function in Caco-2 cells.
PubMed:Effect of Phellinus baumii-Biotransformed Soybean Powder on Lipid Metabolism in Rats.
PubMed:S-(-)equol producing status not associated with breast cancer risk among low isoflavone-consuming US postmenopausal women undergoing a physician-recommended breast biopsy.
PubMed:Pharmacokinetics of equol, a soy isoflavone metabolite, changes with the form of equol (dietary versus intestinal production) in ovariectomized rats.
PubMed:The effects of dietary treatment with S-equol on learning and memory processes in middle-aged ovariectomized rats.
PubMed:Daidzein regulates proinflammatory adipokines thereby improving obesity-related inflammation through PPARγ.
PubMed:Xylitol affects the intestinal microbiota and metabolism of daidzein in adult male mice.
PubMed:Whole soy, but not purified daidzein, had a favorable effect on improvement of cardiovascular risks: a 6-month randomized, double-blind, and placebo-controlled trial in equol-producing postmenopausal women.
PubMed:Deglycosylation of isoflavones in isoflavone-rich soy germ flour by Aspergillus oryzae KACC 40247.
PubMed:Estrogen receptor and PI3K/Akt signaling pathway involvement in S-(-)equol-induced activation of Nrf2/ARE in endothelial cells.
PubMed:Effects of daidzein and kiwifruit on bone mineral density and equol production in ovariectomised rats.
PubMed:Daidzein supplementation decreases serum triglyceride and uric acid concentrations in hypercholesterolemic adults with the effect on triglycerides being greater in those with the GA compared with the GG genotype of ESR-β RsaI.
PubMed:Metabolomic analysis of the polyphenols in germinating mung beans (Vigna radiata) seeds and sprouts.
PubMed:Transport mechanisms for soy isoflavones and microbial metabolites dihydrogenistein and dihydrodaidzein across monolayers and membranes.
PubMed:Habitual consumption of soy products and risk of nasopharyngeal carcinoma in Chinese adults: a case-control study.
PubMed:Evaluation of estrogenic activity in animal diets using in vitro assay.
PubMed:Ultra-high-performance liquid chromatography-tandem mass spectrometry for pharmacokinetics of bakuchiol in rats.
PubMed:Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects: A Development of Potential Health Products and Therapeutic Drugs against Alzheimer's Disease.
PubMed:Kinetic changes of nutrients and antioxidant capacities of germinated soybean (Glycine max L.) and mung bean (Vigna radiata L.) with germination time.
PubMed:Effect of phytoestrogens on basal and GnRH-induced gonadotropin secretion.
PubMed:Antihyperglycemic effect of equol, a daidzein derivative, in cultured L6 myocytes and ob/ob mice.
PubMed:Inhibition of hydroxycinnamic acid sulfation by flavonoids and their conjugated metabolites.
PubMed:Effects of short-term fructooligosaccharide intake on equol production in Japanese postmenopausal women consuming soy isoflavone supplements: a pilot study.
PubMed:Equol-producing status, isoflavone intake, and breast density in a sample of U.S. Chinese women.
PubMed:The isoflavone irilone contributes to the estrogenic potential of dietary supplements containing red clover.
PubMed:Urinary concentrations of environmental contaminants and phytoestrogens in adults in Israel.
PubMed:Daidzein causes cytochrome c-mediated apoptosis via the Bcl-2 family in human hepatic cancer cells.
PubMed:Biochanin A affects steroidogenesis and estrogen receptor-β expression in porcine granulosa cells.
PubMed:Inhibitory effects of a major soy isoflavone, genistein, on human DNA topoisomerase II activity and cancer cell proliferation.
PubMed:The inhibitory effect of black soybean on hepatic cholesterol accumulation in high cholesterol and high fat diet-induced non-alcoholic fatty liver disease.
PubMed:Rapid magnetic solid-phase extraction for the selective determination of isoflavones in soymilk using baicalin-functionalized magnetic nanoparticles.
PubMed:Possible role of S-equol on bone loss via amelioration of inflammatory indices in ovariectomized mice.
PubMed:Effect of soybean processing on content and bioaccessibility of folate, vitamin B12 and isoflavones in tofu and tempe.
PubMed:Combination of low dose of genistein and daidzein has synergistic preventive effects on isogenic human prostate cancer cells when compared with individual soy isoflavone.
PubMed:Isolation and characterization of novel S-equol-producing bacteria from brines of stinky tofu, a traditional fermented soy food in Taiwan.
PubMed:Urinary phytoestrogen levels related to idiopathic male infertility in Chinese men.
PubMed:Development of a simple, fast, and accurate method for the direct quantification of selective estrogen receptor modulators using stable isotope dilution mass spectrometry.
PubMed:Endocrine disrupting effects in rats perinatally exposed to a dietary relevant mixture of phytoestrogens.
PubMed:Pharmacological administration of the isoflavone daidzein enhances cell proliferation and reduces high fat diet-induced apoptosis and gliosis in the rat hippocampus.
PubMed:A metabolite of daidzein, 6,7,4'-trihydroxyisoflavone, suppresses adipogenesis in 3T3-L1 preadipocytes via ATP-competitive inhibition of PI3K.
PubMed:Diverse effects of phytoestrogens on the reproductive performance: cow as a model.
PubMed:Urinary flavonoid excretion and risk of acute coronary syndrome in a nested case-control study.
PubMed:Response surface methodology as optimization strategy for reduction of reactive carbonyl species in foods by means of phenolic chemistry.
PubMed:Daidzein inhibits carbohydrate digestive enzymes in vitro and alleviates postprandial hyperglycemia in diabetic mice.
PubMed:Mobility and microbial activity of allelochemicals in soil.
PubMed:Activation of AMP-activated protein kinase alleviates homocysteine-mediated neurotoxicity in SH-SY5Y cells.
PubMed:Daidzein, R-(+)equol and S-(-)equol inhibit the invasion of MDA-MB-231 breast cancer cells potentially via the down-regulation of matrix metalloproteinase-2.
PubMed:Self-reported menopausal symptoms in a racially diverse population and soy food consumption.
PubMed:TPGS emulsified zein nanoparticles enhanced oral bioavailability of daidzin: in vitro characteristics and in vivo performance.
PubMed:Influence of isoflavone intake and equol-producing intestinal flora on prostate cancer risk.
PubMed:Population versus hospital controls in the assessment of dietary intake of isoflavone for case-control studies on cancers in China.
PubMed:Determination of the variations in levels of phenolic compounds in soybean (Glycine max Merr.) sprouts infected by anthracnose (Colletotrichum gloeosporioides).
PubMed:Opposing--activating or inhibitory--effects of cimetidine and daidzein on human ADH1C activity depending on substrates and solvents.
PubMed:The emerging potent anti- neoplastic effects of daidzein.
PubMed:Dietary isoflavone intake, urinary isoflavone level, and their relationship with metabolic syndrome diagnostic components in korean postmenopausal women.
PubMed:Safety evaluation of daidzein in laying hens: part I. Effects on laying performance, clinical blood parameters, and organs development.
PubMed:Safety evaluation of daidzein in laying hens: part II. Effects on calcium-related metabolism.
PubMed:Soy protein, genistein, and daidzein improve serum paraoxonase activity and lipid profiles in rheumatoid arthritis in rats.
PubMed:Inhibitory effects of black soybean on platelet activation mediated through its active component of adenosine.
PubMed:Isoflavone metabolism in domestic cats (Felis catus): comparison of plasma metabolites detected after ingestion of two different dietary forms of genistein and daidzein.
PubMed:Development of a food compositional database for the estimation of dietary intake of phyto-oestrogens in a group of postmenopausal women previously treated for breast cancer and validation with urinary excretion.
PubMed:Genistein and daidzein: different molecular effects on prostate cancer.
PubMed:Effect of the genistein metabolite on leptin secretion in murine adipocytes in vitro.
PubMed:Bayesian statistical approaches to compositional analyses of transgenic crops 2. Application and validation of informative prior distributions.
PubMed:Daidzein-estrogen interaction in the rat uterus and its effect on human breast cancer cell growth.
PubMed:A comparative analysis of the photo-protective effects of soy isoflavones in their aglycone and glucoside forms.
PubMed:Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks.
PubMed:Effects of dietary genistein on hormone-dependent rat mammary carcinogenesis induced by ethyl methanesulphonate.
PubMed:A modified QuEChERS method as sample treatment before the determination of isoflavones in foods by ultra-performance liquid chromatography-triple quadrupole mass spectrometry.
PubMed:Isoflavones, genistein and daidzein, regulate mucosal immune response by suppressing dendritic cell function.
PubMed:Genistein and daidzein, typical soy isoflavones, inhibit TNF-α-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes.
PubMed:Relationship between serum isoflavone levels and disability-free survival among community-dwelling elderly individuals: nested case-control study of the Tsurugaya project.
PubMed:Interaction effects between genes involved in the AKT signaling pathway and phytoestrogens in gastric carcinogenesis: a nested case-control study from the Korean Multi-Center Cancer Cohort.
PubMed:Antioxidant and Antityrosinase Activity of Flemingia macrophylla and Glycine tomentella Roots.
PubMed:Fast simultaneous determination of free and conjugated isoflavones in soy milk by UHPLC-UV.
PubMed:Apoptotic effects of cooked and in vitro digested soy on human prostate cancer cells.
PubMed:Postharvest dehydration of wine white grapes to increase genistein, daidzein and the main carotenoids.
PubMed:Bioavailability of glycitein relatively to other soy isoflavones in healthy young Caucasian men.
PubMed:Effects of rice bran oil on the intestinal microbiota and metabolism of isoflavones in adult mice.
PubMed:Constituents from Vigna vexillata and Their Anti-Inflammatory Activity.
PubMed:Urinary isoflavonoids and risk of coronary heart disease.
PubMed:Distribution of isoflavones and coumestrol in neglected tropical and subtropical legumes.
PubMed:Isoflavones suppress the expression of the FcεRI high-affinity immunoglobulin E receptor independent of the estrogen receptor.
PubMed:Mammographic breast density and serum phytoestrogen levels.
PubMed:(±)Equol inhibits invasion in prostate cancer DU145 cells possibly via down-regulation of matrix metalloproteinase-9, matrix metalloproteinase-2 and urokinase-type plasminogen activator by antioxidant activity.
PubMed:Impact of food matrix on isoflavone metabolism and cardiovascular biomarkers in adults with hypercholesterolemia.
PubMed:Phytoestrogens genistein and daidzein affect immunity in the nematode Caenorhabditis elegans via alterations of vitellogenin expression.
PubMed:Differential suppression of intracellular reactive oxygen species-mediated signaling pathway in vascular endothelial cells by several subclasses of flavonoids.
PubMed:The presence of monoiodinated derivates of daidzein and genistein in human urine and its effect on thyroid gland function.
PubMed:Daidzein improves insulin resistance in ovariectomized rats.
PubMed:Isoflavone supplementation reduces DNA oxidative damage and increases O-β-N-acetyl-D-glucosaminidase activity in healthy women.
PubMed:Differential effects of flavonoids on barrier integrity in human intestinal Caco-2 cells.
PubMed:Study on the interference of rat feed to pharmacokinetics of flavonoids.
PubMed:Nutraceutical-mediated restoration of wild-type levels of IKBKAP-encoded IKAP protein in familial dysautonomia-derived cells.
PubMed:Correlations of urinary phytoestrogen excretion with lifestyle factors and dietary intakes among middle-aged and elderly Chinese women.
PubMed:Regulation of the immune response by soybean isoflavones.
PubMed:Bactericidal activity of soymilk fermentation broth by in vitro and animal models.
PubMed:Elucidation of the metabolic pathway of S-equol in rat, monkey and man.
PubMed:Effect of Aspergillus oryzae-challenged germination on soybean isoflavone content and antioxidant activity.
PubMed:Toxicokinetics and lack of uterotropic effect of orally administered S-equol.
PubMed:Does equol production determine soy endocrine effects?
PubMed:Mesquite pod extract modifies the reproductive physiology and behavior of the female rat.
PubMed:Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities.
PubMed:Genistein as a potential inducer of the anti-atherogenic enzyme paraoxonase-1: studies in cultured hepatocytes in vitro and in rat liver in vivo.
PubMed:Antiallergic activity of novel isoflavone methyl-glycosides from Cordyceps militaris grown on germinated soybeans in antigen-stimulated mast cells.
PubMed:[Equol-producing phenotype and in relation to serum sex hormones among healthy adults in Beijing].
PubMed:Soy germ isoflavones improve menopausal symptoms but have no effect on blood lipids in early postmenopausal Chinese women: a randomized placebo-controlled trial.
PubMed:Effect of daidzein-low-calorie diet on body weight, serum levels of glucose, resistin, and high sensitive C-reactive protein in high fat, high calorie diet induced rats.
PubMed:Effect of Lactobacillus sporogenes on oral isoflavones bioavailability: single dose pharmacokinetic study in menopausal women.
PubMed:Analysis of isoflavones in soybeans employing direct analysis in real-time ionization-high-resolution mass spectrometry.
PubMed:Reproductive consequences of developmental phytoestrogen exposure.
PubMed:Effect of Dietary l-arabinose on the Intestinal Microbiota and Metabolism of Dietary Daidzein in Adult Mice.
PubMed:Dietary isoflavone absorption, excretion, and metabolism in captive cheetahs (Acinonyx jubatus).
PubMed:Mutagenicity of ipriflavone in vivo and in vitro.
PubMed:Legume, soy, tofu, and isoflavone intake and endometrial cancer risk in postmenopausal women in the multiethnic cohort study.
PubMed:Antimicrobial compounds profile during Cheonggukjang fermentation against Xanthomonas oryzae pv. oryzae (Xoo).
PubMed:DNA methylation and soy phytoestrogens: quantitative study in DU-145 and PC-3 human prostate cancer cell lines.
PubMed:Soy isoflavones and cardiovascular disease epidemiological, clinical and -omics perspectives.
PubMed:Effects of high temperature stress at different development stages on soybean isoflavone and tocopherol concentrations.
PubMed:Quantification of a novel natural antioxidant (UP302) in rat plasma using ultra-high performance liquid chromatography-tandem mass spectrometry.
PubMed:Soyabean glyceollins: biological effects and relevance to human health.
PubMed:Chemical Structures of 4-Oxo-Flavonoids in Relation to Inhibition of Oxidized Low-Density Lipoprotein (LDL)-Induced Vascular Endothelial Dysfunction.
PubMed:Chain length effects in isoflavonoid daidzein alkoxy derivatives as antioxidants: a quantum mechanical approach.
PubMed:NTP-CERHR expert panel report on the developmental toxicity of soy infant formula.
PubMed:Experimentally induced mastitis and metritis modulate soy bean derived isoflavone biotransformation in diary cows.
PubMed:Polyphenol content and antioxidant properties of colored soybean seeds from central Europe.
PubMed:Red clover and soy isoflavones--an in vitro safety assessment.
PubMed:Lesser in vitro anaerobic cecal isoflavone disappearance was associated with greater apparent absorption of daidzein and genistein in Golden Syrian hamsters.
PubMed:The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems.
PubMed:Association between dietary phyto-oestrogens and bone density in men and postmenopausal women.
PubMed:Occurrence and mass balance of isoflavones on an experimental grassland field.
PubMed:Effects of S-equol and natural S-equol supplement (SE5-OH) on the growth of MCF-7 in vitro and as tumors implanted into ovariectomized athymic mice.
PubMed:Soybean isoflavones regulate dendritic cell function and suppress allergic sensitization to peanut.
PubMed:The role of soy isoflavones in menopausal health: report of The North American Menopause Society/Wulf H. Utian Translational Science Symposium in Chicago, IL (October 2010).
PubMed:High serum isoflavone concentrations are associated with the risk of precocious puberty in Korean girls.
PubMed:Apparent bioavailability of isoflavones in urinary excretions of postmenopausal Malay women consuming tempeh compared with milk.
PubMed:Increasing soy isoflavonoid content and diversity by simultaneous malting and challenging by a fungus to modulate estrogenicity.
PubMed:Reduction of body weight, liver steatosis and expression of stearoyl-CoA desaturase 1 by the isoflavone daidzein in diet-induced obesity.
PubMed:Resistant starch promotes equol production and inhibits tibial bone loss in ovariectomized mice treated with daidzein.
PubMed:Secondary metabolites from Glycine soja and their growth inhibitory effect against Spodoptera litura.
PubMed:Effects of riboflavin photosensitization on daidzein and its photosensitized derivatives.
PubMed:Soy-derived isoflavones inhibit HeLa cell growth by inducing apoptosis.
PubMed:The metabolism of [14C]-zibotentan (ZD4054) in rat, dog and human, the loss of the radiolabel and the identification of an anomalous peak, derived from the animal feed.
PubMed:Dairy consumption is a significant correlate of urinary equol concentration in a representative sample of US adults.
PubMed:Lactobacillus rhamnosus JCM 2771: impact on metabolism of isoflavonoids in the fecal flora from a male equol producer.
PubMed:Single-dose and steady-state pharmacokinetic studies of S-equol, a potent nonhormonal, estrogen receptor β-agonist being developed for the treatment of menopausal symptoms.
PubMed:β-carboline derivatives and diphenols from soy sauce are in vitro quinone reductase (QR) inducers.
PubMed:Effects of dietary soy intake on maternal thyroid functions and serum anti-thyroperoxidase antibody level during early pregnancy.
PubMed:Comparison of three thermostable β-glucosidases for application in the hydrolysis of soybean isoflavone glycosides.
PubMed:Effect of flavonoids on basal and insulin-stimulated 2-deoxyglucose uptake in adipocytes.
PubMed:PAMPA permeability, plasma protein binding, blood partition, pharmacokinetics and metabolism of formononetin, a methoxylated isoflavone.
PubMed:Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women: a pilot randomized, placebo-controlled trial.
PubMed:Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6).
PubMed:HPLC/DAD/MS and antioxidant activity of isoflavone-based food supplements.
PubMed:Quantification of five isoflavones and coumestrol in various solid agroenvironmental matrices using ¹³c₃-labeled internal standards.
PubMed:Estrogen receptor-β mediates the inhibition of DLD-1 human colon adenocarcinoma cells by soy isoflavones.
PubMed:Daidzein supplementation prevents non-alcoholic fatty liver disease through alternation of hepatic gene expression profiles and adipocyte metabolism.
PubMed:Higher bioavailability of isoflavones after a single ingestion of aglycone-rich fermented soybeans compared with glucoside-rich non-fermented soybeans in Japanese postmenopausal women.
PubMed:Is equol production beneficial to health?
PubMed:Genistein and daidzein repress adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells via Wnt/β-catenin signalling or lipolysis.
PubMed:Improved in vitro assays of superoxide anion and 1,1-diphenyl- 2-picrylhydrazyl (DPPH) radical-scavenging activity of isoflavones and isoflavone metabolites.
PubMed:Optimizing time and temperature of enzymatic conversion of isoflavone glucosides to aglycones in soy germ flour.
PubMed:Urinary isoflavone phytoestrogens in German children and adolescents--a longitudinal examination in the DONALD cohort.
PubMed:Genotoxicity assessment of S-equol in bacterial mutation, chromosomal aberration, and rodent bone marrow micronucleus tests.
PubMed:Synthesis of isoflavone aglycones and equol in soy milks fermented by food-related lactic acid bacteria and their effect on human intestinal Caco-2 cells.
PubMed:Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose.
PubMed:Mixture effects of dietary flavonoids on steroid hormone synthesis in the human adrenocortical H295R cell line.
PubMed:Profiles of phytoestrogens in human urine from several Asian countries.
PubMed:Free fruit at workplace intervention increases total fruit intake: a validation study using 24 h dietary recall and urinary flavonoid excretion.
PubMed:Thermodynamic versus kinetic control of antioxidant synergism between β-carotene and (iso)flavonoids and their glycosides in liposomes.
PubMed:Influence of natural coagulants on isoflavones and antioxidant activity of tofu.
PubMed:Effect of dietary intake of isoflavones on the estrogen and progesterone receptor status of breast cancer.
PubMed:Brief telephone intervention increases soy intake in peri- and postmenopausal US women: the Herbal Alternatives Trial (HALT).
PubMed:Evaluation of quality of Radix Puerariae herbal medicine by isoflavonoids.
PubMed:Induction effect of coadministration of soybean isoflavones and sodium nitrite on DNA damage in mouse stomach.
PubMed:Flavonoid binding to human serum albumin.
PubMed:Variability in the distribution of phenolic compounds in milled fractions of chickpea and horse gram: evaluation of their antioxidant properties.
PubMed:Differential effects of formononetin and cladrin on osteoblast function, peak bone mass achievement and bioavailability in rats.
PubMed:PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation.
PubMed:Isoflavonoids and peptides from meju, long-term fermented soybeans, increase insulin sensitivity and exert insulinotropic effects in vitro.
PubMed:Suppression of colonic aberrant crypt foci by soy isoflavones is dose-independent in dimethylhydrazine-treated rats.
PubMed:Exogenous gibberellic acid reprograms soybean to higher growth and salt stress tolerance.
PubMed:Formation of succinyl genistin and succinyl daidzin by Bacillus species.
PubMed:Bioconversion of isoflavone glycosides to aglycones, mineral bioavailability and vitamin B complex in fermented soymilk by probiotic bacteria and yeast.
PubMed:Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells.
PubMed:Effect of genistein and daidzein on the proliferation and differentiation of human preadipocyte cell line.
PubMed:Characterization of fermented black soybean natto inoculated with Bacillus natto during fermentation.
PubMed:Antioxidant activity and phenolic profile of pistachio (Pistacia vera L., variety Bronte) seeds and skins.
PubMed:Overnight urinary excretion of isoflavones as an indicator for dietary isoflavone intake in Korean girls of pubertal age.
PubMed:[Prevalence of equol producer phenotype and its relations to lifestyle factors and dietary intakes among lifestyle factors and dietary intakes among healthy Chinese adults in Beijing].
PubMed:Comprehensive profiling of isoflavones, phytosterols, tocopherols, minerals, crude protein, lipid, and sugar during soybean (Glycine max) germination.
PubMed:Absolute bioavailability of isoflavones from soy protein isolate-containing food in female BALB/c mice.
PubMed:Metabolomics revealed novel isoflavones and optimal cultivation time of Cordyceps militaris fermentation.
PubMed:Protective effect of isoflavones against homocysteine-mediated neuronal degeneration in SH-SY5Y cells.
PubMed:Semipurified fractions from the submerged-culture broth of Agaricus blazei Murill reduce blood glucose levels in streptozotocin-induced diabetic rats.
PubMed:Estrogenic activity of glyceollins isolated from soybean elicited with Aspergillus sojae.
PubMed:1H NMR fingerprinting of soybean extracts, with emphasis on identification and quantification of isoflavones.
PubMed:Isoflavones in coffee: influence of species, roast degree, and brewing method.
PubMed:Comparison of Puerariae Radix and its hydrolysate on stimulation of hyaluronic acid production in NHEK cells.
PubMed:Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells.
PubMed:Dietary intake of isoflavones and polyunsaturated fatty acids associated with lung function, breathlessness and the prevalence of chronic obstructive pulmonary disease: possible protective effect of traditional Japanese diet.
PubMed:Developmental and Reproductive Effects of SE5-OH: An Equol-Rich Soy-Based Ingredient.
PubMed:Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity.
PubMed:Impact of elevated levels of atmospheric CO2 and herbivory on flavonoids of soybean (Glycine max Linnaeus).
PubMed:Biotic elicitation of isoflavone metabolism with plant growth promoting rhizobacteria in early stages of development in Glycine max var. Osumi.
PubMed:Absorption of red clover isoflavones in human subjects: results from a pilot study.
PubMed:Regulation of phase II enzymes by genistein and daidzein in male and female Swiss Webster mice.
PubMed:Breast, colorectal, and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition-Norfolk in relation to phytoestrogen intake derived from an improved database.
PubMed:Dietary cholesterol lowers plasma and cecal equol concentrations in mice.
PubMed:Greater apparent absorption of flavonoids is associated with lesser human fecal flavonoid disappearance rates.
PubMed:Enhancement of aglycone, vitamin K2 and superoxide dismutase activity of black soybean through fermentation with Bacillus subtilis BCRC 14715 at different temperatures.
PubMed:Antitumor and antiangiogenic activity of soy phytoestrogen on 7,12-dimethylbenz[alpha]anthracene-induced mammary tumors following ovariectomy in Sprague-Dawley rats.
PubMed:Cosupplementation of isoflavones, prenylflavonoids, and lignans alters human exposure to phytoestrogen-derived 17beta-estradiol equivalents.
PubMed:Soy food consumption and risk of prostate cancer: a meta-analysis of observational studies.
PubMed:Chromatographic quantification of isoflavone content from soy derivates using HPLC technique.
PubMed:Changes of isoflavone profile in the hypocotyls and cotyledons of soybeans during dry heating and germination.
PubMed:The adverse effect of phytoestrogens on the synthesis and secretion of ovarian oxytocin in cattle.
PubMed:Determination of phytoestrogen composition in soybean cultivars in Serbia.
PubMed:Lactobacillus collinoides JCM1123(T): effects on mouse plasma cholesterol and isoflavonoids in the caecum.
PubMed:Glycosylation of dietary flavonoids decreases the affinities for plasma protein.
PubMed:[Exposure of phytoestrogens intake through diet in a sample of females].
PubMed:Transport and metabolism of equol by Caco-2 human intestinal cells.
PubMed:Hypolipidemic effects of Monascus-fermented soybean extracts in rats fed a high-fat and -cholesterol diet.
PubMed:Enterorhabdus caecimuris sp. nov., a member of the family Coriobacteriaceae isolated from a mouse model of spontaneous colitis, and emended description of the genus Enterorhabdus Clavel et al. 2009.
PubMed:Inhibition of angiogenesis and inflammation by an extract of red clover (Trifolium pratense L.).
PubMed:Isolation of a new metabolite from biotransformation of daidzein by Aspergillus oryzae.
PubMed:Changes in isoflavone profiles of soybean treated with gamma irradiation.
PubMed:Effects of equol on oxidized low-density lipoprotein-induced apoptosis in endothelial cells.
PubMed:Isoflavones prevent endoplasmic reticulum stress-mediated neuronal degeneration by inhibiting tau hyperphosphorylation in SH-SY5Y cells.
PubMed:Equol in milk of dairy cows is derived from forage legumes such as red clover.
PubMed:Influence of ethnic origin (Asian v. Caucasian) and background diet on the bioavailability of dietary isoflavones.
PubMed:Identification of a naturally-occurring 8-[alpha-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl]daidzein from cultivated kudzu root.
PubMed:Effect of an isoflavones-containing red clover preparation and alkaline supplementation on bone metabolism in ovariectomized rats.
PubMed:Quantification of almond skin polyphenols by liquid chromatography-mass spectrometry.
PubMed:Apparent bioavailability of isoflavones after intake of liquid and solid soya foods.
PubMed:Effect of glycosidation of isoflavones on their bioavailability and pharmacokinetics in aged male rats.
PubMed:A comparative analysis of genistein and daidzein in affecting lipid metabolism in rat liver.
PubMed:Long-term effects of dietary isoflavones on uterine gene expression profiles.
PubMed:Nanonized black soybean enhances immune response in senescence-accelerated mice.
PubMed:Isoflavone effect on gene expression profile and biomarkers of inflammation.
PubMed:Phytoestrogen content of cereals and cereal-based foods consumed in the UK.
PubMed:Soybean isoflavones in bone health.
PubMed:Differential effect of pure isoflavones and soymilk on estrogen receptor activity in mice.
PubMed:Is equol the key to the efficacy of soy foods?
PubMed:Effect of forage on the content of phyto-oestrogens in bovine milk.
PubMed:Comparison of flavonoids and isoflavonoids as antioxidants.
PubMed:Antiproliferation effect and mechanism of prostate cancer cell lines as affected by isoflavones from soybean cake.
PubMed:Stability of isoflavone isomers in steamed black soybeans and black soybean koji stored under different conditions.
PubMed:Intake of plant foods and associated nutrients in prostate cancer risk.
PubMed:Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: the Life After Cancer Epidemiology study.
PubMed:Prevalence, sources, and predictors of soy consumption in breast cancer.
PubMed:Ileal and faecal digestibility of daidzein and genistein and plasma bioavailability of these isoflavones and their bioactive metabolites in the ovariectomised rat.
PubMed:Dose-dependent effects of genistein and daidzein on protein metabolism in porcine myotube cultures.
PubMed:The role of diet in the metabolism of daidzein by human faecal microbiota sampled from Italian volunteers.
PubMed:Respective contribution exerted by AF-1 and AF-2 transactivation functions in estrogen receptor alpha induced transcriptional activity by isoflavones and equol: consequence on breast cancer cell proliferation.
PubMed:Bowman-Birk inhibitor and genistein among soy compounds that synergistically inhibit nitric oxide and prostaglandin E2 pathways in lipopolysaccharide-induced macrophages.
PubMed:Effects of germination and osmopriming treatment on enhancement of isoflavone contents in various soybean cultivars and cheonggukjang (fermented unsalted soybean paste).
PubMed:Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells.
PubMed:Soy, isoflavones, and prostate cancer.
PubMed:Phytoestrogens and phytoestrogen metabolites differentially modulate immune parameters in human leukocytes.
PubMed:Phytoestrogen content of foods of animal origin: dairy products, eggs, meat, fish, and seafood.
PubMed:Techniques for quantifying effects of dietary antioxidants on transcription factor translocation and nitric oxide production in cultured cells.
PubMed:Effect of frequency and duration of ultrasonication on the extraction efficiency of selected isoflavones and trans-resveratrol from peanuts (Arachis hypogaea).
PubMed:Daidzein as an antioxidant of lipid: effects of the microenvironment in relation to chemical structure.
PubMed:Gastrointestinal absorption and metabolism of soy isoflavonoids in ileal-canulated swine.
PubMed:Novel process of fermenting black soybean [Glycine max (L.) Merrill] yogurt with dramatically reduced flatulence-causing oligosaccharides but enriched soy phytoalexins.
PubMed:Food frequency questionnaires and overnight urines are valid indicators of daidzein and genistein intake in U.S. women relative to multiple 24-h urine samples.
PubMed:Characterization of phenolic substances and antioxidant properties of food soybeans grown in the North Dakota-Minnesota region.
PubMed:Antioxidant capacity of seed coat, dehulled bean, and whole black soybeans in relation to their distributions of total phenolics, phenolic acids, anthocyanins, and isoflavones.
PubMed:Characterisation of bioactive compounds in infant formulas using immobilised recombinant estrogen receptor-alpha affinity columns.
PubMed:Genistein- and daidzein 7-O-beta-D-glucuronic acid retain the ability to inhibit copper-mediated lipid oxidation of low density lipoprotein.
PubMed:Concentrations of isoflavones and their metabolites in the blood of pregnant and non-pregnant heifers fed soy bean.
PubMed:Protective effect of isoflavones from Trifolium pratense on dopaminergic neurons.
PubMed:Isoflavonoid composition of a callus culture of the relict tree Maackia amurensis Rupr. et Maxim.
PubMed:Isoflavones in urine, saliva, and blood of infants: data from a pilot study on the estrogenic activity of soy formula.
PubMed:Biomolecules and nutritional quality of soymilk fermented with probiotic yeast and bacteria.
PubMed:Effects of isoflavone supplements vs. soy foods on blood concentrations of genistein and daidzein in adults.
PubMed:Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells.
PubMed:Effects of clover-grass silages and concentrate supplementation on the content of phytoestrogens in dairy cow milk.
PubMed:Acute and subchronic toxicity and genotoxicity of SE5-OH, an equol-rich product produced by Lactococcus garvieae.
PubMed:Tissue distribution of isoflavones in ewes after consumption of red clover silage.
PubMed:Phytoestrogens modulate the expression of 17alpha-estradiol metabolizing enzymes in cultured MCF-7 cells.
PubMed:Environmental exposures and puberty in inner-city girls.
PubMed:Determination of phytoestrogens in dietary supplements by LC-MS/MS.
PubMed:Detection of estrogenically active substances in diets for sows by an in vitro bioassay supported by HPLC analysis.
PubMed:beta-Conglycinins among sources of bioactives in hydrolysates of different soybean varieties that inhibit leukemia cells in vitro.
PubMed:Validation of soy protein estimates from a food-frequency questionnaire with repeated 24-h recalls and isoflavonoid excretion in overnight urine in a Western population with a wide range of soy intakes.
PubMed:Dietary and lifestyle correlates of urinary excretion status of equol in Japanese women.
PubMed:Oral antibiotics decrease urinary isoflavonoid excretion in children after soy consumption.
PubMed:Docosahexaenoic acid and 17 beta-estradiol co-treatment is more effective than 17 beta-estradiol alone in maintaining bone post-ovariectomy.
PubMed:Long-term effects of phytoestrogen daidzein on penile cavernosal structures in adult rats.
PubMed:Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.S. adults.
PubMed:Demographic, anthropometric, and lifestyle factors and dietary intakes in relation to daidzein-metabolizing phenotypes among premenopausal women in the United States.
PubMed:Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from the Japan Public Health Center-based prospective study group.
PubMed:Pilot study to assess isoflavone intake in middle-aged italian subjects.
PubMed:Isoflavone composition, phenol content, and antioxidant activity of soybean seeds from India and Bulgaria.
PubMed:Stability of isoflavone daidzein and genistein in riboflavin, chlorophyll b, or methylene blue photosensitization.
PubMed:Protective effects of soy-isoflavones in cardiovascular disease. Identification of molecular targets.
PubMed:Urinary isoflavonoid excretion is similar after consuming soya milk and miso soup in Japanese-American women.
PubMed:Dietary soy isoflavone-aglycone lowers food intake in female rats with and without ovariectomy.
PubMed:Chitosan treatments affect growth and selected quality of sunflower sprouts.
PubMed:Equol status modifies the association of soy intake and mammographic density in a sample of postmenopausal women.
PubMed:Soy isoflavones decrease the catechol-O-methyltransferase-mediated inactivation of 4-hydroxyestradiol in cultured MCF-7 cells.
PubMed:Antioxidant and antigenotoxic activities of Korean fermented soybean.
PubMed:Food matrix and isoflavones bioavailability in early post menopausal women: a European clinical study.
PubMed:Estrogenic activities of isoflavones and flavones and their structure-activity relationships.
PubMed:Variations in phytoestrogen content between different mill dates of the same diet produces significant differences in the time of vaginal opening in CD-1 mice and F344 rats but not in CD Sprague-Dawley rats.
PubMed:[Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60].
PubMed:Cloning, expression, and characterization of two beta-glucosidases from isoflavone glycoside-hydrolyzing Bacillus subtilis natto.
PubMed:Increased expression of catalase in human hepatoma cells by the soy isoflavone, daidzein.
PubMed:Effects of dietary isoflavones on proliferation and DNA integrity of myoblasts derived from newborn piglets.
PubMed:Isoflavone glycitein diminished plasma cholesterol in female golden Syrian hamsters.
PubMed:Fermentation of calcium-fortified soymilk with Lactobacillus: effects on calcium solubility, isoflavone conversion, and production of organic acids.
PubMed:Dietary phytoestrogens, including isoflavones, lignans, and coumestrol, in nonvitamin, nonmineral supplements commonly consumed by women in Canada.
PubMed:Conversion of isoflavone glucosides to aglycones in soymilk by fermentation with lactic acid bacteria.
PubMed:Soy isoflavones protect the intestine from lipid hydroperoxide mediated oxidative damage.
PubMed:Dietary combination of soy with a probiotic or prebiotic food significantly reduces total and LDL cholesterol in mildly hypercholesterolaemic subjects.
PubMed:Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non-obese diabetic (NOD) mice.
PubMed:Studies on the anti-tumor activities of the soy isoflavone daidzein on murine neuroblastoma cells.
PubMed:Estimated dietary isoflavone intake among Korean adults.
PubMed:Quantification of six phytoestrogens at the nanogram per liter level in aqueous environmental samples using 13C3-labeled internal standards.
PubMed:Influence of food polyphenols on aryl hydrocarbon receptor-signaling pathway estimated by in vitro bioassay.
PubMed:Soy and prostate cancer study results mixed.
PubMed:Inhibition by soya isoflavones of human polymorphonuclear leukocyte function: possible relevance for the beneficial effects of soya intake.
PubMed:The spectrum of phytoestrogens in nature: our knowledge is expanding.
PubMed:Effect of daidzein, a soy isoflavone, on bone metabolism in Cd-treated ovariectomized rats.
PubMed:A comparison of changes in the transformation of isoflavones in soymilk using varying concentrations of exogenous and probiotic-derived endogenous beta-glucosidases.
PubMed:Solvent effects on extraction and HPLC analysis of soybean isoflavones and variations of isoflavone compositions as affected by crop season.
PubMed:Analysis of flavonoid phytoestrogens in botanical and ephedra-containing dietary supplements.
PubMed:Dietary isoflavones in the prevention of cardiovascular disease--a molecular perspective.
PubMed:8-Prenylnaringenin, inhibits estrogen receptor-alpha mediated cell growth and induces apoptosis in MCF-7 breast cancer cells.
PubMed:Higher bioavailability of isoflavones after a single ingestion of a soya-based supplement than a soya-based food in young healthy males.
PubMed:Anti-obesity activities of fermented soygerm isoflavones by Bifidobacterium breve.
PubMed:Exposure of juvenile rats to the phytoestrogen daidzein impairs erectile function in a dose-related manner in adulthood.
PubMed:Effect of dietary daidzein on egg production, shell quality, and gene expression of ER-alpha, GH-R, and IGF-IR in shell glands of laying hens.
PubMed:Extraction and purification of isoflavones from soybeans and characterization of their estrogenic activities.
PubMed:Chemical composition and biological activity of a new type of Brazilian propolis: red propolis.
PubMed:Autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents.
PubMed:Age-related uterotrophic response of soy isoflavone intake in rats.
PubMed:The association between isoflavone and lower urinary tract symptoms in elderly men.
PubMed:Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone in vitro.
PubMed:Differential effects of isoflavones on bone formation in growing male and female mice.
PubMed:Soy isoflavones and fatty acids: effects on bone tissue postovariectomy in mice.
PubMed:Simultaneous determination of daidzein, equol, genistein and bisphenol A in human urine by a fast and simple method using SPE and GC-MS.
PubMed:Metabolism of dietary soy isoflavones to equol by human intestinal microflora--implications for health.
PubMed:In vitro and in vivo metabolism of the soy isoflavone glycitein.
PubMed:Bioavailability of soy isoflavones in rats Part I: application of accurate methodology for studying the effects of gender and source of isoflavones.
PubMed:High levels of equol in organic skimmed Finnish cow milk.
PubMed:[High intake of phytoestrogens and precocious thelarche: case report with a possible correlation].
PubMed:Effect of daidzein in rats on cadmium excretion.
PubMed:Review of the factors affecting bioavailability of soy isoflavones in humans.
PubMed:Proteome analysis suggests that mitochondrial dysfunction in stressed endothelial cells is reversed by a soy extract and isolated isoflavones.
PubMed:Tissue distribution of lignans in rats in response to diet, dose-response, and competition with isoflavones.
PubMed:Flavonoid glycosides are not transported by the human Na+/glucose transporter when expressed in Xenopus laevis oocytes, but effectively inhibit electrogenic glucose uptake.
PubMed:Phytoestrogens levels determination in the cord blood from Malaysia rural and urban populations.
PubMed:Rapid and convenient detection of urinary equol by thin-layer chromatography.
PubMed:Analysis of isoflavonoids from leguminous plant extracts by RPHPLC/DAD and electrospray ionization mass spectrometry.
PubMed:Biotransformation of common bean (Phaseolus vulgaris L.) flavonoid glycosides by bifidobacterium species from human intestinal origin.
PubMed:Effects of dietary equol on body weight gain, intra-abdominal fat accumulation, plasma lipids, and glucose tolerance in ovariectomized Sprague-Dawley rats.
PubMed:Inhibition of lipoxygenase by soy isoflavones: evidence of isoflavones as redox inhibitors.
PubMed:Validation of a phytoestrogen food frequency questionnaire with urinary concentrations of isoflavones and lignan metabolites in premenopausal women.
PubMed:Soy product and isoflavone consumption in relation to prostate cancer in Japanese men.
PubMed:Puerarin and conjugate bases as radical scavengers and antioxidants: molecular mechanism and synergism with beta-carotene.
PubMed:Phytoestrogens activate estrogen receptor beta1 and estrogenic responses in human breast and bone cancer cell lines.
PubMed:Antioxidant activity of Sicilian pistachio (Pistacia vera L. var. Bronte) nut extract and its bioactive components.
PubMed:Comparison of extraction methods for the quantification of selected phytochemicals in peanuts (Arachis hypogaea).
PubMed:Estrogenic activity of the chlorinated derivatives of estrogens and flavonoids using a GFP expression system.
PubMed:Intake of dietary phytoestrogen and indices of antioxidant and bone metabolism of pre- and post-menopausal Korean women.
PubMed:Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk.
PubMed:Isoflavone phytoestrogen degradation in fermented soymilk with selected beta-glucosidase producing L. acidophilus strains during storage at different temperatures.
PubMed:Equol producer status, salivary estradiol profile and urinary excretion of isoflavones in Irish Caucasian women, following ingestion of soymilk.
PubMed:Enhanced estrogenic responses and sensitivity to azoxymethane following dietary soy isoflavone supplementation in older female rats.
PubMed:Estimated intakes of isoflavones and coumestrol in Korean population.
PubMed:The isoflavonoid aglycone-rich fractions of Chungkookjang, fermented unsalted soybeans, enhance insulin signaling and peroxisome proliferator-activated receptor-gamma activity in vitro.
PubMed:Isolation of an isoflavone-metabolizing, Clostridium-like bacterium, strain TM-40, from human faeces.
PubMed:Consumption of Lactobacillus acidophilus and Bifidobacterium longum does not alter phytoestrogen metabolism and plasma hormones in men: a pilot study.
PubMed:Regulatory mechanism of food factors in bone metabolism and prevention of osteoporosis.
PubMed:Soybean isoflavones preserve bone mass in hindlimb-unloaded mice.
PubMed:High urinary isoflavone excretion phenotype decreases plasma cholesterol in golden Syrian hamsters fed soy protein.
PubMed:Urinary excretion of equol by postmenopausal women consuming soymilk fermented by probiotic bifidobacteria.
PubMed:Detection of isoflavones in mouse tibia after feeding daidzein.
PubMed:Safety and antioxidant effects of a modest soy protein intervention in hemodialysis patients.
PubMed:Sulfation of the isoflavones genistein and daidzein in human and rat liver and gastrointestinal tract.
PubMed:Heat and pH effects on the conjugated forms of genistin and daidzin isoflavones.
PubMed:The influence of polychlorinated biphenyls (PCBs) and phytoestrogens in vitro on functioning of reproductive tract in cow.
PubMed:Intakes and sources of soya foods and isoflavones in a UK population cohort study (EPIC-Norfolk).
PubMed:Transformation of isoflavone phytoestrogens during the fermentation of soymilk with lactic acid bacteria and bifidobacteria.
PubMed:Bioavailability of isoflavones after ingestion of soy beverages in healthy adults.
PubMed:Factors affecting the bioavailability of soy isoflavones in humans.
PubMed:Quantification of tamoxifen and metabolites and soy isoflavones in human plasma using liquid chromatography with electrospray ionization tandem mass spectrometry.
PubMed:An accurate and reproducible method for the quantitative analysis of isoflavones and their metabolites in rat plasma using liquid chromatography/mass spectrometry combined with photodiode array detection.
PubMed:Analysis of isoflavones in foods and dietary supplements.
PubMed:Equol: a comparison of the effects of the racemic compound with that of the purified S-enantiomer on the growth, invasion, and DNA integrity of breast and prostate cells in vitro.
PubMed:Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan.
PubMed:An efficient HPLC method for the quantification of isoflavones in soy extracts and soy dietary supplements in routine quality control.
PubMed:Isoflavone profiles of red clovers and their distribution in different parts harvested at different growing stages.
PubMed:Soya isoflavones suppress phorbol 12-myristate 13-acetate-induced COX-2 expression in MCF-7 cells.
PubMed:Effects of phyto-oestrogens on veal calf prostate histology.
PubMed:Dietary genistein intake and cognitive performance in a multiethnic cohort of midlife women.
PubMed:Activation of glutathione peroxidase via Nrf1 mediates genistein's protection against oxidative endothelial cell injury.
PubMed:Preliminary investigation into the absorption of genistein and daidzein by domestic cats (Felis catus).
PubMed:Polyphenols in wild and weedy Mexican common beans (Phaseolus vulgaris L.).
PubMed:The isoflavone content of commercially-available feline diets in New Zealand.
PubMed:Inverse association of antioxidant and phytoestrogen nutrient intake with adult glioma in the San Francisco Bay Area: a case-control study.
PubMed:Oncogenicity evaluations of chemopreventive soy components in p53((+/-)) (p53 knockout) mice.
PubMed:Isoflavonoids are present in Arabidopsis thaliana despite the absence of any homologue to known isoflavonoid synthases.
PubMed:Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice.
PubMed:Soy protein with and without isoflavones fails to substantially increase postprandial antioxidant capacity.
PubMed:Prevalence of daidzein-metabolizing phenotypes differs between Caucasian and Korean American women and girls.
PubMed:Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women.
PubMed:Antioxidant activity of isoflavones and their major metabolites using different in vitro assays.
PubMed:Toxicokinetics of bisphenol A in pregnant DA/Han rats after single i.v. application.
PubMed:Stimulation of estradiol glucuronidation: a protective mechanism against estradiol-mediated carcinogenesis?
PubMed:Thermal degradation kinetics of isoflavone aglycones from soy and red clover.
PubMed:Phytoestrogens and lipoproteins in women.
PubMed:Cooperative effects of isoflavones and exercise on bone and lipid metabolism in postmenopausal Japanese women: a randomized placebo-controlled trial.
PubMed:LDL-antioxidant pterocarpans from roots of Glycine max (L.) Merr.
PubMed:Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: interactions with genotype and equol production.
PubMed:Concentrations of isoflavones in plasma and urine of post-menopausal women chronically ingesting high quantities of soy isoflavones.
PubMed:Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities.
PubMed:Soy extract has different effects compared with the isolated isoflavones on the proteome of homocysteine-stressed endothelial cells.
PubMed:High performance liquid chromatographic analysis of isoflavones in medicinal herbs.
PubMed:Distribution profiles of isoflavone isomers in black bean kojis prepared with various filamentous fungi.
PubMed:Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activity.
PubMed:Actual levels of soy phytoestrogens in children correlate with thyroid laboratory parameters.
PubMed:Regiospecific flavonoid 7-O-methylation with Streptomyces avermitilis O-methyltransferase expressed in Escherichia coli.
PubMed:A newly constructed and validated isoflavone database for the assessment of total genistein and daidzein intake.
PubMed:A spectroscopic study of the interaction of isoflavones with human serum albumin.
PubMed:Determination of isoflavones in dietary supplements containing soy, Red Clover and kudzu: extraction followed by basic or acid hydrolysis.
PubMed:Reliability and validity of an assessment of usual phytoestrogen consumption (United States).
PubMed:Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice.
PubMed:Isoflavone levels in five soybean (Glycine max) genotypes are altered by phytochrome-mediated light treatments.
PubMed:Genistein inhibits insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells: a possible mechanism of the growth inhibitory effect of Genistein.
PubMed:Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods.
PubMed:Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production.
PubMed:Phytoestrogen metabolites are much more active than phytoestrogens themselves in increasing prostaglandin F(2alpha) synthesis via prostaglanin F(2alpha) synthase-like 2 stimulation in bovine endometrium.
PubMed:The effect of a soy-rich diet on urogenital atrophy: a randomized, cross-over trial.
PubMed:Isoflavone genistein and daidzein up-regulate LPS-induced inducible nitric oxide synthase activity through estrogen receptor pathway in RAW264.7 cells.
PubMed:Characterization and quantification of soy isoflavone metabolites in serum of renal transplanted patients by high-performance liquid chromatography/electrospray ionization mass spectrometry.
PubMed:Suppression of arachidonic acid metabolism and nitric oxide formation by kudzu isoflavones in murine macrophages.
PubMed:Puerariae radix prevents bone loss in castrated male mice.
PubMed:Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in men.
PubMed:Contrasting effects of puerarin and daidzin on glucose homeostasis in mice.
PubMed:Soy processing affects metabolism and disposition of dietary isoflavones in ovariectomized BALB/c mice.
PubMed:Metabolism of glycitein (7,4'-dihydroxy-6-methoxy-isoflavone) by human gut microflora.
PubMed:Phyto-oestrogen intake in Scottish men: use of serum to validate a self-administered food-frequency questionnaire in older men.
PubMed:Structural elucidation of hydroxylated metabolites of the isoflavan equol by gas chromatography-mass spectrometry and high-performance liquid chromatography-mass spectrometry.
PubMed:Contents and bioactivities of lunasin, bowman-birk inhibitor, and isoflavones in soybean seed.
PubMed:Isoflavone contents in germinated soybean seeds.
PubMed:In vitro effects of soy phytoestrogens on rat L6 skeletal muscle cells.
PubMed:Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).
PubMed:Supercritical fluid extraction of isoflavones from biological samples with ultra-fast high-performance liquid chromatography/mass spectrometry.
PubMed:[Effect of soybean isoflavone on the cognitive function in ovariectomized mice].
PubMed:Association of serum phytoestrogen concentration and dietary habits in a sample set of the JACC Study.
PubMed:Absorption of isoflavones in humans: effects of food matrix and processing.
PubMed:Isoflavone conjugates are underestimated in tissues using enzymatic hydrolysis.
PubMed:Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense).
PubMed:Isoflavones modulate the glucuronidation of estradiol in human liver microsomes.
PubMed:Characterization of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor from Pueraria thunbergiana.
PubMed:Evaluation of isoflavone aglycon and glycoside distribution in soy plants and soybeans by fast column high-performance liquid chromatography coupled with a diode-array detector.
PubMed:Bioavailability of isoflavone phytoestrogens in postmenopausal women consuming soya milk fermented with probiotic bifidobacteria.
PubMed:Effect of vitamin E and polyphenols on ochratoxin A-induced cytotoxicity in liver (HepG2) cells.
PubMed:Identification of urolithin a as a metabolite produced by human colon microflora from ellagic acid and related compounds.
PubMed:Estrogenic and genotoxic potential of equol and two hydroxylated metabolites of Daidzein in cultured human Ishikawa cells.
PubMed:Anti-oxidative and anti-inflammatory activities of two different species of a Chinese herb I-Tiao-Gung.
PubMed:Long-term dietary habits affect soy isoflavone metabolism and accumulation in prostatic fluid in caucasian men.
PubMed:DPPH radical-scavenging compounds from dou-chi, a soybean fermented food.
PubMed:Genotoxicity of phytoestrogens.
PubMed:Chemical compositions and physicochemical properties of the fiber-rich materials prepared from shoyu mash residue.
PubMed:Experimental determination of octanol-water partition coefficients of quercetin and related flavonoids.
PubMed:Human gut microbial degradation of flavonoids: structure-function relationships.
PubMed:Phytoestrogens derived from red clover: an alternative to estrogen replacement therapy?
PubMed:Effect of dietary intake of phytoestrogens on estrogen receptor status in premenopausal women with breast cancer.
PubMed:Isoflavone supplements exert hormonal and antioxidant effects in postmenopausal Korean women with diabetic retinopathy.
PubMed:Phytoestrogens modulate prostaglandin production in bovine endometrium: cell type specificity and intracellular mechanisms.
PubMed:Phytoestrogens possess a weak antioxidant activity on low density lipoprotein in contrast to the flavonoid quercetin in vitro in postmenopausal women.
PubMed:Long-term combined administration of quercetin and daidzein inhibits quercetin-induced suppression of glutathione antioxidant defenses.
PubMed:Pharmacokinetics of a slow-release formulation of soybean isoflavones in healthy postmenopausal women.
PubMed:The effect of soy consumption on the urinary 2:16-hydroxyestrone ratio in postmenopausal women depends on equol production status but is not influenced by probiotic consumption.
PubMed:Soybean-derived phytoestrogens regulate prostaglandin secretion in endometrium during cattle estrous cycle and early pregnancy.
PubMed:Comprehensive analysis of the effect of phytoestrogen, daidzein, on a testicular cell line, using mRNA and protein expression profile.
PubMed:Transcriptional regulation by phytoestrogens in neuronal cell lines.
PubMed:Determination of unusual soya and non-soya phytoestrogen sources in beer, fish products and other foods.
PubMed:Analysis of isoflavone daidzein in Puerariae radix with micelle-mediated extraction and preconcentration.
PubMed:Analysis of isoflavone contents in vegetable soybeans.
PubMed:Accumulation of genistein and daidzein, soybean isoflavones implicated in promoting human health, is significantly elevated by irrigation.
PubMed:Quality, labeling accuracy, and cost comparison of purified soy isoflavonoid products.
PubMed:Soy isoflavones modify liver free radical scavenger systems and liver parameters in Sprague-Dawley rats.
PubMed:A semiquantitative food frequency questionnaire is a valid indicator of the usual intake of phytoestrogens by south Asian women in the UK relative to multiple 24-h dietary recalls and multiple plasma samples.
PubMed:Sulfation of environmental estrogens by cytosolic human sulfotransferases.
PubMed:[Determination of soybean isoflavones in foods by HPLC].
PubMed:Phytoestrogens as cardioprotective agents.
PubMed:A simple method for the characterization and quantification of soy isoflavone metabolites in the serum of MMTV-Neu mice using high-performance liquid chromatography/electrospray ionization mass spectrometry with multiple reaction monitoring.
PubMed:Effects of subcutaneous administration of daidzein on blastocyst implantation in rats.
PubMed:Comparison between daidzein and genistein antioxidant activity in primary and cancer lymphocytes.
PubMed:In vitro enzymatic modification of puerarin to puerarin glycosides by maltogenic amylase.
PubMed:Lactobacillus gasseri: effects on mouse intestinal flora enzyme activity and isoflavonoids in the caecum and plasma.
PubMed:Prostate cancer in native Japanese and Japanese-American men: effects of dietary differences on prostatic tissue.
PubMed:Soy and isoflavone intake are associated with reduced risk of ovarian cancer in southeast china.
PubMed:Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover).
PubMed:Equol, a metabolite of daidzein, inhibits bone loss in ovariectomized mice.
PubMed:The apparent absorptions of isoflavone glucosides and aglucons are similar in women and are increased by rapid gut transit time and low fecal isoflavone degradation.
PubMed:Behavioral effects of endocrine-disrupting substances: phytoestrogens.
PubMed:Frequency of soy food consumption and serum isoflavone concentrations among Chinese women in Shanghai.
PubMed:[Soy isoflavones--a therapy for menopausal symptoms?].
PubMed:Influence of 10 wk of soy consumption on plasma concentrations and excretion of isoflavonoids and on gut microflora metabolism in healthy adults.
PubMed:Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy.
PubMed:Biphasic effect of daidzein on cell growth of human colon cancer cells.
PubMed:Kudzu root extract suppresses voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol.
PubMed:Assessment of the reactivity of selected isoflavones against proteins in comparison to quercetin.
PubMed:Isolation of flavonoids and a cerebroside from the stem bark of Albizzia julibrissin.
PubMed:Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types.
PubMed:Enhancement of tofu isoflavone recovery by pretreatment of soy milk with koji enzyme extract.
PubMed:A pilot study of phytoestrogen content of soy foods and traditional Chinese medicines for women's health in Hong Kong.
PubMed:Isolation of 8-hydroxyglycitein and 6-hydroxydaidzein from soybean miso.
PubMed:Plant lignans in soy-based health supplements.
PubMed:Dietary exposure estimates of isoflavones from the 1998 UK Total Diet Study.
PubMed:Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometry.
PubMed:Determination of isoflavones in soybean food and human urine using liquid chromatography with electrochemical detection.
PubMed:Isoflavones found in Korean soybean paste as 3-hydroxy-3-methylglutaryl Coenzyme A reductase inhibitors.
PubMed:Evaluation of the preventive effect of isoflavone extract on bone loss in ovariectomized rats.
PubMed:LC/UV/ESI-MS analysis of isoflavones in Edamame and Tofu soybeans.
PubMed:Distribution of soy-derived phytoestrogens in human breast tissue and biological fluids.
PubMed:Studies of the in vitro intestinal metabolism of isoflavones aid in the identification of their urinary metabolites.
PubMed:Biotechnological production of highly soluble daidzein glycosides using Thermotoga maritima maltosyltransferase.
PubMed:Differential effects of isoflavones and lignans on invasiveness of MDA-MB-231 breast cancer cells in vitro.
PubMed:Effect of circulating forms of soy isoflavones on the oxidation of low density lipoprotein.
PubMed:Effect of water-to-bean ratio on the contents and compositions of isoflavones in tofu.
PubMed:Lack of an inducible effect of dietary soy isoflavones on the mRNA abundance of hepatic cytochrome P-450 isozymes in rats.
PubMed:Soy protein formulas in children: no hormonal effects in long-term feeding.
PubMed:Comparison of Caco-2, IEC-18 and HCEC cell lines as a model for intestinal absorption of genistein, daidzein and their glycosides.
PubMed:Influence of soya-based infant formula consumption on isoflavone and gut microflora metabolite concentrations in urine and on faecal microflora composition and metabolic activity in infants and children.
PubMed:Urinary isoflavone kinetics: the effect of age, gender, food matrix and chemical composition.
PubMed:Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer.
PubMed:Isoflavones inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro.
PubMed:Trace determination of bisphenol A and phytoestrogens in infant formula powders by gas chromatography-mass spectrometry.
PubMed:Lack of dose-responsive effect of dietary phyto-oestrogens on transepithelial calcium transport in human intestinal-like Caco-2 cells.
PubMed:Simultaneous determination of isoflavones and bisphenol A in rat serum by high-performance liquid chromatography coupled with coulometric array detection.
PubMed:Higher consumption of green tea may enhance equol production.
PubMed:Dietary phytoestrogens accelerate the time of vaginal opening in immature CD-1 mice.
PubMed:Stability and bioaccessibility of isoflavones from soy bread during in vitro digestion.
PubMed:Inhibition of reactive nitrogen species effects in vitro and in vivo by isoflavones and soy-based food extracts.
PubMed:Phytoestrogens modulate binding response of estrogen receptors alpha and beta to the estrogen response element.
PubMed:Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.
PubMed:Oestrogen receptor-beta and neurohypophysial hormones: functional interaction and neuroanatomical localisation.
PubMed:Estrogenic compounds suppressed interferon-gamma production in mouse splenocytes through direct cell-cell interaction.
PubMed:Anticarcinogenic properties of a daidzein-rich fraction isolated from soybean.
PubMed:Effects of alpha-tocopherol, beta-carotene, and soy isoflavones on lipid oxidation of structured lipid-based emulsions.
PubMed:Antioxidant isoflavones in Osage orange, Maclura pomifera (Raf.) Schneid.
PubMed:Plasma isoflavone levels versus self-reported soy isoflavone levels in Asian-American women in Los Angeles County.
PubMed:Soy protein with or without isoflavones, soy germ and soy germ extract, and daidzein lessen plasma cholesterol levels in golden Syrian hamsters.
PubMed:Rapid gut transit time and slow fecal isoflavone disappearance phenotype are associated with greater genistein bioavailability in women.
PubMed:Antioxidant and free radical scavenging activity of isoflavone metabolites.
PubMed:Effects of soy oligosaccharides on plasma and cecal isoflavones, and cecal enzyme activities in mice.
PubMed:The OECD program to validate the rat uterotrophic bioassay. Phase 2: dietary phytoestrogen analyses.
PubMed:Serum isoflavones and soya food intake in Japanese, Thai and American end-stage renal disease patients on chronic haemodialysis.
PubMed:Puerariae radix prevents bone loss in ovariectomized mice.
PubMed:Polyphenolic content in different plant parts of soy cultivars grown under natural conditions.
PubMed:Reduction of genistein clastogenicity in Chinese hamster V79 cells by daidzein and other flavonoids.
PubMed:Plant derivatives in the treatment of alcohol dependency.
PubMed:Effects of the phytoestrogens genistein and daidzein on BRCA2 tumor suppressor gene expression in breast cell lines.
PubMed:Soy and isoflavone consumption in relation to prostate cancer risk in China.
PubMed:Thermal stability of genistein and daidzein and its effect on their antioxidant activity.
PubMed:Influence of dietary soy isoflavones on the accessory sex organs of the Wistar rat.
PubMed:Flavonoid structure affects the inhibition of lipid peroxidation in Caco-2 intestinal cells at physiological concentrations.
PubMed:The effect of oestrogen and dietary phyto-oestrogens on transepithelial calcium transport in human intestinal-like Caco-2 cells.
PubMed:Variations in isoflavone levels in soy foods and soy protein isolates and issues related to isoflavone databases and food labeling.
PubMed:Identification of phytoestrogens in bovine milk using liquid chromatography/electrospray tandem mass spectrometry.
PubMed:Antimutagenic activity of 8-hydroxyisoflavones and 6-hydroxydaidzein from soybean miso.
PubMed:Effect of daidzein on CYP1A2 activity and pharmacokinetics of theophylline in healthy volunteers.
PubMed:Dietary exposure to xenoestrogens in New Zealand.
PubMed:Bioavailability of phyto-oestrogens.
PubMed:Food sources of phyto-oestrogens and their precursors in Europe.
PubMed:Phyto-oestrogen database of foods and average intake in Finland.
PubMed:Isoflavone intake in four different European countries: the VENUS approach.
PubMed:Phyto-oestrogen levels in foods: the design and construction of the VENUS database.
PubMed:Effect of genistein and daidzein on platelet aggregation and monocyte and endothelial function.
PubMed:Quantification of isoflavones and lignans in urine using gas chromatography/mass spectrometry.
PubMed:Stability of isoflavones in soy milk stored at elevated and ambient temperatures.
PubMed:Evaluation of the estrogenic effects of legume extracts containing phytoestrogens.
PubMed:Soy extract inhibits mammary adenocarcinoma growth in a syngeneic mouse model.
PubMed:Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats.
PubMed:Hydrolysis by lactase phlorizin hydrolase is the first step in the uptake of daidzein glucosides by rat small intestine in vitro.
PubMed:[Comparison of soyasaponin and isoflavone contents between genetically modified (GM) and non-GM soybeans].
PubMed:The soya isoflavone content of rat diet can increase anxiety and stress hormone release in the male rat.
PubMed:Isoflavonoid and lignan phytoestrogens as dietary biomarkers.
PubMed:Determination of isoflavones in ready-to-feed soy-based infant formula.
PubMed:Validation of a soy food-frequency questionnaire and evaluation of correlates of plasma isoflavone concentrations in postmenopausal women.
PubMed:Determination of daidzein and genistein in soybean foods by automated on-line in-tube solid-phase microextraction coupled to high-performance liquid chromatography.
PubMed:Glucuronides are the main isoflavone metabolites in women.
PubMed:Role of soy isoflavones in the hypotriglyceridemic effect of soy protein in the rat.
PubMed:Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women.
PubMed:Isoflavone, glyphosate, and aminomethylphosphonic acid levels in seeds of glyphosate-treated, glyphosate-resistant soybean.
PubMed:Composition, red blood cell uptake, and serum protein binding of phytoestrogens extracted from commercial kudzu-root and soy preparations.
PubMed:Validation study of soya intake and plasma isoflavone levels among British women.
PubMed:Quantitative analysis using gas chromatography/combustion/isotope ratio mass spectrometry and standard addition of intrinsically labelled standards (SAIL)--application to isoflavones in foods.
PubMed:Stabilities of daidzin, glycitin, genistin, and generation of derivatives during heating.
PubMed:Validation of a soy food frequency questionnaire with plasma concentrations of isoflavones in US adults.
PubMed:Inhibitory effects of isoflavones on nitric oxide- or peroxynitrite-mediated DNA damage in RAW 264.7 cells and phiX174 DNA.
PubMed:Measurement of intact sulfate and glucuronide phytoestrogen conjugates in human urine using isotope dilution liquid chromatography-tandem mass spectrometry with [13C(3)]isoflavone internal standards.
PubMed:Daidzein and genistein content of cereals.
PubMed:Soy isoflavones increase latency of spontaneous mammary tumors in mice.
PubMed:Effects of rice starch-isoflavone diet or potato starch-isoflavone diet on plasma isoflavone, plasma lipids, cecal enzyme activity, and composition of fecal microflora in adult mice.
PubMed:Isoflavonoids inhibit catabolism of vitamin D in prostate cancer cells.
PubMed:Oxidative metabolism and genotoxic potential of major isoflavone phytoestrogens.
PubMed:Identification and quantification of polyphenol phytoestrogens in foods and human biological fluids.
PubMed:Hydrolysis of isoflavone glycosides to aglycones by beta-glycosidase does not alter plasma and urine isoflavone pharmacokinetics in postmenopausal women.
PubMed:Metabolism of biochanin A and formononetin by human liver microsomes in vitro.
PubMed:Phytoestrogens and liver disease.
PubMed:Effects of anthocyanins and other phenolic compounds on the production of tumor necrosis factor alpha in LPS/IFN-gamma-activated RAW 264.7 macrophages.
PubMed:Soy milk intake in relation to serum sex hormone levels in British men.
PubMed:Phytoestrogen-low diet for endocrine disruptor studies.
PubMed:Intake of dietary phytoestrogens by Dutch women.
PubMed:Potassium fertilization effects on isoflavone concentrations in soybean [Glycine max (L.) Merr.].
PubMed:Soy product intake and serum isoflavonoid and estradiol concentrations in relation to bone mineral density in postmenopausal Japanese women.
PubMed:Soy milk intake and plasma sex hormones: a cross-sectional study in pre- and postmenopausal women (EPIC-Oxford).
PubMed:Characterization of isoflavones and their conjugates in female rat urine using LC/MS/MS.
PubMed:Effects of soy consumption on gonadotropin secretion and acute pituitary responses to gonadotropin-releasing hormone in women.
PubMed:Phytoestrogens: dietary intake and excretion in postmenopausal Chinese women.
PubMed:Overnight urinary isoflavone excretion in a population of women living in the United States, and its relationship to isoflavone intake.
PubMed:Isoflavone aglycon and glucoconjugate content of high- and low-soy U.K. foods used in nutritional studies.
PubMed:Estrogenic isoflavones in rodent diets.
PubMed:Inhibitory effect of isoflavones on peroxynitrite-mediated low-density lipoprotein oxidation.
PubMed:Identification and concentration of soy isoflavones in commercial cat foods.
PubMed:Inhibitory effects of anthocyanins and other phenolic compounds on nitric oxide production in LPS/IFN-gamma-activated RAW 264.7 macrophages.
PubMed:Phytoestrogens and thyroid cancer risk: the San Francisco Bay Area thyroid cancer study.
PubMed:Dietary soy isoflavone intake in older Japanese American women.
PubMed:Determination of isoflavones in soy and selected foods containing soy by extraction, saponification, and liquid chromatography: collaborative study.
PubMed:Soy for breast cancer survivors: a critical review of the literature.
PubMed:Regulation of phenobarbital-mediated induction of CYP102 (cytochrome P450(BM-3)) in Bacillus megaterium by phytochemicals from soy and green tea.
PubMed:Pilot study of a specific dietary supplement in tumor-bearing mice and in stage IIIB and IV non-small cell lung cancer patients.
PubMed:Validity and reproducibility of a self-administered food-frequency questionnaire to assess isoflavone intake in a japanese population in comparison with dietary records and blood and urine isoflavones.
PubMed:Soya intake and plasma concentrations of daidzein and genistein: validity of dietary assessment among eighty British women (Oxford arm of the European Prospective Investigation into Cancer and Nutrition).
PubMed:Quantitative analysis of the principle soy isoflavones genistein, daidzein and glycitein, and their primary conjugated metabolites in human plasma and urine using reversed-phase high-performance liquid chromatography with ultraviolet detection.
PubMed:Isoflavone transformation during soybean koji preparation and subsequent miso fermentation supplemented with ethanol and NaCl.
PubMed:Estimated dietary isoflavone intake of Korean population based on National Nutrition Survey.
PubMed:Oxidative metabolism of the soy isoflavones daidzein and genistein in humans in vitro and in vivo.
PubMed:Changes in the profile of genistein, daidzein, and their conjugates during thermal processing of tofu.
PubMed:Intake of dietary phytoestrogens is low in postmenopausal women in the United States: the Framingham study(1-4).
PubMed:Effect of a phytoestrogen food supplement on reproductive health in normal males.
PubMed:Suppression effect of soy isoflavones on nitric oxide production in RAW 264.7 macrophages.
PubMed:Syntheses of daidzein-7-yl beta-D-glucopyranosiduronic acid and daidzein-4',7-yl di-beta-D-glucopyranosiduronic acid.
PubMed:[Selected phytoestrogens with potential beneficial effects on risk of certain environmental diseases].
PubMed:Comparative assessment of endocrine modulators with oestrogenic activity: I. Definition of a hygiene-based margin of safety (HBMOS) for xeno-oestrogens against the background of European developments.
PubMed:Daidzein and genistein contents of vegetables.
PubMed:Assessing the accuracy of a food frequency questionnaire for estimating usual intake of phytoestrogens.
PubMed:The therapeutic potential of phytoestrogens.
PubMed:Oxidative in vitro metabolism of the soy phytoestrogens daidzein and genistein.
PubMed:Daidzein and genistein content of fruits and nuts.
PubMed:Soy isoflavonoid aglycons genistein and daidzein Do not increase the cytochrome P-450 content of the liver microsomes of mice.
PubMed:Effect of extrusion on isoflavone content and antiproliferative bioactivity of soy/corn mixtures.
PubMed:Quantitative determination of isoflavones and coumestrol in soybean by column liquid chromatography.
PubMed:Estrogenic activity of flavonoids in mice. The importance of estrogen receptor distribution, metabolism and bioavailability.
PubMed:Isoflavone phytoestrogens consumed in soy decrease F(2)-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans.
PubMed:Premenopausal equol excretors show plasma hormone profiles associated with lowered risk of breast cancer.
PubMed:Determination of the levels of isoflavonoids in soybeans and soy-derived foods and estimation of isoflavonoids in the Japanese daily intake.
PubMed:Soy isoflavone conjugation differs in fed and food-deprived rats.
PubMed:Assessing phytoestrogen exposure in epidemiologic studies: development of a database (United States).
PubMed:Characterization of an ATP-dependent pathway of activation for the heterocyclic amine carcinogen N-hydroxy-2-amino-3-methylimidazo[4, 5-f]quinoline.
PubMed:Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora.
PubMed:Soybean meal fermented by Aspergillus awamori increases the cytochrome P-450 content of the liver microsomes of mice.
PubMed:Urinary isoflavonoid and lignan excretion on a Western diet: relation to soy, vegetable, and fruit intake.
PubMed:Neither background diet nor type of soy food affects short-term isoflavone bioavailability in women.
PubMed:Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase.
PubMed:Synthesis of haptens and conjugates for ELISAs of phytoestrogens. Development of the immunological tests.
PubMed:Influence of dietary components on the gastrointestinal metabolism and transport of drugs.
PubMed:Quantification of soy isoflavones, genistein and daidzein, and conjugates in rat blood using LC/ES-MS.
PubMed:Development of a simple method for the determination of genistein, daidzein, biochanin A, and formononetin (biochanin B) in human urine.
PubMed:Improved method for gas chromatographic analysis of genistein and daidzein from soybean (Glycine max) seeds.
PubMed:New potent antioxidative o-dihydroxyisoflavones in fermented Japanese soybean products.
PubMed:Estrogenic activity of glycitein, a soy isoflavone.
PubMed:Antimutagenic activity of isoflavones from soybean seeds (Glycine max merrill).
PubMed:Stability of isoflavones during extrusion processing of corn/soy mixture.
PubMed:Purification of cytosolic beta-glucosidase from pig liver and its reactivity towards flavonoid glycosides.
PubMed:Phytoestrogen content of purified, open- and closed-formula laboratory animal diets.
PubMed:Antioxidant action and potential antidiabetic properties of an isoflavonoid-containing soyabean phytochemical extract (SPE).
PubMed:Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice.
PubMed:Analysis of phyto-oestrogens by gas chromatography-mass spectrometry.
PubMed:Bioavailability of genistein, daidzein, and their glycosides in intestinal epithelial Caco-2 cells.
PubMed:Phytoestrogens. State of the art.
PubMed:Phytoestrogen content in foods.
PubMed:Phytoestrogens and bone.
PubMed:Dietary intake and sources of isoflavones among Japanese.
PubMed:Development of a soy food frequency questionnaire to estimate isoflavone consumption in US adults.
PubMed:Usual dietary consumption of soy foods and its correlation with the excretion rate of isoflavonoids in overnight urine samples among Chinese women in Shanghai.
PubMed:Daidzein and genistein but not their glucosides are absorbed from the rat stomach.
PubMed:The phytoestrogens coumoestrol and genistein induce structural chromosomal aberrations in cultured human peripheral blood lymphocytes.
PubMed:Serum levels and metabolic clearance of the isoflavones genistein and daidzein in hemodialysis patients.
PubMed:Volume 264, number 1 (1998), in article no. AB982825, "Extraction and quantification of daidzein and genistein in Food," by jason liggins, leslie J. C. Bluck, W. Andy coward, and sheila A. Bingham, pages 1-7
PubMed:Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations.
PubMed:Urinary excretion of isoflavonoids and the risk of breast cancer.
PubMed:Isoflavone-mediated inhibition of tyrosine kinase: a novel antiinflammatory approach.
PubMed:Immunoassay of phytoestrogens in human plasma.
PubMed:Chemical synthesis of [(13)c]daidzein.
PubMed:Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats.
PubMed:Soy isoflavone analysis: quality control and a new internal standard.
PubMed:Isoflavones in human breast milk and other biological fluids.
PubMed:Daily intake and urinary excretion of genistein and daidzein by infants fed soy- or dairy-based infant formulas.
PubMed:Isoflavone content of infant formulas and the metabolic fate of these phytoestrogens in early life.
PubMed:Phyto-oestrogen excretion and rate of bone loss in postmenopausal women.
PubMed:Extraction and quantification of daidzein and genistein in food.
PubMed:Japanese intake of flavonoids and isoflavonoids from foods.
PubMed:Inhibition of neoplastic transformation and bioavailability of dietary flavonoid agents.
PubMed:Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity.
PubMed:The effect of soy isoflavones on the development of intestinal neoplasia in ApcMin mouse.
PubMed:Characterization of flavonoids as monofunctional or bifunctional inducers of quinone reductase in murine hepatoma cell lines.
PubMed:Inhibition of PhIP mutagenicity by caffeine, lycopene, daidzein, and genistein.
PubMed:Phytoestrogens have agonistic and combinatorial effects on estrogen-responsive gene expression in MCF-7 human breast cancer cells.
PubMed:A simple method for the extraction and quantification of daidzein and genistein in food using gas chromatography mass spectrometry.
PubMed:Detection of weak estrogenic flavonoids using a recombinant yeast strain and a modified MCF7 cell proliferation assay.
PubMed:The measurement of the isoflavone daidzein by time resolved fluorescent immunoassay: a method for assessment of dietary soya exposure.
PubMed:Isoflavone content of infant foods and formulas.
PubMed:Evolution of the health benefits of soy isoflavones.
PubMed:Urinary equol excretion with a soy challenge: influence of habitual diet.
PubMed:Analysis of phytoestrogens and polyphenols in plasma, tissue, and urine using HPLC with coulometric array detection.
PubMed:Phytoestrogens in soy-based infant foods: concentrations, daily intake, and possible biological effects.
PubMed:Isoflavonoid levels in spot urine are associated with frequency of dietary soy intake in a population-based sample of middle-aged and older Chinese in Singapore.
PubMed:A microbore high performance liquid chromatography/electrospray ionization mass spectrometry method for the determination of the phytoestrogens genistein and daidzein in comminuted baby foods and soya flour.
PubMed:In vivo antioxidant activity of Okara Koji, a fermented okara, by Aspergillus oryzae.
PubMed:Phyto-oestrogens in soy-based infant formula.
PubMed:Exposure of infants to phyto-oestrogens from soy-based infant formula.
PubMed:Urinary isoflavonoid excretion in humans is dose dependent at low to moderate levels of soy-protein consumption.
PubMed:Induction of micronuclei, DNA strand breaks and HPRT mutations in cultured Chinese hamster V79 cells by the phytoestrogen coumoestrol.
PubMed:A comparative survey of leguminous plants as sources of the isoflavones, genistein and daidzein: implications for human nutrition and health.
PubMed:Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells.
PubMed:Isoflavonoid compounds extracted from Pueraria lobata suppress alcohol preference in a pharmacogenetic rat model of alcoholism.
PubMed:A diet high in wheat fiber decreases the bioavailability of soybean isoflavones in a single meal fed to women.
PubMed:Isotope dilution gas chromatographic-mass spectrometric method for the determination of isoflavonoids, coumestrol, and lignans in food samples.
PubMed:Soy isoflavonoids and cancer prevention. Underlying biochemical and pharmacological issues.
PubMed:Phytoestrogen content of foods--a compendium of literature values.
PubMed:Fecal lignan and isoflavonoid excretion in premenopausal women consuming flaxseed powder.
PubMed:Urinary isoflavonoid phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products.
PubMed:Rapid HPLC analysis of dietary phytoestrogens from legumes and from human urine.
PubMed:Effect of diet on lignans and isoflavonoid phytoestrogens in chimpanzees.
PubMed:Urinary lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets.
PubMed:Defining food components as new nutrients.
PubMed:Determination of lignans and isoflavonoids in human female plasma following dietary supplementation.
PubMed:Urinary lignan and isoflavonoid excretion in premenopausal women consuming flaxseed powder.
PubMed:Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women.
PubMed:Cyclic [beta]-1,6-1,3-Glucans of Bradyrhizobium japonicum USDA 110 Elicit Isoflavonoid Production in the Soybean (Glycine max) Host.
PubMed:Therapeutic lessons from traditional Oriental medicine to contemporary Occidental pharmacology.
PubMed:Daidzin and daidzein suppress free-choice ethanol intake by Syrian golden hamsters.
PubMed:Flavonoid inhibition of aromatase enzyme activity in human preadipocytes.
PubMed:Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet.
PubMed:High-performance liquid chromatographic analysis of phytoestrogens in soy protein preparations with ultraviolet, electrochemical and thermospray mass spectrometric detection.
PubMed:Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets.
PubMed:Oestrogenic potency of genistin and daidzin in mice.
PubMed:Soya--a dietary source of the non-steroidal oestrogen equol in man and animals.
PubMed:Oestrogenic response of the CD-1 mouse to the soya-bean isoflavones genistein, genistin and daidzin.
PubMed:Oestrogenic activity of soya-bean products.
Widespread isoflavone in the Leguminosae, esp. Phaseolus spp. (broad beans, lima beans); also found in soy and soy products (tofu, miso), chick peas (Cicer arietinum) and peanuts (Arachis hypogaea). Nutriceutical with anticancer and bone protective props. Daidzein is one of several known isoflavones. Isoflavones compounds are found in a number of plants, but soybeans and soy products like tofu and textured vegetable protein are the primary food source. Up until recently, daidzein was considered to be one of the most important and most studied isoflavones, however more recently attention has shifted to isoflavone metabolites. Equol represents the main active product of daidzein metabolism, produced via specific microflora in the gut. The clinical effectiveness of soy isoflavones may be a function of the ability to biotransform soy isoflavones to the more potent estrogenic metabolite, equol, which may enhance the actions of soy isoflavones, owing to its greater affinity for estrogen receptors, unique antiandrogenic properties, and superior antioxidant activity. However, not all individuals consuming daidzein produce equol. Only approximately one-third to one-half of the population is able to metabolize daidzein to equol. This high variability in equol production is presumably attributable to interindividual differences in the composition of the intestinal microflora, which may play an important role in the mechanisms of action of isoflavones. But, the specific bacterial species in the colon involved in the production of equol are yet to be discovered. (PMID: 18045128, 17579894, Curr Med Chem. 2007;14(26):2824-30., Mol Nutr Food Res. 2007 Jul;51(7):765-81.)
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