EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

fumagillin
2,4,6,8-decatetraenedioic acid 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro(2,5)oct-6-yl ester

Supplier Sponsors

Name:(2E,4E,6E,8E)-10-[[(3R,4S,5S,6R)-5-methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid
CAS Number: 23110-15-8Picture of molecule3D/inchi
Other(deleted CASRN):297-95-0
ECHA EINECS - REACH Pre-Reg:245-433-8
FDA UNII: 7OW73204U1
MDL:MFCD03990453
XlogP3-AA:4.00 (est)
Molecular Weight:458.55138000
Formula:C26 H34 O7
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 194.50 °C. @ 760.00 mm Hg
Boiling Point: 606.90 °C. @ 760.00 mm Hg (est)
Flash Point: 390.00 °F. TCC ( 198.90 °C. ) (est)
logP (o/w): 3.260 (est)
Soluble in:
 water, 0.2653 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Fumagillin >98%
Odor: characteristic
Use: Fumagillin is a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagillin shows promise as both an an anti-infective and antiangiogenic agent.
EMD Millipore
For experimental / research use only.
Fumagillin, Aspergillus fumigatus
sds
Glentham Life Sciences
Fumagillin
Santa Cruz Biotechnology
For experimental / research use only.
Fumagillin ≥95%
Sigma-Aldrich: Sigma
For experimental / research use only.
Fumagillin from Aspergillus fumigatus ≥90%, powder
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 2000 mg/kg
"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 3, Pg. 1834, 1978.

Dermal Toxicity:
subcutaneous-mouse LD50 800 mg/kg
Antibiotics and Chemotherapy Vol. 1, Pg. 54, 1951.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for fumagillin usage levels up to:
 not for fragrance use.
 
Recommendation for fumagillin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6436022
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(2E,4E,6E,8E)-10-[[(3R,4S,5S,6R)-5-methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid
Chemidplus:0023110158
RTECS:HE1750000 for cas# 23110-15-8
 
References:
 (2E,4E,6E,8E)-10-[[(3R,4S,5S,6R)-5-methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:23110-15-8
Pubchem (cid):6436022
Pubchem (sid):135021824
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 amebacillin
2,4,6,8-decatetraene dioic acid 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro(2,5)oct-6-yl ester
2,4,6,8-decatetraenedioic acid 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro(2,5)oct-6-yl ester
 fugilin
 fugillin
 fumagilline
 fumagillinum
(2E,4E,6E,8E)-10-[[(3R,4S,5S,6R)-5-methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid
 

Articles:

PubMed:Fumagillin: an overview of recent scientific advances and their significance for apiculture.
PubMed:Rapid determination of fumagillin residues in honey by liquid chromatography-tandem mass spectrometry using the QuEChERS method.
PubMed:Microsporidiosis: epidemiology, clinical data and therapy.
PubMed:Multiclass determination and confirmation of antibiotic residues in honey using LC-MS/MS.
PubMed:Therapeutic strategies for human microsporidia infections.
PubMed:Microsporidiosis: an emerging and opportunistic infection in humans and animals.
PubMed:Epidemiology of microsporidiosis: sources and modes of transmission.
PubMed:Liquid chromatographic determination of the antibiotic fumagillin in fish meat samples.
PubMed:Toxicity and pharmacokinetics of the antibiotic fumagillin in yearling rainbow trout (Salmo gairdneri).
 
Notes:
a monoester of decatetraenedioic acid (hooc-(c=ch)4-cooh and fumagillin (c16-17h25-26o3); fr 65814 lacks the fat.
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