idebenone
2,5-cyclohexadiene-1,4-dione, 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-
 
Notes:
None found
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    • Jiangyin Healthway International Trade Co.
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
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      Product(s):
      HLC-310 Idebenone
       
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2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione (Click)
CAS Number: 58186-27-9Picture of molecule
FDA UNII: HB6PN45W4J
Nikkaji Web: J22.706D
Beilstein Number: 2001459
MDL: MFCD00274552
XlogP3-AA: 4.30 (est)
Molecular Weight: 338.44410000
Formula: C19 H30 O5
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antioxidants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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PubMed: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 497.30 °C. @ 760.00 mm Hg (est)
Flash Point: 338.00 °F. TCC ( 170.10 °C. ) (est)
logP (o/w): 3.490 (est)
Soluble in:
 water, 11.48 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
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Suppliers:
BOC Sciences
For experimental / research use only.
Idebenone >98%
Odor: characteristic
Use: Idebenone is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.
Jiangyin Healthway
Idebenone
New functional food ingredients
Sigma-Aldrich
For experimental / research use only.
Idebenone
analytical standard
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
unreported-mammal (species unspecified) LD50  > 1000 mg/kg
Chemical and Pharmaceutical Bulletin. Vol. 39, Pg. 367, 1991.

intraperitoneal-mouse LD50  757 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3931, 1985.

oral-mouse LD50  > 10000 mg/kg
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3931, 1985.

intraperitoneal-rat LD50  830 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3931, 1985.

oral-rat LD50  10000 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3931, 1985.

Dermal Toxicity:
subcutaneous-mouse LD50 > 10000 mg/kg
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3931, 1985.

subcutaneous-rat LD50 > 10000 mg/kg
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3931, 1985.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antioxidants
Recommendation for idebenone usage levels up to:
 not for fragrance use.
 
Recommendation for idebenone flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 3686
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
Chemidplus: 0058186279
RTECS: GU5290000 for cas# 58186-27-9
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References:
 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 3686
Pubchem (sid): 135003257
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): D01750
HMDB (The Human Metabolome Database): Search
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 CV 2619
2,5-cyclohexadiene-1,4-dione, 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-
 hydroxydecyl ubiquinone
6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone
2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
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Articles:
PubMed: Pharmacokinetic properties and metabolism of idebenone.
PubMed: A comparison of the relative antioxidant potency of L-ergothioneine and idebenone.
PubMed: Enhancement of nitroxide-reducing activity in rats after chronic administration of vitamin E, vitamin C, and idebenone examined by an in vivo electron spin resonance technique.
PubMed: Idebenone improves learning and memory impairment induced by cholinergic or serotonergic dysfunction in rats.
PubMed: Effects of idebenone on neurological deficits following cerebrovascular lesions in stroke-prone spontaneously hypertensive rats.
PubMed: [Effect of idebenone on scopolamine-induced impairment of short-term memory in rats].
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