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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 491.10 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 418.00 °F. TCC ( 214.20 °C. ) (est)
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| logP (o/w): | 2.870 (est) |
| Soluble in: |
| | water, 39.51 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for kadsurenone usage levels up to: | | | not for fragrance use.
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| Recommendation for kadsurenone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :122159 |
| National Institute of Allergy and Infectious Diseases:Data |
| (2S,3R,3aS)-2-(3,4-dimethoxyphenyl)-3a-methoxy-3-methyl-5-prop-2-enyl-2,3-dihydro-1-benzofuran-6-one |
| Chemidplus:0095851379 |
References:
| | (2S,3R,3aS)-2-(3,4-dimethoxyphenyl)-3a-methoxy-3-methyl-5-prop-2-enyl-2,3-dihydro-1-benzofuran-6-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 122159 |
| Pubchem (sid): | 135077970 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 5- | allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-methyl-3,3a-dihydro-2H-benzofuran-6-one | | (2S,3R,3aS)-5- | allyl-2-(3,4-dimethoxyphenyl)-3a-methoxy-3-methyl-3,3a-dihydro-1-benzofuran-6(2H)-one | | 6(2H)- | benzofuranone, 2-(3,4-dimethoxyphenyl)-3,3a-dihydro-3a-methoxy-3-methyl-5-(2-propen-1-yl)-, (2S,3R,3aS)- | | | denudatin B | | (2S-(2alpha,3beta,3aalpha))-2-(3,4- | dimethoxyphenyl)-3,3a-dihydro-3a-methoxy-3-methyl-5-(2-propenyl)-6(2H)-benzofuranone | | (2S,3R,3aS)-2-(3,4- | dimethoxyphenyl)-3a-methoxy-3-methyl-5-prop-2-enyl-2,3-dihydro-1-benzofuran-6-one |
Articles:
| PubMed:Development of an LC-MS/MS method for quantification of kadsurenone in rat plasma and its application to a pharmacokinetic study. |
| PubMed:Platelet-activating factor (PAF)-antagonists of natural origin. |
| PubMed:[Neolignans and lignan from Piper wallichii]. |
| PubMed:Pharmacokinetics of kadsurenone and its interaction with cyclosporin A in rats using a combined HPLC and microdialysis system. |
| PubMed:[Advances in pharmacological study of Piper kadsura (Choisy) Ohwi]. |
| PubMed:Ambident effect of a p-sulfinyl group for the introduction of two carbon substituents to phenol rings: a convergent synthesis of diverse benzofuran neolignans. |
| PubMed:Platelet-activating factor antagonists. |
| PubMed:The biological activity of acetylated sphingosylphosphorylcholine derivatives. |
| PubMed:[Recent progress in the study of anti-PAF (platelet activating factor) constituents of medicinal herbs]. |
| PubMed:[Anti-platelet activating factor constituents, 2,5-diaryltetrahydrofuran type lignans, from Piper futokadsura Sied. et Zucc]. |
| PubMed:Trimucytin: a collagen-like aggregating inducer isolated from Trimeresurus mucrosquamatus snake venom. |
| PubMed:Stimulation of human polymorphonuclear leukocytes by leukotriene B4 and platelet-activating factor: an ultrastructural and pharmacological study. |
| PubMed:[PAF antagonistic benzofuran neolignans from Piper kadsura]. |
| PubMed:PAF antagonism in vitro and in vivo by aglafoline from Aglaia elliptifolia Merr. |
| PubMed:Stimulation of tumour necrosis factor release by cytotoxic analogues of platelet-activating factor. |
| PubMed:Antagonism of platelet-activating factor-induced increase in cytosolic free calcium concentration in human endothelial cells. |
| PubMed:Platelet-activating factor (PAF) receptor antagonists inhibit arachidonic acid induced platelet aggregation in rabbit whole blood. |
| PubMed:Comparison of the actions of some platelet-activating factor antagonists on platelets and aortic smooth muscles. |
| PubMed:Inhibition of immune complex-induced enteropathy by three different platelet-activating factor receptor antagonists. |
| PubMed:The rational search for natural neolignans. |
| PubMed:Pharmacologic characterization of the rabbit neutrophil receptor for platelet-activating factor. |
| PubMed:Vasorelaxing effect in rat thoracic aorta caused by denudatin B, isolated from the Chinese herb, magnolia fargesii. |
| PubMed:Lipophilicity force field profile: an expressive visualization of the lipophilicity molecular potential gradient. |
| PubMed:Distinct stimulatory effect of platelet-activating factor on prostaglandin I2 and thromboxane A2 biosynthesis by rat dental pulp. |
| PubMed:Inhibition of thrombin- and collagen-induced phosphoinositides breakdown in rabbit platelets by a PAF antagonist--denudatin B, an isomer of kadsurenone. |
| PubMed:Development of specific functionally active receptors for platelet-activating factor in HL-60 cells following granulocytic differentiation. |
| PubMed:Kadsurenone and other related lignans as antagonists of platelet-activating factor receptor. |
| PubMed:Further characterization of PAF receptor and novel antagonists. |
| PubMed:Acute microcirculatory effects of platelet-activating factor. |
| PubMed:Antagonism of platelet activating factor-induced chemiluminescence in guinea-pig peritoneal macrophages in differing states of activation. |
| PubMed:PAF-receptor. 1. 'Cache-oreilles' effect of selected high-potency platelet-activating factor (PAF) antagonists. |
| PubMed:Pharmacologic modulation of D-49 phospholipase A2-induced paw edema in the mouse. |
| PubMed:Preliminary studies on phospholipase A2-induced mouse paw edema as a model to evaluate antiinflammatory agents. |
| PubMed:Antagonism of Paf-induced oedema formation in rabbit skin: a comparison of different antagonists. |
| PubMed:Platelet activating factor is a potent colonic secretagogue with actions independent of specific PAF receptors. |
| PubMed:Platelet-activating factor-induced calcium mobilization in human platelets and neutrophils: effects of PAF-acether antagonists. |
| PubMed:[The isolation and identification of PAF inhibitors from Piper wallichii (Miq.) Hand-Mazz and P. hancei Maxim]. |
| PubMed:Platelet-activating factor stimulates arachidonic acid metabolism in rat liver cells (C-9 cell line) by a receptor-mediated mechanism. |
| PubMed:Metabolism of kadsurenone and 9,10-dihydrokadsurenone in rhesus monkeys and rat liver microsomes. |
| PubMed:Enhanced human monocyte cytotoxicity by platelet-activating factor. |
| PubMed:Differential effect of platelet-activating factor (PAF) receptor antagonists on peptide and PAF-stimulated prostaglandin release in unilateral ureteral obstruction. |
| PubMed:Inhibitory effect of platelet-activating factor (PAF) on luteinizing hormone-releasing hormone and somatostatin release from rat median eminence in vitro correlated with the characterization of specific PAF receptor sites in rat hypothalamus. |
| PubMed:Effect of platelet activating factor on leukocyte-endothelial cell interactions. |
| PubMed:Comparison of the platelet aggregation induced by three thrombin-like enzymes of snake venoms and thrombin. |
| PubMed:Identification of platelet-activating factor receptors in P388D1 murine macrophages. |
| PubMed:Vasoconstrictor effects of platelet-activating factor in the hamster cheek pouch microcirculation: dose-related relations and pathways of action. |
| PubMed:Platelet-activating factor primes neutrophil responses to agonists: role in promoting neutrophil-mediated endothelial damage. |
| PubMed:Effect of platelet-activating factor on microvascular permselectivity: dose-response relations and pathways of action in the hamster cheek pouch microcirculation. |
| PubMed:Platelet activating factor receptor blockade enhances recovery after multifocal brain ischemia. |
| PubMed:Effect of platelet activating factor antagonists on cultured rat mesangial cells. |
| PubMed:Involvement of platelet-activating factor (PAF) in cerebral post-ischemic phase in Mongolian gerbils. |
| PubMed:Specific receptor sites for platelet activating factor on rat liver plasma membranes. |
| PubMed:Evaluation of PAF antagonists using human neutrophils in a microtiter plate assay. |
| PubMed:Pharmacologic modulation of PAF-induced mortality in mice. |
| PubMed:Pharmacological actions of WEB 2086, a new specific antagonist of platelet activating factor. |
| PubMed:Pharmacologic antagonism of platelet activating factor and peptide leukotrienes inhibits guinea pig anaphylaxis. |
| PubMed:Structure-activity relationships of kadsurenone analogues. |
| PubMed:Species difference in the specific receptors of platelet activating factor. |
| PubMed:Specific binding of [3H]dihydrokadsurenone to rabbit platelet membranes and its inhibition by the receptor agonists and antagonists of platelet-activating factor. |
| PubMed:The inflammatory response of rabbit skin to topical arachidonic acid and its pharmacological modulation. |
| PubMed:Characterization of platelet activating factor (PAF)-acether-induced contractions of guinea-pig lung strips by selected inhibitors of arachidonic acid metabolism and by PAF-acether antagonists. |
| PubMed:Crystal and molecular structure of BN 52021, a PAF-acether antagonist. Comparison with the conformation of Kadsurenone and related compounds. |
| PubMed:Relative roles of leukotrienes and platelet activating factor in experimentally-induced gastric ulceration. |
| PubMed:Comparative effects of drugs on leukotrienes-, PAF-acether- and histamine- induced contractions of guinea-pig lung parenchymal strips. |
| PubMed:[Neolignans from Piper hancei Maxim]. |
| PubMed:Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988. |
| PubMed:Kadsurenone distinguishes between different platelet activating factor receptor subtypes on macrophages and polymorphonuclear leucocytes. |
| PubMed:Ionic and GTP regulation of binding of platelet-activating factor to receptors and platelet-activating factor-induced activation of GTPase in rabbit platelet membranes. |
| PubMed:Release of platelet activating factor and its involvement in the first phase of carrageenin-induced rat foot edema. |
| PubMed:Changes in cytosolic free calcium induced by platelet-activating factor in rabbit platelets: specific inhibition by BN 52021 and structurally related compounds. |
| PubMed:Cardiovascular alterations in the rabbit infused with platelet activating factor (PAF): effect of kadsurenone, a PAF-receptor antagonist. |
| PubMed:Inhibition of the platelet activating factor mediated component of guinea pig anaphylaxis by receptor antagonists. |
| PubMed:trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor. |
| PubMed:[Antagonists of platelet activating factor]. |
| PubMed:Characterization of cutaneous vascular permeability induced by platelet-activating factor in guinea pigs and rats and its inhibition by a platelet-activating factor receptor antagonist. |
| PubMed:Specific binding sites for platelet activating factor in human lung tissues. |
| PubMed:Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. |
| PubMed:Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects. |
| PubMed:The isolation and characterization of kadsurenone from haifenteng (Piper futokadsura) as an orally active specific receptor antagonist of platelet-activating factor. |
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3D/inchi