3-hydroxyaspartic acid, 1860-87-3

Articles:

PubMed:Glutamate transporters of blood platelets as potential peripheral markers to analyze changes of glutamate transport activity in brain under altered gravity conditions.

PubMed:Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death.

PubMed:Non-heme hydroxylase engineering for simple enzymatic synthesis of L-threo-hydroxyaspartic acid.

PubMed:Genome-scale analysis of anti-metabolite directed strain engineering.

PubMed:A concise, asymmetric synthesis of (2R,3R)-3-hydroxyaspartic acid.

PubMed:Tryptophan breakdown pathway in bipolar mania.

PubMed:[Modulating effect of glutamate transporter inhibitors on accumulation and release of the neuromediator by the brain nerve terminals in rats].

PubMed:Autophagic degeneration of motor neurons in a model of slow glutamate excitotoxicity in vitro.

PubMed:Effects of the inhibitors on glutamate uptake by nerve terminals after exposure of rats to centrifuge-induced hypergravity.

PubMed:Expression of GFP-tagged neuronal glutamate transporters in cerebellar Purkinje neurons.

PubMed:Structure, conformation and biological activity of a novel lipodepsipeptide from Pseudomonas corrugata: cormycin A.

PubMed:Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density.

PubMed:Activation of protein kinase C reduces GLAST in the plasma membrane of rat Müller cells in primary culture.

PubMed:Identification of glutamate transporters and receptors in mouse testis.

PubMed:Glutamate spillover in the striatum depresses dopaminergic transmission by activating group I metabotropic glutamate receptors.

PubMed:Serine racemase homologue of Saccharomyces cerevisiae has L-threo-3-hydroxyaspartate dehydratase activity.

PubMed:A novel enzyme, D-3-hydroxyaspartate aldolase from Paracoccus denitrificans IFO 13301: purification, characterization, and gene cloning.

PubMed:Electrical and pharmacological properties of the slow depolarization induced by Schaffer collateral stimulation in astrocytes of the rat hippocampal CA1 region.

PubMed:Metabotropic glutamate receptor-mediated hetero-synaptic interaction of red- and green-cone inputs to LHC of carp retina.

PubMed:Isoflurane preconditioning reduces purkinje cell death in an in vitro model of rat cerebellar ischemia.

PubMed:Neuronal glutamate uptake Contributes to GABA synthesis and inhibitory synaptic strength.

PubMed:The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures.

PubMed:Modulation of glutamatergic transmission by bergmann glial cells in rat cerebellum in situ.

PubMed:Involvement of acetylated tubulin in the regulation of Na+,K+ -ATPase activity in cultured astrocytes.

PubMed:Local application of L- threo-hydroxyaspartate and malonate in rats in vivo induces rigidity and damages neurons of the substantia nigra, pars compacta.

PubMed:Glutamate-induced calcium increase in myotubes depends on up-regulation of a sodium-dependent transporter.

PubMed:Feeding-induced decrease in extracellular glutamate level in the rat nucleus accumbens: dependence on glutamate uptake.

PubMed:Beta-amyloid enhances glial glutamate uptake activity and attenuates synaptic efficacy.

PubMed:Inhibitor of glutamate transport alters synaptic transmission at sensorimotor synapses in Aplysia.

PubMed:gamma-glutamate and beta-hydroxyaspartate in proteins.

PubMed:Differing effects of substrate and non-substrate transport inhibitors on glutamate uptake reversal.

PubMed:Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5).

PubMed:Hypoglycemia induces general neuronal death, whereas hypoxia and glutamate transport blockade lead to selective retinal ganglion cell death in vitro.

PubMed:Methylmercury inhibits cysteine uptake in cultured primary astrocytes, but not in neurons.

PubMed:Kinetics and activation of postsynaptic kainate receptors at thalamocortical synapses: role of glutamate clearance.

PubMed:Dopamine-dependent inhibition of glycine release in the nucleus accumbens of the rat brain during food consumption.

PubMed:A Na+-dependent electrogenic glutamate transporter current in voltage-clamped cells of corpora allata in the cricket Gryllus bimaculatus.

PubMed:Methylmercury-mediated inhibition of 3H-D-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase.

PubMed:Release of D,L-threo-beta-hydroxyaspartate as a false transmitter from excitatory amino acid-releasing nerve terminals.

PubMed:Regulation of mitochondrial glutamine/glutamate metabolism by glutamate transport: studies with (15)N.

PubMed:Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes.

PubMed:Possible linkage between glutamate transporter and mitogen-activated protein kinase cascade in cultured rat cortical astrocytes.

PubMed:Transient increase in the high affinity [3H]-L-glutamate uptake activity during in vitro development of hippocampal neurons in culture.

PubMed:Müller cell protection of rat retinal ganglion cells from glutamate and nitric oxide neurotoxicity.

PubMed:3-Nitropropionic acid neurotoxicity in organotypic striatal and corticostriatal slice cultures is dependent on glucose and glutamate.

PubMed:Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats.

PubMed:[Dopamine-dependent inhibition of glycine release in the rat nucleus accumbens during feeding].

PubMed:Synaptically released glutamate does not overwhelm transporters on hippocampal astrocytes during high-frequency stimulation.

PubMed:Na+-dependent high-affinity glutamate transport in macrophages.

PubMed:[Changes in glutamate release in the rat nucleus accumbens during food and pain reinforcement].

PubMed:Glutamate transport blockade has a differential effect on AMPA and NMDA receptor-mediated synaptic transmission in the developing barrel cortex.

PubMed:Control of synaptic depression by glutamate transporters.

PubMed:Transient treatments with L-glutamate and threo-beta-hydroxyaspartate induce swelling of rat cultured astrocytes.

PubMed:Metabotropic glutamate receptors and blockade of glial Krebs cycle depress glycinergic synaptic currents of mouse hypoglossal motoneurons.

PubMed:SNARE protein-dependent glutamate release from astrocytes.

PubMed:Trans-inhibition of glutamate transport prevents excitatory amino acid-induced glycolysis in astrocytes.

PubMed:Biosynthetic origin of syringomycin and syringopeptin 22, toxic secondary metabolites of the phytopathogenic bacterium Pseudomonas syringae pv. syringae.

PubMed:Effects of inhibiting glutamine synthetase and blocking glutamate uptake on b-wave generation in the isolated rat retina.

PubMed:Motor neuron degeneration is attenuated in bax-deficient neurons in vitro.

PubMed:Characterization of (2S,2'R,3'R)-2-(2',3'-[3H]-dicarboxycyclopropyl)glycine binding in rat brain.

PubMed:Action of excitatory amino acids on hypodermis and the motornervous system of Ascaris suum: pharmacological evidence for a glutamate transporter.

PubMed:DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.

PubMed:Modulation of human glutamate transporter activity by phorbol ester.

PubMed:AMPA receptor-mediated slow neuronal death in the rat spinal cord induced by long-term blockade of glutamate transporters with THA.

PubMed:Postsynaptic glutamate transport at the climbing fiber-Purkinje cell synapse.

PubMed:Intracerebral microdialysis study of glutamate reuptake in awake, behaving rats.

PubMed:Glutamatergic enteric neurons.

PubMed:Transporters buffer synaptically released glutamate on a submillisecond time scale.

PubMed:Stimulated release of lactate in freely moving rats is dependent on the uptake of glutamate.

PubMed:Short-lived intermediates in aspartate aminotransferase systems.

PubMed:Inhibition of glutamate uptake causes an acute increase in aqueous humor protein.

PubMed:Aspartate aminotransferase complexed with erythro-beta-hydroxyaspartate: crystallographic and spectroscopic identification of the carbinolamine intermediate.

PubMed:Attenuation of trimethyltin-evoked glutamate (GLU) efflux from rat cortical and hippocampal slices.

PubMed:Glutamate transport modulation of paracellular permeability across LLC-PK1-F+ monolayers.

PubMed:The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: a microdialysis study.

PubMed:Autoradiographic studies indicate regional variations in the characteristics of L-glutamate transporters in the rat brain.

PubMed:Modulation of excitatory synaptic transmission by low concentrations of glutamate in cultured rat hippocampal neurons.

PubMed:Inhibition of glutamate uptake induces progressive accumulation of extracellular glutamate and neuronal damage in rat cortical cultures.

PubMed:Characterization of recombinant human coagulation factor XFriuli.

PubMed:Noise analysis of the glutamate-activated current in photoreceptors.

PubMed:Cone photoreceptors respond to their own glutamate release in the tiger salamander.

PubMed:The glutamate uptake regulatory protein (Grp) of Zymomonas mobilis and its relation to the global regulator Lrp of Escherichia coli.

PubMed:Reaction of aspartate aminotransferase with L-erythro-3-hydroxyaspartate: involvement of Tyr70 in stabilization of the catalytic intermediates.

PubMed:Microdialysis as a tool for in vivo investigation of glutamate transport capacity in rat brain.

PubMed:Effects of a glutamate uptake inhibitor on glutamate release induced by veratridine and ischemia.

PubMed:Other lipopeptides.

PubMed:Effects of L-trans-pyrrolidine-2,4-dicarboxylate and L-threo-3-hydroxyaspartate on the binding of [3H]L-aspartate, [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), [3H]DL-(E)-2-amino-4-propyl-5-phosphono-3-pentenoate (CGP 39653), [3H]6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and [3H]kainate studied by autoradiography in rat forebrain.

PubMed:L-glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a.

PubMed:Block of glutamate transporters potentiates postsynaptic excitation.

PubMed:Regional differences in the inhibition of L-glutamate and L-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by L-trans-pyrrolidine-2,4-dicarboxylate, threo-3-hydroxy-D-aspartate and D-aspartate.

PubMed:Pre- and post-synaptic modulators of excitatory neurotransmission: comparative effects on hypoxia/hypoglycemia in cortical cultures.

PubMed:Glial contributions to excitatory neurotransmission in cultured hippocampal cells.

PubMed:Na(+)-dependent high affinity uptake of L-glutamate in primary cultures of human fibroblasts isolated from three different types of tissue.

PubMed:The Na(+)-dependent binding of [3H]L-aspartate in thaw-mounted sections of rat forebrain.

PubMed:Glucose can fuel glutamate uptake in ischemic brain.

PubMed:Depolarization elicits, while hyperpolarization blocks uptake of endogenous glutamate by retinal horizontal cells of the turtle.

PubMed:(2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate.

PubMed:Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity.

PubMed:Modulatory action of kainic acid on glutamate release from rat brain cortical synaptosomes.

PubMed:Binding of protein S to C4b-binding protein. Mutagenesis of protein S.

PubMed:Evidence for the existence of O-linked sugar chains consisting of glucose and xylose in bovine thrombospondin.

PubMed:Philanthotoxins block glutamatergic transmission in rat hippocampus--I. Reduction of high affinity glutamate uptake demonstrated by light microscopy surface autoradiography.

PubMed:The pharmacological profile of glutamate-evoked ascorbic acid efflux measured by in vivo electrochemistry.

PubMed:beta-Hydroxyaspartic acid and beta-hydroxyasparagine residues in recombinant human protein S are not required for anticoagulant cofactor activity or for binding to C4b-binding protein.

PubMed:Structure-function relationships of epidermal growth factor modules in vitamin K-dependent clotting factors.

PubMed:Prepeptide sequence of cinnamycin (Ro 09-0198): the first structural gene of a duramycin-type lantibiotic.

PubMed:Electrogenic uptake of glutamate and aspartate into glial cells isolated from the salamander (Ambystoma) retina.

PubMed:DL-threo-3-hydroxyaspartate reduces NMDA receptor activation by glutamate in cultured neurons.

PubMed:Characterization of glutamate uptake systems in astrocyte primary cultures from rat brain.

PubMed:Anatomical and pharmacological heterogeneity of D-[3H]aspartate binding sites.

PubMed:Excitatory amino acid pathways in brain-stimulation reward.

PubMed:Calcium binding to the isolated beta-hydroxyaspartic acid-containing epidermal growth factor-like domain of bovine factor X.

PubMed:The neurotoxicity of 1-methyl-4-phenylpyridinium in cultured cerebellar granule cells.

PubMed:Substitution of a lysyl residue for arginine 386 of Escherichia coli aspartate aminotransferase.

PubMed:Hydroxylation of aspartic acid in domains homologous to the epidermal growth factor precursor is catalyzed by a 2-oxoglutarate-dependent dioxygenase.

PubMed:Beta-hydroxyaspartic acid in the first epidermal growth factor-like domain of protein C. Its role in Ca2+ binding and biological activity.

PubMed:The role of beta-hydroxyaspartate and adjacent carboxylate residues in the first EGF domain of human factor IX.

PubMed:Potentiation by kainate of excitatory amino acid release in striatum: complementary in vivo and in vitro experiments.

PubMed:beta-Hydroxyaspartic acid or beta-hydroxyasparagine in bovine low density lipoprotein receptor and in bovine thrombomodulin.

PubMed:Occurrence of beta-hydroxylated asparagine residues in non-vitamin K-dependent proteins containing epidermal growth factor-like domains.

PubMed:Continuous glutamate leakage from brain cells is balanced by compensatory high-affinity reuptake transport.

PubMed:Na+-dependent "binding" of D-aspartate in brain membranes is largely due to uptake into membrane-bounded saccules.

PubMed:Binding of iron by factor IX. Possible role for beta-hydroxyaspartic acid.

PubMed:Protein C in bovine plasma after warfarin treatment. Purification, partial characterization, and beta-hydroxyaspartic acid content.

PubMed:Calcium binding to a human factor IXa derivative lacking gamma-carboxyglutamic acid: evidence for two high-affinity sites that do not involve beta-hydroxyaspartic acid.

PubMed:Inhibitors of high-affinity uptake augment depolarizations of hippocampal neurons induced by glutamate, kainate and related compounds.

PubMed:Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum.

PubMed:Interaction of aspartate and aspartate-derived antimetabolites with the enzymes of the threonine biosynthetic pathway of Escherichia coli.

PubMed:Structure and function of protein C.

PubMed:Beta-hydroxyaspartic acid in vitamin K-dependent plasma proteins from scorbutic and warfarin-treated guinea pigs.

PubMed:erythro-beta-Hydroxyaspartic acid in bovine factor IX and factor X.

PubMed:Beta-hydroxyaspartic acid in vitamin K-dependent proteins.

PubMed:The occurrence of beta-hydroxyaspartic acid in the vitamin K-dependent blood coagulation zymogens.

PubMed:Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid.

PubMed:Effects of anoxia on the stimulated release of amino acid neurotransmitters in the cerebellum in vitro.

PubMed:Potentiation of L-glutamate and L-aspartate excitation of cat spinal neurones by the stereoisomers of threo-3-hydroxyaspartate.

3-hydroxyaspartic acid
aspartic acid, 3-hydroxy-

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3-hydroxyaspartic acid
aspartic acid, 3-hydroxy-