Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Assay: | 95.00 to 100.00
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Food Chemicals Codex Listed: | No |
Boiling Point: | 550.90 °C. @ 760.00 mm Hg (est)
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Flash Point: | 415.00 °F. TCC ( 212.60 °C. ) (est)
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logP (o/w): | 1.380 (est) |
Soluble in: |
| water, 1.90E+04 mg/L @ 10 °C (exp) | | water, 7988 mg/L @ 25 °C (est) |
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
unreported-guinea pig LDLo 2 mg/kg BEHAVIORAL: COMA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmacology and Experimental Therapeutics. Vol. 2, Pg. 73, 1910.
intraperitoneal-mouse LD50 3 mg/kg Journal of Medicinal Chemistry. Vol. 11, Pg. 729, 1968.
intravenous-rabbit LD50 1244 ug/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 2, 1940.
unreported-rabbit LDLo 1666 ug/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: COMA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 2, Pg. 73, 1910.
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Dermal Toxicity: |
subcutaneous-mouse LD50 3613 ug/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 2, 1940.
subcutaneous-rabbit LD50 1521 ug/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 2, 1940.
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | natural substances and extractives |
Recommendation for tutin usage levels up to: | | not for fragrance use.
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Recommendation for tutin flavor usage levels up to: |
| not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
(1S,2R,3S,5R,6R,7R,8S,9R,12R)-2,8- | dihydroxy-12-isopropenyl-7-methyl-11H-spiro[4,10-dioxatetracyclo[7.2.1.02,7.03,5]dodecane-6,2'-oxiran]-11-one | (1aS,1bR,2S,5R,6S,6aR,7R,7aR,8R)-1b,6- | dihydroxy-6a-methyl-8-(prop-1-en-2-yl)hexahydrospiro[2,5-methanooxireno[3,4]cyclopenta[1,2-d]oxepine-7,2'-oxiran]-3(2H)-one | (1S,2R,3S,5R,6R,7R,8S,9R,12R)-2,8- | dihydroxy-7-methyl-12-(prop-1-en-2-yl)-11H-spiro[4,10-dioxatetracyclo[7.2.1.02,7.03,5]dodecane-6,2'-oxiran]-11-one | | toot poison | | tutine |
Articles:
PubMed:Human pharmacokinetic study of tutin in honey; a plant-derived neurotoxin. |
PubMed:Chimpanzees (Pan troglodytes verus) and their mammalian sympatriates: Mt. Assirik, Niokolo-Koba National Park, Senegal. |
PubMed:Phytochemistry and biology of Loranthus parasiticus Merr, a commonly used herbal medicine. |
PubMed:Assessment of landscape-scale distribution of sympatric great apes in African rainforests: concurrent use of nest and camera-trap surveys. |
PubMed:Uncontrolled donors with controlled reperfusion after sixty minutes of asystole: a novel reliable resource for kidney transplantation. |
PubMed:Semisynthesis of N-acyl homoserinelactone derivatives and the antifeedant activity against Mythimna separata. |
PubMed:A bitter-sweet tale from the land of milk and honey. |
PubMed:Tutu toxicity: three case reports of Coriaria arborea ingestion, review of literature and recommendations for management. |
PubMed:[Optimization of kidney transplantation from elderly donors]. |
PubMed:Sesquiterpenoids and diarylheptanoids from Nidus vespae and their inhibitory effects on nitric oxide production. |
PubMed:Inhibitory activities on mammalian central nervous system receptors and computational studies of three sesquiterpene lactones from Coriaria ruscifolia subsp. ruscifolia. |
PubMed:Potentiation and inhibition of glycine receptors by tutin. |
PubMed:An ethnobotanical survey of medicinal plants in Sivrice (Elazığ-Turkey). |
PubMed:Preliminary screening of acetylcholinesterase inhibitory and antioxidant activities of Anatolian Heptaptera species. |
PubMed:Investigation of the possible biological activities of a poisonous South African plant; Hyaenanche globosa (Euphorbiaceae). |
PubMed:[Parent satisfaction with the Loire Infant Follow-up Team (LIFT) premature and at-risk infant network in the Pays-de-la-Loire area (France)]. |
PubMed:Effects of Athamanta turbith fruit essential oils on CCl4-induced hepatic failure in mice and their antioxidant properties. |
PubMed:Chemical and principal-component analyses of the essential oils of Apioideae taxa (Apiaceae) from central Balkan. |
PubMed:The role of Pleistocene refugia and rivers in shaping gorilla genetic diversity in central Africa. |
PubMed:Who killed Porthos? Genetic tracking of a gorilla death. |
PubMed:Seed protein variations of Salicornia L. and allied taxa in Turkey. |
PubMed:Relationship between heavy fuel oil phytotoxicity and polycyclic aromatic hydrocarbon contamination in Salicornia fragilis. |
PubMed:Inhibitory effects of tutin on glycine receptors in spinal neurons. |
PubMed:A new rat model of acute seizures induced by tutin. |
PubMed:Evidence for bioaccumulation of PAHs within internal shoot tissues by a halophytic plant artificially exposed to petroleum-polluted sediments. |
PubMed:Gas chromatographic-mass spectrometric method for polycyclic aromatic hydrocarbon analysis in plant biota. |
PubMed:The isolation and structure elucidation of a new sesquiterpene lactone from the poisonous plant Coriaria japonica (Coriariaceae). |
PubMed:Western gorilla diet: a synthesis from six sites. |
PubMed:The epizootiological occurrence of bluetongue in the central Balkans. |
PubMed:[Tutin-induced epileptiform discharge of CA1 pyramidal cells in rat hippocampal slices]. |
PubMed:Mitochondrial DNA phylogeography of western lowland gorillas (Gorilla gorilla gorilla). |
PubMed:Phase I trial of concurrent twice-weekly recombinant human interleukin-12 plus low-dose IL-2 in patients with melanoma or renal cell carcinoma. |
PubMed:Primates in caves: two new reports of Papio spp. |
PubMed:Catastrophic ape decline in western equatorial Africa. |
PubMed:Radial variation in sap flow in five laurel forest tree species in Tenerife, Canary Islands. |
PubMed:[Nerve tissue morphological study of tutin microinjection into pontine NPBM in two hours]. |
PubMed:A phase II pilot trial of concurrent biochemotherapy with cisplatin, vinblastine, temozolomide, interleukin 2, and IFN-alpha 2B in patients with metastatic melanoma. |
PubMed:Quantitation of trimethyl amine by headspace gas chromatography-mass spectrometry using a base-modified column. |
PubMed:[Studies on chemical constituents from the root of Coriaria nepalensis wall (Coriaria sinica Maxim)]. |
PubMed:Saving the gorillas (Gorilla g. gorilla) and chimpanzees (Pan t. troglodytes) of the Congo Basin. |
PubMed:[Diagnostic value of hysterosalpingography in examination of fallopian tubes in infertile women]. |
PubMed:NOESY on neurotoxins: NMR and conformational assignments of picrotoxins. |
PubMed:[Diagnostic value of hysterosalpingography in examination of Fallopian tubes in infertile women]. |
PubMed:[Ecology and social organization of African tropical forest primates: aid in understanding retrovirus transmission]. |
PubMed:Initial studies on the contributions of body size and gastrointestinal passage rates to dietary flexibility among gorillas. |
PubMed:Cultures in chimpanzees. |
PubMed:Fragmented living: Behavioural ecology of primates in a forest fragment in the Lopé Reserve, Gabon. |
PubMed:Lowland gorillas and seed dispersal: the importance of nest sites. |
PubMed:The primate community of the Lopé Reserve, Gabon: diets, responses to fruit scarcity, and effects on biomass. |
PubMed:Actions of picrodendrin antagonists on dieldrin-sensitive and -resistant Drosophila GABA receptors. |
PubMed:Filariae from a wild gorilla in Gabon with description of a new species of Mansonella. |
PubMed:Intestinal parasites of sympatric gorillas and chimpanzees in the Lopé Reserve, Gabon. |
PubMed:A school-based anger management program for developmentally and emotionally disabled high school students. |
PubMed:[Respiratory effects of tutin microinjection into NPBM of rabbits]. |
PubMed:Foraging profiles of sympatric lowland gorillas and chimpanzees in the Lopé Reserve, Gabon. |
PubMed:Possible osteomyelitis of skull causes death of a wild lowland gorilla in the Lopé Reserve, Gabon. |
PubMed:[Effects of microinjection of tutin into nucleus tractus solitarius region on the morphology of neural tissue of this area in rabbit]. |
PubMed:[Effects of microinjection of tutin into the nucleus tractus solitarius on the phrenic nerve discharge in rabbits]. |
PubMed:Simultaneous attack by adult males of a polyspecific troop of monkeys against a crowned hawk eagle. |
PubMed:A multivariate analysis of dropout status by length of stay in a rural community mental health center. |
PubMed:Contemporary lake transport processes determined from sedimentary records of copper mining activity. |
PubMed:Actions of picrotoxinin and related compounds on the frog spinal cord: the role of a hydroxyl-group at the 6-position in antagonizing the actions of amino acids and presynaptic inhibition. |
PubMed:The intestinal entodiniomorph ciliates of wild lowland gorillas (Gorilla gorilla gorilla) in Gabon, West Africa. |
PubMed:A new intestinal parasitic entodiniomorph ciliate from wild lowland gorillas (Gorilla gorilla gorilla) in Gabon? |
PubMed:Reproductive behaviour of wild chimpanzees in the Gombe National Park, Tanzania. |
PubMed:[Clinical observations on the effects of Lactoni Coriariae and Tutin in the treatment of schizophrenia (report of 140 cases) (author's transl)]. |
PubMed:[Nutritional and dietetic problems arising particularly in prolonged corticotherapy]. |
PubMed:[Physiopathology of diabetic microangiopathy: value of control of the diabetes]. |
PubMed:[Value of fractionation in diabetology therapy and particularly for glibenclamide]. |
PubMed:The intestinal parasites of a community of feral chimpanzees, Pan troglodytes schweinfurthii. |
PubMed:Tool use in a group of captive chimpanzees I. Escape. |
PubMed:[Current results and methods in eradication of typhus fever on the Serbian territory excluding autonomic provinces]. |
PubMed:[How to advance antidiabetic therapy]. |
PubMed:Letter: Central inhibition, G.A.B.A., and tutin. |
PubMed:Central actions of shikimin and tutin. |
PubMed:Chimpanzee copulatory behaviour. |
PubMed:Sexual behaviour of group-living adolescent chimpanzees. |
PubMed:Chimpanzee dentistry. |
PubMed:[Toxic hypoglycemia]. |
PubMed:[Chronic pancreatitis, diabetes mellitus and specific microangiopathy]. |
PubMed:[Psychosociologic study of therapeutic constraints in diabetes mellitus]. |
PubMed:[Psychological consequences of the therapeutic constraints in the diabetic patient (apropos of a survey of 77 cases]. |
PubMed:[Diabetic retinopathy and insulin therapy]. |
PubMed:[Can retinopathy be prevented by a more physiological treatment of diabetes?]. |
PubMed:[Survey on the influence of multiple injections of insulin on the diabetic retinal micro-angiopathy]. |
PubMed:[For a more physiological treatment of diabetes mellitus. Is it possible to prevent the appearance of angiopathy?]. |
PubMed:[Diabetes mellitus and chronic pancreatitis]. |
PubMed:[Specific angiopathy in diabetes secondary to pancreatitis]. |
PubMed:[Place of hypoglycemic sulfonamides in treatment of steatosis of nutritional origin]. |
PubMed:[Value of average chain triglycerides in fat malabsorption]. |
PubMed:[Horton's disease with bilateral eye involvment, cutaneous and lingual necrosis]. |
PubMed:[Apparently idiopathic bullous dermatosis in a diabetic]. |
PubMed:[Misleading manifestations of intestinal malabsorption]. |
PubMed:[Idiopathic bullous eruption in a diabetic]. |
PubMed:[Study of 41 cases of acute carbon monoxide poisoning with dynamic tests of glycoregulation]. |
PubMed:The correlation of coriamyrtin and tutin, and their absolute configurations. |
PubMed:[Postalcoholic hypoglycemia of the adult. Clinical, biological and physiopathological consideration on 6 cases]. |
PubMed:[Effects of different diets in obesity]. |
PubMed:[Disorders of glyco-regulation after portacaval anastomosis: Study of the outcome of carbohydrate metabolism disorders in liver cirrhosis]. |
PubMed:The central nervous system and carbon monoxide poisoning. I. Clinical data with reference to 20 fatal cases. |
PubMed:[Specific angiopathy in diabetes secondary to pancreatitis and hemochromatosis (61 cases)]. |
PubMed:[Glycoregulation and carbon monoxide coma]. |
PubMed:[Physiopathological studies of hypoglycemia induced by alcohol (post-alcoholic hypoglycemia)]. |
PubMed:[Diabetic retinopathy and current concepts of diabetic angiopathy]. |
PubMed:[Elevation of transaminases during acute respiratory insufficiency]. |
PubMed:[Apropos of the association of cancer of the kidney, neuromyopathy and hypercalcemia with hypophosphoremia. Discussion of a paraneoplastic hyperparathyroidism]. |
PubMed:[Electroencephalographic aspects during acute carbon monoxide poisoning and its sequelae]. |
PubMed:[Diabetes and pancreatopathies]. |
PubMed:[Thoughts on nonspherocytic chronic congenital hemolytic anemia: apropos of a case]. |
PubMed:[Intestinal bilharziasis of 1st invasion. Serologic diagnosis. (Apropos of a case)]. |
PubMed:[Hypereosinophilia in cancer. Considerations apropos of a case in cancer of the kidney]. |
PubMed:[NUTRITION AND DIET IN 1964]. |
PubMed:[INFECTIOUS JAUNDICE SECONDARY TO SEPTICEMIA OF URINARY ONSET IN ADULTS]. |
PubMed:[The heart and hemochromatosis]. |
PubMed:[ORGANIC PHOSPHORUS POISONING]. |
PubMed:[THROMBOPENIC PURPURA OF SARCOIDOSIC ORIGIN. REFLECTIONS APROPOS OF A RETROCESSIVE CASE WITHOUT SPLENECTOMY]. |
PubMed:[THE TREATMENT OF HEMOCHROMATOSIS]. |
PubMed:[INVESTIGATION ON THE RESULTS OF TREATMENT OF HEMOCHROMATOSIS BY BLOODLETTING]. |
PubMed:[CHILD GROWTH FROM 0 TO 7 YEARS OF AGE. (MEASUREMENTS OF CHILDREN OF THE PARIS AREA FROM 1953 TO 1962)]. |
PubMed:[UNSTABLE DIABETES AND ITS TREATMENT]. |
PubMed:[DIETETICS IN THE TREATMENT OF EDEMA]. |
PubMed:[Gallbladder neck disease. 54 anatomo-clinical cases without cholelithiasis]. |
PubMed:[Vitamins in gastroenterology]. |
PubMed:[Hepatitis and anuria]. |
PubMed:[Malabsorption syndromes. III. Whipple's disease]. |
PubMed:[Malabsorption syndromes. II. Secondary steatorrheas caused by malabsorption of the small intestine]. |
PubMed:[Orthostatic hypotension. (Apropos of a case)]. |
PubMed:[Acute cholostatic hepatitis]. |
PubMed:[Polycystic disease of the liver and kidneys]. |
PubMed:[Metabolic study of a case of Whipple's disease]. |
PubMed:[Gastroenterology]. |
PubMed:[Cancer of the pylorus. Symptoms and diagnosis]. |
PubMed:[The phosphocalcium syndrome of cirrhosis]. |
PubMed:[Diagnosis of non-traumatic coma]. |
PubMed:[Idiopathic hypercalciuria -- 28 cases from personal practice]. |
PubMed:[Data on systematic endocrine examinations of 65 young patients with apparently isolated endocrine cataracts]. |
PubMed:[Clinical forms of cancer of the pancreas]. |
PubMed:[Aplasia of the labia minora, genital infantilism & ovarian sclerosis in genetically male women]. |
PubMed:[Clinical forms, diagnosis & treatment of viral hepatitis]. |
PubMed:[Severe diabetes treated by intrahypophyseal administration of a radiogold pellet]. |
PubMed:[Diabetes new medical agents for oral administration]. |
PubMed:[Acute kidney disease after ingestion of mercuric nitrate; findings on the treatment of kidney diseases caused by mercurials]. |
PubMed:[Not Available]. |
PubMed:Chemical Investigations of Fruits and their Products: The Fate of Sugar during "Cider Sickness.". |
PubMed:Chemical Investigations of Fruits and their Products: Apple Juice as a Source of Sorbitol. |
PubMed:The Pectin Content of Normal and "Silvered" Apple Leaves. |
PubMed:Pectin and its Hypothetical Precursor, "Protopectin.". |
PubMed:A Note on the Hydrolysis of Pectin. |
PubMed:The Behaviour of Pectin towards Alkalis and Pectase. |
PubMed:Carnosine, Constitution and Synthesis. |
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