ajoene, 92285-01-3

Articles:

PubMed:Development of garlic bioactive compounds analytical methodology based on liquid phase microextraction using response surface design. Implications for dual analysis: Cooked and biological fluids samples.

PubMed:The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review.

PubMed:The synthetic ajoene analog SPA3015 induces apoptotic cell death through crosstalk between NF-κB and PPARγ in multidrug-resistant cancer cells.

PubMed:Chemical composition and bioactive compounds of garlic (Allium sativum L.) as affected by pre- and post-harvest conditions: A review.

PubMed:The redox-active drug metronidazole and thiol-depleting garlic compounds act synergistically in the protist parasite Spironucleus vortens.

PubMed:Exploiting the antivirulence efficacy of an ajoene-ciprofloxacin combination against Pseudomonas aeruginosa biofilm associated murine acute pyelonephritis.

PubMed:Antileishmanial and Immunomodulatory Activity of Allium sativum (Garlic): A Review.

PubMed:Natural compounds for pediatric cancer treatment.

PubMed:ROS-mediated activation of JNK/p38 contributes partially to the pro-apoptotic effect of ajoene on cells of lung adenocarcinoma.

PubMed:The garlic compound ajoene targets protein folding in the endoplasmic reticulum of cancer cells.

PubMed:Virtual Screening of Natural and Synthetic Ligands Against Diabetic Retinopathy by Molecular Interaction With Angiopoietin-2.

PubMed:Optimizing conditions for E-and Z-ajoene formation from garlic juice using response surface methodology.

PubMed:Applications of thin-layer chromatography in extraction and characterisation of ajoene from garlic bulbs.

PubMed:Antioxidant defences of Spironucleus vortens: Glutathione is the major non-protein thiol.

PubMed:Systemic approaches identify a garlic-derived chemical, Z-ajoene, as a glioblastoma multiforme cancer stem cell-specific targeting agent.

PubMed:Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs.

PubMed:Neuroprotective effects of Z-ajoene, an organosulfur compound derived from oil-macerated garlic, in the gerbil hippocampal CA1 region after transient forebrain ischemia.

PubMed:Solid phase microextraction coupled to liquid chromatography. Analysis of organosulphur compounds avoiding artifacts formation.

PubMed:Investigating the responses of Cronobacter sakazakii to garlic-drived organosulfur compounds: a systematic study of pathogenic-bacterium injury by use of high-throughput whole-transcriptome sequencing and confocal micro-raman spectroscopy.

PubMed:Enhancement of intestinal IgA production by Ajoene in mice.

PubMed:Application of the DataChip/MetaChip technology for the evaluation of ajoene toxicity in vitro.

PubMed:Molecular mechanisms for the anti-cancer effects of diallyl disulfide.

PubMed:A rethinking on the benefits and drawbacks of common antioxidants and a proposal to look for the antioxidants in allium products as ideal agents: a review.

PubMed:Garlic as an anti-diabetic agent: recent progress and patent reviews.

PubMed:Anti-inflammatory activity of sulfur-containing compounds from garlic.

PubMed:Disrupted intracellular redox balance of the diplomonad fish parasite Spironucleus vortens by 5-nitroimidazoles and garlic-derived compounds.

PubMed:Transformation of synthetic allicin: the influence of ultrasound, microwaves, different solvents and temperatures, and the products isolation.

PubMed:[In vitro synergisms among hydrazones, ajoeno and posaconazole against Cryptococcus spp].

PubMed:A comprehensive review of vaginitis phytotherapy.

PubMed:Structure-activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells.

PubMed:Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing.

PubMed:Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.

PubMed:[In vitro antifungal activity of ajoene on five clinical isolates of Histoplasma capsulatum var. capsulatum].

PubMed:Potential beneficial effects of garlic in oncohematology.

PubMed:Anti-proliferation activity of synthetic ajoene analogues on cancer cell-lines.

PubMed:Effect of garlic and allium-derived products on the growth and metabolism of Spironucleus vortens.

PubMed:Antithrombotic effects of naturally derived products on coagulation and platelet function.

PubMed:Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activation.

PubMed:Ajoene, a stable garlic by-product, has an antioxidant effect through Nrf2-mediated glutamate-cysteine ligase induction in HepG2 cells and primary hepatocytes.

PubMed:Garlic-derived anticancer agents: structure and biological activity of ajoene.

PubMed:Garlic derivatives (PTS and PTS-O) differently affect the ecology of swine faecal microbiota in vitro.

PubMed:Enhanced activation of the transient receptor potential channel TRPA1 by ajoene, an allicin derivative.

PubMed:[In vitro inhibitory effect of ajoene on Candida isolates recovered from vaginal discharges].

PubMed:Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells.

PubMed:Ajoene exerts potent effects in 3T3-L1 adipocytes by inhibiting adipogenesis and inducing apoptosis.

PubMed:Thermostability of allicin determined by chemical and biological assays.

PubMed:Antifungal activity of ajoene on experimental murine paracoccidioidomycosis.

PubMed:[Synergy between ajoene and ketoconazole in isolates of Microsporum canis. A preliminary study using fractional inhibitory concentration technique (FIC)].

PubMed:Substituted ajoenes as novel anti-cancer agents.

PubMed:Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds.

PubMed:Phytochemicals and regulation of the adipocyte life cycle.

PubMed:[Activity of ajoene on dermatophytes, Candida albicans and Malassezia furfur.].

PubMed:Experimental paracoccidioidomycosis: alternative therapy with ajoene, compound from Allium sativum, associated with sulfamethoxazole/trimethoprim.

PubMed:Activities of Z-ajoene against tumour and viral spreading in vitro.

PubMed:[Characteristics of uptake, transport and efflux of Z- and E-ajoenes in Caco-2 cell monolayers in vitro].

PubMed:Enhancement of ajoene-induced apoptosis by conjugated linoleic acid in 3T3-L1 adipocytes.

PubMed:Virucidal agents in the eve of manorapid synergy.

PubMed:Chromoblastomycosis in children and adolescents in the endemic area of the Falcón State, Venezuela.

PubMed:[Ajoene the main active compound of garlic (Allium sativum): a new antifungal agent].

PubMed:Molecular mechanisms of apoptosis induced by ajoene in 3T3-L1 adipocytes.

PubMed:Prophylactic effects of ajoene on cerebral injury in stroke-prone spontaneously hypertensive rats (SHRSP).

PubMed:[Z-ajoene causes cell cycle arrest at G2/M and decrease of telomerase activity in HL-60 cells].

PubMed:Antidiabetic effects of ajoene in genetically diabetic KK-A(y) mice.

PubMed:Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 mice.

PubMed:Paracoccidioides brasiliensis, paracoccidioidomycosis, and antifungal antibiotics.

PubMed:Novel treatments for obesity and osteoporosis: targeting apoptotic pathways in adipocytes.

PubMed:Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents.

PubMed:[An ELISA test for the study of the therapeutic evolution of chromoblastomycosis by Cladophialophora carrionii in the endemic area of Falcon State, Venezuela].

PubMed:Allicin and allicin-derived garlic compounds increase breath acetone through allyl methyl sulfide: use in measuring allicin bioavailability.

PubMed:Beneficial effects of a polar fraction of garlic (Allium sativum Linn) oil in rats fed with two different high fat diets.

PubMed:Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning.

PubMed:Improvement of scopolamine-induced memory impairment by Z-ajoene in the water maze in mice.

PubMed:Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy.

PubMed:Effect of ajoene, a natural antitumor small molecule, on human 20S proteasome activity in vitro and in human leukemic HL60 cells.

PubMed:Apoptotic and anti-adhesion effect of ajoene, a garlic derived compound, on the murine melanoma B16F10 cells: possible role of caspase-3 and the alpha(4)beta(1) integrin.

PubMed:Ajoene and 5-fluorouracil in the topical treatment of Cladophialophora carrionii chromoblastomycosis in humans: a comparative open study.

PubMed:Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoene.

PubMed:Ajoene inhibits the activation of human endothelial cells induced by porcine cells: implications for xenotransplantation.

PubMed:The garlic-derived organosulfur component ajoene decreases basal cell carcinoma tumor size by inducing apoptosis.

PubMed:Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation.

PubMed:The in vitro susceptibility of Scedosporium prolificans to ajoene, allitridium and a raw extract of garlic (Allium sativum).

PubMed:Ajoene-induced cell death in human promyeloleukemic cells does not require JNK but is amplified by the inhibition of ERK.

PubMed:Inhibition by ajoene of skin-tumor promotion in mice.

PubMed:Z-ajoene induces apoptosis of HL-60 cells: involvement of Bcl-2 cleavage.

PubMed:Antiproliferative and leishmanicidal effect of ajoene on various Leishmania species: ultrastructural study.

PubMed:Antitumor activity of Z-ajoene, a natural compound purified from garlic: antimitotic and microtubule-interaction properties.

PubMed:Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells.

PubMed:Ajoene, an experimental anti-leukemic drug: mechanism of cell death.

PubMed:Protective effect of ajoene on acetaminophen-induced hepatic injury in mice.

PubMed:Garlic extract for HIV?

PubMed:Ajoene, a natural product with non-steroidal anti-inflammatory drug (NSAID)-like properties?

PubMed:Thermochemical transformation of sulfur compounds in Japanese domestic Allium, Allium victorialis L.

PubMed:Efficacy of ajoene in the treatment of tinea pedis: a double-blind and comparative study with terbinafine.

PubMed:Structure-activity relationships for selected sulfur-rich antithrombotic compounds.

PubMed:Ajoene in the topical short-term treatment of tinea cruris and tinea corporis in humans. Randomized comparative study with terbinafine.

PubMed:An organosulfur compound isolated from oil-macerated garlic extract, and its antimicrobial effect.

PubMed:Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies.

PubMed:Tityus discrepans venom produces a respiratory distress syndrome in rabbits through an indirect mechanism.

PubMed:Ajoene [(e,z)-4,5,9-trithiadodeca-1,6,11-triene 9 oxide] does not exhibit antiviral activity at subtoxic concentrations.

PubMed:Selective in vitro protection of SIVagm-induced cytolysis by ajoene, [(E)-(Z)-4,5,9-trithiadodeca-1,6,11-triene-9 oxide].

PubMed:Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase.

PubMed:Antimicrobial activity of a compound isolated from an oil-macerated garlic extract.

PubMed:Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB.

PubMed:[Effect of the garlic tablets allicor on thrombocyte aggregation in vitro and ex vivo].

PubMed:Inhibition of Paracoccidioides brasiliensis by ajoene is associated with blockade of phosphatidylcholine biosynthesis.

PubMed:Inhibition by ajoene of protein tyrosine phosphatase activity in human platelets.

PubMed:Effects of Ajoene on lymphocyte and macrophage membrane-dependent functions.

PubMed:In vitro suppression of HIV-1 replication by ajoene [(e)-(z)-4,5,9-trithiadodeca-1,6,11-triene-9 oxide].

PubMed:Lipid biosynthesis pathways as chemotherapeutic targets in kinetoplastid parasites.

PubMed:Antimutagenic effects of ajoene, an organosulfur compound derived from garlic.

PubMed:Inhibition of microbial growth by ajoene, a sulfur-containing compound derived from garlic.

PubMed:Efficacy of ajoene, an organosulphur derived from garlic, in the short-term therapy of tinea pedis.

PubMed:Therapeutic actions of garlic constituents.

PubMed:Synergistic effects of ajoene and the microwave power density memories of water on germination inhibition of fungal spores.

PubMed:A garlic derivative, ajoene, inhibits platelet deposition on severely damaged vessel wall in an in vivo porcine experimental model.

PubMed:Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells.

PubMed:In vivo activity of ajoene against rodent malaria.

PubMed:Injuries to cultivated BJA-B cells by ajoene, a garlic-derived natural compound: cell viability, glutathione metabolism, and pools of acidic amino acids.

PubMed:Effects of a garlic-derived principle (ajoene) on aggregation and arachidonic acid metabolism in human blood platelets.

PubMed:Inhibition of phosphatidylcholine biosynthesis and cell proliferation in Trypanosoma cruzi by ajoene, an antiplatelet compound isolated from garlic.

PubMed:Effect of ajoene on dimorphism of Paracoccidioides brasiliensis.

PubMed:Effect of ajoene, the major antiplatelet compound from garlic, on platelet thrombus formation.

PubMed:In vitro virucidal effects of Allium sativum (garlic) extract and compounds.

PubMed:Ajoene antagonizes integrin-dependent processes in HIV-infected T-lymphoblasts.

PubMed:Kinetics of merthiolate-induced aggregation of human platelets.

PubMed:Wine and coronary heart disease.

PubMed:Functional implications of tyrosine protein phosphorylation in platelets. Simultaneous studies with different agonists and inhibitors.

PubMed:Inhibition of cholesterol synthesis in vitro by extracts and isolated compounds prepared from garlic and wild garlic.

PubMed:[Kinetics of merthiolate-induced aggregation of human platelets].

PubMed:Inhibition of whole blood platelet-aggregation by compounds in garlic clove extracts and commercial garlic products.

PubMed:Potassium channel activation in vascular smooth muscle.

PubMed:[The ajoene blockade of integrin-dependent processes in an HIV-infected cell system].

PubMed:Binding of aflatoxin B1 to DNA inhibited by ajoene and diallyl sulfide.

PubMed:Evidence for direct coupling of primary agonist-receptor interaction to the exposure of functional IIb-IIIa complexes in human blood platelets. Results from studies with the antiplatelet compound ajoene.

PubMed:Isolation and Identification of Homologues of Ajoene and Alliin from Bulb-Extracts of Allium ursinum.

PubMed:[Formation of allicin from dried garlic (Allium sativum): a simple HPTLC method for simultaneous determination of allicin and ajoene in dried garlic and garlic preparations].

PubMed:Identification and HPLC quantitation of the sulfides and dialk(en)yl thiosulfinates in commercial garlic products.

PubMed:Influence of thiols and inhibitors of prostaglandin biosynthesis on the carcinogen-induced development of mammary lesions in vitro.

PubMed:The role of adhesive interactions and extracellular matrix fibronectin from human polymorphonuclear leukocytes in the respiratory burst.

PubMed:Organosulfur compounds of garlic modulate mutagenesis, metabolism, and DNA binding of aflatoxin B1.

PubMed:Potassium channel activation, hyperpolarization, and vascular relaxation.

PubMed:The cytotoxic effect of ajoene, a natural product from garlic, investigated with different cell lines.

PubMed:Products of Allicin Transformation: Ajoenes and Dithiins, Characterization and their Determination by HPLC*.

PubMed:[Adhesion receptors--regulators of respiratory burst in neutrophils].

PubMed:Ajoene prevents fat digestion by human gastric lipase in vitro.

PubMed:Inhibition of growth of the dimorphic fungus Paracoccidioides brasiliensis by ajoene.

PubMed:Ajoene, the antiplatelet compound derived from garlic, specifically inhibits platelet release reaction by affecting the plasma membrane internal microviscosity.

PubMed:Interaction of antiaggregant molecule ajoene with membranes. An ESR and 1H, 2H, 31P-NMR study.

PubMed:Inhibition of soybean lipoxygenase and mouse skin tumor promotion by onion and garlic components.

PubMed:Reversible prevention of platelet activation by (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide (ajoene) in dogs under extracorporeal circulation.

PubMed:Ajoene inhibition of platelet aggregation: possible mediation by a hemoprotein.

PubMed:Antifungal activity of ajoene derived from garlic.

PubMed:The molecular basis of the antiplatelet action of ajoene: direct interaction with the fibrinogen receptor.

PubMed:Ajoene, the antiplatelet principle of garlic, synergistically potentiates the antiaggregatory action of prostacyclin, forskolin, indomethacin and dypiridamole on human platelets.

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4,5,9-trithiadodeca-1,6,11-triene 9-oxide

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