EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

silydianin
silidianin

Supplier Sponsors

CAS Number: 29782-68-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:249-848-5
FDA UNII: 7P89L7W179
MDL:MFCD09970974
XlogP3-AA:0.80 (est)
Molecular Weight:482.44234000
Formula:C25 H22 O10
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 481.9 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Silydianin 98%
BOC Sciences
For experimental / research use only.
Silidianin >98%
Odor: characteristic
Use: Silydianin is an active constituent of Silybium marianum and is known the exhibit anti-inflammatory activity which regulates caspase-3 activation which affects cell membranes and acts as a free radical scavenger.
Santa Cruz Biotechnology
For experimental / research use only.
Silydianin
Sigma-Aldrich
For experimental / research use only.
Silydianin analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for silydianin usage levels up to:
 not for fragrance use.
 
Recommendation for silydianin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :11982272
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0029782681
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):11982272
Pubchem (cas):29782-68-1
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB30584
FooDB:FDB002477
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 milk thistle
Search Trop Picture
 
Synonyms:
 silidianin
 

Articles:

PubMed:The study of flavonolignan association patterns in fruits of diverging Silybum marianum (L.) Gaertn. chemotypes provides new insights into the silymarin biosynthetic pathway.
PubMed:Flavonolignans reduce the response of blood platelet to collagen.
PubMed:Flavonolignans inhibit the arachidonic acid pathway in blood platelets.
PubMed:The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.
PubMed:Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells.
PubMed:Chemotaxonomic and biosynthetic relationships between flavonolignans produced by Silybum marianum populations.
PubMed:Effects of Potassium Sulfate [K2SO4] on The Element Contents, Polyphenol Content, Antioxidant and Antimicrobial Activities of Milk Thistle [Silybum Marianum].
PubMed:Effects of Silymarin on Diabetes Mellitus Complications: A Review.
PubMed:Flavonolignans inhibit ADP induced blood platelets activation and aggregation in whole blood.
PubMed:A new approach to the rapid separation of isomeric compounds in a Silybum marianum extract using UHPLC core-shell column with F5 stationary phase.
PubMed:Variation in the flavonolignan composition of fruits from different Silybum marianum chemotypes and suspension cultures derived therefrom.
PubMed:Silymarin content in Silybum marianum populations growing in Egypt.
PubMed:Is Silybin the Best Free Radical Scavenger Compound in Silymarin?
PubMed:Phototoxic potential of silymarin and its bioactive components.
PubMed:Head-to-Head Comparison of Ultra-High-Performance Liquid Chromatography with Diode Array Detection versus Quantitative Nuclear Magnetic Resonance for the Quantitative Analysis of the Silymarin Complex in Silybum marianum Fruit Extracts.
PubMed:Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages.
PubMed:Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity.
PubMed:Supercritical CO₂ extraction of oil, fatty acids and flavonolignans from milk thistle seeds: Evaluation of their antioxidant and cytotoxic activities in Caco-2 cells.
PubMed:Synchronous microencapsulation of multiple components in silymarin into PLGA nanoparticles by an emulsification/solvent evaporation method.
PubMed:Accumulation of silymarin in milk thistle seeds under drought stress.
PubMed:Simplified procedure of silymarin extraction from Silybum marianum L. Gaertner.
PubMed:Biotransformation on the flavonolignan constituents of Silybi Fructus by an intestinal bacterial strain Eubacterium limosum ZL-II.
PubMed:An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study.
PubMed:An integrated proteomic approach to decipher the effect of methyl jasmonate elicitation on the proteome of Silybum marianum L. hairy roots.
PubMed:Free Radical Scavenging and Antioxidant Activities of Silymarin Components.
PubMed:Synchronized and controlled release of multiple components in silymarin achieved by the osmotic release strategy.
PubMed:Absorption and metabolism of milk thistle flavanolignans in humans.
PubMed:A sensitive LC-MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma.
PubMed:[Determination of active components in silymarin by UPLC-ESIMS].
PubMed:Silymarin prevents the toxicity induced by benzo(a)pyrene in human erythrocytes by preserving its membrane integrity: an in vitro study.
PubMed:Pyrazinecarboxamides as potential elicitors of flavonolignan and flavonoid production in Silybum marianum and Ononis arvensis cultures in vitro.
PubMed:Effects of silymarin nanoemulsion against carbon tetrachloride-induced hepatic damage.
PubMed:Rapid separation and characterization of active flavonolignans of Silybum marianum by ultra-performance liquid chromatography coupled with electrospray tandem mass spectrometry.
PubMed:Enhanced production of silymarin by Ag+ elicitor in cell suspension cultures of Silybum marianum.
PubMed:Milk thistle in liver diseases: past, present, future.
PubMed:Topical delivery of silymarin constituents via the skin route.
PubMed:Influence of exogenous salicylic acid on flavonolignans and lipoxygenase activity in the hairy root cultures of Silybum marianum.
PubMed:[Silymarin in the treatment of chronic liver diseases: past and future].
PubMed:Drug-drug interactions of silymarin on the perspective of pharmacokinetics.
PubMed:Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2).
PubMed:Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells.
PubMed:Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract.
PubMed:Separation and characterization of active flavonolignans of Silybum marianum by liquid chromatography connected with hybrid ion-trap and time-of-flight mass spectrometry (LC-MS/IT-TOF).
PubMed:Pretreatment of milk thistle seed to increase the silymarin yield: an alternative to petroleum ether defatting.
PubMed:Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine.
PubMed:Anticancer potential of silymarin: from bench to bed side.
PubMed:Synchronized and sustained release of multiple components in silymarin from erodible glyceryl monostearate matrix system.
PubMed:Synthesis and antihepatotoxic activity of some new chalcones containing 1, 4 - dioxane ring system.
PubMed:Silymarin and its components scavenge phenylglyoxylic ketyl radicals.
PubMed:Analysis and comparison of active constituents in commercial standardized silymarin extracts by liquid chromatography-electrospray ionization mass spectrometry.
PubMed:Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry.
PubMed:Silymarin as a new hepatoprotective agent in experimental cholestasis: new possibilities for an ancient medication.
PubMed:An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species.
PubMed:Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin.
PubMed:A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos).
PubMed:Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans.
PubMed:Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).
PubMed:Extraction of nutraceuticals from milk thistle: part II. Extraction with organic solvents.
PubMed:Synthesis and antihepatotoxic activity of some heterocyclic compounds containing the 1,4-dioxane ring system.
PubMed:Analysis of the active components of silymarin.
PubMed:Primary cultures of human hepatocytes as a tool in cytotoxicity studies: cell protection against model toxins by flavonolignans obtained from Silybum marianum.
PubMed:Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities.
PubMed:Stability of the constituents of Calendula, milk-thistle and passionflower tinctures by LC-DAD and LC-MS.
PubMed:[Determination of the active flavonoids in silymarine].
PubMed:Influence of silymarin and its flavonolignans on doxorubicin-iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin.
PubMed:Inhibition of the superoxide anion release and hydrogen peroxide formation in PMNLs by flavonolignans.
PubMed:Determination of active component in silymarin by RP-LC and LC/MS.
PubMed:[Separation and determination of effective components in silymarin and preparations of silymarin by MECC].
PubMed:Flavonolignan production from Silybum marianum transformed and untransformed root cultures.
PubMed:Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase.
PubMed:Activities of silymarin and its flavonolignans upon low density lipoprotein oxidizability in vitro.
PubMed:Silybin and silydianin diminish the oxidative metabolism of human polymorphonuclear neutrophils.
PubMed:Comparative pharmacokinetics of silipide and silymarin in rats.
PubMed:Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients.
PubMed:[Effects of flavobion on nucleic acids in tissues of rats irradiated with gamma rays].
PubMed:Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes.
PubMed:[Milk thistle (Silybum marianum, L., Gaertn.) in the feed of ketotic cows].
PubMed:Advances in pharmacological studies of silymarin.
PubMed:Silymarin: potent inhibitor of cyclic AMP phosphodiesterase.
PubMed:[Structure of silandrin and silymonin, two new flavanolignans from a white blooming Silybum marianum variety].
PubMed:[Bioavailability of silymarin, I: Volumes of distribution of silybin, silydianin, and silychristin from in-vitro data (author's transl)].
PubMed:Silymarin, an inhibitor of prostaglandin synthetase.
PubMed:Silymarin, an inhibitor of lipoxygenase.
PubMed:[Changes in erythrocyte shape and volume caused by silymarin].
PubMed:[Peroxidase isoenzymes in cress seedlings (Lepidium sativum L.) and their inhibition by silybin, silydianin and silychristin].
PubMed:[Silymarin--an inhibitor of horseradish peroxidase (author's transl)].
 
Notes:
Constit. of Silybum marianum (milk thistle)
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