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Category:antioxidants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 567.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 390.00 °F. TCC ( 198.80 °C. ) (est)
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| logP (o/w): | 2.470 (est) |
| Soluble in: |
| | water, 23.08 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Arctigenin 98%
|
| BOC Sciences |
| For experimental / research use only. |
| Arctigenin >98%
Odor: characteristic Use: Arctigenin is the aglycone of arctiin and is a lignan found in certain plants of the Asteraceae. It has shown antiviral and anticancer effects in glass. It showed potent in vitro antiviral activities against influenza A virus (A/NWS/33, H1N1) (IFV). |
| Carbosynth |
| For experimental / research use only. |
| Arctigenin
|
| Coompo |
| For experimental / research use only. |
| Arctigenin from Plants ≥98%
Odor: characteristic Use: Arctigenin is the aglycone of arctiin. It has shown antiviral and anticancer effects.
Here it was found to activate AMP-activated protein kinase (AMPK), and the mechanism by which this occurred, as well as the effects on glucose and lipid metabolism were investigated. A new role for arctigenin as a potent indirect activator of AMPK via inhibition of respiratory complex I, with beneficial effects on metabolic disorders in ob/ob mice. This highlights the potential value of arctigenin as a possible treatment of type 2 diabetes. arctigenin might be used as a potential lead compound for the discovery of the agents with mimic exercise training effects to treat metabolic diseases.
Arctigenin selectively promoted glucose-starved A549 tumor cells to undergo necrosis by inhibiting mitochondrial respiration. arctigenin elevated cellular level of reactive oxygen species (ROS) and blocked cellular energy metabolism in the glucose-starved tumor cells. combined arctigenin with the glucose analogue 2-deoxyglucose (2DG) and examined their effects on tumor cell growth. The combination of arctigenin and 2DG may represent a promising new cancer therapy with minimal normal tissue toxicity.
Arctigenin inhibited T lymphocyte proliferation and decreased the gene expression of IL-2, IFN-? and NF-AT. |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Arctigenin ≥97%
|
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| (-)-Arctigenin
|
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | antioxidants |
| Recommendation for arctigenin usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for arctigenin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
| | (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 64981 |
| Pubchem (sid): | 135022167 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | arctigenen | | | dibenzylbutyrolactone lignanolide | | (3R,4R)-4-(3,4- | dimethoxy-benzyl)-3-(4-hydroxy-3-methoxy-benzyl)-dihydro-furan-2-one | | (3R,4R)-4-(3,4- | dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)-dihydrofuran-2(3H)-one | | (3R,4R)-4-(3,4- | dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one | | (3R,4R)-4-((3,4- | dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-2(3H)-furanone | | (3R,4R)-4-[(3,4- | dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one | | 4-[(3,4- | dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-(3R-trans)-2(3H)-Furanone | | 4-[(3,4- | dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-(3R,4R)-2(3H)-Furanone | | (3R,4R)-4-[(3,4- | dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone | | 2(3H)- | furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R,4R)- | | 2(3H)- | furanone, 4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-, (3R,4R)- |
Articles:
| PubMed:Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of Th1 and Th17 cells via an mTORC1-dependent pathway. |
| PubMed:Arctigenin antagonizes mineralocorticoid receptor to inhibit the transcription of Na/K-ATPase. |
| PubMed:Arctigenin Suppress Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis Through AMPK and PPAR-γ/ROR-γt Signaling. |
| PubMed:Comparative pharmacokinetics of arctigenin in normal and type 2 diabetic rats after oral and intravenous administration. |
| PubMed:Arctigenin Protects against Lipopolysaccharide-Induced Pulmonary Oxidative Stress and Inflammation in a Mouse Model via Suppression of MAPK, HO-1, and iNOS Signaling. |
| PubMed:Arctigenin but not arctiin acts as the major effective constituent of Arctium lappa L. fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice. |
| PubMed:[Protective effect of arctigenin in GK rats combined with hypertension macroangiopathy]. |
| PubMed:The effects of arctigenin on human rheumatoid arthritis fibroblast-like synoviocytes. |
| PubMed:Arctigenin, a Natural Lignan Compound, Induces Apoptotic Death of Hepatocellular Carcinoma Cells via Suppression of PI3-K/Akt Signaling. |
| PubMed:PDK1/Akt/PDE4D axis identified as a target for asthma remedy synergistic with β2 AR agonists by a natural agent arctigenin. |
| PubMed:Arctigenin promotes apoptosis in ovarian cancer cells via the iNOS/NO/STAT3/survivin signalling. |
| PubMed:Arctigenin Increases Hemeoxygenase-1 Gene Expression by Modulating PI3K/AKT Signaling Pathway in Rat Primary Astrocytes. |
| PubMed:Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways. |
| PubMed:Cytotoxicity of arctigenin and matairesinol against the T-cell lymphoma cell line CCRF-CEM. |
| PubMed:Design and synthesis of novel arctigenin analogues for the amelioration of metabolic disorders. |
| PubMed:Arctigenin enhances chemosensitivity to cisplatin in human nonsmall lung cancer H460 cells through downregulation of survivin expression. |
| PubMed:Arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways. |
| PubMed:The inhibition of activated hepatic stellate cells proliferation by arctigenin through G0/G1 phase cell cycle arrest: persistent p27(Kip1) induction by interfering with PI3K/Akt/FOXO3a signaling pathway. |
| PubMed:Isolation and purification of arctigenin from Fructus Arctii by enzymatic hydrolysis combined with high-speed counter-current chromatography. |
| PubMed:Arctigenin, a Potent Ingredient of Arctium lappa L., Induces Endothelial Nitric Oxide Synthase and Attenuates Subarachnoid Hemorrhage-Induced Vasospasm through PI3K/Akt Pathway in a Rat Model. |
| PubMed:[Suppression of VEGF protein expression by arctigenin in oral squamous cell carcinoma]. |
| PubMed:Arctigenin exhibits relaxation effect on bronchus by affecting transmembrane flow of calcium. |
| PubMed:Inhibition of angiogenesis: a novel antitumor mechanism of the herbal compound arctigenin. |
| PubMed:Development of an LC/MS/MS method in order to determine arctigenin in rat plasma: its application to a pharmacokinetic study. |
| PubMed:Arctigenin promotes cholesterol efflux from THP-1 macrophages through PPAR-γ/LXR-α signaling pathway. |
| PubMed:Extensive intestinal first-pass metabolism of arctigenin: evidenced by simultaneous monitoring of both parent drug and its major metabolites. |
| PubMed:Protective effect of arctigenin against MPP+ and MPTP-induced neurotoxicity. |
| PubMed:Synthesis and biological evaluation of arctigenin ester and ether derivatives as activators of AMPK. |
| PubMed:Arctigenin in combination with quercetin synergistically enhances the antiproliferative effect in prostate cancer cells. |
| PubMed:Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages. |
| PubMed:Hydrolysis is the dominating in vivo metabolism pathway for arctigenin: identification of novel metabolites of arctigenin by LC/MS/MS after oral administration in rats. |
| PubMed:Identification and characterization of human UDP-glucuronosyltransferases responsible for the in-vitro glucuronidation of arctigenin. |
| PubMed:Antiausterity activity of arctigenin enantiomers: importance of (2R,3R)-absolute configuration. |
| PubMed:Arctigenin, a potential anti-arrhythmic agent, inhibits aconitine-induced arrhythmia by regulating multi-ion channels. |
| PubMed:Elucidation of arctigenin pharmacokinetics after intravenous and oral administrations in rats: integration of in vitro and in vivo findings via semi-mechanistic pharmacokinetic modeling. |
| PubMed:Arctigenin from Fructus Arctii (Seed of Burdock) Reinforces Intestinal Barrier Function in Caco-2 Cell Monolayers. |
| PubMed:Mechanism of arctigenin-mediated specific cytotoxicity against human lung adenocarcinoma cell lines. |
| PubMed:Arctigenin promotes degradation of inducible nitric oxide synthase through CHIP-associated proteasome pathway and suppresses its enzyme activity. |
| PubMed:[Determination of plasma protein binding rate of arctiin and arctigenin with ultrafiltration]. |
| PubMed:Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation. |
| PubMed:Arctigenin anti-tumor activity in bladder cancer T24 cell line through induction of cell-cycle arrest and apoptosis. |
| PubMed:(-) Arctigenin and (+) pinoresinol are antagonists of the human thyroid hormone receptor β. |
| PubMed:Integrated in silico and experimental methods revealed that Arctigenin inhibited angiogenesis and HCT116 cell migration and invasion through regulating the H1F4A and Wnt/β-catenin pathway. |
| PubMed:Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance. |
| PubMed:Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells. |
| PubMed:Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism. |
| PubMed:Arctigenin suppresses receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclast differentiation in bone marrow-derived macrophages. |
| PubMed:Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice. |
| PubMed:Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy. |
| PubMed:Study on human intestinal bacterium Blautia sp. AUH-JLD56 for the conversion of arctigenin to (-)-3'-desmethylarctigenin. |
| PubMed:Pharmacokinetic study of arctigenin in rat plasma and organ tissue by RP-HPLC method. |
| PubMed:Arctigenin attenuates lipopolysaccharide-induced acute lung injury in rats. |
| PubMed:Inhibitory Effect of Arctigenin from Fructus Arctii Extract on Melanin Synthesis via Repression of Tyrosinase Expression. |
| PubMed:Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721. |
| PubMed:Arctigenin protects focal cerebral ischemia-reperfusion rats through inhibiting neuroinflammation. |
| PubMed:Arctigenin suppresses transforming growth factor-β1-induced expression of monocyte chemoattractant protein-1 and the subsequent epithelial-mesenchymal transition through reactive oxygen species-dependent ERK/NF-κB signaling pathway in renal tubular epithelial cells. |
| PubMed:Ligand binding affinities of arctigenin and its demethylated metabolites to estrogen receptor alpha. |
| PubMed:Arctigenin induces cell cycle arrest by blocking the phosphorylation of Rb via the modulation of cell cycle regulatory proteins in human gastric cancer cells. |
| PubMed:Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway. |
| PubMed:Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L. |
| PubMed:Neuroprotective effect of arctigenin via upregulation of P-CREB in mouse primary neurons and human SH-SY5Y neuroblastoma cells. |
| PubMed:[Research on the preparative method of Arctigenin]. |
| PubMed:(-)-Arctigenin as a lead compound for anticancer agent. |
| PubMed:Inhibitory effect of arctigenin on lymphocyte activation stimulated with PMA/ionomycin. |
| PubMed:Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway. |
| PubMed:Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice. |
| PubMed:Cell and nuclear enlargement of SW480 cells induced by a plant lignan, arctigenin: evaluation of cellular DNA content using fluorescence microscopy and flow cytometry. |
| PubMed:Integrated compound profiling screens identify the mitochondrial electron transport chain as the molecular target of the natural products manassantin, sesquicillin, and arctigenin. |
| PubMed:Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. |
| PubMed:Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells. |
| PubMed:Arctigenin alleviates ER stress via activating AMPK. |
| PubMed:Synthesis of (-)-arctigenin derivatives and their anticancer activity. |
| PubMed:Arctigenin efficiently enhanced sedentary mice treadmill endurance. |
| PubMed:Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits type I-IV allergic inflammation and pro-inflammatory enzymes. |
| PubMed:Synthesis and cytotoxicity evaluation of 4-amino-4-dehydroxylarctigenin derivatives in glucose-starved A549 tumor cells. |
| PubMed:Arctigenin from Arctium lappa inhibits interleukin-2 and interferon gene expression in primary human T lymphocytes. |
| PubMed:Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity. |
| PubMed:In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway. |
| PubMed:Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus. |
| PubMed:Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan. |
| PubMed:Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition. |
| PubMed:pH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymeric vaginal delivery system. |
| PubMed:Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor. |
| PubMed:Mass fragmentation study of the trimethylsilyl derivatives of arctiin, matairesinoside, arctigenin, phylligenin, matairesinol, pinoresinol and methylarctigenin: their gas and liquid chromatographic analysis in plant extracts. |
| PubMed:New expectations from the well-known medicinal properties of Arctium lappa. |
| PubMed:Anti-inflammatory activity of arctigenin from Forsythiae Fructus. |
| PubMed:Microemulsion electrokinetic chromatography for the separation of arctiin and arctigenin in Fructus Arctii and its herbal preparations. |
| PubMed:Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-alpha and nitric oxide production, and lymphocyte proliferation. |
| PubMed:[Effect of anti-influenza virus of Arctigenin in vivo]. |
| PubMed:Arctigenin from Fructus Arctii is a novel suppressor of heat shock response in mammalian cells. |
| PubMed:Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. |
| PubMed:Determination of arctiin and arctigenin in Fructus Arctii by reverse-phase HPLC. |
| PubMed:Isolation and characterization of a human intestinal bacterium, Eubacterium sp. ARC-2, capable of demethylating arctigenin, in the essential metabolic process to enterolactone. |
| PubMed:A preparative isolation and purification of arctigenin and matairesinol from Forsythia koreana by centrifugal partition chromatography. |
| PubMed:Isolation and identification of arctiin and arctigenin in leaves of burdock (Arctium lappa L.) by polyamide column chromatography in combination with HPLC-ESI/MS. |
| PubMed:Biotransformation of the naturally occurring lignan (-)-arctigenin in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms. |
| PubMed:Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase. |
| PubMed:Lignans inhibit cell growth via regulation of Wnt/beta-catenin signaling. |
| PubMed:[Induction of apoptosis of the human leukemia cells by arctigenin and its mechanism of action]. |
| PubMed:Free-radical-mediated conjugate additions. Enantioselective synthesis of butyrolactone natural products: (-)-enterolactone, (-)-arctigenin, (-)-isoarctigenin, (-)-nephrosteranic acid, and (-)-roccellaric acid. |
| PubMed:(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase. |
| PubMed:Natural lignans from Arctium lappa modulate P-glycoprotein efflux function in multidrug resistant cancer cells. |
| PubMed:Radical carboxyarylation approach to lignans. Total synthesis of (-)-arctigenin, (-)-matairesinol, and related natural products. |
| PubMed:Antioxidants: potential antiviral agents for Japanese encephalitis virus infection. |
| PubMed:Anti-austeritic Constituents of the Congolese Medicinal Plant Aframomum melegueta. |
| PubMed:Three new lignans from the seeds of Saussurea involucrata. |
| PubMed:Optimum yields of dibenzylbutyrolactone-type lignans from Cynareae fruits, during their ripening, germination and enzymatic hydrolysis processes, determined by on-line chromatographic methods. |
| PubMed:Plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by HPLC-UV and LC-MS. |
| PubMed:Phytochemical profile and apoptotic activity of Onopordum cynarocephalum. |
| PubMed:Tumour-growth inhibiting substances of plant origin. II. The experimental animal tumour-pharmacology of arctigenin-mustard. |
| PubMed:Chemical analysis of raw and processed Fructus arctii by high-performance liquid chromatography/diode array detection-electrospray ionization-mass spectrometry. |
| PubMed:Arctigenin: a lignan from Arctium lappa. |
| PubMed:Active components with inhibitory activities on IFN-γ/STAT1 and IL-6/STAT3 signaling pathways from Caulis Trachelospermi. |
| PubMed:Update on phase I studies in advanced pancreatic adenocarcinoma. Hunting in darkness? |
| PubMed:Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. |
| PubMed:Simultaneous determination of arctiin and its metabolites in rat urine and feces by HPLC. |
| PubMed:Steroidal esters from Ferula sinkiangensis. |
| PubMed:Searching for synergistic bronchodilators and novel therapeutic regimens for chronic lung diseases from a traditional Chinese medicine, Qingfei Xiaoyan Wan. |
| PubMed:Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. |
| PubMed:Ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry coupled with hierarchical cluster analysis to evaluate Wikstroemia indica (L.) C. A. Mey. from different geographical regions. |
| PubMed:Specific hydrolysis and accumulation of antiproliferative lignans in the fruit of Leuzea carthamoides (Willd.) DC. |
| PubMed:Optimization of the processing technology of Fructus Arctii by response surface methodology. |
| PubMed:Arctigenic acid, the key substance responsible for the hypoglycemic activity of Fructus Arctii. |
| PubMed:Pharmacokinetics screening for multi-components absorbed in the rat plasma after oral administration of traditional Chinese medicine Flos Lonicerae Japonicae-Fructus Forsythiae herb couple by sequential negative and positive ionization ultra-high-performance liquid chromatography/tandem triple quadrupole mass spectrometric detection. |
| PubMed:Cytotoxic components of bardanae fructus (goboshi). |
| PubMed:Complementary fragmentation pattern analysis by gas chromatography-mass spectrometry and liquid chromatography tandem mass spectrometry confirmed the precious lignan content of Cirsium weeds. |
| PubMed:Seasonal alteration in amounts of lignans and their glucosides and gene expression of the relevant biosynthetic enzymes in the Forsythia suspense leaf. |
| PubMed:Dibenzylbutyrolactone lignans from Forsythia koreana fruits attenuate lipopolysaccharide-induced inducible nitric oxide synthetase and cyclooxygenase-2 expressions through activation of nuclear factor-κb and mitogen-activated protein kinase in RAW264.7 cells. |
| PubMed:Determination of the major constituents in fruit of Arctium lappa L. by matrix solid-phase dispersion extraction coupled with HPLC separation and fluorescence detection. |
| PubMed:New guaian-type sesquiterpene from Wikstroemia indica. |
| PubMed:Simultaneous determination of five bioactive secolignans in rat plasma by LC-MS/MS for pharmacokinetic studies following oral administration of Peperomia dindygulensis Miq. extract. |
| PubMed:Bioassay-guided isolation and identification of active compounds from Fructus Arctii against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus). |
| PubMed:Inhibitory effect of nordihydroguaiaretic acid, a plant lignan, on Helicobacter pylori-associated gastric carcinogenesis in Mongolian gerbils. |
| PubMed:[Anti-inflammatory mechanism of qingfei xiaoyan wan studied with network pharmacology]. |
| PubMed:Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. |
| PubMed:Anti-austeric activity of phenolic constituents of seeds of Arctium lappa. |
| PubMed:Induction of caspase-8 and death receptors by a new dammarane skeleton from the dried fruits of Forsythia koreana. |
| PubMed:Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kappaBalpha phosphorylation and of p65 nuclear translocation in macrophages. |
| PubMed:Dual-bioactivity-based liquid chromatography-coupled quadrupole time-of-flight mass spectrometry for NF-κB inhibitors and β2AR agonists identification in Chinese Medicinal Preparation Qingfei Xiaoyan Wan. |
| PubMed:The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme. |
| PubMed:Ion-sparing diuresis by 2,3-dibenzylbutane-1,4-diol, a synthetic mammalian-lignan derivative. |
| PubMed:[Trace chemical constituents contained in Trachelospermum jasminoides and structure identification]. |
| PubMed:Antiasthmatic action of dibenzylbutyrolactone lignans from fruits of Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea-pigs. |
| PubMed:Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat. |
| PubMed:Metabolism of ginsenoside Rb1 by human intestinal microflora and cloning of its metabolizing β-D-glucosidase from Bifidobacterium longum H-1. |
| PubMed:Bioactivity-guided isolation of antiproliferative compounds from Centaurea arenaria. |
| PubMed:Differential in vitro anti-HIV activity of natural lignans. |
| PubMed:Antioxidative and in vitro antiproliferative activity of Arctium lappa root extracts. |
| PubMed:Biological activities of Fructus arctii fermented with the basidiomycete Grifola frondosa. |
| PubMed:[A comparative research on quality of Vitmin C Yinqiao tablets from different manufacturers]. |
| PubMed:[Dyuamical studies on metabolic chemistry of lignans from seeds of Arctium lappa]. |
| PubMed:[Constituents of Gymnadenia conopsea]. |
| PubMed:Evaluation of estrogen receptor Beta binding of pruni cortex and its constituents. |
| PubMed:Application of gradient-enhanced nuclear Overhauser effect spectroscopy GOESY) in the structure elucidation of plant secondary metabolites. |
| PubMed:Cytotoxic activity of Ipomoea cairica. |
| PubMed:Lignan profile in seeds of modern and old Italian soft wheat (Triticum aestivum L.) cultivars as revealed by CE-MS analyses. |
| PubMed:Antiproliferative and apoptotic effects of butyrolactone lignans from Arctium lappa on leukemic cells. |
| PubMed:Hepatoprotective dibenzylbutyrolactone lignans of Torreya nucifera against CCl4-induced toxicity in primary cultured rat hepatocytes. |
| PubMed:In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterodiol. |
| PubMed:Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells. |
| PubMed:Preventive strategies for frequent outbreaks of Japanese encephalitis in Northern India. |
| PubMed:Americanin, a bioactive dibenzylbutyrolactone lignan, from the seeds of Centaurea americana. |
| PubMed:Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells. |
| PubMed:Sesquiterpene lactones from Centaurea tweediei. |
| PubMed:Savinin, a lignan from Pterocarpus santalinus inhibits tumor necrosis factor-alpha production and T cell proliferation. |
| PubMed:Studies on differentiation inducers. VI. Lignan derivatives from Arctium fructus. (2). |
| PubMed:[Chemical components of Trachelospelmun jasminoides (Lindl.) Lem. var. heterophyllum Tsiang]. |
| PubMed:Structural transformation of lignan compounds in rat gastrointestinal tract. |
| PubMed:Lignans and Other Constituents of Centaurea sphaerocephala ssp. polyacantha. |
| PubMed:alpha-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae). |
| PubMed:Assessing exposure to lignans and their metabolites in humans. |
| PubMed:Lignans from Saussurea conica and their NO production suppressing activity. |
| PubMed:A phytochemical study of lignans in whole plants and cell suspension cultures of Anthriscus sylvestris. |
| PubMed:Transformation of arctiin to estrogenic and antiestrogenic substances by human intestinal bacteria. |
| PubMed:Stereochemical diversity in lignan biosynthesis of Arctium lappa L. |
| PubMed:Neuroprotective dibenzylbutyrolactone lignans of Torreya nucifera. |
| PubMed:Arctiin and onopordopicrin from Carduus micropterus ssp. perspinosus. |
| PubMed:Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa. |
| PubMed:Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection. |
| PubMed:Constituents of the Egyptian Centaurea scoparia. III. Phenolic constituents of the aerial parts. |
| PubMed:[Studies on the chemical constituents of Arctium lappa L]. |
| PubMed:A Contribution to the Phytochemistry of Zanthoxylum tessmannii1. |
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precursor to catechols; in many plants. Isol. from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD)
Arctigenin is a lignan found in certain plants of the Asteraceae , including the Greater burdock (Arctium lappa) and Saussurea heteromalla. It has shown antiviral and anticancer effects. It is the aglycone of arctiin. (Wikipedia)
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3D/inchi