arctigenin
(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
 
Notes:
precursor to catechols; in many plants. Isol. from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD) Arctigenin is a lignan found in certain plants of the Asteraceae , including the Greater burdock (Arctium lappa) and Saussurea heteromalla. It has shown antiviral and anticancer effects. It is the aglycone of arctiin. (Wikipedia)
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(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one (Click)
CAS Number: 7770-78-7Picture of molecule
FDA UNII: U76MR9VS6M
Nikkaji Web: J16.086E
MDL: MFCD00870597
XlogP3-AA: 3.60 (est)
Molecular Weight: 372.41748000
Formula: C21 H24 O6
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antioxidants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 567.00 °C. @ 760.00 mm Hg (est)
Flash Point: 390.00 °F. TCC ( 198.80 °C. ) (est)
logP (o/w): 2.470 (est)
Soluble in:
 water, 23.08 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
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Suppliers:
Carbosynth
For experimental / research use only.
Arctigenin
Coompo
For experimental / research use only.
Arctigenin from Plants ≥98%
Odor: characteristic
Use: Arctigenin is the aglycone of arctiin. It has shown antiviral and anticancer effects. Here it was found to activate AMP-activated protein kinase (AMPK), and the mechanism by which this occurred, as well as the effects on glucose and lipid metabolism were investigated. A new role for arctigenin as a potent indirect activator of AMPK via inhibition of respiratory complex I, with beneficial effects on metabolic disorders in ob/ob mice. This highlights the potential value of arctigenin as a possible treatment of type 2 diabetes. arctigenin might be used as a potential lead compound for the discovery of the agents with mimic exercise training effects to treat metabolic diseases. Arctigenin selectively promoted glucose-starved A549 tumor cells to undergo necrosis by inhibiting mitochondrial respiration. arctigenin elevated cellular level of reactive oxygen species (ROS) and blocked cellular energy metabolism in the glucose-starved tumor cells. combined arctigenin with the glucose analogue 2-deoxyglucose (2DG) and examined their effects on tumor cell growth. The combination of arctigenin and 2DG may represent a promising new cancer therapy with minimal normal tissue toxicity. Arctigenin inhibited T lymphocyte proliferation and decreased the gene expression of IL-2, IFN-? and NF-AT.
Santa Cruz Biotechnology
For experimental / research use only.
Arctigenin ≥97%
Sigma-Aldrich: Sigma
For experimental / research use only.
(-)-Arctigenin
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antioxidants
Recommendation for arctigenin usage levels up to:
 not for fragrance use.
 
Recommendation for arctigenin flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 64981
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
Chemidplus: 0007770787
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References:
 (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 64981
Pubchem (sid): 135022167
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C10545
HMDB (The Human Metabolome Database): HMDB30087
FooDB: FDB001442
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
EFSA Update of results on the monitoring of furan levels in food: Read Report
EFSA Previous report: Results on the monitoring of furan levels in food: Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 burdock
Search Trop  Picture
 burdock fruit
Search Trop  Picture
 burdock seed
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 cardoon
Search Trop  Picture
 forsythia viridissima
Search Trop  Picture
 ipomoea cairica
Search Trop  Picture
 thistle holy thistle
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 wikstroemia indica
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Synonyms:
 arctigenen
 dibenzylbutyrolactone lignanolide
(3R,4R)-4-(3,4-dimethoxy-benzyl)-3-(4-hydroxy-3-methoxy-benzyl)-dihydro-furan-2-one
(3R,4R)-4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)-dihydrofuran-2(3H)-one
(3R,4R)-4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one
(3R,4R)-4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-2(3H)-furanone
(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-(3R-trans)-2(3H)-Furanone
4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-(3R,4R)-2(3H)-Furanone
(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
2(3H)-furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R,4R)-
2(3H)-furanone, 4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-, (3R,4R)-
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Articles:
PubMed: Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of Th1 and Th17 cells via an mTORC1-dependent pathway.
PubMed: Arctigenin antagonizes mineralocorticoid receptor to inhibit the transcription of Na/K-ATPase.
PubMed: Arctigenin Suppress Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis Through AMPK and PPAR-γ/ROR-γt Signaling.
PubMed: Comparative pharmacokinetics of arctigenin in normal and type 2 diabetic rats after oral and intravenous administration.
PubMed: Arctigenin Protects against Lipopolysaccharide-Induced Pulmonary Oxidative Stress and Inflammation in a Mouse Model via Suppression of MAPK, HO-1, and iNOS Signaling.
PubMed: Arctigenin but not arctiin acts as the major effective constituent of Arctium lappa L. fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice.
PubMed: [Protective effect of arctigenin in GK rats combined with hypertension macroangiopathy].
PubMed: The effects of arctigenin on human rheumatoid arthritis fibroblast-like synoviocytes.
PubMed: Arctigenin, a Natural Lignan Compound, Induces Apoptotic Death of Hepatocellular Carcinoma Cells via Suppression of PI3-K/Akt Signaling.
PubMed: PDK1/Akt/PDE4D axis identified as a target for asthma remedy synergistic with β2 AR agonists by a natural agent arctigenin.
PubMed: Arctigenin promotes apoptosis in ovarian cancer cells via the iNOS/NO/STAT3/survivin signalling.
PubMed: Arctigenin Increases Hemeoxygenase-1 Gene Expression by Modulating PI3K/AKT Signaling Pathway in Rat Primary Astrocytes.
PubMed: Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways.
PubMed: Cytotoxicity of arctigenin and matairesinol against the T-cell lymphoma cell line CCRF-CEM.
PubMed: Design and synthesis of novel arctigenin analogues for the amelioration of metabolic disorders.
PubMed: Arctigenin enhances chemosensitivity to cisplatin in human nonsmall lung cancer H460 cells through downregulation of survivin expression.
PubMed: Arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways.
PubMed: The inhibition of activated hepatic stellate cells proliferation by arctigenin through G0/G1 phase cell cycle arrest: persistent p27(Kip1) induction by interfering with PI3K/Akt/FOXO3a signaling pathway.
PubMed: Isolation and purification of arctigenin from Fructus Arctii by enzymatic hydrolysis combined with high-speed counter-current chromatography.
PubMed: Arctigenin, a Potent Ingredient of Arctium lappa L., Induces Endothelial Nitric Oxide Synthase and Attenuates Subarachnoid Hemorrhage-Induced Vasospasm through PI3K/Akt Pathway in a Rat Model.
PubMed: [Suppression of VEGF protein expression by arctigenin in oral squamous cell carcinoma].
PubMed: Arctigenin exhibits relaxation effect on bronchus by affecting transmembrane flow of calcium.
PubMed: Inhibition of angiogenesis: a novel antitumor mechanism of the herbal compound arctigenin.
PubMed: Development of an LC/MS/MS method in order to determine arctigenin in rat plasma: its application to a pharmacokinetic study.
PubMed: Arctigenin promotes cholesterol efflux from THP-1 macrophages through PPAR-γ/LXR-α signaling pathway.
PubMed: Extensive intestinal first-pass metabolism of arctigenin: evidenced by simultaneous monitoring of both parent drug and its major metabolites.
PubMed: Protective effect of arctigenin against MPP+ and MPTP-induced neurotoxicity.
PubMed: Synthesis and biological evaluation of arctigenin ester and ether derivatives as activators of AMPK.
PubMed: Arctigenin in combination with quercetin synergistically enhances the antiproliferative effect in prostate cancer cells.
PubMed: Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages.
PubMed: Hydrolysis is the dominating in vivo metabolism pathway for arctigenin: identification of novel metabolites of arctigenin by LC/MS/MS after oral administration in rats.
PubMed: Identification and characterization of human UDP-glucuronosyltransferases responsible for the in-vitro glucuronidation of arctigenin.
PubMed: Antiausterity activity of arctigenin enantiomers: importance of (2R,3R)-absolute configuration.
PubMed: Arctigenin, a potential anti-arrhythmic agent, inhibits aconitine-induced arrhythmia by regulating multi-ion channels.
PubMed: Elucidation of arctigenin pharmacokinetics after intravenous and oral administrations in rats: integration of in vitro and in vivo findings via semi-mechanistic pharmacokinetic modeling.
PubMed: Arctigenin from Fructus Arctii (Seed of Burdock) Reinforces Intestinal Barrier Function in Caco-2 Cell Monolayers.
PubMed: Mechanism of arctigenin-mediated specific cytotoxicity against human lung adenocarcinoma cell lines.
PubMed: Arctigenin promotes degradation of inducible nitric oxide synthase through CHIP-associated proteasome pathway and suppresses its enzyme activity.
PubMed: [Determination of plasma protein binding rate of arctiin and arctigenin with ultrafiltration].
PubMed: Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation.
PubMed: Arctigenin anti-tumor activity in bladder cancer T24 cell line through induction of cell-cycle arrest and apoptosis.
PubMed: (-) Arctigenin and (+) pinoresinol are antagonists of the human thyroid hormone receptor β.
PubMed: Integrated in silico and experimental methods revealed that Arctigenin inhibited angiogenesis and HCT116 cell migration and invasion through regulating the H1F4A and Wnt/β-catenin pathway.
PubMed: Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance.
PubMed: Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells.
PubMed: Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism.
PubMed: Arctigenin suppresses receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclast differentiation in bone marrow-derived macrophages.
PubMed: Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice.
PubMed: Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy.
PubMed: Study on human intestinal bacterium Blautia sp. AUH-JLD56 for the conversion of arctigenin to (-)-3'-desmethylarctigenin.
PubMed: Pharmacokinetic study of arctigenin in rat plasma and organ tissue by RP-HPLC method.
PubMed: Arctigenin attenuates lipopolysaccharide-induced acute lung injury in rats.
PubMed: Inhibitory Effect of Arctigenin from Fructus Arctii Extract on Melanin Synthesis via Repression of Tyrosinase Expression.
PubMed: Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721.
PubMed: Arctigenin protects focal cerebral ischemia-reperfusion rats through inhibiting neuroinflammation.
PubMed: Arctigenin suppresses transforming growth factor-β1-induced expression of monocyte chemoattractant protein-1 and the subsequent epithelial-mesenchymal transition through reactive oxygen species-dependent ERK/NF-κB signaling pathway in renal tubular epithelial cells.
PubMed: Ligand binding affinities of arctigenin and its demethylated metabolites to estrogen receptor alpha.
PubMed: Arctigenin induces cell cycle arrest by blocking the phosphorylation of Rb via the modulation of cell cycle regulatory proteins in human gastric cancer cells.
PubMed: Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway.
PubMed: Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L.
PubMed: Neuroprotective effect of arctigenin via upregulation of P-CREB in mouse primary neurons and human SH-SY5Y neuroblastoma cells.
PubMed: [Research on the preparative method of Arctigenin].
PubMed: (-)-Arctigenin as a lead compound for anticancer agent.
PubMed: Inhibitory effect of arctigenin on lymphocyte activation stimulated with PMA/ionomycin.
PubMed: Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway.
PubMed: Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice.
PubMed: Cell and nuclear enlargement of SW480 cells induced by a plant lignan, arctigenin: evaluation of cellular DNA content using fluorescence microscopy and flow cytometry.
PubMed: Integrated compound profiling screens identify the mitochondrial electron transport chain as the molecular target of the natural products manassantin, sesquicillin, and arctigenin.
PubMed: Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase.
PubMed: Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells.
PubMed: Arctigenin alleviates ER stress via activating AMPK.
PubMed: Synthesis of (-)-arctigenin derivatives and their anticancer activity.
PubMed: Arctigenin efficiently enhanced sedentary mice treadmill endurance.
PubMed: Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits type I-IV allergic inflammation and pro-inflammatory enzymes.
PubMed: Synthesis and cytotoxicity evaluation of 4-amino-4-dehydroxylarctigenin derivatives in glucose-starved A549 tumor cells.
PubMed: Arctigenin from Arctium lappa inhibits interleukin-2 and interferon gene expression in primary human T lymphocytes.
PubMed: Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity.
PubMed: In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway.
PubMed: Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus.
PubMed: Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan.
PubMed: Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition.
PubMed: pH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymeric vaginal delivery system.
PubMed: Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor.
PubMed: Mass fragmentation study of the trimethylsilyl derivatives of arctiin, matairesinoside, arctigenin, phylligenin, matairesinol, pinoresinol and methylarctigenin: their gas and liquid chromatographic analysis in plant extracts.
PubMed: New expectations from the well-known medicinal properties of Arctium lappa.
PubMed: Anti-inflammatory activity of arctigenin from Forsythiae Fructus.
PubMed: Microemulsion electrokinetic chromatography for the separation of arctiin and arctigenin in Fructus Arctii and its herbal preparations.
PubMed: Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-alpha and nitric oxide production, and lymphocyte proliferation.
PubMed: [Effect of anti-influenza virus of Arctigenin in vivo].
PubMed: Arctigenin from Fructus Arctii is a novel suppressor of heat shock response in mammalian cells.
PubMed: Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation.
PubMed: Determination of arctiin and arctigenin in Fructus Arctii by reverse-phase HPLC.
PubMed: Isolation and characterization of a human intestinal bacterium, Eubacterium sp. ARC-2, capable of demethylating arctigenin, in the essential metabolic process to enterolactone.
PubMed: A preparative isolation and purification of arctigenin and matairesinol from Forsythia koreana by centrifugal partition chromatography.
PubMed: Isolation and identification of arctiin and arctigenin in leaves of burdock (Arctium lappa L.) by polyamide column chromatography in combination with HPLC-ESI/MS.
PubMed: Biotransformation of the naturally occurring lignan (-)-arctigenin in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.
PubMed: Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase.
PubMed: Lignans inhibit cell growth via regulation of Wnt/beta-catenin signaling.
PubMed: [Induction of apoptosis of the human leukemia cells by arctigenin and its mechanism of action].
PubMed: Free-radical-mediated conjugate additions. Enantioselective synthesis of butyrolactone natural products: (-)-enterolactone, (-)-arctigenin, (-)-isoarctigenin, (-)-nephrosteranic acid, and (-)-roccellaric acid.
PubMed: (-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase.
PubMed: Natural lignans from Arctium lappa modulate P-glycoprotein efflux function in multidrug resistant cancer cells.
PubMed: Radical carboxyarylation approach to lignans. Total synthesis of (-)-arctigenin, (-)-matairesinol, and related natural products.
PubMed: Antioxidants: potential antiviral agents for Japanese encephalitis virus infection.
PubMed: Anti-austeritic Constituents of the Congolese Medicinal Plant Aframomum melegueta.
PubMed: Three new lignans from the seeds of Saussurea involucrata.
PubMed: Optimum yields of dibenzylbutyrolactone-type lignans from Cynareae fruits, during their ripening, germination and enzymatic hydrolysis processes, determined by on-line chromatographic methods.
PubMed: Plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by HPLC-UV and LC-MS.
PubMed: Phytochemical profile and apoptotic activity of Onopordum cynarocephalum.
PubMed: Tumour-growth inhibiting substances of plant origin. II. The experimental animal tumour-pharmacology of arctigenin-mustard.
PubMed: Chemical analysis of raw and processed Fructus arctii by high-performance liquid chromatography/diode array detection-electrospray ionization-mass spectrometry.
PubMed: Arctigenin: a lignan from Arctium lappa.
PubMed: Active components with inhibitory activities on IFN-γ/STAT1 and IL-6/STAT3 signaling pathways from Caulis Trachelospermi.
PubMed: Update on phase I studies in advanced pancreatic adenocarcinoma. Hunting in darkness?
PubMed: Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I.
PubMed: Simultaneous determination of arctiin and its metabolites in rat urine and feces by HPLC.
PubMed: Steroidal esters from Ferula sinkiangensis.
PubMed: Searching for synergistic bronchodilators and novel therapeutic regimens for chronic lung diseases from a traditional Chinese medicine, Qingfei Xiaoyan Wan.
PubMed: Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans.
PubMed: Ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry coupled with hierarchical cluster analysis to evaluate Wikstroemia indica (L.) C. A. Mey. from different geographical regions.
PubMed: Specific hydrolysis and accumulation of antiproliferative lignans in the fruit of Leuzea carthamoides (Willd.) DC.
PubMed: Optimization of the processing technology of Fructus Arctii by response surface methodology.
PubMed: Arctigenic acid, the key substance responsible for the hypoglycemic activity of Fructus Arctii.
PubMed: Pharmacokinetics screening for multi-components absorbed in the rat plasma after oral administration of traditional Chinese medicine Flos Lonicerae Japonicae-Fructus Forsythiae herb couple by sequential negative and positive ionization ultra-high-performance liquid chromatography/tandem triple quadrupole mass spectrometric detection.
PubMed: Cytotoxic components of bardanae fructus (goboshi).
PubMed: Complementary fragmentation pattern analysis by gas chromatography-mass spectrometry and liquid chromatography tandem mass spectrometry confirmed the precious lignan content of Cirsium weeds.
PubMed: Seasonal alteration in amounts of lignans and their glucosides and gene expression of the relevant biosynthetic enzymes in the Forsythia suspense leaf.
PubMed: Dibenzylbutyrolactone lignans from Forsythia koreana fruits attenuate lipopolysaccharide-induced inducible nitric oxide synthetase and cyclooxygenase-2 expressions through activation of nuclear factor-κb and mitogen-activated protein kinase in RAW264.7 cells.
PubMed: Determination of the major constituents in fruit of Arctium lappa L. by matrix solid-phase dispersion extraction coupled with HPLC separation and fluorescence detection.
PubMed: New guaian-type sesquiterpene from Wikstroemia indica.
PubMed: Simultaneous determination of five bioactive secolignans in rat plasma by LC-MS/MS for pharmacokinetic studies following oral administration of Peperomia dindygulensis Miq. extract.
PubMed: Bioassay-guided isolation and identification of active compounds from Fructus Arctii against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus).
PubMed: Inhibitory effect of nordihydroguaiaretic acid, a plant lignan, on Helicobacter pylori-associated gastric carcinogenesis in Mongolian gerbils.
PubMed: [Anti-inflammatory mechanism of qingfei xiaoyan wan studied with network pharmacology].
PubMed: Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay.
PubMed: Anti-austeric activity of phenolic constituents of seeds of Arctium lappa.
PubMed: Induction of caspase-8 and death receptors by a new dammarane skeleton from the dried fruits of Forsythia koreana.
PubMed: Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kappaBalpha phosphorylation and of p65 nuclear translocation in macrophages.
PubMed: Dual-bioactivity-based liquid chromatography-coupled quadrupole time-of-flight mass spectrometry for NF-κB inhibitors and β2AR agonists identification in Chinese Medicinal Preparation Qingfei Xiaoyan Wan.
PubMed: The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme.
PubMed: Ion-sparing diuresis by 2,3-dibenzylbutane-1,4-diol, a synthetic mammalian-lignan derivative.
PubMed: [Trace chemical constituents contained in Trachelospermum jasminoides and structure identification].
PubMed: Antiasthmatic action of dibenzylbutyrolactone lignans from fruits of Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea-pigs.
PubMed: Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat.
PubMed: Metabolism of ginsenoside Rb1 by human intestinal microflora and cloning of its metabolizing β-D-glucosidase from Bifidobacterium longum H-1.
PubMed: Bioactivity-guided isolation of antiproliferative compounds from Centaurea arenaria.
PubMed: Differential in vitro anti-HIV activity of natural lignans.
PubMed: Antioxidative and in vitro antiproliferative activity of Arctium lappa root extracts.
PubMed: Biological activities of Fructus arctii fermented with the basidiomycete Grifola frondosa.
PubMed: [A comparative research on quality of Vitmin C Yinqiao tablets from different manufacturers].
PubMed: [Dyuamical studies on metabolic chemistry of lignans from seeds of Arctium lappa].
PubMed: [Constituents of Gymnadenia conopsea].
PubMed: Evaluation of estrogen receptor Beta binding of pruni cortex and its constituents.
PubMed: Application of gradient-enhanced nuclear Overhauser effect spectroscopy GOESY) in the structure elucidation of plant secondary metabolites.
PubMed: Cytotoxic activity of Ipomoea cairica.
PubMed: Lignan profile in seeds of modern and old Italian soft wheat (Triticum aestivum L.) cultivars as revealed by CE-MS analyses.
PubMed: Antiproliferative and apoptotic effects of butyrolactone lignans from Arctium lappa on leukemic cells.
PubMed: Hepatoprotective dibenzylbutyrolactone lignans of Torreya nucifera against CCl4-induced toxicity in primary cultured rat hepatocytes.
PubMed: In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterodiol.
PubMed: Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells.
PubMed: Preventive strategies for frequent outbreaks of Japanese encephalitis in Northern India.
PubMed: Americanin, a bioactive dibenzylbutyrolactone lignan, from the seeds of Centaurea americana.
PubMed: Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells.
PubMed: Sesquiterpene lactones from Centaurea tweediei.
PubMed: Savinin, a lignan from Pterocarpus santalinus inhibits tumor necrosis factor-alpha production and T cell proliferation.
PubMed: Studies on differentiation inducers. VI. Lignan derivatives from Arctium fructus. (2).
PubMed: [Chemical components of Trachelospelmun jasminoides (Lindl.) Lem. var. heterophyllum Tsiang].
PubMed: Structural transformation of lignan compounds in rat gastrointestinal tract.
PubMed: Lignans and Other Constituents of Centaurea sphaerocephala ssp. polyacantha.
PubMed: alpha-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae).
PubMed: Assessing exposure to lignans and their metabolites in humans.
PubMed: Lignans from Saussurea conica and their NO production suppressing activity.
PubMed: A phytochemical study of lignans in whole plants and cell suspension cultures of Anthriscus sylvestris.
PubMed: Transformation of arctiin to estrogenic and antiestrogenic substances by human intestinal bacteria.
PubMed: Stereochemical diversity in lignan biosynthesis of Arctium lappa L.
PubMed: Neuroprotective dibenzylbutyrolactone lignans of Torreya nucifera.
PubMed: Arctiin and onopordopicrin from Carduus micropterus ssp. perspinosus.
PubMed: Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa.
PubMed: Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection.
PubMed: Constituents of the Egyptian Centaurea scoparia. III. Phenolic constituents of the aerial parts.
PubMed: [Studies on the chemical constituents of Arctium lappa L].
PubMed: A Contribution to the Phytochemistry of Zanthoxylum tessmannii1.
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