EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

norwogonin
5,7,8-trihydroxyflavone

Supplier Sponsors

CAS Number: 4443-09-8Picture of molecule3D/inchi
FDA UNII: 70U0WT21IB
Nikkaji Web:J126.069C
Beilstein Number:0272168
XlogP3-AA:2.70 (est)
Molecular Weight:270.24070000
Formula:C15 H10 O5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 528.40 °C. @ 760.00 mm Hg (est)
Flash Point: 403.00 °F. TCC ( 206.00 °C. ) (est)
logP (o/w): 1.970 (est)
Soluble in:
 water, 67.79 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Norwogonin 98%
BOC Sciences
For experimental / research use only.
5,7,8-Trihydroxyflavone
Coompo
For experimental / research use only.
norWogonin from Plants ≥98%
ExtraSynthese
For experimental / research use only.
5,7,8-Trihydroxyflavone (HPLC) ≥90%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for norwogonin usage levels up to:
 not for fragrance use.
 
Recommendation for norwogonin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281674
National Institute of Allergy and Infectious Diseases:Data
5,7,8-trihydroxy-2-phenylchromen-4-one
Chemidplus:0004443098
 
References:
 5,7,8-trihydroxy-2-phenylchromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5281674
Pubchem (sid):134985399
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10113
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
4H-1-benzopyran-4-one, 2-phenyl-5,7,8-trihydroxy- (9CI)
4H-1-benzopyran-4-one, 5,7,8-trihydroxy-2-phenyl-
 flavone, 5,7,8-trihydroxy-
2-phenyl-5,7,8-trihydroxy-4H-1-benzopyran-4-one
5,7,8-trihydroxy-2-phenyl-4H-chromen-4-one
5,7,8-trihydroxy-2-phenylchromen-4-one
5,7,8-trihydroxyflavone
 

Articles:

PubMed:Simulated gastrointestinal tract metabolism and pharmacological activities of water extract of Scutellaria baicalensis roots.
PubMed:Isolation and characterization of antimicrobial compounds in plant extracts against multidrug-resistant Acinetobacter baumannii.
PubMed:Suppressive effects of T-412, a flavone on interleukin-4 production in T cells.
PubMed:Empirically predicted 13C NMR chemical shifts for 8-hydroxyflavone starting from 7,8,4'-trihydroxyflavone and from 7,8-dihydroxyflavone.
PubMed:Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells.
PubMed:Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages.
PubMed:Studies on the constituents of roots of Scutellaria planipes.
PubMed:The antioxidative effect of icariin in human erythrocytes against free-radical-induced haemolysis.
PubMed:Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships.
PubMed:Inhibition of mitochondrial respiration and cyanide-stimulated generation of reactive oxygen species by selected flavonoids.
PubMed:[Studies on the structures of new flavonoids from the root of Scutellaria amoena].
PubMed:Flavone mutagenicity in Salmonella typhimurium: dependence on the pKM101 plasmid and excision-repair deficiency.
PubMed:Mutagenicity of flavones, chromones and acetophenones in Salmonella typhimurium. New structure-activity relationships.
 
Notes:
None found
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