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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 229.00 to 230.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 886.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 591.00 °F. TCC ( 310.80 °C. ) (est)
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| logP (o/w): | -1.320 (est) |
| Soluble in: |
| | water, 4.391e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-guinea pig LD50 26300 ug/kg
Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 647, 1959.
intraperitoneal-rat LD50 2240 mg/kg
Indian Journal of Pharmacology. Vol. 10, Pg. 277, 1978.
intravenous-rat LD50 125 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 647, 1959.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for gossypin usage levels up to: | | | not for fragrance use.
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| Recommendation for gossypin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5281621 |
| Pubchem (sid): | 135077470 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2-(3,4- | dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | | 2-(3,4- | dihydroxyphenyl)-8-(beta-D-glucopyranosyloxy)-3,5,7-trihydroxy-4H-1-benzopyran-4-one | | 2-(3,4- | dihydroxyphenyl)-8-(beta-dextro-glucopyranosyl oxy)-3,5,7-trihydroxy-4H-1-benzopyran-4-one | | | gossypetin-8-glucoside | | 3,5,7,8,3',4'- | hexahydroxyflavone-8-glucoside |
Articles:
| PubMed:Neuroprotective activity of gossypin from Hibiscus vitifolius against global cerebral ischemia model in rats. |
| PubMed:Isolation of methyl 27-caffeoyloxyoleanolate--a new oleanane Triterpenoid from the roots of Hibiscus vitifolius. |
| PubMed:Gossypin as a novel selective dual inhibitor of V-RAF murine sarcoma viral oncogene homolog B1 and cyclin-dependent kinase 4 for melanoma. |
| PubMed:Gossypin induces G2/M arrest in human malignant glioma U251 cells by the activation of Chk1/Cdc25C pathway. |
| PubMed:Antidiabetic activity of gossypin, a pentahydroxyflavone glucoside, in streptozotocin-induced experimental diabetes in rats. |
| PubMed:[Effect of seven kinds of flavonoids on recombinant human protein tyrosine phosphatase]. |
| PubMed:Evaluation of anti-allergic activity of gossypin and suramin in mast cell-mediated allergy model. |
| PubMed:Oral supplementation of gossypin during lead exposure protects alteration in heme synthesis pathway and brain oxidative stress in rats. |
| PubMed:The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. |
| PubMed:Antiinflammatory and antinociceptive activities of gossypin and procumbentin--cyclooxygenase-2 (COX-2) inhibition studies. |
| PubMed:Gossypin up-regulates LDL receptor through activation of ERK pathway: a signaling mechanism for the hypocholesterolemic effect. |
| PubMed:Comparative evaluation of some flavonoids and tocopherol acetate against the systemic toxicity induced by sulphur mustard. |
| PubMed:Influence of some bioflavonoids on the transport of nitrendipine. |
| PubMed:A flavonoid gossypin binds to cyclin-dependent kinase 2. |
| PubMed:Prophylactic effect of gossypin against percutaneously administered sulfur mustard. |
| PubMed:Interaction of flavonoids and intestinal facilitated glucose transporters. |
| PubMed:Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. |
| PubMed:Gossypin protects primary cultured rat cortical cells from oxidative stress- and beta-amyloid-induced toxicity. |
| PubMed:Free radical scavenging, antitumor and anticarcinogenic activity of gossypin. |
| PubMed:Interaction of hydrated electron with dietary flavonoids and phenolic acids: rate constants and transient spectra studied by pulse radiolysis. |
| PubMed:Influence of gossypin on the development of acute tolerance to morphine induced antinociception. |
| PubMed:A study on the role of cholinergic and gamma amino butyric acid systems in the anti-nociceptive effect of gossypin. |
| PubMed:Protective effects of phenolic compounds on CCl4-induced toxicity in isolated rat hepatocytes. |
| PubMed:Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids. |
| PubMed:Dermal intoxication of mice with bis(2-chloroethyl)sulphide and the protective effect of flavonoids. |
| PubMed:Possible development of dependence on gossypin: role of gossypin on morphine dependence. |
| PubMed:Inhibition of sheep platelet arachidonate metabolism by flavonoids from Spanish and Indian medicinal herbs. |
| PubMed:Loss of plasmid linked antibiotic resistance in Escherichia coli on treatment with some phenolic compounds. |
| PubMed:Anti-inflammatory and anti-allergic properties of flavonoids. |
| PubMed:Studies on possible tolerance and mechanism of gossypin analgesia. |
| PubMed:Flavonoid-induced delay in the small intestinal transit: possible mechanism of action. |
| PubMed:Gossypin-induced analgesia in mice. |
| PubMed:Effect of gossypin, a flavonoid, on the formation of galactose-induced cataracts in rats. |
| PubMed:SOME OBSERVATIONS ON THE INFLUENCE OF RUTIN AND GOSSYPIN IN EXPERIMENTAL FROST-BITE. |
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3D/inchi