EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

artesunate
artesunic acid

Supplier Sponsors

CAS Number: 88495-63-0Picture of molecule3D/inchi
Other(deleted CASRN):112346-66-4
FDA UNII: 60W3249T9M
Nikkaji Web:J258.545F
MDL:MFCD00866204
XlogP3-AA:2.50 (est)
Molecular Weight:384.42576000
Formula:C19 H28 O8
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 507.12 °C. @ 760.00 mm Hg (est)
Vapor Pressure:3.200000 mmHg @ 25.00 °C. (est)
Flash Point: 348.00 °F. TCC ( 175.60 °C. ) (est)
logP (o/w): 3.291 (est)
Soluble in:
 water, 56.25 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Artesunate 98%
BOC Sciences
For experimental / research use only.
Artesunate >98%
Odor: characteristic
Use: Artesunat, a semisynthetic derivative of artemisinin,effectively kills the malarial parasites P. falciparum and P. vivax (IC50 = 1.3 nM).
Coompo
For experimental / research use only.
Artesunate from Plants ≥98%
Santa Cruz Biotechnology
For experimental / research use only.
Artesunate 98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Artesunate from Artemisia annua
sds
Sinoway Industrial
For experimental / research use only.
Artesunate
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for artesunate usage levels up to:
 not for fragrance use.
 
Recommendation for artesunate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6917864
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0088495630
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6917864
Pubchem (sid):135022215
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D02482
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2932.99.0090
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
artesunate is dispensed as a powder of artesunic acid. this is dissolved in sodium bicarbonate (5%) to form sodium artesunate. the solution is then diluted in approximately 5 ml of 5% dextrose and given by intravenous injection or by intramuscular injection to the anterior thigh. the solution should be prepared freshly for each administration and should not be stored.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 arsumax
 artesunatum
 artesunic acid
 butanedioic acid, mono((3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-yl) ester
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol hydrogen succinate
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol, hydrogen succinate
 dihydroartemisinine-12-alpha-succinate
 dihydroqinghasu hemsuccinate
 plasmotrim
 plasmotrin
 qinghaozhi
 quinghaosu reduced succinate ester
 succinyl dihydroartemisinin
1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadec-10-yl propionicacid
4-oxo-4-{[(4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadec-10-yl]oxy}butanoic acid
4-oxo-4-{[(1S,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy}butanoic acid
4-oxo-4-{[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}butanoic acid
4-oxo-4-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10-yl]oxy}butanoic acid
4-oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic acid
 

Articles:

PubMed:Embryotoxicity and toxicokinetics of the antimalarial artesunate in rats.
PubMed:Efficacy of artesunate-amodiaquine and artemether-lumefantrine fixed-dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria among children aged six to 59 months in Nimba County, Liberia: an open-label randomized non-inferiority trial.
PubMed:Defining the timing of action of antimalarial drugs against Plasmodium falciparum.
PubMed:Pharmacokinetic properties and bioequivalence of two sulfadoxine/pyrimethamine fixed-dose combination tablets: a parallel-design study in healthy Chinese male volunteers.
PubMed:Management of imported malaria in Europe.
PubMed:Pyronaridine-artesunate combination therapy for the treatment of malaria.
PubMed:Genotoxicity assessment of the antimalarial compound artesunate in somatic cells of mice.
PubMed:Malaria: severe, life-threatening.
PubMed:Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production.
PubMed:Adaptive response and tolerance to weak acids in Saccharomyces cerevisiae: a genome-wide view.
PubMed:Effects of co-administration of artesunate and amodiaquine on some cardiovascular disease indices in rats.
PubMed:Intravenous artesunate for the treatment of severe malaria.
PubMed:Successful introduction of artesunate combination therapy is not enough to fight malaria: results from an adherence study in Sierra Leone.
PubMed:Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects.
PubMed:Bioavailability of a co-formulated combination of amodiaquine and artesunate under fed and fasted conditions. A randomised, open-label crossover study.
PubMed:Treatment of malaria from monotherapy to artemisinin-based combination therapy by health professionals in urban health facilities in Yaoundé, central province, Cameroon.
PubMed:A stratified random survey of the proportion of poor quality oral artesunate sold at medicine outlets in the Lao PDR - implications for therapeutic failure and drug resistance.
PubMed:Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate.
PubMed:Artemisinins and synthetic trioxolanes in the treatment of helminth infections.
PubMed:[The treatment of falciparum malaria].
PubMed:Malaria: severe, life-threatening.
PubMed:Malaria: uncomplicated, caused by Plasmodium falciparum.
PubMed:Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia.
PubMed:Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).
PubMed:Effect of artesunate and artemether against Clonorchis sinensis and Opisthorchis viverrini in rodent models.
PubMed:Counterfeit and substandard antimalarial drugs in Cambodia.
PubMed:Fatty food does not alter blood mefloquine concentrations in the treatment of falciparum malaria.
PubMed:Artemisinin-based combination therapies for uncomplicated malaria.
PubMed:Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.
PubMed:Drugs. Reinventing an ancient cure for malaria.
PubMed:Studies of the neurotoxicity of oral artemisinin derivatives in mice.
PubMed:Arteether toxicokinetics and pharmacokinetics in rats after 25 mg/kg/day single and multiple doses.
PubMed:Antiparasitic agents.
PubMed:Pharmacokinetics of mefloquine combined with artesunate in children with acute falciparum malaria.
PubMed:Artemisinin enhances heme-catalysed oxidation of lipid membranes.
PubMed:The iron environment in heme and heme-antimalarial complexes of pharmacological interest.
PubMed:Antimalarial agents, 2. Artesunate, an inhibitor of cytochrome oxidase activity in Plasmodium berghei.
 
Notes:
succinic ester of artemether.
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