EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

hydrocortisone acetate
21-(acetyl oxy)-11,17-pregn-4-ene-3,20-dione

Supplier Sponsors

CAS Number: 50-03-3Picture of molecule3D/inchi
Other(deleted CASRN):42016-02-4
ECHA EINECS - REACH Pre-Reg:200-004-4
FDA UNII: 3X7931PO74
Nikkaji Web:J4.096G
Beilstein Number:2066841
MDL:MFCD00037714
XlogP3:2.20 (est)
Molecular Weight:404.50324000
Formula:C23 H32 O6
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 223.00 °C. @ 760.00 mm Hg
Boiling Point: 576.56 °C. @ 760.00 mm Hg (est)
Flash Point: 385.00 °F. TCC ( 196.20 °C. ) (est)
logP (o/w): 2.190
Soluble in:
 water, 38.71 mg/L @ 25 °C (est)
 water, 14.1 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
American International Chemical, LLC.
HYDROCORTISONE ACETATE USP MICRONIZED
BOC Sciences
For experimental / research use only.
Hydrocortisone acetate >98.5%
Glentham Life Sciences
Hydrocortisone acetate
Penta International
HYDROCORTISONE ACETATE USP (Micronized)
Sigma-Aldrich: Sigma
For experimental / research use only.
Hydrocortisone 21-acetate ≥98% (HPLC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 2300 mg/kg
Compilation of LD50 Values of New Drugs.

Dermal Toxicity:
subcutaneous-mouse LD50 45050 ug/kg
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986

subcutaneous-rat LDLo 250 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 2102, 1977.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for hydrocortisone acetate usage levels up to:
 not for fragrance use.
 
Recommendation for hydrocortisone acetate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5744
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Chemidplus:0000050033
RTECS:GM8960000 for cas# 50-03-3
 
References:
 [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:50-03-3
Pubchem (cid):5744
Pubchem (sid):134970850
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C02821
HMDB (The Human Metabolome Database):Search
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 ab bocort
 abbocort
 acepolcort-H
 acetate-AS
 aceto-cort
21-(acetyl oxy)-11,17-pregn-4-ene-3,20-dione
21-O-acetylcortisol
 alfacorton
 allocort
 bacicoline
 bambicort
 berlison
 biocortar
 caldecort
 carmol HC
 carmol-HC
 chemysone
 chloromycetin hydrocortisone ophthalmic
 clear-aid
 colifoam
 collusul-HC
 colofoam
 cortacream
 cortaid
 cortef acetate
 cortell
 cortes
 corti
 crema transcutan
 crematranscutan
 derminovag
 dermosa hidrocortisona
[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
 dricort
 efcolin
 efcorlin
 efzem
 ekzemsalbe F
 epifoam
 fenitral
 fernisone
 glycocortison
 hemsol-HC
 hipokort
 hycor eye oitment
 hycortole acetate
 hyderm
 hydrin-2
 hydrison
 hydrocal
17a-hydrocorticosterone-21-acetate
 hydrocortisat
 hydrocortison
 hydrocortisone 21-acetate
 hydrocortistab
 hydrocortole acetate
 hydrocortone acetate
 hydrosone
17-hydroxycorticosterone 21-acetate
17-a-hydroxycorticosterone 21-acetate
 hydroxycorticosterone acetate
17-a-hydroxycorticosterone acetate
17-hydroxycorticosterone, 21-acetate
 hysone-A
 idrocort
 iracetisone
 korti
 lanacort
 latimit
 lenirit
 lidaform-HC
 lidamantle-HC
 mantadil
 medithane
 micort-HC
 ophticor
 orabase HCA
 pabracort
 pannocort
 pregn-4-ene-3, 20-dione, 11b,17,21-trihydroxy-, 21-acetate
 pregn-4-ene-3, 20-dione, 21- (acetyloxy)-11,17-dihydroxy-, (11b)-
 pregn-4-ene-3,20-dione, 11-b,17,21-trihydroxy-, 21-acetate
 pregn-4-ene-3,20-dione, 11b,17,21-trihydroxy-, 21-acetate
 pregn-4-ene-3,20-dione, 21-(acetoxy)-11,17-dihydroxy-, (11-b)-
isopto-hydrocortisone
 resicort
 sagittacortin
 sanadermil
 sigma cort
 sigmacort
 siguent hycor
 sintotrat
 soenol hydrocortison
 squibb-HC
 supralef
 urecortyn
 velopural
 wycort
 

Articles:

PubMed:[Detection of glucocorticoids by pressurized capillary electrochromatography with ultra-violet detection and its application in hair analysis].
PubMed:Comparison of HPLC and multivariate regression methods for hydrocortisone and lidocaine analysis of pharmaceutical preparations.
PubMed:Food restriction-like effects of dehydroepiandrosterone: decreased lymphocyte numbers and functions with increased apoptosis.
PubMed:Pulmonary pathohistological changes in mice in experimental infection with Pneumocystis carinii.
PubMed:Influence of hydrocortisone acetate of the longissimus dorsi muscle during gestation of rats.
PubMed:Influence of gestation and hydrocortisone-acetate treatment on the nutritive utilization of protein.
PubMed:Effect of cortisol on some nutritional and biochemical parameters in pregnant rats and their foetuses.
PubMed:Effects of hydrocortisone acetate and estradiol in normal and adrenalectomized salt deficient rabbits.
 
Notes:
None found
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