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5-hydroxypyrazinoic acid
2-pyrazinecarboxylic acid, 5-hydroxy-

Supplier Sponsors

Name:6-oxo-1H-pyrazine-3-carboxylic acid
CAS Number: 34604-60-9Picture of molecule3D/inchi
FDA UNII: M2V0DP3ENP
Nikkaji Web:J47.668D
Beilstein Number:775641
MDL:MFCD00190599
XlogP3-AA:-1.00 (est)
Molecular Weight:140.09848000
Formula:C5 H4 N2 O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 608.50 °C. @ 760.00 mm Hg (est)
Flash Point: 611.00 °F. TCC ( 321.80 °C. ) (est)
logP (o/w): -1.820 (est)
Soluble in:
 water, 6.99e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
5-hydroxypyrazine-2-carboxylic acid >98%
Matrix Scientific
For experimental / research use only.
5-Hydroxypyrazine-2-carboxylic acid
sds
Santa Cruz Biotechnology
For experimental / research use only.
5-Hydroxy-2-pyrazinecarboxylic acid 97%
Sigma-Aldrich: Aldrich
For experimental / research use only.
5-Hydroxy-2-pyrazinecarboxylic acid ≥96.0% (T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for 5-hydroxypyrazinoic acid usage levels up to:
 not for fragrance use.
 
Recommendation for 5-hydroxypyrazinoic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :161825
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
6-oxo-1H-pyrazine-3-carboxylic acid
Chemidplus:0034604609
 
References:
 6-oxo-1H-pyrazine-3-carboxylic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):161825
Pubchem (sid):135117814
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
5-hydroxy-2-pyrazinecarboxylic acid
5-hydroxypyrazine-2-carboxylic acid
6-oxo-1H-pyrazine-3-carboxylic acid
2-pyrazinecarboxylic acid, 5-hydroxy-
 

Articles:

PubMed:A novel mechanism underlies the hepatotoxicity of pyrazinamide.
PubMed:Investigation of the effects of concomitant caffeine administration on the metabolic disposition of pyrazinamide in rats.
PubMed:Quantification of pyrazinamide and its metabolites in plasma by ionic-pair high-performance liquid chromatography. Implications for the separation mechanism.
PubMed:Determination of pyrazinamide and its main metabolites in rat urine by high-performance liquid chromatography.
PubMed:Ethanol as a xanthine dehydrogenase inhibitor.
PubMed:Xylitol-induced increase in the concentration of oxypurines and its mechanism.
PubMed:In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase.
PubMed:A case of xanthinuria: a study on the metabolism of pyrazinamide and allopurinol.
PubMed:Pharmacokinetics of pyrazinamide and its metabolites in patients with hepatic cirrhotic insufficiency.
PubMed:Metabolism of pyrazinamide and allopurinol in hereditary xanthine oxidase deficiency.
PubMed:[Microdetermination of pyrazinamide and its metabolites (pyrazinoic acid, 5-hydroxypyrazinoic acid, 5-hydroxypyrazinamide and pyrazinuric acid) in plasma and urine with liquid chromatography].
PubMed:In vitro conversion of pyrazinamide into 5-hydroxypyrazinamide and that of pyrazinoic acid into 5-hydroxypyrazinoic acid by xanthine oxidase from human liver.
PubMed:Metabolic disposition of pyrazinamide in the rat: identification of a novel in vivo metabolite common to both rat and human.
PubMed:Study of the metabolism of pyrazinamide using a high-performance liquid chromatographic analysis of urine samples.
PubMed:Study of urinary pyrazinamide metabolites and their action on the renal excretion of xanthine and hypoxanthine in a xanthinuric patient.
PubMed:Mass fragmentographic determination of pyrazinamide and its metabolites in serum and urine.
PubMed:Observations on the reduction of the renal elimination of urate in man caused by the administration of pyrazinamide.
 
Notes:
metabolite of pyrazinamide.
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