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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 389.40 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 277.00 °F. TCC ( 136.20 °C. ) (est)
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| logP (o/w): | 6.350 (est) |
| Soluble in: |
| | water, 0.2007 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Coompo |
| For experimental / research use only. |
| Dehydroabietinol from Plants ≥96%
Odor: characteristic Use: Dehydroabietinol was found to inhibit growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM). However, erythrocytes exposed to dehydroabietinol were transformed in a dose-dependent manner towards spherostomatocytic forms with concomitant formation of endovesicles, as disclosed by transmission electron microscopy. The erythrocyte shape alterations caused by dehydroabietinol correlated well with its apparent IC50 value. Thus, dehydroabietinol incorporates into the erythrocyte membrane, and since invasion and survival of Plasmodium parasites is known to depend on the function of the erythrocyte membrane, the observed antiplasmodial effect of dehydroabietinol is presumably an indirect effect on the host cell. Because of these findings, microscopic investigations should be generally used to support claims of antimalarial effects of apolar natural products. |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Dehydroabietol
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Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for dehydroabietol usage levels up to: | | | not for fragrance use.
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| Recommendation for dehydroabietol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 15586718 |
| Pubchem (sid): | 135063931 |
| Pherobase: | View |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | abieta-8,11,13-trien-18-ol | | | dehydroabeityl alcohol | | | dehydroabietadienol | | | dehydroabietinol | | [(1R,4aS,10aR)-1,4a- | dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanol | | (1R-(1alpha,4abeta,10aalpha))-1,2,3,4,4a,9,10,10a- | octahydro-7-isopropyl-1,4a-dimethyl phenanthren-1-methanol | | 1- | phenanthrenemethanol, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, (1R,4aS,10aR)- | | | podocarpa-8,11,13-trien-15-ol, 13-isopropyl- | | | pomiferin A | | [(1R,4aS,10aR)-7-iso | propyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl]methanol |
Articles:
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3D/inchi