|
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 576.66 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 577.00 °F. TCC ( 302.60 °C. ) (est)
|
| logP (o/w): | 3.153 (est) |
| Soluble in: |
| | water, 0.1593 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Schizandrol A 98%
|
| BOC Sciences |
| For experimental / research use only. |
| Schizandrin >98%
Odor: characteristic Use: Schisandrin has various therapeutic effects on a range of medical conditions such as anti-asthmatic, anti-cancer, and anti-inflammatory effects. |
| Changsha Organic Herb |
| Schisandra chinensis Extract
|
| Coompo |
| For experimental / research use only. |
| Schisandrin A from Plants ≥96%
Odor: characteristic Use: Schisandrin A and schisandrin B inhibited cytochrome P450 (CYP3A) activity with IC(50) values of 6.60 and 5.51 microM and K(i) values of 5.83 and 4.24 microM, respectively. A dilution assay plot of each inhibitor gave a slope value of up to 91% that of the control samples. The inactivation of CYP3A activity by schisandrin A and schisandrin B was found to be both time-and concentration-dependent (schisandrin A: K(I) = 4.51 microM, K(inact) = 0.134/min; schisandrin B: K(I) = 3.01 microM, K(inact) = 0.112/min). We conclude that the inhibition of CYP3A activity in rat liver microsomes by schisandrin A and schisandrin B is mostly attributed to a mixed noncompetitive and complete inhibition. Changes in the pharmacokinetic profiles of peroral MDZ in the rat model were contributed mainly to Schisandrin A inhibition of CYP3A activity. These results suggest that Schisandrin A, as an inhibitor of CYP3A, possesses a clinically beneficial property of altering the disposition of drugs metabolized by CYP3A.
Schisantherin A demonstrated strong and comparable activities to reverse the drug resistance and the intracellular drug accumulation in four mediated multidrug resistance (MDR) cell lines. Schisantherin A are potent P-gp inhibitor and is of potential for future clinical application.
Pretreating mice with Sch A at a daily oral dose of 1 mmol/kg for 3 days did not protect against CCl4 hepatotoxicity, whereas pretreatment with Sch B or Sch C at the same dosage regimen produced almost complete protection. The hepatoprotection afforded by Sch B or Sch C pretreatment was associated with significant increases in the hepatic mitochondrial GSH level and glutathione reductase (EC 1.6.4.2) activity. Our results indicate that the methylenedioxy group of the dibenzocyclooctadiene skeleton of schisandrin is an important structural determinant in the stimulation of hepatic mitochondrial GSH, particularly under conditions of CCl4 intoxication. |
| Layn Natural ingredients |
| Schisandra Extract Schisandrins 2% - 7%
|
| Nacalai USA |
| For experimental / research use only. |
| Schisandrin
|
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Schisandrin ≥99%
|
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Schisandrin ≥98% (HPLC)
|
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 518 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"
Yakugaku Zasshi. Journal of Pharmacy. Vol. 101, Pg. 1030, 1981.
oral-mouse LD50 1448 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"
Yakugaku Zasshi. Journal of Pharmacy. Vol. 101, Pg. 1030, 1981.
|
| Dermal Toxicity: |
subcutaneous-mouse LD50 1861 mg/kg
BEHAVIORAL: SLEEP
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakugaku Zasshi. Journal of Pharmacy. Vol. 101, Pg. 1030, 1981.
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for schisandrin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for schisandrin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | dibenzo(a,c)cycloocten-6-ol, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, stereoisomer | | | dibenzo(a,c)cycloocten-6-ol, 5,6,7,8-tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxy-, stereoisomer | | | dibenzo[a,c]cycloocten-6-ol, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl- | | 1,2,3,10,11,12- | hexamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulen-6-ol | | | schisandra chinensis P.E | | | schizandra | | | schizandrin | | | wuweizi alcohol | | | wuweizichun |
Articles:
| PubMed:[Correlation study on lignin contents of Schisandra chinensis and ecological factors]. |
| PubMed:[High performance preparation and structural confirmation of lignans from Schisandrae chinensis fructus by using HSCCC combined with ESI-MSn method]. |
| PubMed:Two-steps extraction of essential oil, polysaccharides and biphenyl cyclooctene lignans from Schisandra chinensis Baill fruits. |
| PubMed:Tissue distribution and excretion of herbal components after intravenous administration of a Chinese medicine (Shengmai injection) in rat. |
| PubMed:Simultaneous determination of calycosin-7-O-β-d-glucoside, calycosin, formononetin, astragaloside IV and schisandrin in rat plasma by LC-MS/MS: application to a pharmacokinetic study after oral administration of Shenqi Wuwei chewable tablets. |
| PubMed:Simultaneous determination of puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma and its application to a pharmacokinetic study of Ge-Gen Decoction by a liquid chromatography-electrospray ionization-tandem mass spectrometry. |
| PubMed:Schisandrin B suppresses TGFβ1-induced stress fiber formation by inhibiting myosin light chain phosphorylation. |
| PubMed:Schisandra chinensis peptidoglycan-assisted transmembrane transport of lignans uniquely altered the pharmacokinetic and pharmacodynamic mechanisms in human HepG2 cell model. |
| PubMed:Comparative pharmacokinetics and tissue distribution of schisandrin, deoxyschisandrin and schisandrin B in rats after combining acupuncture and herb medicine (schisandra chinensis). |
| PubMed:A pharmacokinetic and pharmacodynamic study of drug-drug interaction between ginsenoside Rg1, ginsenoside Rb1 and schizandrin after intravenous administration to rats. |
| PubMed:Effect of Tacrolimus on the pharmacokinetics of bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp. |
| PubMed:[Determination of lignans in four fruits of Schisandra genus in Qinling mountains]. |
| PubMed:Screening of herbal components for attenuating amiodarone-induced hepatotoxicity on gel-entrapped rat hepatocytes. |
| PubMed:Beneficial effects of schisandrin B on the cardiac function in mice model of myocardial infarction. |
| PubMed:Schisandrin B attenuates acetaminophen-induced hepatic injury through heat-shock protein 27 and 70 in mice. |
| PubMed:In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A/P-glycoprotein-mediated absorption and metabolism of tacrolimus. |
| PubMed:An efficient strategy for the extraction and purification of lignans from Schisandra chinensis by a combination of supercritical fluid extraction and high-speed counter-current chromatography. |
| PubMed:Determination of lignans in Wuweizi by using magnetic bar microextraction and HPLC. |
| PubMed:A novel mouse model of combined hyperlipidemia associated with steatosis and liver injury by a single-dose intragastric administration of schisandrin B/cholesterol/bile salts mixture. |
| PubMed:Ultrasound-assisted extraction and purification of schisandrin B from Schisandra chinensis (Turcz.) Baill seeds: optimization by response surface methodology. |
| PubMed:Chemical-pharmacokinetic-pharmacodynamic fingerprints of Schisandra chinensis alcoholic extract. |
| PubMed:Comprehensive chemical analysis of Schisandra chinensis by HPLC-DAD-MS combined with chemometrics. |
| PubMed:Ultra-performance liquid-chromatography with tandem mass spectrometry for rapid analysis of pharmacokinetics, biodistribution and excretion of schisandrin after oral administration of Shengmaisan. |
| PubMed:Differential effect of schisandrin B stereoisomers on ATR-mediated DNA damage checkpoint signaling. |
| PubMed:[Quality evaluation and antioxidant activity research of Schisandra chinensis from various habitats]. |
| PubMed:Inhibiting cancer metastasis via targeting NAPDH oxidase 4. |
| PubMed:Effects of traditional chinese medicine Wuzhi capsule on pharmacokinetics of tacrolimus in rats. |
| PubMed:UFLC-MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. in normal and insomniac rats brain microdialysates and homogenate samples: towards an in-depth study for its sedative-hypnotic activity. |
| PubMed:In vivo effect of Schisandrin B on cytochrome P450 enzyme activity. |
| PubMed:Gender-dependent pharmacokinetics of lignans in rats after single and multiple oral administration of Schisandra chinensis extract. |
| PubMed:Pharmacokinetics and tissue distribution study of schisandrin B in rats by ultra-fast liquid chromatography with tandem mass spectrometry. |
| PubMed:Effect of acupuncture on target tissue distribution of Schisandra lignans. |
| PubMed:Development of a UFLC-MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. in rat plasma and its application to a comparative pharmacokinetic study in normal and insomnic rats. |
| PubMed:Purification of lignans from Schisandra chinensis fruit by using column fractionation and supercritical antisolvent precipitation. |
| PubMed:[Schisandrin B protects against nephrotoxicity induced by cisplatin in HK-2 cells via Nrf2-ARE activation]. |
| PubMed:Lipidomics identification of metabolic biomarkers in chemically induced hypertriglyceridemic mice. |
| PubMed:Pharmacokinetic study of schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B in rat plasma after oral administration of Shengmaisan formula by UPLC-MS. |
| PubMed:Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: absolute configuration, and their estrogenic and anti-proliferative activity. |
| PubMed:[Simultaneous quantitative analysis of four lignanoids in Schisandra chinensis by quantitative analysis of multi-components by single marker]. |
| PubMed:Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats. |
| PubMed:Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-κB. |
| PubMed:Chemical analysis of twelve lignans in the fruit of Schisandra sphenanthera by HPLC-PAD-MS. |
| PubMed:Schisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transition. |
| PubMed:Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates Aβ1-42-induced memory impairment in mice. |
| PubMed:[Correlation of lignans content and antioxidant activities of Schisandra chinensis fruits by using stoichiometry method]. |
| PubMed:Quantitative analysis of biologically active ingredients of Five Seeds Combo by liquid chromatography-quadrupole time-of-flight mass spectrometry for quality control of commercial herbal product. |
| PubMed:Protective effect of schisandrin B against cyclosporine A-induced nephrotoxicity in vitro and in vivo. |
| PubMed:Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia. |
| PubMed:Schisandrin B as a hormetic agent for preventing age-related neurodegenerative diseases. |
| PubMed:[Effect of schizandrin B on H(2)O(2)-induced apoptosis of human hepatocytes in vitro: role of Fas pathway]. |
| PubMed:Cytochrome P-450-catalyzed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in H9c2 cardiomyocytes. |
| PubMed:[Pharmacokinetics and tissue distribution of Schisandra chinensis extract in mice]. |
| PubMed:Beneficial effect of (-)schisandrin B against 3-nitropropionic acid-induced cell death in PC12 cells. |
| PubMed:Prooxidant-induced glutathione antioxidant response in vitro and in vivo: a comparative study between schisandrin B and curcumin. |
| PubMed:Response surface modeling and optimization of accelerated solvent extraction of four lignans from fructus schisandrae. |
| PubMed:Effects of H(2)O(2), paraquat, and ethephon on herbal drug quality of Schiandra chinensis based on reactive oxygen species system. |
| PubMed:[Pharmacokinetics interaction among three major active compounds of Shengmai formula in rats]. |
| PubMed:[Determination of six lignin components in crude and different processed products of Schisandra chinensis]. |
| PubMed:On-line continuous sampling dynamic microwave-assisted extraction coupled with high performance liquid chromatographic separation for the determination of lignans in Wuweizi and naphthoquinones in Zicao. |
| PubMed:Schisandrin B prevents doxorubicin-induced chronic cardiotoxicity and enhances its anticancer activity in vivo. |
| PubMed:Schisandrin B suppresses TGFβ1 signaling by inhibiting Smad2/3 and MAPK pathways. |
| PubMed:Cytochrome P450-catalysed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in AML12 hepatocytes. |
| PubMed:Schisandrin B, attenuates cisplatin-induced oxidative stress, genotoxicity and neurotoxicity through modulating NF-κB pathway in mice. |
| PubMed:Schisandrin B enhances the glutathione redox cycling and protects against oxidant injury in different types of cultured cells. |
| PubMed:Prevention and treatment of doxorubicin-induced cardiotoxicity by dexrazoxane and schisandrin B in rabbits. |
| PubMed:Effects of Schisandra chinensis extract on the contractility of corpus cavernosal smooth muscle (CSM) and Ca2+ homeostasis in CSM cells. |
| PubMed:[Effect of schisandrin B on lung mRNA expression of transforming growth factor-beta1 signal transduction molecule in rat lungs exposed to silica]. |
| PubMed:Inhibitory Effects of Continuous Ingestion of Schisandrin A on CYP3A in the Rat. |
| PubMed:Mitochondrial decay in ageing: 'Qi-invigorating' schisandrin B as a hormetic agent for mitigating age-related diseases. |
| PubMed:Relaxant effects of Schisandra chinensis and its major lignans on agonists-induced contraction in guinea pig ileum. |
| PubMed:[Identification of the lignans components after oral administration of fuzheng huayu decoction in rat serum by HPLC-MSn]. |
| PubMed:Upregulation of heme oxygenase-1 via PI3K/Akt and Nrf-2 signaling pathways mediates the anti-inflammatory activity of Schisandrin in Porphyromonas gingivalis LPS-stimulated macrophages. |
| PubMed:Inhibitory effect of schisandrin B on free fatty acid-induced steatosis in L-02 cells. |
| PubMed:Different role of Schisandrin B on mercury-induced renal damage in vivo and in vitro. |
| PubMed:Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice. |
| PubMed:Effective kinetics of schisandrin B on serum/hepatic triglyceride and total cholesterol levels in mice with and without the influence of fenofibrate. |
| PubMed:Inhibitory effect of schisandrin on spontaneous contraction of isolated rat colon. |
| PubMed:Combined effects of the proteasome inhibitor bortezomib and Hsp70 inhibitors on the B16F10 melanoma cell line. |
| PubMed:Differential function of protective agents at each stage of the hypothermic preservation of hepatocytes. |
| PubMed:The protective effects of tea polyphenols and schisandrin B on nephrotoxicity of mercury. |
| PubMed:Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts. |
| PubMed:[Dual effects of extract of Schisandra chinensis Baill on rat hepatic CYP3A]. |
| PubMed:(-)Schisandrin B ameliorates paraquat-induced oxidative stress by suppressing glutathione depletion and enhancing glutathione recovery in differentiated PC12 cells. |
| PubMed:Schisandrin enhances dendrite outgrowth and synaptogenesis in primary cultured hippocampal neurons. |
| PubMed:Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in AML12 hepatocytes. |
| PubMed:Compounds from Kadsura angustifolia with anti-HIV activity. |
| PubMed:Protective effect of bicyclol on lipopolysaccharide-induced acute lung injury in mice. |
| PubMed:Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in H9c2 cells. |
| PubMed:A proteomic approach in investigating the hepatoprotective mechanism of Schisandrin B: role of raf kinase inhibitor protein. |
| PubMed:Schisandrin B protects against solar irradiation-induced oxidative stress in rat skin tissue. |
| PubMed:Quantitative analysis of major dibenzocyclooctane lignans in Schisandrae fructus by online TLC-DART-MS. |
| PubMed:Identification of marker compounds in herbal drugs on TLC with DART-MS. |
| PubMed:[Intestinal absorption of the effective components of Schisandra chinensis Baill by rats single-pass perfusion in situ]. |
| PubMed:[Simultaneous determination of five lignans in Schisandra chinensis by HPLC]. |
| PubMed:[Effect of Schisandrin B on mitogen-activated protein kinases and nuclear factor-kappaB in rat lungs exposed to silica]. |
| PubMed:Enhanced oral bioavailability of Wurenchun (Fructus Schisandrae Chinensis extracts) by self-emulsifying drug delivery systems. |
| PubMed:A new 3,4-seco-lupane-type triterpenoid from the pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms. |
| PubMed:Schisandrin B co-treatment ameliorates the impairment on mitochondrial antioxidant status in various tissues of long-term ethanol treated rats. |
| PubMed:Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells. |
| PubMed:Schisandrin B-induced glutathione antioxidant response and cardioprotection are mediated by reactive oxidant species production in rat hearts. |
| PubMed:Evaluation of cytotoxic activity of Schisandra chinensis lignans. |
| PubMed:Inhibitory effects of schisandrin A and schisandrin B on CYP3A activity. |
| PubMed:[Schisandrin B prevents doxorubicin-induced cardiotoxicity in rabbits]. |
| PubMed:[Changes of lignans' content in stems of Schisandra chinensis]. |
| PubMed:[Research on liposoluble ingredients of Quchiling]. |
| PubMed:Dibenzocyclooctadiene lignans from Fructus Schisandrae Chinensis improve glucose uptake in vitro. |
| PubMed:Derivatives of schisandrin with increased inhibitory potential on prostaglandin E(2) and leukotriene B(4) formation in vitro. |
| PubMed:Simultaneous determination of five lignan constituents of Wuzhi capsule in rat plasma by LC-MS/MS: application to pharmacokinetic study. |
| PubMed:A simple and sensitive HPLC method for the simultaneous determination of eight bioactive components and fingerprint analysis of Schisandra sphenanthera. |
| PubMed:Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis. |
| PubMed:Highly sensitive determination of Schisandrin and Schisandrin B in plasma of rats after administration of Wurenchun (Fructus Schisandrae Chinensis Extracts) preparations by LC-ESI-MS/MS. |
| PubMed:Non-thermal extraction of effective ingredients from Schisandra chinensis Baill and the antioxidant activity of its extract. |
| PubMed:[Selection of mobile phases for the determination of gamma-schisandrin and multi-active constituents in Schisandra chinensis and its preparations by high performance liquid chromatography]. |
| PubMed:Schisandrin B stimulates a cytoprotective response in rat liver exposed to mercuric chloride. |
| PubMed:Induction of G1 arrest and apoptosis by schisandrin C isolated from Schizandra chinensis Baill in human leukemia U937 cells. |
| PubMed:Schisandrin B protects rat cortical neurons against Abeta1-42-induced neurotoxicity. |
| PubMed:Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response. |
| PubMed:Effects of schisandrin on transcriptional factors in lipopolysaccharide-pretreated macrophages. |
| PubMed:Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and associated changes in the Ca(2+)-induced mitochondrial permeability transition and mitochondrial membrane potential in AML12 hepatocytes. |
| PubMed:Resolution of two-way chromatographic data of Schisandra chinensis Baill. using a modified slice-scan method for direct determination of the components in overlapping peaks. |
| PubMed:Effect of schisandrin B and sesamin mixture on CCl(4)-induced hepatic oxidative stress in rats. |
| PubMed:Wuweizisu C from Schisandra chinensis decreases membrane potential in C6 glioma cells. |
| PubMed:Optimization of extraction and purification of active fractions from Schisandra chinensis (Turcz.) and its osteoblastic proliferation stimulating activity. |
| PubMed:Nordihydroguaiaretic acid autoxidation produces a schisandrin-like dibenzocyclooctadiene lignan. |
| PubMed:Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill. |
| PubMed:Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats. |
| PubMed:Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and inhibit associated changes in Ca2+-induced mitochondrial permeability transition and mitochondrial membrane potential in H9c2 cardiomyocytes. |
| PubMed:Schisandrin B Enhances Renal Mitochondrial Antioxidant Status, Functional and Structural Integrity, and Protects against Gentamicin-Induced Nephrotoxicity in Rats. |
| PubMed:Simultaneous quantification of four active schisandra lignans from a traditional Chinese medicine Schisandra chinensis(Wuweizi) in rat plasma using liquid chromatography/mass spectrometry. |
| PubMed:Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice. |
| PubMed:Transport of Schisandra chinensis extract and its biologically-active constituents across Caco-2 cell monolayers - an in-vitro model of intestinal transport. |
| PubMed:Long-term schisandrin B treatment mitigates age-related impairments in mitochondrial antioxidant status and functional ability in various tissues, and improves the survival of aging C57BL/6J mice. |
| PubMed:Inhibitory effect of schisandrin B on gastric cancer cells in vitro. |
| PubMed:Schisandrin B prevents doxorubicin-induced cardiotoxicity via enhancing glutathione redox cycling. |
| PubMed:Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against ischemia-reperfusion injury in rat hearts. |
| PubMed:Validation of a method for the simultaneous determination of four schisandra lignans in the raw herb and commercial dried aqueous extracts of Schisandra chinensis (Wu Wei Zi) by RP-LC with DAD. |
| PubMed:Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against carbon tetrachloride toxicity in mouse livers. |
| PubMed:A survey of Chinese herbal ingredients with liver protection activities. |
| PubMed:Development of a quality evaluation method for Fructus schisandrae by pressurized capillary electrochromatography. |
| PubMed:[Study on supercritical carbon dioxide fluid extraction process of lignans from Kadsura heteroclita (Roxb.) Craib]. |
| PubMed:Microwave-assisted extraction and fingerprint studies of Schisandra chinensis (Turcz.) by high performance liquid chromatography and gas chromatography. |
| PubMed:[Gamma-Schisandrin inhibits production of amyloid beta-protein 42 in M146L cells]. |
| PubMed:Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora. |
| PubMed:Dibenzocyclooctadiene lignans: a class of novel inhibitors of multidrug resistance-associated protein 1. |
| PubMed:Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells. |
| PubMed:[Relationship between components changes and efficacy of Shengmaisan VII. Chemical dynamic change of schisandrin in Shengmaisan]. |
| PubMed:Bifendate treatment attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. |
| PubMed:[Deterimination of schisandrin in Kadsura heteroclita (Roxb.) Craib by RP-HPLC]. |
| PubMed:Schisandrin B induced antioxidant response is partly mediated by cytochrome P-4502E1 catalyzed reaction in mouse liver. |
| PubMed:(-)Schisandrin B is more potent than its enantiomer in enhancing cellular glutathione and heat shock protein production as well as protecting against oxidant injury in H9c2 cardiomyocytes. |
| PubMed:Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine. |
| PubMed:Effects of schisandrin B enantiomers on cellular glutathione and menadione toxicity in AML12 hepatocytes. |
| PubMed:Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats. |
| PubMed:A novel experimental model of acute hypertriglyceridemia induced by schisandrin B. |
| PubMed:Schisandrin B: a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1. |
| PubMed:Schisandrin B enhances doxorubicin-induced apoptosis of cancer cells but not normal cells. |
| PubMed:Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. |
| PubMed:Dibenzocyclooctadiene lingnans: a class of novel inhibitors of P-glycoprotein. |
| PubMed:[Effects of schisandrin B on reversing multidrug resistance in human breast cancer cells transfected with mdr1 gene]. |
| PubMed:Structural determinants of schisandrin B which enhance mitochondrial functional ability and glutathione status as well as heat shock protein expression in rat hearts and H9c2 cells. |
| PubMed:Schisandrin B--a novel inhibitor of P-glycoprotein. |
| PubMed:Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver. |
| PubMed:Preparative separation and purification of deoxyschisandrin and gamma-schisandrin from Schisandra chinensis (Turcz.) Baill by high-speed counter-current chromatography. |
| PubMed:[Study on the simultaneous spectrophotometric determination of three components including deoxyschizandrin by ridge regression method]. |
| PubMed:Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats. |
| PubMed:[Determination of lignans of Schisandra medicinal plants by HPLC]. |
| PubMed:Down-modulation of heat shock protein 70 and up-modulation of Caspase-3 during schisandrin B-induced apoptosis in human hepatoma SMMC-7721 cells. |
| PubMed:Determination of specific receptor sites for platelet activating factor in bovine neutrophils. |
| PubMed:Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity. |
| PubMed:[Determination of schisandrin in shengmaiyin by HPLC]. |
| PubMed:Time-dependent enhancement in mitochondrial glutathione status and ATP generation capacity by schisandrin B treatment decreases the susceptibility of rat hearts to ischemia-reperfusion injury. |
| PubMed:Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial glutathione status and induction of heat shock proteins in mice. |
| PubMed:Hepatoprotective mechanism of schisandrin B: role of mitochondrial glutathione antioxidant status and heat shock proteins. |
| PubMed:[Study on supercritical CO2 fluid extraction and separation of components from fruits of Schisandra sphenanthera]. |
| PubMed:Lignans with inhibitory activity against NFAT transcription from Schisandra chinensis. |
| PubMed:In vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin. |
| PubMed:Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation. |
| PubMed:Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain. |
| PubMed:Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice. |
| PubMed:Effects of schisandrin B pretreatment on tumor necrosis factor-alpha induced apoptosis and Hsp70 expression in mouse liver. |
| PubMed:Schisandrin B modulates the ischemia-reperfusion induced changes in non-enzymatic antioxidant levels in isolated-perfused rat hearts. |
| PubMed:Schisandrin B protects against menadione-induced hepatotoxicity by enhancing DT-diaphorase activity. |
| PubMed:Differential effect of schisandrin B and dimethyl diphenyl bicarboxylate (DDB) on hepatic mitochondrial glutathione redox status in carbon tetrachloride intoxicated mice. |
| PubMed:Effect of plant matrix and fluid ethanol concentration on supercritical fluid extraction efficiency of schisandrin derivatives. |
| PubMed:Schisandrin B protects against myocardial ischemia-reperfusion injury by enhancing myocardial glutathione antioxidant status. |
| PubMed:Effectiveness of the analogue of natural Schisandrin C (HpPro) in treatment of liver diseases: an experience in Indonesian patients. |
| PubMed:Methylenedioxy group and cyclooctadiene ring as structural determinants of schisandrin in protecting against myocardial ischemia-reperfusion injury in rats. |
| PubMed:Alterations in susceptibility to carbon tetrachloride toxicity and hepatic antioxidant/detoxification system in streptozotocin-induced short-term diabetic rats: effects of insulin and Schisandrin B treatment. |
| PubMed:Lignans with platelet activating factor antagonist activity from Schisandra chinensis (Turcz.) Baill. |
| PubMed:Anti-AIDS agents--XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues. |
| PubMed:Methylenedioxy group as determinant of schisandrin in enhancing hepatic mitochondrial glutathione in carbon tetrachloride-intoxicated mice. |
| PubMed:Effects of Schisandrin B and alpha-tocopherol on lipid peroxidation, in vitro and in vivo. |
| PubMed:The crucial antioxidant action of schisandrin B in protecting against carbon tetrachloride hepatotoxicity in mice: a comparative study with butylated hydroxytoluene. |
| PubMed:Schisandrin B protects against carbon tetrachloride toxicity by enhancing the mitochondrial glutathione redox status in mouse liver. |
| PubMed:Effect of schisandrin B on hepatic glutathione antioxidant system in mice: protection against carbon tetrachloride toxicity. |
| PubMed:Effect of schisandrin B on lipoperoxidative damage to plasma membrane of rat liver in vitro. |
| PubMed:Bioactivity of neolignans from fructus Schizandrae. |
| PubMed:[Effect of gamma-schisandrin on metabolism of DNA, ATP and nucleoprotein of cancer cells]. |
| PubMed:Studies on the active principles of Schisandra sphenanthera Rehd. et Wils. The structures of schisantherin A, B, C, D, E, and the related compounds. |
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3D/inchi