5-hydroxydecanoic acid, 624-00-0

Articles:

PubMed:Comparison of effects of ATP-gated potassium channel blockers on activity variations of rat CA1 pyramidal neurons in hippocampal slices triggered by short-term hypoxia.

PubMed:Opening of astrocytic mitochondrial ATP-sensitive potassium channels upregulates electrical coupling between hippocampal astrocytes in rat brain slices.

PubMed:Effect of potential-dependent potassium uptake on calcium accumulation in rat brain mitochondria.

PubMed:Biosynthesis and characterization of a new copolymer, poly(3-hydroxyvalerate-co-5-hydroxydecenoate), from Pseudomonas aeruginosa.

PubMed:Pretreatment with xenon protected immature rabbit heart from ischaemia/reperfusion injury by opening of the mitoKATP channel.

PubMed:Postconditioning promotes the cardiac repair through balancing collagen degradation and synthesis after myocardial infarction in rats.

PubMed:K(ATP) channels mediate the antihypertrophic effects afforded by κ-opioid receptor stimulation in neonatal rat ventricular myocytes.

PubMed:Ischemic preconditioning reduces right ventricular infarct size through opening of mitochondrial potassium channels.

PubMed:Ischemic preconditioning of the right ventricle: a new application for an old concept?.

PubMed:Pretreatment with brain natriuretic peptide reduces skeletal muscle mitochondrial dysfunction and oxidative stress after ischemia-reperfusion.

PubMed:Skeletal muscle post-conditioning by diazoxide, anti-oxidative and anti-apoptotic mechanisms.

PubMed:The neuroprotective effect of diazoxide is mediated by mitochondrial ATP-dependent potassium channels in a rat model of acute subdural hematoma.

PubMed:CYP-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels.

PubMed:Acute and chronic cardioprotection by the enkephalin analogue, Eribis peptide 94, is mediated via activation of nitric oxide synthase and adenosine triphosphate-regulated potassium channels.

PubMed:Ischemia reperfusion injury, KATP channels, and exercise-induced cardioprotection against apoptosis.

PubMed:Levosimendan protection against kidney ischemia/reperfusion injuries in anesthetized pigs.

PubMed:Bacterial lipopolysaccharide protects the retina from light-induced damage.

PubMed:Mitochondrial K+ channels are involved in ischemic postconditioning in rat hearts.

PubMed:H(2) mediates cardioprotection via involvements of K(ATP) channels and permeability transition pores of mitochondria in dogs.

PubMed:Is preconditioning by oxytocin administration mediated by iNOS and/or mitochondrial K(ATP) channel activation in the in vivo anesthetized rabbit heart?

PubMed:Thiazolidinedione drugs promote onset, alter characteristics, and increase mortality of ischemic ventricular fibrillation in pigs.

PubMed:High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels.

PubMed:Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction.

PubMed:Protective effect of delayed remote limb ischemic postconditioning: role of mitochondrial K(ATP) channels in a rat model of focal cerebral ischemic reperfusion injury.

PubMed:Hypercholesterolemia abrogates sevoflurane-induced delayed preconditioning against myocardial infarct in rats by alteration of nitric oxide synthase signaling.

PubMed:[The effect of 5-HD on expression of PKC-alpha in rats of chronic hypoxic pulmonary hypertension].

PubMed:Isoflurane decreases death of human embryonic stem cell-derived, transcriptional marker Nkx2.5(+) cardiac progenitor cells.

PubMed:A possible subcellular mechanism underlying the "French paradox": the opening of mitochondrial K(ATP) channels.

PubMed:Factors which determine the duration of follower potentials in longitudinal smooth muscle isolated from the guinea-pig stomach antrum.

PubMed:Mechanisms involved in the desflurane-induced post-conditioning of isolated human right atria from patients with type 2 diabetes.

PubMed:Delayed neuroprotection induced by sevoflurane via opening mitochondrial ATP-sensitive potassium channels and p38 MAPK phosphorylation.

PubMed:Mitochondrial ATP-sensitive potassium channels enhance angiotensin-induced oxidative damage and dopaminergic neuron degeneration. Relevance for aging-associated susceptibility to Parkinson's disease.

PubMed:Modulation of myocardial mitochondrial mechanisms during severe polymicrobial sepsis in the rat.

PubMed:Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels.

PubMed:Diazoxide inhibits aortic endothelial cell apoptosis in diabetic rats via activation of ERK.

PubMed:ATP-dependent potassium channels and mitochondrial permeability transition pores play roles in the cardioprotection of theaflavin in young rat.

PubMed:Mitochondrial KATP channels participate in the limitation of infarct size by cariporide.

PubMed:Diazoxide preconditioning against seizure-induced oxidative injury is via the PI3K/Akt pathway in epileptic rat.

PubMed:Gα(i2)-mediated protection from ischaemic injury is modulated by endogenous RGS proteins in the mouse heart.

PubMed:Effects of preconditioning with sevoflurane on TNF-α-induced permeability and activation of p38 MAPK in rat pulmonary microvascular endothelial cells.

PubMed:Nicorandil preserves myocardial function following brain death in rats by mitochondrial adenosine triphosphate-sensitive potassium channel-dependent mechanism.

PubMed:Synthesis and biological evaluation of 5-membered spiro heterocycle-benzopyran derivatives against myocardial ischemia.

PubMed:Mitochondrial uncoupling agents trigger ventricular fibrillation in isolated rat hearts.

PubMed:Role of PI3K/Akt in diazoxide preconditioning against rat hippocampal neuronal death in pilocarpine-induced seizures.

PubMed:Minocycline attenuates ischemia-induced ventricular arrhythmias in rats.

PubMed:[Hydrogen sulfide inhibits Ca(2+)-induced mitochondrial permeability transition pore opening in adult and old rat heart].

PubMed:Postconditioning in focal cerebral ischemia: role of the mitochondrial ATP-dependent potassium channel.

PubMed:Opioid peptide deltorphin II simulates the cardioprotective effect of ischemic preconditioning: role of δ₂-opioid receptors, protein kinase C, and K(ATP) channels.

PubMed:Noninvasive delayed limb ischemic preconditioning attenuates myocardial ischemia-reperfusion injury in rats by a mitochondrial K(ATP) channel-dependent mechanism.

PubMed:AIF-mediated mitochondrial pathway is critical for the protective effect of diazoxide against SH-SY5Y cell apoptosis.

PubMed:Effect of inhibitors of NADPH oxidase complex and mitochondrial ATP-sensitive potassium channels on generation of dopaminergic neurons from neurospheres of mesencephalic precursors.

PubMed:Dark chocolate receptors: epicatechin-induced cardiac protection is dependent on delta-opioid receptor stimulation.

PubMed:Postconditioning effect of granulocyte colony-stimulating factor is mediated through activation of risk pathway and opening of the mitochondrial KATP channels.

PubMed:Regulation of AMPA receptor currents by mitochondrial ATP-sensitive K+ channels in anoxic turtle neurons.

PubMed:Effects of K openers on the QT prolongation induced by HERG-blocking drugs in guinea-pigs.

PubMed:[Role of protein kinase C in protecting rats against pulmonary ischemia reperfusion injury through opening of mitochondrial ATP sensitive potassium channel].

PubMed:Diazoxide preconditioning alleviates caspase-dependent and caspase-independent apoptosis induced by anoxia-reoxygenation of PC12 cells.

PubMed:Late cardiac preconditioning by exercise in dogs is mediated by mitochondrial potassium channels.

PubMed:Mitochondrial KATP channel inhibition blunts arrhythmia protection in ischemic exercised hearts.

PubMed:Involvement of mitochondrial ATP-sensitive potassium channels in etomidate preconditioning-induced protection in human myeloid HL-60 cells.

PubMed:Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase.

PubMed:Oxytocin protects rat heart against ischemia-reperfusion injury via pathway involving mitochondrial ATP-dependent potassium channel.

PubMed:Antidiabetic drug voglibose is protective against ischemia-reperfusion injury through glucagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway in rabbits.

PubMed:The Anrep effect requires transactivation of the epidermal growth factor receptor.

PubMed:KATP channel blocker does not abolish the protective effect of Na+/H+ exchange 1 inhibition against ischaemia/reperfusion in aged myocardium.

PubMed:The phosphatidylinositol-3 kinase/Akt pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats.

PubMed:Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts.

PubMed:Transplantation of mesenchymal stem cells preconditioned with diazoxide, a mitochondrial ATP-sensitive potassium channel opener, promotes repair of myocardial infarction in rats.

PubMed:Mitochondria as a source of mechanical signals in cardiomyocytes.

PubMed:Sildenafil citrate augments myocardial protection in heart transplantation.

PubMed:Inhibition of oxygen consumption in skeletal muscle-derived mitochondria by pinacidil, diazoxide, and glibenclamide, but not by 5-hydroxydecanoate.

PubMed:Stimulation of neuronal KATP channels by cGMP-dependent protein kinase: involvement of ROS and 5-hydroxydecanoate-sensitive factors in signal transduction.

PubMed:Parstatin(1-26): the putative signal peptide of protease-activated receptor 1 confers potent protection from myocardial ischemia-reperfusion injury.

PubMed:Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels.

PubMed:5-Hydroxydecanoate and coenzyme A are inhibitors of native sarcolemmal KATP channels in inside-out patches.

PubMed:Intracisternal administration of glibenclamide or 5-hydroxydecanoate does not reverse the neuroprotective effect of ketogenic diet against ischemic brain injury-induced neurodegeneration.

PubMed:The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion.

PubMed:Single channel studies of the ATP-regulated potassium channel in brain mitochondria.

PubMed:[The role of sarcolemmal and mitochondrial K(ATP)-channels in realization of the cardioprotection and antiarrhythmic effect of different regimens of hypobaric adaptation].

PubMed:Variable effects of the mitoK(ATP) channel modulators diazoxide and 5-HD in ATP-depleted renal epithelial cells.

PubMed:Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel.

PubMed:Effects of mitochondrial potassium channel and membrane potential on hypoxic human pulmonary artery smooth muscle cells.

PubMed:Pharmacological preconditioning in type 2 diabetic rat hearts: the roles of mitochondrial ATP-sensitive potassium channels and the phosphatidylinositol 3-kinase-Akt pathway.

PubMed:Impact of modulators of mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) on hypoxic pulmonary vasoconstriction.

PubMed:Involvement of P2Y receptors in pyridoxal-5'-phosphate-induced cardiac preconditioning.

PubMed:Long-acting phosphodiesterase-5 inhibitor, tadalafil, induces sustained cardioprotection against lethal ischemic injury.

PubMed:Role of mitochondrial ATP-sensitive potassium channels on fatigue in mouse muscle fibers.

PubMed:Preconditioning with diazoxide prevents reoxygenation-induced rigor-type hypercontracture.

PubMed:The mitochondrial ATP-sensitive potassium channel blocker 5-hydroxydecanoate inhibits toxicity of 6-hydroxydopamine on dopaminergic neurons.

PubMed:The ceiling effect of pharmacological postconditioning with the phytoestrogen genistein is reversed by the GSK3beta inhibitor SB 216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione] through mitochondrial ATP-dependent potassium channel opening.

PubMed:Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction.

PubMed:Activation of peripheral delta2 opioid receptors increases cardiac tolerance to ischemia/reperfusion injury Involvement of protein kinase C, NO-synthase, KATP channels and the autonomic nervous system.

PubMed:The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels.

PubMed:Hyperthermia-induced cardioprotection is potentiated by ischemic postconditioning in rats.

PubMed:[Cardioprotective effects of flokalin: relative role of activation of sarcolemmal and mitochondrial adenosine triphosphate-dependent potassium channels].

PubMed:Early anesthetic preconditioning in mixed cortical neuronal-glial cell cultures subjected to oxygen-glucose deprivation: the role of adenosine triphosphate dependent potassium channels and reactive oxygen species in sevoflurane-induced neuroprotection.

PubMed:Phosphodiesterase 5 inhibitors prevent 3,4-methylenedioxymethamphetamine-induced 5-HT deficits in the rat.

PubMed:Nicorandil attenuates FeCl(3)-induced thrombus formation through the inhibition of reactive oxygen species production.

PubMed:Effect of several flavonoid-containing plant preparations on activity of mitochondrial ATP-dependent potassium channel.

PubMed:The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning.

PubMed:Spirocyclic benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel.

PubMed:Peroxynitrite decreases arrhythmias induced by ischaemia reperfusion in anaesthetized dogs, without involving mitochondrial KATP channels.

PubMed:Oral glyburide, but not glimepiride, blocks the infarct-size limiting effects of pioglitazone.

PubMed:Involvement of mitoKATP channel in protective mechanisms of cerebral ischemic tolerance.

PubMed:Iptakalim protects against MPP+-induced degeneration of dopaminergic neurons in association with astrocyte activation.

PubMed:Pre-conditioning induced by carbon monoxide provides neuronal protection against apoptosis.

PubMed:Exogenous zinc protects cardiac cells from reperfusion injury by targeting mitochondrial permeability transition pore through inactivation of glycogen synthase kinase-3beta.

PubMed:Anti-apoptotic and anti-inflammatory effects of hydrogen sulfide in a rat model of regional myocardial I/R.

PubMed:The positive inotropic effect of endothelin-1 is mediated by mitochondrial reactive oxygen species.

PubMed:Delayed anti-arrhythmic effect of nitroglycerin in anesthetized rats: involvement of CGRP, PKC and mK ATP channels.

PubMed:Postconditioning with isoflurane reduced ischemia-induced brain injury in rats.

PubMed:Exogenous hydrogen sulfide postconditioning protects isolated rat hearts against ischemia-reperfusion injury.

PubMed:Adenosine A1 receptor activation mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortical neurons.

PubMed:KR-31762, a novel KATP channel opener, exerts cardioprotective effects by opening SarcKATP channels in rat models of ischemia/reperfusion-induced heart injury.

PubMed:KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions.

PubMed:Design and synthesis of nitrate esters of aromatic heterocyclic compounds as pharmacological preconditioning agents.

PubMed:The antiarrhythmic effect of centrally administered rilmenidine involves muscarinic receptors, protein kinase C and mitochondrial signalling pathways.

PubMed:Effect of diazoxide on flavoprotein oxidation and reactive oxygen species generation during ischemia-reperfusion: a study on Langendorff-perfused rat hearts using optic fibers.

PubMed:Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP- and MPTP-dependent mechanism at reperfusion.

PubMed:Protection against ischemia-induced ventricular arrhythmias and myocardial dysfunction conferred by preconditioning in the rat heart: involvement of mitochondrial K(ATP) channels and reactive oxygen species.

PubMed:Anesthesia's effects on plasma glucose and insulin and cardiac hexokinase at similar hemodynamics and without major surgical stress in fed rats.

PubMed:Preconditioning by isoflurane retains its protection against ischemia-reperfusion injury in postinfarct remodeled rat hearts.

PubMed:Sevoflurane enhances ethanol-induced cardiac preconditioning through modulation of protein kinase C, mitochondrial KATP channels, and nitric oxide synthase, in guinea pig hearts.

PubMed:Morphine postconditioning protects against reperfusion injury in the isolated rat hearts.

PubMed:Mitochondrial ATP-sensitive K+ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle.

PubMed:Noradrenaline reduces ischemia-induced arrhythmia in anesthetized rats: involvement of alpha1-adrenoceptors and mitochondrial K ATP channels.

PubMed:[Effect of postconditioning on rat hearts suffered from long-term hypothermic preservation].

PubMed:Inhibiting protease-activated receptor 4 limits myocardial ischemia/reperfusion injury in rat hearts by unmasking adenosine signaling.

PubMed:Effective pharmacotherapy against oxidative injury: alternative utility of an ATP-sensitive potassium channel opener.

PubMed:Hyperoxia confers myocardial protection in mechanically ventilated rats through the generation of free radicals and opening of mitochondrial ATP-sensitive potassium channels.

PubMed:Essential role of mitochondrial Ca2+-activated and ATP-sensitive K+ channels in sildenafil-induced late cardioprotection.

PubMed:Minoxidil prevents 3,4-methylenedioxymethamphetamine-induced serotonin depletions: role of mitochondrial ATP-sensitive potassium channels, Akt and ERK.

PubMed:epsilonPKC phosphorylates the mitochondrial K(+) (ATP) channel during induction of ischemic preconditioning in the rat hippocampus.

PubMed:Ischemic preconditioning of the whole heart confers protection on subsequently isolated ventricular myocytes.

PubMed:Inhibition of pacemaker currents by nitric oxide via activation of ATP-sensitive K+ channels in cultured interstitial cells of Cajal from the mouse small intestine.

PubMed:Na+/H+ exchanger inhibitor cariporide attenuates the mitochondrial Ca2+ overload and PTP opening.

PubMed:Sevoflurane-induced cardioprotection depends on PKC-alpha activation via production of reactive oxygen species.

PubMed:Selective cardiac plasma-membrane K(ATP) channel inhibition is defibrillatory and improves survival during acute myocardial ischemia and reperfusion.

PubMed:Pravastatin reduces myocardial infarct size via increasing protein kinase C-dependent nitric oxide, decreasing oxyradicals and opening the mitochondrial adenosine triphosphate-sensitive potassium channels in rabbits.

PubMed:5-Hydroxydecanoate inhibits proliferation of hypoxic human pulmonary artery smooth muscle cells by blocking mitochondrial K(ATP) channels.

PubMed:Adenosine and TNF-alpha exert similar inotropic effect on heart cultures, suggesting a cardioprotective mechanism against hypoxia.

PubMed:Interactions of K+ATP channel blockers with Na+/K+-ATPase.

PubMed:Systemic administration of diazoxide induces delayed preconditioning against transient focal cerebral ischemia in rats.

PubMed:Anesthetic preconditioning confers acute cardioprotection via up-regulation of manganese superoxide dismutase and preservation of mitochondrial respiratory enzyme activity.

PubMed:Ex-vivo effect of roxithromycin on human and rat arterial vasoactivity.

PubMed:KATP channel openers facilitate glutamate uptake by GluTs in rat primary cultured astrocytes.

PubMed:Mitochondria are targets for geranylgeranylacetone-induced cardioprotection against ischemia-reperfusion in the rat heart.

PubMed:Activation of alpha1B-adrenoceptors alleviates ischemia/reperfusion injury by limitation of mitochondrial Ca2+ overload in cardiomyocytes.

PubMed:The effects of isosteviol against myocardium injury induced by ischaemia-reperfusion in the isolated guinea pig heart.

PubMed:Modulation of the permeability transition pore by inhibition of the mitochondrial K(ATP) channel in liver vs. brain mitochondria.

PubMed:Cardioprotective effects of stretch are mediated by activation of sarcolemmal, not mitochondrial, ATP-sensitive potassium channels.

PubMed:Intermittent activation of bradykinin B2 receptors and mitochondrial KATP channels trigger cardiac postconditioning through redox signaling.

PubMed:The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis.

PubMed:Celiprolol, a selective beta1-blocker, reduces the infarct size through production of nitric oxide in a rabbit model of myocardial infarction.

PubMed:Chronic preconditioning: a novel approach for cardiac protection.

PubMed:Diazoxide-induced respiratory inhibition - a putative mitochondrial K(ATP) channel independent mechanism of pharmacological preconditioning.

PubMed:Nicorandil improves post-ischemic myocardial dysfunction in association with opening the mitochondrial K(ATP) channels and decreasing hydroxyl radicals in isolated rat hearts.

PubMed:Modulation of 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells by K(ATP) channel block.

PubMed:[Role of gap junction in ischemic preconditioning].

PubMed:The cardioprotective effect of isosteviol on rats with heart ischemia-reperfusion injury.

PubMed:MitoK(ATP)-dependent changes in mitochondrial volume and in complex II activity during ischemic and pharmacological preconditioning of Langendorff-perfused rat heart.

PubMed:Distinct KATP channels mediate the antihypertrophic effects of adenosine receptor activation in neonatal rat ventricular myocytes.

PubMed:Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistance.

PubMed:Effects of postconditioning of adenosine and acetylcholine on the ischemic isolated rat ventricular myocytes.

PubMed:Acute administration of vitamin E triggers preconditioning via K(ATP) channels and cyclic-GMP without inhibiting lipid peroxidation.

PubMed:Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation.

PubMed:Preconditioning modulates pulmonary endothelial dysfunction following ischemia-reperfusion injury in the rat lung: role of potassium channels.

PubMed:Role of oxidative/nitrosative stress in the tolerance to ischemia/reperfusion injury in cardiomyopathic hamster heart.

PubMed:The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat.

PubMed:Pathological circumstances impair the ability of "dark" neurons to undergo spontaneous recovery.

PubMed:Blocking cardiac ATP-sensitive K+ channels reduces hydroxyl radicals caused by potassium chloride-induced depolarization in the rat myocardium.

PubMed:The mechanism of sevoflurane-induced cardioprotection is independent of the applied ischaemic stimulus in rat trabeculae.

PubMed:Diazoxide-induced cardioprotection via DeltaPsim loss depending on timing of application.

PubMed:Distinct roles for sarcolemmal and mitochondrial adenosine triphosphate-sensitive potassium channels in isoflurane-induced protection against oxidative stress.

PubMed:Opening mitoKATP increases superoxide generation from complex I of the electron transport chain.

PubMed:[Protective effect of sevoflurane preconditioning on oxygen-glucose deprivation injury in rat hippocampal slices: the role of mitochondrial K(ATP) channels].

PubMed:Diazoxide protects against methylmalonate-induced neuronal toxicity.

PubMed:K+-independent actions of diazoxide question the role of inner membrane KATP channels in mitochondrial cytoprotective signaling.

PubMed:Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning.

PubMed:Mitochondrial potassium ATP channels and retinal ischemic preconditioning.

PubMed:Different effects of optical isomers of the 5-HT1A receptor antagonist pyrapyridolol against postischemic guinea-pig myocardial dysfunction and apoptosis through the mitochondrial permeability transition pore.

PubMed:The role of ATP sensitive K+ channels and of nitric oxide synthase on myocardial ischemia/reperfusion-induced apoptosis.

PubMed:Isoflurane produces sustained cardiac protection after ischemia-reperfusion injury in mice.

PubMed:Reduction of myocardial infarct size by tetrahydrobiopterin: possible involvement of mitochondrial KATP channels activation through nitric oxide production.

PubMed:Effects of the blockade of cardiac sarcolemmal ATP-sensitive potassium channels on arrhythmias and coronary flow in ischemia-reperfusion model in isolated rat hearts.

PubMed:[Effect of adenosine triphosphate-sensitve potassium channel activator flokalin on the isolated heart functions].

PubMed:Brief antecedent anoxia preserves mitochondrial function after sustained undersupply: a subcellular correlate to ischemic preconditioning?

PubMed:Inhibition of cardiac contractility by 5-hydroxydecanoate and tetraphenylphosphonium ion: a possible role of mitoKATP in response to inotropic stress.

PubMed:Atractyloside and 5-hydroxydecanoate block the protective effect of puerarin in isolated rat heart.

PubMed:Myocardial ischemia tolerance in the newborn rat involving opioid receptors and mitochondrial K+ channels.

PubMed:Early pharmacological preconditioning by erythropoietin mediated by inducible NOS and mitochondrial ATP-dependent potassium channels in the rat heart.

PubMed:Effects of 5-hydroxydecanoate and ischemic preconditioning on the ischemic-reperfused heart of fed and fasted rats.

PubMed:Isoflurane and sevoflurane during reperfusion prevent recovery from ischaemia in mitochondrial KATP channel blocker pretreated hearts.

PubMed:Protective effect of KR-31378 on oxidative stress in cardiac myocytes.

PubMed:Hyperkalemic cardioplegia-induced myocyte swelling and contractile dysfunction: prevention by diazoxide.

PubMed:Characterization of human cardiac mitochondrial ATP-sensitive potassium channel and its regulation by phorbol ester in vitro.

PubMed:Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels.

PubMed:Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes.

PubMed:Nicorandil inhibits serum starvation-induced apoptosis in vascular endothelial cells.

PubMed:Pharmacological preconditioning with bradykinin affords myocardial protection through NO-dependent mechanisms.

PubMed:A role of opening of mitochondrial ATP-sensitive potassium channels in the infarct size-limiting effect of ischemic preconditioning via activation of protein kinase C in the canine heart.

PubMed:The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells.

PubMed:Cardioprotection afforded by chronic exercise is mediated by the sarcolemmal, and not the mitochondrial, isoform of the KATP channel in the rat.

PubMed:Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes.

PubMed:Reduction of infarct size with D-myo-inositol trisphosphate: role of PI3-kinase and mitochondrial K(ATP) channels.

PubMed:The direct physiological effects of mitoK(ATP) opening on heart mitochondria.

PubMed:Initiation of remote microvascular preconditioning requires K(ATP) channel activity.

PubMed:Overexpression of heat-shock protein 20 in rat heart myogenic cells confers protection against simulated ischemia/reperfusion injury.

PubMed:MitoKATP-channel opener protects against neuronal death in rat venous ischemia.

PubMed:Isoflurane preconditioning protects motor neurons from spinal cord ischemia: its dose-response effects and activation of mitochondrial adenosine triphosphate-dependent potassium channel.

PubMed:Lack of manifestations of diazoxide/5-hydroxydecanoate-sensitive KATP channel in rat brain nonsynaptosomal mitochondria.

PubMed:Sevoflurane preconditioning limits intracellular/mitochondrial Ca2+ in ischemic newborn myocardium.

PubMed:2-(1-Hexyn-1-yl)adenosine-induced intraocular hypertension is mediated via K+ channel opening through adenosine A2A receptor in rabbits.

PubMed:Effects of ATP-sensitive potassium channel activators diazoxide and BMS-191095 on membrane potential and reactive oxygen species production in isolated piglet mitochondria.

PubMed:Is the sarcolemmal or mitochondrial K(ATP) channel activation important in the antiarrhythmic and cardioprotective effects during acute ischemia/reperfusion in the intact anesthetized rabbit model?

PubMed:Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats.

PubMed:Acute intermittent hypoxia improves rat myocardium tolerance to ischemia.

PubMed:Short-term caloric restriction improves ischemic tolerance independent of opening of ATP-sensitive K+ channels in both young and aged hearts.

PubMed:Reactive oxygen species mediate the neuroprotection conferred by a mitochondrial ATP-sensitive potassium channel opener during ischemia in the rat hippocampal slice.

PubMed:Properties of BK(Ca) channels in oral keratinocytes.

PubMed:Role of NAD(P)H oxidase- and mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II.

PubMed:Annexin-1 peptide Anx-1(2-26) protects adult rat cardiac myocytes from cellular injury induced by simulated ischaemia.

PubMed:Minoxidil, a K(ATP) channel opener, accelerates DNA synthesis following partial hepatectomy in rats.

PubMed:Involvement of uracil nucleotides in protection of cardiomyocytes from hypoxic stress.

PubMed:Endogenous calcitonin gene-related peptide protects human alveolar epithelial cells through protein kinase Cepsilon and heat shock protein.

PubMed:Somatostatin analogue mimics acute ischemic preconditioning in a rat model of myocardial infarction.

PubMed:Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets.

PubMed:Mitochondria-derived reactive oxygen species and vascular MAP kinases: comparison of angiotensin II and diazoxide.

PubMed:Mitochondrial K(ATP) channels in respiratory neurons and their role in the hypoxic facilitation of rhythmic activity.

PubMed:Endothelin-1 exerts a preconditioning-like cardioprotective effect against ischaemia/reperfusion injury via the ET(A) receptor and the mitochondrial K(ATP) channel in the rat in vivo.

PubMed:Warm ischemic preconditioning improves mitochondrial redox balance during and after mild hypothermic ischemia in guinea pig isolated hearts.

PubMed:Mitochondrial Ca2+-activated K+ channels in cardiac myocytes: a mechanism of the cardioprotective effect and modulation by protein kinase A.

PubMed:KR-31378, a novel benzopyran analog, attenuates hypoxia-induced cell death via mitochondrial KATP channel and protein kinase C-epsilon in heart-derived H9c2 cells.

PubMed:Cytochrome P450 omega-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal KATP channel.

PubMed:Sarcolemmal KATP channel triggers delayed ischemic preconditioning in rats.

PubMed:mitoKATP channel activation in the postanoxic developing heart protects E-C coupling via NO-, ROS-, and PKC-dependent pathways.

PubMed:Inhibition of phenylephrine induced hypertrophy in rat neonatal cardiomyocytes by the mitochondrial KATP channel opener diazoxide.

PubMed:5-Hydroxydecanoate is metabolised in mitochondria and creates a rate-limiting bottleneck for beta-oxidation of fatty acids.

PubMed:Remote preconditioning reduces ischemic injury in the explanted heart by a KATP channel-dependent mechanism.

PubMed:Mechanisms of cardioprotective effects of magnesium on hypoxia-reoxygenation-induced injury.

PubMed:Quinine inhibits mitochondrial ATP-regulated potassium channel from bovine heart.

PubMed:Calcium-activated potassium channel triggers cardioprotection of ischemic preconditioning.

PubMed:[The effect of K(ATP)-channel activation on the electrical stability of myocardium in rats with postinfarction cardiosclerosis].

PubMed:Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways.

PubMed:Sevoflurane-induced preconditioning of rat brain in vitro and the role of KATP channels.

PubMed:Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding protein (CREB) and NFkappaB.

PubMed:Protein kinase C-epsilon primes the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to modulation by isoflurane.

PubMed:Donor heart preservation with pinacidil: the role of the mitochondrial K ATP channel.

PubMed:Adenosine A(1) receptor antagonist and mitochondrial ATP-sensitive potassium channel blocker attenuate the tolerance to focal cerebral ischemia in rats.

PubMed:Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channels.

PubMed:Effect of classic preconditioning and diazoxide on endothelial function and O2- and NO generation in the post-ischemic guinea-pig heart.

PubMed:Diazoxide preconditioning protects against neuronal cell death by attenuation of oxidative stress upon glutamate stimulation.

PubMed:The human mitochondrial KATP channel is modulated by calcium and nitric oxide: a patch-clamp approach.

PubMed:Desflurane-induced preconditioning alters calcium-induced mitochondrial permeability transition.

PubMed:Reactive oxygen species precede protein kinase C-delta activation independent of adenosine triphosphate-sensitive mitochondrial channel opening in sevoflurane-induced cardioprotection.

PubMed:Sevoflurane depolarizes pre-synaptic mitochondria in the central nervous system.

PubMed:Sublethal simulated ischemia promotes delayed resistance against ischemia via ATP-sensitive (K+) channels in murine myocytes: role of PKC and iNOS.

PubMed:[The role of opiate receptors and ATP-dependent potassium channels of mitochondria in the formation of myocardial adaptive resistance to the arrhythmogenic effect of ischemia and reperfusion].

PubMed:Protective effects of the potassium channel opener-diazoxide against injury in neonatal rat ventricular myocytes.

PubMed:Delayed preconditioning of the human myocardium: signal transduction and clinical implications.

PubMed:Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels.

PubMed:Cardiomyocyte mitochondrial KATP channels participate in the antiarrhythmic and antiinfarct effects of KATP activators during ischemia and reperfusion in an intact anesthetized rabbit model.

PubMed:Activation of mitochondrial ATP-sensitive potassium channels delays ischemia-induced cellular uncoupling in rat heart.

PubMed:Nicorandil attenuates the mitochondrial Ca2+ overload with accompanying depolarization of the mitochondrial membrane in the heart.

PubMed:Effects of barium and 5-hydroxydecanoate on the electrophysiologic response to acute regional ischemia and reperfusion in rat hearts.

PubMed:Diazoxide induces delayed pre-conditioning in cultured rat cortical neurons.

PubMed:Nicorandil prevents oxidative stress-induced apoptosis in neurons by activating mitochondrial ATP-sensitive potassium channels.

PubMed:Fructose-fed rats are protected against ischemia/reperfusion injury.

PubMed:Roles of KATP channels in delayed cardioprotection and intracellular Ca(2+) in the rat heart as revealed by kappa-opioid receptor stimulation with U50488H.

PubMed:Protection of myocardium by cyclosporin A and insulin: in vitro simulated ischemia study in human myocardium.

PubMed:Both metabolic inhibition and mitochondrial K(ATP) channel opening are myoprotective and initiate a compensatory sarcolemmal outward membrane current.

PubMed:Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury.

PubMed:P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.

PubMed:Selective ATP-sensitive potassium channel openers: fact or fiction.

PubMed:Sevoflurane confers additional cardioprotection after ischemic late preconditioning in rabbits.

PubMed:Involvement of mitochondrial K+ release and cellular efflux in ischemic and apoptotic neuronal death.

PubMed:Lidocaine attenuates cytokine-induced cell injury in endothelial and vascular smooth muscle cells.

PubMed:ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia/reperfusion injury.

PubMed:Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule.

PubMed:Diazoxide pretreatment induces delayed preconditioning in astrocytes against oxygen glucose deprivation and hydrogen peroxide-induced toxicity.

PubMed:Ischaemic preconditioning and a mitochondrial KATP channel opener both produce cardioprotection accompanied by F1F0-ATPase inhibition in early ischaemia.

PubMed:Mechanisms of sevoflurane-induced myocardial preconditioning in isolated human right atria in vitro.

PubMed:Early biochemical and histological alterations in rat corticoencephalic cell cultures following metabolic damage and treatment with modulators of mitochondrial ATP-sensitive potassium channels.

PubMed:Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects.

PubMed:Activation of peripheral delta opioid receptors eliminates cardiac electrical instability in a rat model of post-infarction cardiosclerosis via mitochondrial ATP-dependent K+ channels.

PubMed:K-ATP channel independent effects of pinacidil on ATP production in isolated cardiomyocyte or pancreatic beta-cell mitochondria.

PubMed:Quinaprilat reduces myocardial infarct size involving nitric oxide production and mitochondrial KATP channel in rabbits.

PubMed:Cardioselective anti-ischemic ATP-sensitive potassium channel (KATP) openers: benzopyranyl indoline and indole analogues.

PubMed:Mitochondrial ATP-sensitive potassium channel: a novel site for neuroprotection.

PubMed:Mitochondrial K ATP channel activation is important in the antiarrhythmic and cardioprotective effects of non-hypotensive doses of nicorandil and cromakalim during ischemia/reperfusion: a study in an intact anesthetized rabbit model.

PubMed:Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion.

PubMed:Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression.

PubMed:Oral nicorandil recaptures the waned protection from preconditioning in vivo.

PubMed:Targeting nucleotide-requiring enzymes: implications for diazoxide-induced cardioprotection.

PubMed:Opening of mitochondrial ATP-sensitive potassium channels is a trigger of 3-nitropropionic acid-induced tolerance to transient focal cerebral ischemia in rats.

PubMed:Antiangiogenic effect of KR-31372 by apoptosis via mediation of mitochondrial KATP channel opening and the phosphatase and tensin homolog deleted from chromosome 10 phosphorylation.

PubMed:Morphine enhances pharmacological preconditioning by isoflurane: role of mitochondrial K(ATP) channels and opioid receptors.

PubMed:Activation of mitochondrial ATP-sensitive potassium channels increases cell viability against rotenone-induced cell death.

PubMed:Modulation of slow waves by hyperpolarization with potassium channel openers in antral smooth muscle of the guinea-pig stomach.

PubMed:Mechanisms of delayed preconditioning with A1 adenosine receptor activation in porcine coronary smooth muscle cells.

PubMed:Effective protection by NHE-1 inhibition in ischemic and reperfused heart under preconditioning blockade.

PubMed:Beta-oxidation of 5-hydroxydecanoate, a putative blocker of mitochondrial ATP-sensitive potassium channels.

PubMed:Preconditioning with sevoflurane reduces changes in nicotinamide adenine dinucleotide during ischemia-reperfusion in isolated hearts: reversal by 5-hydroxydecanoic acid.

PubMed:Mitochondrial K(ATP) channels and sarcoplasmic reticulum influence cardiac force development under anoxia in the Amazonian armored catfish Liposarcus pardalis.

PubMed:Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels.

PubMed:Mitochondrial KATP channel-dependent and -independent phases of ischemic preconditioning against myocardial infarction in the rat.

PubMed:The effects of ischaemic preconditioning, diazoxide and 5-hydroxydecanoate on rat heart mitochondrial volume and respiration.

PubMed:Anesthetic preconditioning attenuates mitochondrial Ca2+ overload during ischemia in Guinea pig intact hearts: reversal by 5-hydroxydecanoic acid.

PubMed:The role of mitochondrial K(ATP) channels in antiarrhythmic effects of ischaemic preconditioning in dogs.

PubMed:The role of mitochondrial K(ATP) channels in the antiarrhythmic effects of ischaemic preconditioning in dogs.

PubMed:Infarct size limitation by nicorandil: roles of mitochondrial K(ATP) channels, sarcolemmal K(ATP) channels, and protein kinase C.

PubMed:The role of serotonin in ischemic cellular damage and the infarct size-reducing effect of sarpogrelate, a 5-hydroxytryptamine-2 receptor blocker, in rabbit hearts.

PubMed:Ischemic preconditioning in chronically hypoxic neonatal rat heart.

PubMed:Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia.

PubMed:Cardioprotection by multiple preconditioning cycles does not require mitochondrial K(ATP) channels in pigs.

PubMed:Ischemic preconditioning changes the pattern of coronary reactive hyperemia regardless of mitochondrial ATP-sensitive K(+) channel blockade.

PubMed:Sheng-Mai-San is protective against post-ischemic myocardial dysfunction in rats through its opening of the mitochondrial KATP channels.

PubMed:The relative order of mK(ATP) channels, free radicals and p38 MAPK in preconditioning's protective pathway in rat heart.

PubMed:Ischemic preconditioning protection against stunning in conscious diabetic sheep: role of glucose, insulin, sarcolemmal and mitochondrial KATP channels.

PubMed:Intestinal ischemia preconditions myocardium: role of protein kinase C and mitochondrial K(ATP) channel.

PubMed:Effects of mitochondrial K(ATP) modulators on cardioprotection induced by chronic high altitude hypoxia in rats.

PubMed:Exercise induces early and late myocardial preconditioning in dogs.

PubMed:Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNFalpha gene.

PubMed:Acetylcholine leads to free radical production dependent on K(ATP) channels, G(i) proteins, phosphatidylinositol 3-kinase and tyrosine kinase.

PubMed:Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?

PubMed:K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart.

PubMed:Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats.

PubMed:Diazoxide protects the rabbit heart following cardioplegic ischemia.

PubMed:Opening of mitochondrial K(ATP) channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioning.

PubMed:Delayed cardioprotection by isoflurane: role of K(ATP) channels.

PubMed:A1 adenosine receptor overexpression decreases stunning from anoxia-reoxygenation: role of the mitochondrial K(ATP) channel.

PubMed:Diazoxide opens the mitochondrial permeability transition pore and alters Ca2+ transients in rat ventricular myocytes.

PubMed:Cardiac preconditioning with 4-h, 17 degrees C ischemia reduces [Ca(2+)](i) load and damage in part via K(ATP) channel opening.

PubMed:Opening of mitochondrial ATP-sensitive potassium channels evokes oxygen radical generation in rabbit heart slices.

PubMed:Mitochondrial ATP-sensitive K+ channels influence force development and anoxic contractility in a flatfish, yellowtail flounder Limanda ferruginea, but not Atlantic cod Gadus morhua heart.

PubMed:Spontaneous electrical activity and associated changes in calcium concentration in guinea-pig gastric smooth muscle.

PubMed:The role of mitochondrial and sarcolemmal K(ATP) channels in canine ethanol-induced preconditioning in vivo.

PubMed:Differential effects of sarcolemmal and mitochondrial K(ATP) channels activated by 17 beta-estradiol on reperfusion arrhythmias and infarct sizes in canine hearts.

PubMed:H(2)O(2) opens mitochondrial K(ATP) channels and inhibits GABA receptors via protein kinase C-epsilon in cardiomyocytes.

PubMed:Preconditioning blocks cardiocyte apoptosis: role of K(ATP) channels and PKC-epsilon.

PubMed:Selective mitochondrial K(ATP) channel activation results in antiarrhythmic effect during experimental myocardial ischemia/reperfusion in anesthetized rabbits.

PubMed:Protection of cardiac mitochondria by diazoxide and protein kinase C: implications for ischemic preconditioning.

PubMed:Role of sarcolemmal K(ATP) channels in cardioprotection against ischemia/reperfusion injury in mice.

PubMed:Delayed preconditioning induced by lipoteichoic acid from B. subtilis and S. aureus is not blocked by administration of 5-hydroxydecanoate.

PubMed:Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation.

PubMed:Anesthetic effects on mitochondrial ATP-sensitive K channel.

PubMed:Characteristics and superoxide-induced activation of reconstituted myocardial mitochondrial ATP-sensitive potassium channels.

PubMed:Distinct myoprotective roles of cardiac sarcolemmal and mitochondrial KATP channels during metabolic inhibition and recovery.

PubMed:Dual signaling via protein kinase C and phosphatidylinositol 3'-kinase/Akt contributes to bradykinin B2 receptor-induced cardioprotection in guinea pig hearts.

PubMed:Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide.

PubMed:Acute alcohol-induced protection against infarction in rabbit hearts: differences from and similarities to ischemic preconditioning.

PubMed:Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection.

PubMed:Opening of mitochondrial K(ATP) channels attenuates the ouabain-induced calcium overload in mitochondria.

PubMed:B16-BL6 melanoma cells release inhibitory factor(s) of active pump activity in isolated lymph vessels.

PubMed:Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits.

PubMed:Ischemic and pharmacological preconditioning in Girardi cells and C2C12 myotubes induce mitochondrial uncoupling.

PubMed:Critical timing of mitochondrial K(ATP) channel opening for enhancement of myocardial tolerance against infarction.

PubMed:Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes.

PubMed:The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes.

PubMed:Mitochondrial K(ATP) channel opening protects a human atrial-derived cell line by a mechanism involving free radical generation.

PubMed:Mitochondrial K(ATP) channel activation reduces anoxic injury by restoring mitochondrial membrane potential.

PubMed:Combination of miglitol, an anti-diabetic drug, and nicorandil markedly reduces myocardial infarct size through opening the mitochondrial K(ATP) channels in rabbits.

PubMed:Acetylcholine, bradykinin, opioids, and phenylephrine, but not adenosine, trigger preconditioning by generating free radicals and opening mitochondrial K(ATP) channels.

PubMed:Signal transduction of opioid-induced cardioprotection in ischemia-reperfusion.

PubMed:Carvedilol in heart mitochondria: protonophore or opener of the mitochondrial K(ATP) channels?

PubMed:Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain.

PubMed:Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells.

PubMed:Additive protective effects of late and early ischaemic preconditioning are mediated by the opening of KATP channels in vivo.

PubMed:Activation of the adenosine triphosphate sensitive mitochondrial potassium channel is involved in the cardioprotective effect of isoflurane.

PubMed:Role of intracellular Na(+) kinetics in preconditioned rat heart.

PubMed:Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity.

PubMed:Sarcolemmal and mitochondrial K(atp)channels mediate cardioprotection in chronically hypoxic hearts.

PubMed:Late preconditioning in rat retina: involvement of adenosine and ATP-sensitive K(+) channel.

PubMed:Opening of mitochondrial K(ATP) channels triggers cardioprotection. Are reactive oxygen species involved?

PubMed:Sevoflurane protects stunned myocardium through activation of mitochondrial ATP-sensitive potassium channels.

PubMed:Chemical preconditioning with 3-nitropropionic acid in hearts: role of mitochondrial K(ATP) channel.

PubMed:Preconditioning limits mitochondrial Ca(2+) during ischemia in rat hearts: role of K(ATP) channels.

PubMed:Mitochondrial K(ATP)channel opening during index ischemia and following myocardial reperfusion in ischemic rat hearts.

PubMed:A(1) or A(3) adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms.

PubMed:Mitochondrial ATP dependent potassium channels mediate non-ischemic preconditioning by tachycardia in dogs.

PubMed:Morphine mimics preconditioning via free radical signals and mitochondrial K(ATP) channels in myocytes.

PubMed:Potassium channel openers depolarize hippocampal mitochondria.

PubMed:Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels.

PubMed:Adenosine A1 receptor activation reduces reactive oxygen species and attenuates stunning in ventricular myocytes.

PubMed:Protection of cardiac myocytes via delta(1)-opioid receptors, protein kinase C, and mitochondrial K(ATP) channels.

PubMed:Role of mitochondrial and sarcolemmal K(ATP) channels in ischemic preconditioning of the canine heart.

PubMed:Dual roles of mitochondrial K(ATP) channels in diazoxide-mediated protection in isolated rabbit hearts.

PubMed:Direct activation of mitochondrial K(ATP) channels mimics preconditioning but protein kinase C activation is less effective in middle-aged rat hearts.

PubMed:Infarct size limitation by bradykinin receptor activation is mediated by the mitochondrial but not by the sarcolemmal K(ATP) channel.

PubMed:Differential role of sarcolemmal and mitochondrial K(ATP) channels in adenosine-enhanced ischemic preconditioning.

PubMed:Effect of combined K(ATP) channel activation and Na(+)/H(+) exchange inhibition on infarct size in rabbits.

PubMed:Increased mitochondrial K(ATP) channel activity during chronic myocardial hypoxia: is cardioprotection mediated by improved bioenergetics?

PubMed:Mechanisms whereby glucose deprivation triggers metabolic preconditioning in the isolated rat heart.

PubMed:Differential role of K(ATP) channels in late preconditioning against myocardial stunning and infarction in rabbits.

PubMed:Chronic ethanol-induced myocardial protection requires activation of mitochondrial K(ATP) channels.

PubMed:Cardioprotective effects of nicorandil in rabbits anaesthetized with halothane: potentiation of ischaemic preconditioning via KATP channels.

PubMed:Cardioprotection by K(ATP) channels in wild-type hearts and hearts overexpressing A(1)-adenosine receptors.

PubMed:The role of mitochondrial KATP channels in cardioprotection.

PubMed:Do mitochondrial K(ATP) channels serve as triggers rather than end-effectors of ischemic preconditioning's protection?

PubMed:Preconditioning reduces myocardial complement gene expression in vivo.

PubMed:Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals.

PubMed:Prevention of isoflurane-induced preconditioning by 5-hydroxydecanoate and gadolinium: possible involvement of mitochondrial adenosine triphosphate-sensitive potassium and stretch-activated channels.

PubMed:Adenosine primes the opening of mitochondrial ATP-sensitive potassium channels: a key step in ischemic preconditioning?

PubMed:Role and mechanism of PKC in ischemic preconditioning of pig skeletal muscle against infarction.

PubMed:Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels.

PubMed:Delayed cardioprotection in a human cardiomyocyte-derived cell line: the role of adenosine, p38MAP kinase and mitochondrial KATP.

PubMed:5-HD abolishes ischemic preconditioning independently of monophasic action potential duration in the heart.

PubMed:Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection.

PubMed:JTV-519, a novel cardioprotective agent, improves the contractile recovery after ischaemia-reperfusion in coronary perfused guinea-pig ventricular muscles.

PubMed:Cardioprotective effects of 17 beta-estradiol produced by activation ofmitochondrial ATP-sensitive K(+)Channels in canine hearts.

PubMed:Block of cardiac ATP-sensitive K(+) channels reduces hydroxyl radicals in the rat myocardium.

PubMed:Sarcolemmal and mitochondrial adenosine triphosphate- dependent potassium channels: mechanism of desflurane-induced cardioprotection.

PubMed:Evidence for mitochondrial K ATP channels as effectors of human myocardial preconditioning.

PubMed:Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion.

PubMed:Cardioprotective effect of diadenosine tetraphosphate (AP4A) preservation in hypothermic storage and its relation with mitochondrial ATP-sensitive potassium channels.

PubMed:Ischemic preconditioning in rats: role of mitochondrial K(ATP) channel in preservation of mitochondrial function.

PubMed:Role of reactive oxygen species in acetylcholine-induced preconditioning in cardiomyocytes.

PubMed:S-T segment voltage during sequential coronary occlusions is an unreliable marker of preconditioning.

PubMed:Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide.

PubMed:Activation of mitochondrial K(ATP) channel elicits late preconditioning against myocardial infarction via protein kinase C signaling pathway.

PubMed:Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs.

PubMed:Structural characterization of substrates for the anion exchange transporter in Caco-2 cells.

PubMed:Modulation of norepinephrine release by ATP-dependent K(+)-channel activators and inhibitors in guinea-pig and human isolated right atrium.

PubMed:Role of an ATP-sensitive potassium channel opener, YM934, in mitochondrial energy production in ischemic/reperfused heart.

PubMed:ATP-sensitive K+ channel openers prevent Ca2+ overload in rat cardiac mitochondria.

PubMed:Mitochondrial ATP-dependent potassium channels. Viable candidate effectors of ischemic preconditioning.

PubMed:Additive effects of late preconditioning produced by monophosphoryl lipid A and the early preconditioning mediated by adenosine receptors and KATP channel.

PubMed:Direct preconditioning of cardiac myocytes via opioid receptors and KATP channels.

PubMed:Pharmacological and histochemical distinctions between molecularly defined sarcolemmal KATP channels and native cardiac mitochondrial KATP channels.

PubMed:ATP-sensitive K+ channels mediate the delayed cardioprotective effect of adenosine A1 receptor activation.

PubMed:The effects of low-flow ischemia on K+ fluxes in isolated rat hearts assessed by 87Rb NMR.

PubMed:Opioid-induced second window of cardioprotection: potential role of mitochondrial KATP channels.

PubMed:Ischemic preconditioning depends on interaction between mitochondrial KATP channels and actin cytoskeleton.

PubMed:Normothermic transfer times up to 3 min will not precondition the isolated rat heart.

PubMed:Reduction of myocardial injury by the EP3 receptor agonist TEI-3356. Role of protein kinase C and of K(ATP)-channels.

PubMed:Preconditioning in immature rabbit hearts: role of KATP channels.

PubMed:Relevance of inter- and intraventricular electrical dispersion to arrhythmogenesis in normal and ischaemic rabbit myocardium: a study with cromakalim, 5-hydroxydecanoate and glibenclamide.

PubMed:Selective activation of adenosine A3 receptors with N6-(3-chlorobenzyl)-5'-N-methylcarboxamidoadenosine (CB-MECA) provides cardioprotection via KATP channel activation.

PubMed:Suppression of reperfusion arrhythmias by preconditioning is inhibited by an ATP-sensitive potassium channel blocker, 5-hydroxydecanoate, but not by protein kinase C blockers in the rat.

PubMed:Protein kinase C-dependent activation of KATP channel enhances adenosine-induced cardioprotection.

PubMed:Pharmacologic preconditioning with monophosphoryl lipid A is abolished by 5-hydroxydecanoate, a specific inhibitor of the K(ATP) channel.

PubMed:Changes in ventricular repolarization during acidosis and low-flow ischemia.

PubMed:Monophosphoryl lipid A attenuates myocardial stunning in dogs: role of ATP-sensitive potassium channels.

PubMed:Modulation of mitochondrial ATP-dependent K+ channels by protein kinase C.

PubMed:5-hydroxydecanoate selectively reduces the initial increase in extracellular K+ in ischemic guinea-pig heart.

PubMed:Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection?

PubMed:State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate.

PubMed:Characterization of K(ATP) channels in intact mammalian skeletal muscle fibres.

PubMed:ATP-sensitive potassium channel mediates delayed ischemic protection by heat stress in rabbit heart.

PubMed:Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection.

PubMed:Effector mechanism of adenosine in acute ischemic preconditioning of skeletal muscle against infarction.

PubMed:Protein kinase C-mediated preconditioning of cardiac myocytes: role of adenosine receptor and KATP channel.

PubMed:Effects of cromakalim and glibenclamide on myocardial high energy phosphates and intracellular pH during ischemia-reperfusion: 31P NMR studies.

PubMed:The ischemia-selective KATP channel antagonist, 5-hydroxydecanoate, blocks ischemic preconditioning in the rat heart.

PubMed:Direct preconditioning of cardiac ventricular myocytes via adenosine A1 receptor and KATP channel.

PubMed:Endothelin-1 can reduce infarct size through protein kinase C and KATP channels in the isolated rat heart.

PubMed:Different responses of epicardium and endocardium to KATP channel modulators during regional ischemia.

PubMed:5-hydroxydecanoate fails to attenuate ventricular fibrillation in a conscious canine model of sudden cardiac death.

PubMed:Limitation of myocardial infarct size in the rabbit by ischaemic preconditioning is abolished by sodium 5-hydroxydecanoate.

PubMed:Glyburide-reversible cardioprotective effects of calcium-independent phospholipase A2 inhibition in ischemic rat hearts.

PubMed:Endothelin-1-induced reduction of myocardial infarct size by activation of ATP-sensitive potassium channels in a rabbit model of myocardial ischaemia and reperfusion.

PubMed:Reduction by prostaglandin E1 or prostaglandin E0 of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels.

PubMed:The KATP blocker sodium 5-hydroxydecanoate does not abolish preconditioning in isolated rat hearts.

PubMed:Cardioprotective profile of the cardiac-selective ATP-sensitive potassium channel opener BMS-180448.

PubMed:Blockade of ATP-sensitive potassium channels by 5-hydroxydecanoate suppresses monophasic action potential shortening during regional myocardial ischemia.

PubMed:Antifibrillatory effects of clofilium in the rabbit isolated heart.

PubMed:A comparison of adenosine-induced cardioprotection and ischemic preconditioning in dogs. Efficacy, time course, and role of KATP channels.

PubMed:The ATP-dependent potassium channel: an endogenous cardioprotective mechanism.

PubMed:Effects of 5-hydroxydecanoate on ATP-regulated potassium ion channels in insulin secreting cells.

PubMed:Blockade of ischaemic preconditioning in dogs by the novel ATP dependent potassium channel antagonist sodium 5-hydroxydecanoate.

PubMed:5-Hydroxydecanoate inhibits ATP-sensitive K+ channel currents in guinea-pig single ventricular myocytes.

PubMed:Blockade of the ATP-sensitive K+ channel by 5-hydroxydecanoate in guinea pig ventricular myocytes.

PubMed:A cAMP-dependent protein kinase inhibitor modulates the blocking action of ATP and 5-hydroxydecanoate on the ATP-sensitive K+ channel.

PubMed:Specific block of the anti-ischemic actions of cromakalim by sodium 5-hydroxydecanoate.

PubMed:Pharmacologic profile of cromakalim in the treatment of myocardial ischemia in isolated rat hearts and anesthetized dogs.

PubMed:Reduction of ischemic damage in isolated rat hearts by the potassium channel opener, RP 52891.

PubMed:[Study of mechanism and effect of sodium 5-hydroxydecanoate on experimental ischemic ventricular arrhythmia].

PubMed:THE REDUCTION OF 5-OXODECANOIC ACID BY NORMAL BAKER'S YEAST.

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