4-hydroxyhexenal, 17427-08-6

Articles:

PubMed:Correction: Paricalcitol Attenuates 4-Hydroxy-2-Hexenal-Induced Inflammation and Epithelial-Mesenchymal Transition in Human Renal Proximal Tubular Epithelial Cells.

PubMed:Re-assessing the mechanism of action of n-3 PUFAs.

PubMed:4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation.

PubMed:Dietary strategy to repair plasma membrane after brain trauma: implications for plasticity and cognition.

PubMed:Exercise facilitates the action of dietary DHA on functional recovery after brain trauma.

PubMed:Lipoxidation adducts with peptides and proteins: deleterious modifications or signaling mechanisms?

PubMed:4-hydroxyhexenal- and 4-hydroxynonenal-modified proteins in pterygia.

PubMed:High-fat diet induces changes in adipose tissue trans-4-oxo-2-nonenal and trans-4-hydroxy-2-nonenal levels in a depot-specific manner.

PubMed:Paricalcitol attenuates 4-hydroxy-2-hexenal-induced inflammation and epithelial-mesenchymal transition in human renal proximal tubular epithelial cells.

PubMed:The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis.

PubMed:Dietary carnosine prevents early atherosclerotic lesion formation in apolipoprotein E-null mice.

PubMed:Mutagenic/recombinogenic effects of four lipid peroxidation products in Drosophila.

PubMed:Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells.

PubMed:A comparative 'bottom up' proteomics strategy for the site-specific identification and quantification of protein modifications by electrophilic lipids.

PubMed:4-Hydroxyhexenal (HHE) impairs glutamate transport in astrocyte cultures.

PubMed:Oxidised fish oil does not influence established markers of oxidative stress in healthy human subjects: a randomised controlled trial.

PubMed:Increasing intake of long-chain n-3 PUFA enhances lipoperoxidation and modulates hepatic gene expression in a dose-dependent manner.

PubMed:Immunohistochemical detection of polyunsaturated fatty acid oxidation markers in acetaminophen-induced liver injury in rats.

PubMed:Aldehyde stress and up-regulation of Nrf2-mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n-3 polyunsaturated fatty acids.

PubMed:Cholesterol secosterol aldehydes induce amyloidogenesis and dysfunction of wild-type tumor protein p53.

PubMed:4-Hydroxy-2-hexenal-induced apoptosis in human renal proximal tubular epithelial cells.

PubMed:Genotoxic analysis of four lipid-peroxidation products in the mouse lymphoma assay.

PubMed:Site-specific proteomic analysis of lipoxidation adducts in cardiac mitochondria reveals chemical diversity of 2-alkenal adduction.

PubMed:Structural and functional changes in human insulin induced by the lipid peroxidation byproducts 4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal.

PubMed:Effect of reactive oxygen and carbonyl species on crucial cellular antioxidant enzymes.

PubMed:Evidence supporting a role for N-(3-formyl-3,4-dehydropiperidino)lysine accumulation in Müller glia dysfunction and death in diabetic retinopathy.

PubMed:Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression.

PubMed:Fate in digestion in vitro of several food components, including some toxic compounds coming from omega-3 and omega-6 lipids.

PubMed:Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells.

PubMed:Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallin.

PubMed:Properties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10).

PubMed:Quantitative structure-activity relationship for 4-hydroxy-2-alkenal induced cytotoxicity in L6 muscle cells.

PubMed:Trans-4-hydroxy-2-hexenal, a product of n-3 fatty acid peroxidation: make some room HNE...

PubMed:Ethanol withdrawal increases glutathione adducts of 4-hydroxy-2-hexenal but not 4-hydroxyl-2-nonenal in the rat cerebral cortex.

PubMed:Effects of Lipid Peroxidation-Derived Products on the Growth of Human Colorectal Cancer Cell Line HT-29.

PubMed:Transgenic expression of proximal tubule peroxisome proliferator-activated receptor-alpha in mice confers protection during acute kidney injury.

PubMed:High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration.

PubMed:Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions.

PubMed:Oxidation products of polyunsaturated fatty acids in infant formulas compared to human milk--a preliminary study.

PubMed:The effects of NaCl on lipid peroxidation-derived aldehyde, 4-hydroxy-2-hexenal formation in boiled yellowtail meat.

PubMed:Immunohistochemical analysis of aldehyde-modified proteins in drusen in cynomolgus monkeys (Macaca fascicularis).

PubMed:Increased susceptibility to oxidant-mediated tissue injury and peritoneal fibrosis in acatalasemic mice.

PubMed:Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress.

PubMed:Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6; n-3) acid oxidation.

PubMed:Aberrant expression of selenoproteins in the progression of colorectal cancer.

PubMed:4-hydroxy-2-alkenals in polyunsaturated fatty acids-fortified infant formulas and other commercial food products.

PubMed:Formaldehyde-protein conjugate-specific antibodies in rats exposed to formaldehyde.

PubMed:Protective effect of TEMPOL derivatives against light-induced retinal damage in rats.

PubMed:Design, synthesis, and application of a hydrazide-functionalized isotope-coded affinity tag for the quantification of oxylipid-protein conjugates.

PubMed:Effects of NaCl on 4-hydroxy-2-hexenal formation in yellowtail meat stored at 0 degrees C.

PubMed:Hydroxy-alkenals from the peroxidation of n-3 and n-6 fatty acids and urinary metabolites.

PubMed:Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice.

PubMed:Effect of bleeding on hemoglobin contents and lipid oxidation in the skipjack muscle.

PubMed:Expression of oxidative stress-related molecules in circulating leukocytes and urine in patients with chronic viral hepatitis.

PubMed:Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina.

PubMed:Estimation of daily exposure to 4-hydroxy-2-alkenals in Korean foods containing n-3 and n-6 polyunsaturated fatty acids.

PubMed:Telmisartan inhibits both oxidative stress and renal fibrosis after unilateral ureteral obstruction in acatalasemic mice.

PubMed:In situ detection of oxidized n-3 polyunsaturated fatty acids in chronic hepatitis C: correlation with hepatic steatosis.

PubMed:Degradation of glyceraldehyde-3-phosphate dehydrogenase triggered by 4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal.

PubMed:Toxicity and detoxification of lipid-derived aldehydes in cultured retinal pigmented epithelial cells.

PubMed:Reduced effect on apoptosis of 4-hydroxyhexenal and oxidized LDL enriched with n-3 fatty acids from postmenopausal women.

PubMed:Comparison between exhaled and sputum oxidative stress biomarkers in chronic airway inflammation.

PubMed:Accumulation of protein-bound 4-hydroxy-2-hexenal in spinal cords from patients with sporadic amyotrophic lateral sclerosis.

PubMed:Induction of endothelial iNOS by 4-hydroxyhexenal through NF-kappaB activation.

PubMed:NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway.

PubMed:Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney.

PubMed:Induction of endothelial apoptosis by 4-hydroxyhexenal.

PubMed:Specific markers of lipid peroxidation issued from n-3 and n-6 fatty acids.

PubMed:Protein-bound 4-hydroxy-2-hexenal as a marker of oxidized n-3 polyunsaturated fatty acids.

PubMed:Acatalasemia sensitizes renal tubular epithelial cells to apoptosis and exacerbates renal fibrosis after unilateral ureteral obstruction.

PubMed:Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A).

PubMed:Determination of patterns of biologically relevant aldehydes in exhaled breath condensate of healthy subjects by liquid chromatography/atmospheric chemical ionization tandem mass spectrometry.

PubMed:Covalent binding of hydroxy-alkenals 4-HDDE, 4-HHE, and 4-HNE to ethanolamine phospholipid subclasses.

PubMed:The NADPH:quinone oxidoreductase P1-zeta-crystallin in Arabidopsis catalyzes the alpha,beta-hydrogenation of 2-alkenals: detoxication of the lipid peroxide-derived reactive aldehydes.

PubMed:Cellular lipid peroxidation end-products induce apoptosis in human lens epithelial cells.

PubMed:N-acetylserotonin suppresses hepatic microsomal membrane rigidity associated with lipid peroxidation.

PubMed:Enrichment of eggs with n-3 polyunsaturated fatty acids: effects of vitamin E supplementation.

PubMed:Involvement of lipid peroxidation in spontaneous pancreatitis in WBN/Kob rats.

PubMed:Involvement of caspases in 4-hydroxy-alkenal-induced apoptosis in human leukemic cells.

PubMed:Formation of 4-hydroxy-2-alkenals in barley leaves.

PubMed:Lipid peroxidation and the oxidative burst associated with infection of capsicum annuum by botrytis cinerea

PubMed:Tandem mass spectrometry of model peptides modified with trans-2-hexenal, a product of lipid peroxidation.

PubMed:Formation of lipoxygenase-pathway-derived aldehydes in barley leaves upon methyl jasmonate treatment.

PubMed:Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase.

PubMed:Facile and general method for preparation of (E)-4-hydroxy-2-alkenals.

PubMed:Cellular response to the redox active lipid peroxidation products: induction of glutathione S-transferase P by 4-hydroxy-2-nonenal.

PubMed:Oxygenation of (3Z)-alkenal to (2E)-4-hydroxy-2-alkenal in soybean seed (Glycine max L.).

PubMed:Monoclonal antibodies for detection of 4-hydroxynonenal modified proteins.

PubMed:Cytotoxic and chemotactic potencies of several aldehydic components of oxidised low density lipoprotein for human monocyte-macrophages.

PubMed:4-Hydroxyhexenal is a potent inducer of the mitochondrial permeability transition.

PubMed:Hydroxyalkenal formation induced by advanced glycosylation of low density lipoprotein.

PubMed:Inhibition of adenine nucleotide translocator by lipid peroxidation products.

PubMed:Generation, characterization, and histochemical application of monoclonal antibodies selectively recognizing oxidatively modified apoB-containing serum lipoproteins.

PubMed:The monoclonal antibody specific for the 4-hydroxy-2-nonenal histidine adduct.

PubMed:Quantitative measurement of 4-hydroxyalkenals in oxidized low-density lipoprotein by gas chromatography-mass spectrometry.

PubMed:Genotoxic properties of 4-hydroxyalkenals and analogous aldehydes.

PubMed:4-Hydroxynonenal, a metabolite of lipid peroxidation, activates phospholipase D in vascular endothelial cells.

PubMed:Oxygenation of (3Z)-nonenal to (2E)-4-hydroxy-2-nonenal in the broad bean (Vicia faba L.).

PubMed:Analysis of mercapturic acid conjugates of xenobiotic compounds using negative ionization and tandem mass spectrometry.

PubMed:Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.

PubMed:Effect of 4-hydroxylalkenals on hepatic phosphatidylinositol-4,5-bisphosphate-phospholipase C.

PubMed:4-Hydroxyhexenal: a lipid peroxidation product derived from oxidized docosahexaenoic acid.

PubMed:Detection of new epitopes formed upon oxidation of low-density lipoprotein, lipoprotein (a) and very-low-density lipoprotein. Use of an antiserum against 4-hydroxynonenal-modified low-density lipoprotein.

PubMed:Effects of the pyrrolizidine alkaloid senecionine and the alkenals trans-4-OH-hexenal and trans-2-hexenal on intracellular calcium compartmentation in isolated hepatocytes.

PubMed:Lipid peroxidation and cellular damage caused by the pyrrolizidine alkaloid senecionine, the alkenal trans-4-hydroxy-2-hexenal, and related alkenals.

PubMed:Distribution of trans-4-hydroxy-2-hexenal and tandem mass spectrometric detection of its urinary mercapturic acid in the rat.

PubMed:Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes.

PubMed:In vitro effects of trans-4-hydroxy-2-alkenals on mouse liver cytochrome P-450.

PubMed:Role of cellular calcium homeostasis in toxic liver injury induced by the pyrrolizidine alkaloid senecionine and the alkenal trans-4-OH-2-hexenal.

PubMed:2,3,7,8-Tetrachlorodibenzo-p-dioxin causes elevation of the levels of the protein tyrosine kinase pp60c-src.

PubMed:Formation of cyclic adducts of deoxyguanosine with the aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro.

PubMed:Cytotoxicity, DNA fragmentation and sister-chromatid exchange in Chinese hamster ovary cells exposed to the lipid peroxidation product 4-hydroxynonenal and homologous aldehydes.

PubMed:Metabolism of the pyrrolizidine alkaloid metabolite trans-4-hydroxy-2-hexenal by mouse liver aldehyde dehydrogenases.

PubMed:In vivo covalent binding of trans-4-hydroxy-2-hexenal to rat liver macromolecules.

PubMed:trans-4-Hydroxy-2-hexenal: a reactive metabolite from the macrocyclic pyrrolizidine alkaloid senecionine.

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