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Category:antioxidants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 98.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 551.00 to 552.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 574.00 °F. TCC ( 301.30 °C. ) (est)
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| logP (o/w): | 3.155 (est) |
| Soluble in: |
| | water, 32.69 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Bisdemethoxycurcumin 98%
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| BOC Sciences |
| For experimental / research use only. |
| Bisdemethoxycurcumin >98%
Odor: characteristic Use: Bisdemethoxycurcumin is one of the three major forms of curcuminoids found in the rhizomes of turmeric. Bisdemethoxycurcumin displays antioxidant, anti-inflammatory as well as chemotherapeutic activity. |
| Coompo |
| For experimental / research use only. |
| Bisdemethoxycurcumin from Plants ≥98%
Odor: characteristic Use: Antiedemic, anti-inflammatory agent. Bile stimulant showing hepatoprotective props. Possesses bactericidal and fungicidal props. Antitumour agent functioning through apoptosis. Nutriceutical. Shows antioxidant activity.
Bisdemethoxycurcumin (BDMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. BDMC shares similar anti-inflammatory properties with demethoxycurcumin. It inhibits LPS-induced nitric oxide (NO) production and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. BDMC also displays unique properties in that it enhances Abeta clearance by upregulating expression MGAT3 and TLR genes. BDMC potently inhibits AKR1B10. |
| Nacalai USA |
| For experimental / research use only. |
| Curcumin 3
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| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Bisdemethoxycurcumin ≥98% (HPLC), solid
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Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | antioxidants |
| Recommendation for (E)-curcumin III usage levels up to: | | | not for fragrance use.
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| Recommendation for (E)-curcumin III flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (E)- | curcumin III | | 1,6- | heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (1E,6E)- | | 1,6- | heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (E,E)- | | (1E,6E)-1,7-bis-(4- | hydroxy-phenyl)-hepta-1,6-diene-3,5-dione | | bis(p- | hydroxycinnamoyl)methane | | bis(para- | hydroxycinnamoyl)methane | | (E,E)-1,7-bis(4- | hydroxyphenyl)-1,6-heptadiene-3,5-dione | | (1E,6E)-1,7-bis(4- | hydroxyphenyl)hepta-1,6-diene-3,5-dione |
Articles:
| PubMed:Quick supramolecular solvent-based microextraction for quantification of low curcuminoid content in food. |
| PubMed:Concurrent inhibition of enzymatic activity and NF-Y-mediated transcription of Topoisomerase-IIα by bis-DemethoxyCurcumin in cancer cells. |
| PubMed:Bioactivity of turmeric-derived curcuminoids and related metabolites in breast cancer. |
| PubMed:Curcumin: from chemistry to chemistry-based functions. |
| PubMed:Antioxidant properties of Mannich bases. |
| PubMed:Production of Curcuminoids in different in vitro organs of Curcuma longa. |
| PubMed:Design, synthesis and biological activity of new polyenolic inhibitors of matrix metalloproteinases: a focus on chemically-modified curcumins. |
| PubMed:Evaluation of naturally occurring curcuminoids and related compounds against mosquito larvae. |
| PubMed:Studies on curcumin and curcuminoids. XLVI. Photophysical properties of dimethoxycurcumin and bis-dehydroxycurcumin. |
| PubMed:Phytochemical and cytotoxic investigations of Curcuma mangga rhizomes. |
| PubMed:Dimethoxycurcumin, a structural analogue of curcumin, induces apoptosis in human renal carcinoma caki cells through the production of reactive oxygen species, the release of cytochrome C, and the activation of caspase-3. |
| PubMed:Development of binding assays to screen ligands for Plasmodium falciparum thioredoxin and glutathione reductases by ultrafiltration and liquid chromatography/mass spectrometry. |
| PubMed:Curcumin derivatives: molecular basis of their anti-cancer activity. |
| PubMed:New synthetic glucosyl-curcuminoids, and their (1)H and (13)C NMR characterization, from Curcuma longa L. |
| PubMed:Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. |
| PubMed:HPLC-photodiode array detection analysis of curcuminoids in Curcuma species indigenous to Indonesia. |
| PubMed:Comparative effects of curcuminoids on endothelial heme oxygenase-1 expression: ortho-methoxy groups are essential to enhance heme oxygenase activity and protection. |
| PubMed:Modulation of the function of the multidrug resistance-linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin. |
| PubMed:Comparison of Anti-inflammatory Activities of Six Curcuma Rhizomes: A Possible Curcuminoid-independent Pathway Mediated by Curcuma phaeocaulis Extract. |
| PubMed:Microemulsion electrokinetic chromatography for separation and analysis of curcuminoids in turmeric samples. |
| PubMed:Metabolism of curcuminoids in tissue slices and subcellular fractions from rat liver. |
| PubMed:Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. |
| PubMed:Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder. |
| PubMed:Quantitative determination of curcuminoids in Curcuma rhizomes and rapid differentiation of Curcuma domestica Val. and Curcuma xanthorrhiza Roxb. by capillary electrophoresis. |
| PubMed:Protection of pancreatic beta-cell by the potential antioxidant bis-o-hydroxycinnamoyl methane, analogue of natural curcuminoid in experimental diabetes. |
| PubMed:In vitro peroxynitrite scavenging activity of diarylheptanoids from Curcuma longa. |
| PubMed:Studies on the role of some synthetic curcuminoid derivatives in the inhibition of tumour specific angiogenesis. |
| PubMed:Syntheses of Curcumin Bioconjugates and Study of Their Antibacterial Activities against beta-Lactamase-Producing Microorganisms. |
| PubMed:Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. |
| PubMed:Effects of turmeric on the activities of benzo(a)pyrene-induced cytochrome P-450 isozymes. |
| PubMed:Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa. |
| PubMed:A simple and efficient separation of the curcumins, the antiprotozoal constituents of Curcuma longa. |
| PubMed:Novel bioactivities of Curcuma longa constituents. |
| PubMed:Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids. |
| PubMed:Anti-tumour and antioxidant activity of natural curcuminoids. |
| PubMed:[Terpenoids and curcuminoids of the rhizoma of Curcuma xanthorrhiza Roxb]. |
| PubMed:Curcumin as an inhibitor of cancer. |
| PubMed:Curcumins as inhibitors of nitrosation in vitro. |
| PubMed:Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit morphine's rewarding effect in rats. |
| PubMed:Curcumin. |
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3D/inchi