demethoxycurcumin
(1E,6E)-1-(4-hydroxy-3-methoxy-phenyl)-7-(4-hydroxy-phenyl)-hepta-1,6-diene-3,5-dione
 
Notes:
Isol. from the rhizomes of Curcuma longa (turmeric)
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(1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione (Click)
CAS Number: 22608-11-3Picture of molecule
FDA UNII: W2F8059T80
Nikkaji Web: J468.369B
MDL: MFCD03427310
XlogP3: 3.30 (est)
Molecular Weight: 338.35946000
Formula: C20 H18 O5
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antioxidants
 
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 571.42 °C. @ 760.00 mm Hg (est)
Flash Point: 402.00 °F. TCC ( 205.50 °C. ) (est)
logP (o/w): 3.113 (est)
Soluble in:
 water, 30.6 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
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Suppliers:
Coompo
For experimental / research use only.
Demethoxycurcumin from Plants ≥98%
Odor: characteristic
Use: Different analogs of curcumin present in turmeric exhibit variable anti-inflammatory and anti-proliferative activities, which do not correlate with their ability to modulate the ROS status. Antioxidant capacities of the extracts, as ascorbic acid equivalent (Ámol/g) were in the order: curcumin > demethoxycurcumin > bisdemethoxycurcumin. In comparison with butylated hydroxyl toluene (BHT), at 100 ppm, the antioxidant activity, by linoleic acid peroxidation, was found to be highest with curcumin, followed by demethoxycurcumin and bisdemethoxycurcumin.
Santa Cruz Biotechnology
For experimental / research use only.
Demethoxycurcumin
Sigma-Aldrich: Sigma
For experimental / research use only.
Demethoxycurcumin ≥98% (HPLC)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antioxidants
Recommendation for demethoxycurcumin usage levels up to:
 not for fragrance use.
 
Recommendation for demethoxycurcumin flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Env. Mutagen Info. Center: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 5469424
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
Chemidplus: 0022608113
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References:
 (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 5469424
Pubchem (sid): 135104208
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
HMDB (The Human Metabolome Database): HMDB39610
FooDB: FDB019237
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 turmeric rhizome
Search Trop  Picture
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Synonyms:
 curcumin II
 desmethoxycurcumin
1,6-heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-, (1E,6E)-
(1E,6E)-1-(4-hydroxy-3-methoxy-phenyl)-7-(4-hydroxy-phenyl)-hepta-1,6-diene-3,5-dione
(1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1E,6E-heptadiene-3,5-dione
(1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-hepta-1,6-diene-3,5-dione
(1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
(1E,6E)-1-(4-hydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
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Articles:
PubMed: Inhibitory Effect of Turmeric Curcuminoids on FLT3 Expression and Cell Cycle Arrest in the FLT3-Overexpressing EoL-1 Leukemic Cell Line.
PubMed: Demethoxycurcumin from Curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model.
PubMed: Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer's disease Drosophila models.
PubMed: A high-throughput quantification method of curcuminoids and curcumin metabolites in human plasma via high-performance liquid chromatography/tandem mass spectrometry.
PubMed: Comparative absorption of curcumin formulations.
PubMed: Determination of antiplasmodial activity and binding affinity of curcumin and demethoxycurcumin towards PfTrxR.
PubMed: Analysis of the anticancer activity of curcuminoids, thiotryptophan and 4-phenoxyphenol derivatives.
PubMed: Quick supramolecular solvent-based microextraction for quantification of low curcuminoid content in food.
PubMed: Optimization and validation of high-performance liquid chromatography method for individual curcuminoids in turmeric by heat-refluxed extraction.
PubMed: Inhibition of anthrax lethal factor by curcumin and chemically modified curcumin derivatives.
PubMed: Curcuminoid metabolism and its contribution to the pharmacological effects.
PubMed: Concurrent inhibition of enzymatic activity and NF-Y-mediated transcription of Topoisomerase-II╬▒ by bis-DemethoxyCurcumin in cancer cells.
PubMed: Therapeutic potential of turmeric in Alzheimer's disease: curcumin or curcuminoids?
PubMed: The binding of Curcuma longa extract with bovine serum albumin monitored via time-resolved fluorescence.
PubMed: A comparative study of PNIPAM nanoparticles of curcumin, demethoxycurcumin, and bisdemethoxycurcumin and their effects on oxidative stress markers in experimental stroke.
PubMed: Demethoxycurcumin inhibits energy metabolic and oncogenic signaling pathways through AMPK activation in triple-negative breast cancer cells.
PubMed: Preparation of monodisperse curcumin-imprinted polymer by precipitation polymerization and its application for the extraction of curcuminoids from Curcuma longa L.
PubMed: Quantification of curcumin, demethoxycurcumin, and bisdemethoxycurcumin in rodent brain by UHPLC/ESI-Q-TOF-MS/MS after intra-nasal administration of curcuminoids loaded PNIPAM nanoparticles.
PubMed: Simultaneous determination of three Curcuminoids in Curcuma wenyujin Y.H.chen et C.Ling. by liquid chromatography-tandem mass spectrometry combined with pressurized liquid extraction.
PubMed: Simultaneous screening of four epidermal growth factor receptor antagonists from Curcuma longa via cell membrane chromatography online coupled with HPLC-MS.
PubMed: Demethoxycurcumin, a major active curcuminoid from Curcuma longa, suppresses balloon injury induced vascular smooth muscle cell migration and neointima formation: an in vitro and in vivo study.
PubMed: Preparation and oral bioavailability study of curcuminoid-loaded microemulsion.
PubMed: Bioactivity of turmeric-derived curcuminoids and related metabolites in breast cancer.
PubMed: Curcuminoids distinctly exhibit antioxidant activities and regulate expression of scavenger receptors and heme oxygenase-1.
PubMed: Development of a validated UPLC-qTOF-MS Method for the determination of curcuminoids and their pharmacokinetic study in mice.
PubMed: A novel approach to active compounds identification based on support vector regression model and mean impact value.
PubMed: Effects of curcumin and demethoxycurcumin on amyloid-╬▓ precursor and tau proteins through the internal ribosome entry sites: a potential therapeutic for Alzheimer's disease.
PubMed: Curcuminoids and resveratrol as anti-Alzheimer agents.
PubMed: Molecular docking studies on inhibition of Stat3 dimerization by curcumin natural derivatives and its conjugates with amino acids.
PubMed: Correlation between Chemical Composition of Curcuma domestica and Curcuma xanthorrhiza and Their Antioxidant Effect on Human Low-Density Lipoprotein Oxidation.
PubMed: Curcumin: from chemistry to chemistry-based functions.
PubMed: A reduced curcuminoid analog as a novel inducer of fetal hemoglobin.
PubMed: The cellular uptake and cytotoxic effect of curcuminoids on breast cancer cells.
PubMed: Anti-Acanthamoebic properties of resveratrol and demethoxycurcumin.
PubMed: Antioxidant properties of Mannich bases.
PubMed: Production of Curcuminoids in different in vitro organs of Curcuma longa.
PubMed: Neurodegenerative Shielding by Curcumin and Its Derivatives on Brain Lesions Induced by 6-OHDA Model of Parkinson's Disease in Albino Wistar Rats.
PubMed: The in vitro protective effects of curcumin and demethoxycurcumin in Curcuma longa extract on advanced glycation end products-induced mesangial cell apoptosis and oxidative stress.
PubMed: Demethoxycurcumin modulates prostate cancer cell proliferation via AMPK-induced down-regulation of HSP70 and EGFR.
PubMed: Design, synthesis and biological activity of new polyenolic inhibitors of matrix metalloproteinases: a focus on chemically-modified curcumins.
PubMed: Forming of demethoxycurcumin nanocrystallite-chitosan nanocarrier for controlled low dose cellular release for inhibition of the migration of vascular smooth muscle cells.
PubMed: Curcuminoid binding to embryonal carcinoma cells: reductive metabolism, induction of apoptosis, senescence, and inhibition of cell proliferation.
PubMed: Isolation and identification of phase 1 metabolites of curcuminoids in rats.
PubMed: Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers.
PubMed: Evaluation of naturally occurring curcuminoids and related compounds against mosquito larvae.
PubMed: Curcumin--from molecule to biological function.
PubMed: Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice.
PubMed: Demethoxycurcumin inhibits cell proliferation, migration and invasion in prostate cancer cells.
PubMed: Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff.
PubMed: Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting.
PubMed: Revisiting curcumin chemistry part I: a new strategy for the synthesis of curcuminoids.
PubMed: Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells.
PubMed: Curcuminoids promote neurite outgrowth in PC12 cells through MAPK/ERK- and PKC-dependent pathways.
PubMed: Studies on curcumin and curcuminoids. XLVI. Photophysical properties of dimethoxycurcumin and bis-dehydroxycurcumin.
PubMed: Curcuminoid analogs inhibit nitric oxide production from LPS-activated microglial cells.
PubMed: Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice.
PubMed: Metabolic and pharmacokinetic studies of curcumin, demethoxycurcumin and bisdemethoxycurcumin in mice tumor after intragastric administration of nanoparticle formulations by liquid chromatography coupled with tandem mass spectrometry.
PubMed: A comparative study of curcuminoids to measure their effect on inflammatory and apoptotic gene expression in an A╬▓ plus ibotenic acid-infused rat model of Alzheimer's disease.
PubMed: Phytochemical and cytotoxic investigations of Curcuma mangga rhizomes.
PubMed: Hypomethylation effects of curcumin, demethoxycurcumin and bisdemethoxycurcumin on WIF-1 promoter in non-small cell lung cancer cell lines.
PubMed: Physiological and therapeutical roles of ginger and turmeric on endocrine functions.
PubMed: Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation.
PubMed: Compounds isolated from Curcuma aromatica Salisb. inhibit human P450 enzymes.
PubMed: Dimethoxycurcumin, a structural analogue of curcumin, induces apoptosis in human renal carcinoma caki cells through the production of reactive oxygen species, the release of cytochrome C, and the activation of caspase-3.
PubMed: Bisdemethoxycurcumin protects endothelial cells against t-BHP-induced cell damage by regulating the phosphorylation level of ERK1/2 and Akt.
PubMed: Anti-inflammatory mechanisms of compounds from Curcuma mangga rhizomes using RAW264.7 macrophage cells.
PubMed: Reactions of reactive oxygen species (ROS) with curcumin analogues: Structure-activity relationship.
PubMed: Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices.
PubMed: The inhibitory effects of different curcuminoids on ╬▓-amyloid protein, ╬▓-amyloid precursor protein and ╬▓-site amyloid precursor protein cleaving enzyme 1 in swAPP HEK293 cells.
PubMed: Suppression of TGF-╬▓1/SMAD pathway and extracellular matrix production in primary keloid fibroblasts by curcuminoids: its potential therapeutic use in the chemoprevention of keloid.
PubMed: Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity.
PubMed: The inhibitory effect of turmeric curcuminoids on matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells.
PubMed: Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease.
PubMed: Effects of Curcuma extracts and curcuminoids on expression of P-glycoprotein and cytochrome P450 3A4 in the intestinal cell culture model LS180.
PubMed: Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa.
PubMed: Development of binding assays to screen ligands for Plasmodium falciparum thioredoxin and glutathione reductases by ultrafiltration and liquid chromatography/mass spectrometry.
PubMed: [Chemical constituents from Piper longum].
PubMed: Inhibitory effects of curcuminoids on passive cutaneous anaphylaxis reaction and scratching behavior in mice.
PubMed: Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-kappaB signaling pathways in N9 microglia induced by lipopolysaccharide.
PubMed: Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species.
PubMed: Effects of Curcuma spp. on P-glycoprotein function.
PubMed: Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line.
PubMed: Comparison of extraction methods for the analysis of natural dyes in historical textiles by high-performance liquid chromatography.
PubMed: Optimized turmeric extracts have potent anti-amyloidogenic effects.
PubMed: Potent and selective inhibition of the tumor marker AKR1B10 by bisdemethoxycurcumin: probing the active site of the enzyme with molecular modeling and site-directed mutagenesis.
PubMed: Identification and characterization of multiple curcumin synthases from the herb Curcuma longa.
PubMed: Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research.
PubMed: Curcumin derivatives: molecular basis of their anti-cancer activity.
PubMed: Direct analysis of curcumin in turmeric by DART-MS.
PubMed: New synthetic glucosyl-curcuminoids, and their (1)H and (13)C NMR characterization, from Curcuma longa L.
PubMed: Demethoxycurcumin induces Bcl-2 mediated G2/M arrest and apoptosis in human glioma U87 cells.
PubMed: Metabolite analysis in Curcuma domestica using various GC-MS and LC-MS separation and detection techniques.
PubMed: A simple HPLC-fluorescence method for quantitation of curcuminoids and its application to turmeric products.
PubMed: [Study on stability of curcumine, demethoxycurcumin and bisdemethoxycurcumin].
PubMed: A simple 2-directional high-performance thin-layer chromatographic method for the simultaneous determination of curcumin, metanil yellow, and sudan dyes in turmeric, chili, and curry powders.
PubMed: Induction of antioxidant enzymes by curcumin and its analogues in human islets: implications in transplantation.
PubMed: [Fingerprint of Curcuma phaeocaulis by LC-MS].
PubMed: Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300.
PubMed: Demethoxycurcumin and its semisynthetic analogues as antitubercular agents.
PubMed: Differential solubility of curcuminoids in serum and albumin solutions: implications for analytical and therapeutic applications.
PubMed: Standardization of the ayurvedic formulation Haridra Khanda using high-performance thin-layer chromatography-densitometry.
PubMed: Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease.
PubMed: Comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide.
PubMed: Purification of curcumin, demethoxycurcumin, and bisdemethoxycurcumin by high-speed countercurrent chromatography.
PubMed: Quantitation of curcuminoids in curcuma rhizome by near-infrared spectroscopic analysis.
PubMed: Qualitative and quantitative analysis of four species of Curcuma rhizomes using twice development thin layer chromatography.
PubMed: [Study on effect of demethoxycurcumin in Curcuma long on stability of curcumin].
PubMed: Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA.
PubMed: Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS.
PubMed: Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor.
PubMed: Comparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators in vitro and in vivo.
PubMed: Molecularly imprinted poly (methacrylamide-co-methacrylic acid) composite membranes for recognition of curcumin.
PubMed: Effect of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin on WT1 gene expression in leukemic cell lines.
PubMed: Separation and free radical-scavenging activity of major curcuminoids of Curcuma longa using HPTLC-DPPH method.
PubMed: Curcuminoids-cellular uptake by human primary colon cancer cells as quantitated by a sensitive HPLC assay and its relation with the inhibition of proliferation and apoptosis.
PubMed: Isolation and identification of phase 1 metabolites of demethoxycurcumin in rats.
PubMed: Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells.
PubMed: Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.
PubMed: HPLC-photodiode array detection analysis of curcuminoids in Curcuma species indigenous to Indonesia.
PubMed: Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS.
PubMed: Formulation and characterization of curcuminoids loaded solid lipid nanoparticles.
PubMed: Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male Wistar rats.
PubMed: Comparative study of copper(II)-curcumin complexes as superoxide dismutase mimics and free radical scavengers.
PubMed: Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives.
PubMed: Biological evaluation of curcumin and related diarylheptanoids.
PubMed: Comparative effects of curcuminoids on endothelial heme oxygenase-1 expression: ortho-methoxy groups are essential to enhance heme oxygenase activity and protection.
PubMed: Modulation of the function of the multidrug resistance-linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin.
PubMed: Comparison of Anti-inflammatory Activities of Six Curcuma Rhizomes: A Possible Curcuminoid-independent Pathway Mediated by Curcuma phaeocaulis Extract.
PubMed: [Effect of three different curcumin pigmens on the prdiferation of vascular smooth muscle cells by ox-LDL and the expression of LDL-R].
PubMed: Microemulsion electrokinetic chromatography for separation and analysis of curcuminoids in turmeric samples.
PubMed: Use of liquid chromatography-electrospray ionization tandem mass spectrometry to identify diarylheptanoids in turmeric (Curcuma longa L.) rhizome.
PubMed: Metabolism of curcuminoids in tissue slices and subcellular fractions from rat liver.
PubMed: Alpha-glucosidase inhibition of natural curcuminoids and curcumin analogs.
PubMed: Curcuma longa L. constituents inhibit sortase A and Staphylococcus aureus cell adhesion to fibronectin.
PubMed: Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid.
PubMed: Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities.
PubMed: A labdane diterpene glucoside from the rhizomes of Curcuma mangga.
PubMed: Application of capillary zone electrophoresis in the separation and determination of the curcuminoids in urine.
PubMed: Inhibition of multidrug resistance proteins MRP1 and MRP2 by a series of alpha,beta-unsaturated carbonyl compounds.
PubMed: Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice.
PubMed: Antioxidative constituents of Etlingera elatior.
PubMed: Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice.
PubMed: Detection and quantitation of curcumin in mouse lung cell cultures by matrix-assisted laser desorption ionization time of flight mass spectrometry.
PubMed: Antitumour-promoting and cytotoxic constituents of etlingera elatior.
PubMed: Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder.
PubMed: Inhibitory activity of diarylheptanoids on farnesyl protein transferase.
PubMed: Quantitative determination of curcuminoids in Curcuma rhizomes and rapid differentiation of Curcuma domestica Val. and Curcuma xanthorrhiza Roxb. by capillary electrophoresis.
PubMed: Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids.
PubMed: Protection of pancreatic beta-cell by the potential antioxidant bis-o-hydroxycinnamoyl methane, analogue of natural curcuminoid in experimental diabetes.
PubMed: Extraction of essential oil and pigments from Curcuma longa [L] by steam distillation and extraction with volatile solvents.
PubMed: Inhibitory effect of curcumin and its natural analogues on genotoxicity of heterocyclic amines from cooked food.
PubMed: In vitro peroxynitrite scavenging activity of diarylheptanoids from Curcuma longa.
PubMed: Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa).
PubMed: Microarray-based analysis of anti-angiogenic activity of demethoxycurcumin on human umbilical vein endothelial cells: crucial involvement of the down-regulation of matrix metalloproteinase.
PubMed: Discovery of natural products from Curcuma longa that protect cells from beta-amyloid insult: a drug discovery effort against Alzheimer's disease.
PubMed: Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits.
PubMed: Improved HPLC method for the determination of curcumin, demethoxycurcumin, and bisdemethoxycurcumin.
PubMed: Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa.
PubMed: Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue.
PubMed: [Study on the characterizations of genus Curcuma plants on the strains of C. longa L. and C. aromatica Salisb preserved at Izu station of NIHS].
PubMed: Antifungal activity of Curcuma longa grown in Thailand.
PubMed: Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo.
PubMed: Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult.
PubMed: Effects of turmeric on the activities of benzo(a)pyrene-induced cytochrome P-450 isozymes.
PubMed: Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma.
PubMed: Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa.
PubMed: A simple and efficient separation of the curcumins, the antiprotozoal constituents of Curcuma longa.
PubMed: Pro-oxidant, anti-oxidant and cleavage activities on DNA of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin.
PubMed: Cytotoxicity of curcuminoids and some novel compounds from Curcuma zedoaria.
PubMed: Inhibitory effect of curcuminoids on MCF-7 cell proliferation and structure-activity relationships.
PubMed: Inhibitory effects of curcumin on tumorigenesis in mice.
PubMed: Nitric oxide scavenging by curcuminoids.
PubMed: Free radical scavenging activity of curcuminoids.
PubMed: Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion.
PubMed: Effects of curcumin on the formation of benzo[a]pyrene derived DNA adducts in vitro.
PubMed: Curcuminoids as potent inhibitors of lipid peroxidation.
PubMed: Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice.
PubMed: Nematocidal activity of turmeric: synergistic action of curcuminoids.
PubMed: [Terpenoids and curcuminoids of the rhizoma of Curcuma xanthorrhiza Roxb].
PubMed: Action of curcuminoids on the hemolysis and lipid peroxidation of mouse erythrocytes induced by hydrogen peroxide.
PubMed: [Separation and determination of curcuminoids in Curcuma longa L. and its preparation by HPLC].
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