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teprenone
geranylgeranylacetone

Supplier Sponsors

Name:(5E,9E,13E)-6,10,14,18-tetramethylnonadeca-5,9,13,17-tetraen-2-one
CAS Number: 6809-52-5Picture of molecule3D/inchi
FDA UNII: S8S8451A4O
Nikkaji Web:J24.196B
MDL:MFCD00869547
XlogP3-AA:7.40 (est)
Molecular Weight:330.55506000
Formula:C23 H38 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 442.20 °C. @ 760.00 mm Hg (est)
Flash Point: 334.00 °F. TCC ( 168.00 °C. ) (est)
logP (o/w): 8.200 (est)
Soluble in:
 water, 0.0001836 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Teprenone 95%
BOC Sciences
For experimental / research use only.
Geranylgeranylacetone >95%
Odor: characteristic
Use: Geranylgeranylacetone is commonly utilized to protect the gastric mucosa in peptic ulcer disease can induce expression of HSP70, HSPB8, and HSPB1. An anti-ulcerative.
Santa Cruz Biotechnology
For experimental / research use only.
Geranylgeranylacetone
Sigma-Aldrich: Sigma
For experimental / research use only.
Geranylgeranylacetone
TCI AMERICA
For experimental / research use only.
Teprenone [mixture of (5E,9E,13E)- and (5Z,9E,13E)- isomers] >95.0%(GC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-dog LD50 > 1000 mg/kg
Drugs in Japan Vol. -, Pg. 703, 1990.

intramuscular-mouse LD50 > 5000 mg/kg
Drugs in Japan Vol. -, Pg. 703, 1990.

intraperitoneal-mouse LD50 3750 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 357, 1985.

intramuscular-rat LD50 > 5000 mg/kg
Drugs in Japan Vol. -, Pg. 703, 1990.

oral-rat LD50 > 15000 mg/kg
Drugs in Japan Vol. -, Pg. 703, 1990.

intraperitoneal-rat LDLo 3500 mg/kg
Drugs in Japan Vol. -, Pg. 703, 1990.

Dermal Toxicity:
subcutaneous-mouse LD50 > 10000 mg/kg
Drugs in Japan Vol. -, Pg. 703, 1990.

subcutaneous-rat LD50 > 10000 mg/kg
Drugs in Japan Vol. -, Pg. 703, 1990.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents
Recommendation for teprenone usage levels up to:
 not for fragrance use.
 
Recommendation for teprenone flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5282199
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(5E,9E,13E)-6,10,14,18-tetramethylnonadeca-5,9,13,17-tetraen-2-one
Chemidplus:0006809525
RTECS:RA5391300 for cas# 6809-52-5
 
References:
 (5E,9E,13E)-6,10,14,18-tetramethylnonadeca-5,9,13,17-tetraen-2-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5282199
Pubchem (sid):135232510
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C13297
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2914.19.0000
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 geranyl geranyl acetone
 geranylgeranylacetone
 teprenonum
6,10,14,18-tetramethyl-5,9,13,17-nonadecatetraen-2-one
(5E,9E,13E)-6,10,14,18-tetramethylnonadeca-5,9,13,17-tetraen-2-one
 

Articles:

PubMed:Geranylgeranylacetone selectively binds to the HSP70 of Helicobacter pylori and alters its coccoid morphology.
PubMed:Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy.
PubMed:Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70.
PubMed:Long-term efficacy and safety of rabeprazole in patients taking low-dose aspirin with a history of peptic ulcers: a phase 2/3, randomized, parallel-group, multicenter, extension clinical trial.
PubMed:The future of atrial fibrillation therapy: intervention on heat shock proteins influencing electropathology is the next in line.
PubMed:HSP70 inhibits stress-induced cardiomyocyte apoptosis by competitively binding to FAF1.
PubMed:Protective effect of geranylgeranylacetone against hydrogen peroxide-induced oxidative stress in human neuroblastoma cells.
PubMed:Geranylgeranylacetone ameliorates lung ischemia/reperfusion injury by HSP70 and thioredoxin redox system: NF-kB pathway involved.
PubMed:Geranylgeranylacetone suppresses colitis‑related mouse colon carcinogenesis.
PubMed:Geranylgeranylacetone protects against small-intestinal injuries induced by diclofenac in patients with rheumatic diseases: a prospective randomized study.
PubMed:Effect of rebamipide on gastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats.
PubMed:Comparison of teprenone and famotidine against gastroduodenal mucosal damage in patients taking low-dose aspirin.
PubMed:Geranylgeranylacetone protects against cerebral ischemia and reperfusion injury: HSP90 and eNOS phosphorylation involved.
PubMed:Heat shock protein 72 suppresses apoptosis by increasing the stability of X-linked inhibitor of apoptosis protein in renal ischemia/reperfusion injury.
PubMed:PPI vs. teprenone in preventing recurrence of ulcers during low-dose aspirin.
PubMed:PPI vs. teprenone in preventing recurrence of ulcers during low-dose aspirin - authors' reply.
PubMed:Antioxidant signaling involving the microtubule motor KIF12 is an intracellular target of nutrition excess in beta cells.
PubMed:Inducing Muscle Heat Shock Protein 70 Improves Insulin Sensitivity and Muscular Performance in Aged Mice.
PubMed:Randomised clinical trial: prevention of recurrence of peptic ulcers by rabeprazole in patients taking low-dose aspirin.
PubMed:Endoplasmic reticulum-associated degradation of Niemann-Pick C1: evidence for the role of heat shock proteins and identification of lysine residues that accept ubiquitin.
PubMed:Modulation of human basophil degranulation by geranylgeranyl compounds.
PubMed:Geranylgeranylacetone blocks doxorubicin-induced cardiac toxicity and reduces cancer cell growth and invasion through RHO pathway inhibition.
PubMed:Induction of heat-shock protein 70 expression by geranylgeranylacetone shows cytoprotective effects in cardiomyocytes of mice under humid heat stress.
PubMed:Geranylgeranylacetone and volatile anesthetic-induced cardiac protection synergism is dependent on caveolae and caveolin-3.
PubMed:Protective effect of geranylgeranylacetone via enhanced induction of HSPB1 and HSPB8 in mitochondria of the failing heart following myocardial infarction in rats.
PubMed:Geranylgeranylacetone protects the heart via caveolae and caveolin-3.
PubMed:Increased gap density predicts weakness of the epithelial barrier in vivo by confocal laser endomicroscopy in indomethacin-induced enteropathy.
PubMed:Geranylgeranylacetone, a gastromucoprotective drug, protects against NSAID-induced esophageal, gastroduodenal and small intestinal mucosal injury in healthy subjects: A prospective randomized study involving a comparison with famotidine.
PubMed:Chaperone heat shock protein 70 in nucleus accumbens core: a novel biological target of behavioural sensitization to morphine in rats.
PubMed:Suppression of Alzheimer's disease-related phenotypes by geranylgeranylacetone in mice.
PubMed:Protective effect of geranylgeranylacetone against methamphetamine-induced neurotoxicity in rat pheochromocytoma cells.
PubMed:Neuroprotective effects of geranylgeranylacetone in experimental traumatic brain injury.
PubMed:Evaluation of Helicobacter pylori eradication and drug therapy in patients with functional dyspepsia.
PubMed:The heat-shock protein-70-induced renoprotective effect is partially mediated by CD4+ CD25+ Foxp3 + regulatory T cells in ischemia/reperfusion-induced acute kidney injury.
PubMed:Heat shock protein inducer modifies arrhythmogenic substrate and inhibits atrial fibrillation in the failing heart.
PubMed:Immediate induction of heat shock proteins is not protective against cryopreservation in normal human fibroblasts.
PubMed:Geranylgeranylacetone inhibits melanin synthesis via ERK activation in Mel-Ab cells.
PubMed:Animal models of gastric bleeding induced by dual antiplatelet therapy using aspirin and clopidogrel--prophylactic effect of antiulcer drugs.
PubMed:The role of heat shock protein 70 induced by geranylgeranylacetone in carbon tetrachloride-exposed adult rat testes.
PubMed:Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice.
PubMed:Protective effect of geranylgeranylacetone against radiation-induced delayed effects on human keratinocytes.
PubMed:Geranylgeranylacetone protects against morphine-induced hepatic and renal damage in mice.
PubMed:Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism.
PubMed:Bisphosphonate-induced gastrointestinal mucosal injury is mediated by mitochondrial superoxide production and lipid peroxidation.
PubMed:Heat shock protein-inducing compounds as therapeutics to restore proteostasis in atrial fibrillation.
PubMed:Poor awareness of preventing aspirin-induced gastrointestinal injury with combined protective medications.
PubMed:[Identification of a molecular mechanism for actions of existing medicines and its application for drug development].
PubMed:Preventive effects of geranylgeranylacetone on rat ethanol-induced gastritis.
PubMed:Efficacy of omeprazole, famotidine, mosapride and teprenone in patients with upper gastrointestinal symptoms: an omeprazole-controlled randomized study (J-FOCUS).
PubMed:Geranylgeranylacetone attenuates cisplatin-induced reductions in cell viability by suppressing the elevation of intracellular p53 content without heat shock protein induction.
PubMed:A new model of gastric bleeding induced in rats by aspirin plus clopidogrel under stimulation of acid secretion. Prophylactic effects of antiulcer drugs.
PubMed:Loss of proteostatic control as a substrate for atrial fibrillation: a novel target for upstream therapy by heat shock proteins.
PubMed:Is routine stress ulcer prophylaxis of benefit for patients undergoing cardiac surgery?
PubMed:Management of NSAID/aspirin-induced small intestinal damage by GI-sparing NSAIDs, anti-ulcer drugs and food constituents.
PubMed:Geranylgeranylacetone protects mice against morphine-induced hyperlocomotion, rewarding effect, and withdrawal syndrome.
PubMed:The role of T-cell leukemia translocation-associated gene protein in human tumorigenesis and osteoclastogenesis.
PubMed:[Improved virologic response in chronic hepatitis C treated with peginterferon, ribavirin and add-on drug].
PubMed:Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis.
PubMed:Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by inhibiting high-mobility group box 1 protein in rats.
PubMed:Geranylgeranylacetone has anti-hepatitis C virus activity via activation of mTOR in human hepatoma cells.
PubMed:Large-scale randomized clinical study on functional dyspepsia treatment with mosapride or teprenone: Japan Mosapride Mega-Study (JMMS).
PubMed:Heat shock protein 72 enhances autophagy as a protective mechanism in lipopolysaccharide-induced peritonitis in rats.
PubMed:Geranylgeranylacetone, heat shock protein 90/AMP-activated protein kinase/endothelial nitric oxide synthase/nitric oxide pathway, and endothelial function in humans.
PubMed:Geranylgeranylacetone suppresses hydrogen peroxide-induced apoptosis of osteoarthritic chondrocytes.
PubMed:Geranylgeranylacetone suppresses noise-induced expression of proinflammatory cytokines in the cochlea.
PubMed:Effects of different small HSPB members on contractile dysfunction and structural changes in a Drosophila melanogaster model for Atrial Fibrillation.
PubMed:Stimulation of gastric ulcer healing by heat shock protein 70.
PubMed:[The correlation between the up-regulation of Hsp90 and drug resistance to cisplatin in lung cancer cell line].
PubMed:Anti-ulcer agent teprenone inhibits hepatitis C virus replication: potential treatment for hepatitis C.
PubMed:Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase.
PubMed:Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys.
PubMed:Induction of heat shock protein 70 inhibits ischemic renal injury.
PubMed:Transcriptional activation of the anchoring protein SAP97 by heat shock factor (HSF)-1 stabilizes K(v) 1.5 channels in HL-1 cells.
PubMed:Protective effect of geranylgeranylacetone against loxoprofen sodium-induced small intestinal lesions in rats.
PubMed:Isoprenoid geranylgeranylacetone inhibits human colon cancer cells through induction of apoptosis and cell cycle arrest.
PubMed:Geranylgeranylacetone preconditioning may attenuate heat-induced inflammation and multiorgan dysfunction in rats.
PubMed:An acylic polyisoprenoid derivative, geranylgeranylacetone protects against visceral adiposity and insulin resistance in high-fat-fed mice.
PubMed:Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice.
PubMed:Geranylgeranylacetone ameliorates acute cochlear damage caused by 3-nitropropionic acid.
PubMed:The phosphatidylinositol-3 kinase/Akt pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats.
PubMed:HSP-dependent protection against gastrointestinal diseases.
PubMed:HSP72 inhibits Smad3 activation and nuclear translocation in renal epithelial-to-mesenchymal transition.
PubMed:Influence of geranylgeranylacetone on the expression of HSP70 in retina of rats with chronic IOP elevation.
PubMed:Heat shock proteins in neurodegenerative diseases: pathogenic roles and therapeutic implications.
PubMed:Expression and function of stress (heat shock) proteins in gastrointestinal tract.
PubMed:Randomized, double-blind, pilot study of geranylgeranylacetone versus placebo in patients taking low-dose enteric-coated aspirin. Low-dose aspirin-induced small bowel damage.
PubMed:Pharmacological targeting of the Hsp70 chaperone.
PubMed:Geranylgeranylacetone protects against diclofenac-induced gastric and small intestinal mucosal injuries in healthy subjects: a prospective randomized placebo-controlled double-blind cross-over study.
PubMed:Lysophosphatidic acid and invasion.
PubMed:Protective effect of geranylgeranylacetone, an inducer of heat shock protein 70, against drug-induced lung injury/fibrosis in an animal model.
PubMed:Geranylgeranylacetone protects rat and striatum neurons against heat injury via induction of Hsp70.
PubMed:Induction of heat shock proteins prevents the arrhythmogenic substrate for atrial fibrillation.
PubMed:Effect of geranylgeranylacetone on optic neuritis in experimental autoimmune encephalomyelitis.
PubMed:[Side effects of non-steroidal anti-inflammatory drugs on gastric mucosa and preventive effects of teprenone].
PubMed:Geranylgeranylacetone, a non-toxic inducer of heat shock protein, induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
PubMed:HSP70 confers protection against indomethacin-induced lesions of the small intestine.
PubMed:A role for HSP70 in protecting against indomethacin-induced gastric lesions.
PubMed:[Effects of biologic therapies on systemic osteoporosis in patients with rheumatoid arthritis].
PubMed:Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy.
PubMed:Increased heat-shock protein 90 expression contributes to impaired adaptive cytoprotection in the gastric mucosa of portal hypertensive rats.
PubMed:Antitumor effect of pretreatment for colon cancer cells with hyperthermia plus geranylgeranylacetone in experimental metastasis models and a subcutaneous tumor model of colon cancer in mice.
PubMed:Mechanism of liver regeneration after liver resection and portal vein embolization (ligation) is different?
PubMed:Preinduction of HSP70 promotes hypoxic tolerance and facilitates acclimatization to acute hypobaric hypoxia in mouse brain.
PubMed:Protective effect of geranylgeranylacetone on cisplatin ototoxicity.
PubMed:HPLC-APCI-MS for the determination of vitamin K(1) in human plasma: method and clinical application.
PubMed:Low-dose sevoflurane inhalation enhances late cardioprotection from the anti-ulcer drug geranylgeranylacetone.
PubMed:Geranylgeranylacetone prevents acute liver damage after massive hepatectomy in rats through suppression of a CXC chemokine GRO1 and induction of heat shock proteins.
PubMed:Mosapride in gastrointestinal disorders.
PubMed:Attenuation of progressive hearing loss in a model of age-related hearing loss by a heat shock protein inducer, geranylgeranylacetone.
PubMed:HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy.
PubMed:[Effects of teprenone on expression of heat shock protein 70 and c-fos in stomach following prednisolone ingestion: experiment with rats].
PubMed:Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia.
PubMed:Geranylgeranylacetone ameliorates inflammatory response to lipopolysaccharide (LPS) in murine macrophages: inhibition of LPS binding to the cell surface.
PubMed:[Side effects of gastric muco-protective agents].
PubMed:Reduction of ethanol-induced injury in portal hypertensive gastric mucosa of rats by induction of heat shock protein 72 by geranylgeranylacetone.
PubMed:Comparison of the effectiveness of geranylgeranylacetone with cimetidine in gastritis patients with dyspeptic symptoms and gastric lesions: a randomized, double-blind trial in Japan.
PubMed:Blunted activation of NF-kappaB and NF-kappaB-dependent gene expression by geranylgeranylacetone: involvement of unfolded protein response.
PubMed:[Role of heat shock protein in gastric mucosal protection].
PubMed:Neuroprotective effect of geranylgeranylacetone against ischemia-induced retinal injury.
PubMed:Geranylgeranylacetone, an inducer of the 70-kDa heat shock protein (HSP70), elicits unfolded protein response and coordinates cellular fate independently of HSP70.
PubMed:Geranylgeranylacetone protects the human gastric mucosa from diclofenac-induced injury via induction of heat shock protein 70.
PubMed:Protective effects of heat shock protein70 induced by geranylgeranylacetone in atrophic gastritis in rats.
PubMed:Mitochondria are targets for geranylgeranylacetone-induced cardioprotection against ischemia-reperfusion in the rat heart.
PubMed:Hyperthermia ameliorates 2,4,6-trinitrobenzene sulphonic acid-induced colitis in rats: the role of heat shock proteins.
PubMed:Hyperthermia attenuates TNF-alpha-induced up regulation of endothelial cell adhesion molecules in human arterial endothelial cells.
PubMed:Geranylgeranylaceton induces heat shock protein 72 in skeletal muscle cells.
PubMed:HPLC-APCI-MS for the determination of teprenone in human plasma: method and clinical application.
PubMed:Geranylgeranylacetone induces cyclooxygenase-2 expression in cultured rat gastric epithelial cells through NF-kappaB.
PubMed:Geranylgeranylacetone inhibits ovarian cancer progression in vitro and in vivo.
PubMed:[Effect of mucosal protective on the quality of gastric ulcer healing].
PubMed:Association of heat shock protein 70 induction and the amelioration of experimental autoimmune uveoretinitis in mice.
PubMed:Pharmacological induction of heat shock protein exerts neuroprotective effects in experimental intracerebral hemorrhage.
PubMed:[Non-steroidal anti-inflammatory drug induced gastropathy and preventive effects of teprenone on the gastropathy in rats].
PubMed:Genetic evidence for a protective role of heat shock factor 1 against irritant-induced gastric lesions.
PubMed:The induction mechanism of the molecular chaperone HSP70 in the gastric mucosa by Geranylgeranylacetone (HSP-inducer).
PubMed:Induction of heat shock response protects the heart against atrial fibrillation.
PubMed:Impact of blockade of histamine H2 receptors on chronic heart failure revealed by retrospective and prospective randomized studies.
PubMed:Effect of geranylgeranylacetone on gentamycin ototoxicity in rat cochlea culture.
PubMed:Heat shock protein upregulation protects against pacing-induced myolysis in HL-1 atrial myocytes and in human atrial fibrillation.
PubMed:Role of protein kinase C in neuroprotective effect of geranylgeranylacetone, a noninvasive inducing agent of heat shock protein, on delayed neuronal death caused by transient ischemia in rats.
PubMed:[Preventive effects of teprenone on gastric mucosal lesions induced by Helicobacter pylori in mice].
PubMed:Heat shock proteins and mitogen-activated protein kinases in steatotic livers undergoing ischemia-reperfusion: some answers.
PubMed:Geranylgeranylacetone, an inducer of HSP 70, attenuates REM sleep rebound after sleep deprivation.
PubMed:Protective effects of heat shock protein 70 induced by geranylgeranylacetone on oxidative injury in rat intestinal epithelial cells.
PubMed:Geranylgeranylacetone, a noninvasive heat shock protein inducer, induces protein kinase C and leads to neuroprotection against cerebral infarction in rats.
PubMed:Protective effect of geranylgeranylacetone on trinitrobenzene sulfonic acid-induced colitis in mice.
PubMed:Geranylgeranylacetone protects against acetaminophen-induced hepatotoxicity by inducing heat shock protein 70.
PubMed:Geranylgeranylacetone inhibits formation and function of human osteoclasts and prevents bone loss in tail-suspended rats and ovariectomized rats.
PubMed:[Protection of gastric mucosa against steroids-induced damage by teprenone].
PubMed:Geranylgeranylacetone, a heat shock protein inducer, prevents acoustic injury in the guinea pig.
PubMed:Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease.
PubMed:Oral administration of geranylgeranylacetone improves survival rate in a rat endotoxin shock model: administration timing and heat shock protein 70 induction.
PubMed:Gastric mucosal protection via enhancement of MUC5AC and MUC6 by geranylgeranylacetone.
PubMed:Oral administration of geranylgeranylacetone plus local somatothermal stimulation: a simple, effective, safe and operable preconditioning combination for conferring tolerance against ischemia-reperfusion injury in rat livers.
PubMed:Geranylgeranylacetone protects mice from dextran sulfate sodium-induced colitis.
PubMed:An anti-ulcer drug, geranylgeranylacetone, suppresses inducible nitric oxide synthase in cultured vascular smooth muscle cells.
PubMed:Effect of gefarnate on acute gastric mucosal lesion progression in rats treated with compound 48/80, a mast cell degranulator, in comparison with that of teprenone.
PubMed:Geranylgeranylacetone limits secondary injury, neuronal death, and progressive necrosis and cavitation after spinal cord injury.
PubMed:Geranylgeranylacetone protects membranes against nonsteroidal anti-inflammatory drugs.
PubMed:[Possible candidates for the compound which is expected to attenuate dioxin toxicity].
PubMed:Heat shock proteins: new keys to the development of cytoprotective therapies.
PubMed:Upregulation of HSP by geranylgeranylacetone protects the cochlear lateral wall from endotoxin-induced inflammation.
PubMed:Effects of insulin resistance on geranylgeranylacetone-induced expression of heat shock protein 72 and cardioprotection in high-fat diet rats.
PubMed:Oral administration of geranylgeranylacetone blunts the endothelial dysfunction induced by ischemia and reperfusion in the rat heart.
PubMed:Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70.
PubMed:Biphasic effects of geranylgeraniol, teprenone, and phytol on the growth of Staphylococcus aureus.
PubMed:Heat shock protein 70 delays gentamicin-induced vestibular hair cell death.
PubMed:Cytoprotective effects of geranylgeranylacetone against retinal photooxidative damage.
PubMed:Geranylgeranylacetone inhibits lysophosphatidic acid-induced invasion of human ovarian carcinoma cells in vitro.
PubMed:Prospective randomized trial for optimal prophylactic treatment of the upper gastrointestinal complications after open heart surgery.
PubMed:Neuroprotective effect of a heat shock protein inducer, geranylgeranylacetone in permanent focal cerebral ischemia.
PubMed:Neuroprotective effect of geranylgeranylacetone, a noninvasive heat shock protein inducer, on cerebral infarction in rats.
PubMed:Potential role for heat shock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid hemorrhage.
PubMed:Restoration of heat shock protein70 suppresses gastric mucosal inducible nitric oxide synthase expression induced by Helicobacter pylori.
PubMed:Geranylgeranylacetone attenuates suppression by Helicobacter pylori extract of human umbilical vein epithelial cell growth.
PubMed:A single oral dose of geranylgeranylacetone attenuates kainic acid-induced seizures and neuronal cell death in rat hippocampus.
PubMed:Reduction of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice using an antiulcer drug, geranylgeranylacetone.
PubMed:Single oral dose of geranylgeranylacetone for protection against delayed neuronal death induced by transient ischemia.
PubMed:[Basic studies for the development of anticancer, antidementia, and taste modifier drugs].
PubMed:Teprenone, but not H2-receptor blocker or sucralfate, suppresses corpus Helicobacter pylori colonization and gastritis in humans: teprenone inhibition of H. pylori-induced interleukin-8 in MKN28 gastric epithelial cell lines.
PubMed:[Geranylgeranylacetone, an antiulcer drug, potently inhibits formation and function of human osteoclasts in vitro and bone loss in ovariectomized rats].
PubMed:Preventive effect of teprenone on acute gastric mucosal lesion progression in compound 48/80-treated rats.
PubMed:Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model.
PubMed:[Agranulocytosis due to anti-tuberculosis drugs including isoniazid (INH) and rifampicin (RFP)--a report of four cases and review of the literature].
PubMed:Protective effect of teprenone against acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats.
PubMed:Influence of anti-ulcer drugs used in Japan on the result of (13)C-urea breath test for the diagnosis of Helicobacter pylori infection.
PubMed:Proposed mechanism for induction of heat shock protein 70 by geranylgeranyl acetone by prenylation of Ras proteins.
PubMed:Geranylgeranylacetone attenuates septic diaphragm dysfunction by induction of heat shock protein 70.
PubMed:Astroglial activation accompanies heat shock protein upregulation in rat brain following single oral dose of geranylgeranylacetone.
PubMed:Cholesteryl glucoside-induced protection against gastric ulcer.
PubMed:Antiviral effects of geranylgeranylacetone: enhancement of MxA expression and phosphorylation of PKR during influenza virus infection.
PubMed:Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart.
PubMed:Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model.
PubMed:[Molecular chaperone inducers in medicine and diseases].
PubMed:Suppression of Helicobacter pylori-induced interleukin-8 production in gastric cancer cell lines by an anti-ulcer drug, geranylgeranylacetone.
PubMed:Mevastatin, an inhibitor of HMG-CoA reductase, induces apoptosis, differentiation and Rap1 expression in HL-60 cells.
PubMed:Effects of anti-ulcer agents on ethanol-induced gastric mucosal lesions in D-galactosamine-induced hepatitis rats.
PubMed:Geranylgeranylacetone protects guinea pig gastric mucosal cells from gastric stressor-induced apoptosis.
PubMed:Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons.
PubMed:Thioredoxin superfamily and thioredoxin-inducing agents.
PubMed:Geranylgeranylacetone suppresses inflammatory responses and improves survival after massive hepatectomy in rats.
PubMed:[New therapeutic approaches to peptic ulcer using mucosal protective agents].
PubMed:Thioredoxin suppresses 1-methyl-4-phenylpyridinium-induced neurotoxicity in rat PC12 cells.
PubMed:Geranylgeranylacetone promotes induction and secretion of thioredoxin in gastric mucosal cells and peripheral blood lymphocytes.
PubMed:Geranylgeranylacetone protects human monocytes from mitochondrial membrane depolarization independently of Hsp70 expression.
PubMed:Single oral dose of geranylgeranylacetone induces heat-shock protein 72 and renders protection against ischemia/reperfusion injury in rat heart.
PubMed:Geranylgeranylacetone protects guinea pig gastric mucosal cells from gastric stressor-induced necrosis by induction of heat-shock proteins.
PubMed:A non-toxic heat shock protein 70 inducer, geranylgeranylacetone, suppresses apoptosis of cultured rat hepatocytes caused by hydrogen peroxide and ethanol.
PubMed:Geranylgeranylacetone, a heat shock protein inducer, prevents primary graft nonfunction in rat liver transplantation.
PubMed:High dose of geranylgeranylacetone accumulate HSP72 mRNA in rat liver.
PubMed:Effect of teprenone on gastric mucosal injury induced by Helicobacter pylori in rats.
PubMed:Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues.
PubMed:Geranylgeranylacetone induces antiviral gene expression in human hepatoma cells.
PubMed:Induction of heat shock protein-70 (hsp-70) by intraarterial administration of geranylgeranylacetone.
PubMed:Prevention of warm ischemic injury in rat liver transplantation by geranylgeranylacetone.
PubMed:Efficacy of HSP72 induction in rat liver by orally administered geranylgeranylacetone.
PubMed:Geranylgeranylacetone stimulates mucin synthesis in cultured guinea pig gastric pit cells by inducing a neuronal nitric oxide synthase.
PubMed:Geranylgeranylacetone protects cultured guinea pig gastric mucosal cells from indomethacin.
PubMed:Geranylgeranylacetone enhances expression of thioredoxin and suppresses ethanol-induced cytotoxicity in cultured hepatocytes.
PubMed:A non-toxic heat shock protein 70 inducer, geranyl-geranyl-acetone, restores the heat shock response in gastric mucosa of protein-malnourished rats.
PubMed:Effects of geranyl-geranyl-acetone administration before heat shock preconditioning for conferring tolerance against ischemia-reperfusion injury in rat livers.
PubMed:Role of heat shock proteins in gastric mucosal protection.
PubMed:Role of vascular endothelial growth factor in portal hypertensive gastropathy.
PubMed:Oral administration of geranylgeranylacetone protects rat livers from warm ischemic injury.
PubMed:Geranylgeranylacetone suppresses spontaneous apoptotic DNA fragmentation in cultured guinea pig gastric pit cells.
PubMed:Geranylgeranylacetone induces apoptosis in HL-60 cells.
PubMed:Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice.
PubMed:Effects of ammonia solution on the gastric mucosa in cirrhotic rats and therapeutic effects of geranylgeranylacetone.
PubMed:Influence of rebamipide on indometacin-induced gastric hemorrhage in rats under restraint stress.
PubMed:Preventive effect of teprenone on stress-induced gastric mucosal lesions and its relation to gastric mucosal constitutive nitric oxide synthase activity.
PubMed:[Protective effects of teprenone and gefarnate against taurocholate/hydrochloric acid-induced acute gastric mucosal lesions in rats].
PubMed:Geranylgeranylacetone induces heat shock protein-73 in rat small intestine.
PubMed:Suppression of ethanol-induced apoptotic DNA fragmentation by geranylgeranylacetone in cultured guinea pig gastric mucosal cells.
PubMed:Teprenone, an anti-ulcer agent, increases gastric mucosal mucus level via nitric oxide in rats.
PubMed:Effects of rebamipide in combination with lansoprazole and amoxicillin on Helicobacter pylori-infected gastric ulcer patients.
PubMed:Geranylgeranylacetone, an anti-ulcer drug, stimulates hexosamine production in a rat gastric mucosal cell line through binding to a specific cytosolic protein.
PubMed:Protective and preventive effects of teprenone on gastric mucosal lesions in rats.
PubMed:Effects of teprenone on gastric epithelial restoration in a rabbit cultured cell model.
PubMed:Prevention of gastric ulcer recurrence with tetraprenylacetone.
PubMed:[Gastric lymphoma--a case report].
PubMed:Gefarnate stimulates secretion of mucin-like glycoproteins by corneal epithelium in vitro and protects corneal epithelium from desiccation in vivo.
PubMed:Geranylgeranylacetone and cetraxate hydrochloride increase UDP-galactosyltransferase activity in rat gastric mucosa.
PubMed:[A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump].
PubMed:Suppressive effect of tetraprenylacetone on gastric atrophy induced by short-term administration of N-methyl-N'-nitro-N-nitrosoguanidine in rats.
PubMed:[The effects of teprenone on the ulcer healing rate and the quality of healing in the treatment of active gastric ulcers].
PubMed:Increase in hepatic tissue blood flow by teprenone.
PubMed:Effects of heat shock and teprenone on ethanol-induced damage to cultured rabbit gastric mucosal cells.
PubMed:Anti-gastric acid secretory mechanism of 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylic acid. Effect on mucosal mast cell.
PubMed:Gastric mucus generation in cirrhotic patients with portal hypertension. Effects of tetraprenylacetone.
PubMed:Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa.
PubMed:In-vitro and in-vivo antibacterial activity of plaunotol, a cytoprotective antiulcer agent, against Helicobacter pylori.
PubMed:Protective effect of teprenone on blood flow and incidence of histologic lesions in rat gastric mucosa after hemorrhage and retransfusion.
PubMed:Effect of the eradication of Helicobacter pylori on duodenal ulcer healing and ulcer relapse: randomized controlled study in Japan.
PubMed:[Teprenone in the treatment of chronic superficial gastritis, a multicentre study].
PubMed:Effect of teprenone on portal hypertensive gastric mucosa.
PubMed:Pharmacological regulation of gastric mucous glycoprotein secretion.
PubMed:Clinical evaluation of teprenone, a mucosal protective agent, in the treatment of patients with gastric ulcers: a nationwide, multicenter clinical study.
PubMed:Role of mucus in gastric mucosal injury induced by local ischemia/reperfusion.
PubMed:Effects of tetraprenylacetone on pancreatic exocrine secretion and acute pancreatitis in two experimental models in rats.
PubMed:Scanning electron microscopic observations on gastric mucus secretion in rats, and the effects of tetraprenylacetone.
PubMed:[Preventive effects of troxipide on a newly developed model of acute gastric mucosal lesion (AGML) induced by ischemia/reperfusion plus ammonia in the rat].
PubMed:Binding properties of KB-5492, a novel anti-ulcer agent, at sigma receptors in porcine gastric fundic mucosa.
PubMed:Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain.
PubMed:Gastric subcellular organelle fragility and impaired gastric energy charge levels in rats with caerulein-induced acute pancreatitis: protective effect of anti-ulcer agent, teprenone.
PubMed:Gastric damage and body weight loss in LHA-lesioned rats: effects of cytoprotective geranylgeranylacetone.
PubMed:Effects of KB-5492, a new anti-ulcer agent with a selective affinity for the sigma-receptor, on aspirin-induced disruption of the rat gastric mucosal barrier.
PubMed:Antibacterial activity of teprenone, a non water-soluble antiulcer agent, against Helicobacter pylori.
PubMed:Role for mucous glycoprotein in protecting cultured rat gastric mucosal cells against toxic oxygen metabolites.
PubMed:Geranylgeranylacetone used as an antiulcer agent is a potent inducer of differentiation of various human myeloid leukemia cell lines.
PubMed:Effects of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy]propyl] urea with potent gastric mucosal protective activity on acute gastric lesions and duodenal ulcers in rats.
PubMed:Effects of antiulcer drugs on phosphatidylcholine synthesis in isolated guinea pig gastric glands.
PubMed:Effects of a gastric mucosal protecting agent in rats with liver cirrhosis.
PubMed:Effect of teprenone on acute gastric mucosal lesions induced by cold-restraint stress.
PubMed:Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine.
PubMed:Effects of MCI-727, a new anti-ulcer agent, on plasma secretin concentration in rats and dogs and pancreatic exocrine secretion in rats.
PubMed:Gastric mucosal hexosamine content in various liver diseases.
PubMed:Effects of MCI-727, a new antiulcer agent, on various gastric and duodenal lesions in experimental animals.
PubMed:The inhibitory effect of anti-tumor drugs on phosphatidylcholine synthesis and its reversal by geranylgeranylacetone in the isolated guinea pig gastric glands.
PubMed:Tetraprenylacetone promotes healing process of ethanol-induced gastric damage in the rat.
PubMed:Secretin as a potential mediator of antiulcer actions of mucosal protective agents.
PubMed:Changes in gastric mucosal content of adenosine, xanthine and hypoxanthine induced by restrained water immersion stress: antiulcer effects of tetraprenylacetone.
PubMed:[Effect of teprenone and H2-receptor antagonists on phosphatidylcholine synthesis in the isolated guinea pig gastric glands].
PubMed:Geranyl-geranyl acetone: a novel stimulant of secretin release in the dog.
PubMed:Effect of tetraprenylacetone, a novel anti-ulcer agent, on healing process of ethanol-induced gastric injury in rat.
PubMed:Effect of antiulcer agents on the physicochemical properties of gastric mucus.
PubMed:The measurement of gastric mucus using a computer image processing system.
PubMed:The anti-ulcer effect in rats of ginger constituents.
PubMed:Determination of tetraprenylacetone in human plasma by high-performance liquid chromatography with fluorescence derivatization using dansylhydrazine.
PubMed:Gastric cytoprotection by tetraprenylacetone in human subjects.
PubMed:[Drug administration schedule of anti-ulcer agents to prevent recurrence of peptic ulcer; administration of synergistic drugs for protective factors in peptic ulcer--criteria of drug selection according to clinical symptoms and administration methods].
PubMed:Protection against alcohol-induced gastric mucosal injury by geranylgeranylacetone: effect of indomethacin.
PubMed:Effects of taurocholic acid/HCl alone or after pretreatment with geranylgeranylacetone on phospholipid metabolism in rat gastric mucosa.
PubMed:Enhancement of the lipid content and physical properties of gastric mucus by geranylgeranylacetone.
PubMed:Identification of urinary and microsomal metabolites of geranylgeranylacetone in rats.
PubMed:Incorporation of radioactivity into amino acids and fatty acids after administration of 14C-geranylgeranylacetone to rats.
PubMed:Advances in drug therapy for peptic ulcer disease.
PubMed:Effect of teprenone on the content of phospholipids in gastric secretion in man.
PubMed:Increasing action of teprenone, a new antiulcer agent, on high-molecular-weight glycoprotein in gastric mucus during the healing process of acetic acid-induced ulcer in rats.
PubMed:Protective action of tetraprenylacetone against ethanol-induced damage in rat gastric mucosa.
PubMed:Geranylgeranylacetone, a novel anti-ulcer drug, stimulates mucus synthesis and secretion in rat gastric cultured cells.
PubMed:Healing-promoting action of teprenone, a new antiulcer agent on acetic acid ulcer in rats.
PubMed:Serum and stomach tissue levels of geranylgeranylacetone in patients.
PubMed:Effect of geranylgeranylacetone on aspirin-induced changes in gastric glycoproteins.
PubMed:Effect of synthetic acyclic polyisoprenoids on the cold-restraint stress induced gastric ulcer in rats.
PubMed:Effect of geranylgeranylacetone (GGA) on gastric lesions induced by topical aspirin plus HCl.
PubMed:Determination of the anti-ulcer agent geranylgeranylacetone in serum by gas chromatography-mass spectrometry.
PubMed:[Study on the kinetics of mucus secreting cells in the gastrointestinal tract --effects of various drugs and hormones on the cell kinetics of the generative zone in mouse gastric mucosa].
PubMed:Effects of the antiulcer drug geranylgeranylacetone on aspirin-induced gastric ulcers in rats.
PubMed:Effects of geranylgeranylacetone on gastrointestinal secretion in rats.
PubMed:Effect of acyclic polyisoprenoids on the biosynthesis of mannose-labeled glycolipids in rat liver microsomes.
PubMed:[Effect of prostaglandin E2, cimetidine and geranyl-geranyl-acetone on rat gastric mucosal damage (author's transl)].
PubMed:Antiulcer effect of geranylgeranylacetone, a new acyclic polyisoprenoid on experimentally induced gastric and duodenal ulcers in rats.
 
Notes:
mixture of (5e,9e,13e) & (5z,9e,13e)-isomers.
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