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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for pangamic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for pangamic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | (2R,3S,4R,5R)-6-[2,2-bis[di(propan-2-yl)amino]acetyl]oxy-2,3,4,5-tetrahydroxyhexanoic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 83182 |
| Pubchem (cas): | 13149-69-4 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (2R,3S,4R,5R)-6-[2,2-bis[ | di(propan-2-yl)amino]acetyl]oxy-2,3,4,5-tetrahydroxyhexanoic acid | | | dimethyl-amino-acetyl gluconic acid | | D- | gluconic acid, 6-(bis(1-methylethyl)amino)acetate) | | D- | gluconic acid, 6-ester with N,N-dimethylglycine | | 6-(bis(bis(iso | propyl)amino)acetate)-D-gluconic acid | | | vitamin B15 |
Articles:
| PubMed:Communication and education for families dealing with end-of-life decisions. |
| PubMed:A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance - part 28. |
| PubMed:Studies on the chemical identity and biological functions of pangamic acid. |
| PubMed:[Chemotherapy of destructive pulmonary tuberculosis with antioxidants and antihypoxic agents]. |
| PubMed:[The nutritional prevention of postradiation effects]. |
| PubMed:[Effects of administration of vitamin A, B 2 and B 15 to guinea pigs during the larval stage of ascariasis on alpha-amylase activity in the lungs and kidneys]. |
| PubMed:[The prevention of neurotoxic reactions during the treatment of pulmonary tuberculosis in middle-aged and elderly patients]. |
| PubMed:Examination of toxicity of diisopropylammonium dichloracetate (DADA), remedies for cardiac diseases, toward isolated rat hepatocytes. |
| PubMed:[Pringle's adenoma of the sebaceous glands combined with vitiligo and logoneurosis]. |
| PubMed:The effect of long-term enrichment of diet with selenium, vitamin E and B15 on the activity of certain enzymes in rat brain. |
| PubMed:[The effect of pangamic acid on the course of larval ascariasis and riboflavin levels in the liver of guinea pigs]. |
| PubMed:[Combined focal scleroderma with generalized myasthenia]. |
| PubMed:[Bile secretion in chronic cholecystitis patients undergoing intragastric oxygen therapy combined with vitamin B15]. |
| PubMed:The effect of vitamin and mineral supplements and health foods on physical endurance and performance. |
| PubMed:[Oxygen therapy in the complex treatment of patients with chronic cholecystitis associated with reactive hepatitis]. |
| PubMed:[Differential treatment children who have sustained closed craniocerebral injuries]. |
| PubMed:Effect of long-term diet enrichment with selenium, vitamin E and vitamin B15 on the degree of fatty infiltration of the liver. |
| PubMed:[Existence of "pangamic acid" alias "vitamin B 15"?]. |
| PubMed:[Effect of pangamic acid on the course of larval ascariasis and vitamin C concentrations in the adrenal glands and liver of guinea pigs]. |
| PubMed:[Effect of calcium pangamate on the cholesterol index of atherogenicity in cerebral arteriosclerosis patients]. |
| PubMed:[Autopsy of a phantom: pangamic acid, alias vitamin B15]. |
| PubMed:Pangamic acid, a stamina building, antistress and anti-hyperlipidemic principle from Cicer arietinum L. |
| PubMed:[Effect of vitamin B15 on cholesterol levels in the intestinal wall of rabbits]. |
| PubMed:Effects of commercial preparations of pangamic acid (B15) on exercised rats. |
| PubMed:[Effect of oxygen therapy on liver functional indices in chronic cholecystitis]. |
| PubMed:The effect of pangamic acid on maximal treadmill performance. |
| PubMed:Critical evaluation of the current studies on pangamic acid--vitamin B15. |
| PubMed:Mutagenicity of diisopropylamine dichloroacetate, the "active constituent" of vitamin B15 (pangamic acid). |
| PubMed:Vitamins and cancer prevention: issues and dilemmas. |
| PubMed:[Effect of calcium pangamate on catecholamine metabolism in rheumatoid arthritis patients]. |
| PubMed:[Reflections on some vitamins and a modern vitaminology]. |
| PubMed:[Effect of orotic acid, calcium pangamate, and lipamide on ultrastructural changes in lipocytes in hepatic dystrophy]. |
| PubMed:Effects of pangamic acid (B-15) ingestion on metabolic response to exercise. |
| PubMed:[Effect of methionine and vitamins B12 and B15 on the content and distribution of proteins, glycogen and lipids in the hepatic lobules of chickens]. |
| PubMed:FDA's hands loosely tied. |
| PubMed:Vitamin B15--whatever it is, it won't help. |
| PubMed:Mutagenicity of dichloroacetate, an ingredient of some formulations of pangamic acid (trade-named "vitamin B15"). |
| PubMed:Mutagenicity of dimethylglycine when mixed with nitrite: possible significance in human use of pangamates. |
| PubMed:From those wonderful people who brought you laetrile. |
| PubMed:[Pathogenesis and treatment of rosacea and perioral dermatitis]. |
| PubMed:Vitamin B15. |
| PubMed:Pangamic acid ("vitamin B15"). |
| PubMed:The effects of vitamin B15 on contraction of striated muscle. |
| PubMed:FDA notes lack of evidence on pangamic acid claims. |
| PubMed:[Vitamin B15 and oxygen treatment of chronic cholecystocholangitis]. |
| PubMed:Pangamic acid ('vitamin B15'). A review. |
| PubMed:Alpha adrenergic blocking effect exerted by vitamin B15. |
| PubMed:[Use of pangamic acid in hyperlipidemia]. |
| PubMed:The application of ferrihydroxamic complexes to photocolorimetric determination of drugs. Part 2: Quantitative determination of calcium pangamate (vitamin B15) and its calcium gluconate mixtures. |
| PubMed:[Effect of pangamic acid (Calgam) in type II hyperlipidemia]. |
| PubMed:[Vitamin B15 as a choleretic agent]. |
| PubMed:[Some biochemical indices of the clinical course of infectious hepatitis (Botkin's disease) in children and the effect of vitamin B15]. |
| PubMed:[Effect of pangamic acid (vitamin B 15) on the functional state of the thyroid gland of rats during a dietary deficiency of iodine]. |
| PubMed:Participation of pangamic acid (vitamin B 15 ) in synthesis of methyl group of methionine and biosynthesis of corrinoids. |
| PubMed:[Effect of vitamin B15 on the excretion of vanilylamygdalic acid and catecholamines in cardiac ischemia]. |
| PubMed:[Effect of pangamic acid (vitamin B15) during starvation]. |
| PubMed:[Effect of vitamin B15 on blood serum transaminases in experimental disease of the liver]. |
| PubMed:[Present state of research on pangamic acid (Vitamin B 15)]. |
| PubMed:[Experience with the use of pangamic acid (vitamin B-15) in arteriosclerosis of the vessels of the brain with mental disorders]. |
| PubMed:[Effect of pangamic acid on oxidative phosphorylation in skeletal muscle mitochondria]. |
| PubMed:[Effect of galascorbin and pangamic acid on activity of oxidative enzymes of liver mitochondria of rats in experimental toxic hepatitis]. |
| PubMed:[Pangamic acid in migraine]. |
| PubMed:[Distribution of injected pangamic acid (vitamin B 15) in the organism and its effect on oxidative metabolism of the brain]. |
| PubMed:[Effect of galascorbin and pangamic acid on some indices of energy metabolism of mitochondria of livers from rats with experimental toxic hepatitis]. |
| PubMed:[Mechanism of the effect of physical work on cholesterol metabolism. Effect of prolonged administration of pangamic acid (vitamin B 15) on muscle chemism]. |
| PubMed:[Effect of pangamic acid on biochemical changes in the blood and tissues of aging organisms during muscular exertion and rest]. |
| PubMed:[Vitamin B15 therapy in diabetes mellitus]. |
| PubMed:Partial characterization of synthetic pangamic acid vitamin B 15. |
| PubMed:[Effect of pangamic acid on experimental myocarditis in rabbits]. |
| PubMed:[The effect of vitamin B15 on the cholinesterase-acetylcholine system in exudative diathesis]. |
| PubMed:[The effect of diisopropyl-ammonium dichloroacetate--a pangamic acid synthetic analogue (vitamin B 15)--on some metabolic indices in experimental toxic chronic hepatitis]. |
| PubMed:[Pangamic acid--vitamin B 15 (clinical review)]. |
| PubMed:[The effect of pangamic acid, methionine and of combinations of calcium gluconate and glycine on biochemical changes in the blood of sportsmen performing physical exercises]. |
| PubMed:The effect of pangamic acid on fatty liver in experimental alcohol intoxication. |
| PubMed:[Effect of pangamic acid (vitamin B 15) on the efficiency of experimental training]. |
| PubMed:[An analysis of the effect of pangamic acid on lipid metabolism during muscular efforts]. |
| PubMed:[Experiences with the use of vitamin B15 in the treatment of certain diseases of the liver]. |
| PubMed:Pangamic acid (vitamin B 15, pangametin, sopangamine): Its composition and determination in pharmaceutical dosage forms. |
| PubMed:[An analysis of the influence exerted by pangamic acid (vitamin B 15) on the carbohydrate-phosphorus metabolism in muscle activity]. |
| PubMed:[Vitamin B15 and B13 in the treatment of some skin diseases]. |
| PubMed:[Pangamic acid in migraine]. |
| PubMed:[Effect of pangamic acid, methionine and a mixture of gluconate and glycine on the metabolism in the myocardium and on the ECG during muscular activity]. |
| PubMed:PREVENTIVE EFFECT OF VITAMIN B15 IN EXPERIMENTAL FATTY INFILTRATION OF LIVER. |
| PubMed:[Psoriasis and pangamic acid (vitamin B-15)]. |
| PubMed:[Pangamic acid (vitamin B-15), its nature, properties and production]. |
| PubMed:[Pangamic acid or vitamin B-15]. |
| PubMed:Some pharmacologic properties of pangamic acid (vitamin B-15). |
| PubMed:Transmethylation in cardiopathies: the role of pangamic acid (vitamin B15). |
| PubMed:A clinical study and evaluation on pangamic acid. |
| PubMed:[Dichloroacetate of diisopropylammonium as molecule responsible for several pharmacological activities attributed to the so-called pangamic acid]. |
| PubMed:[Clinical applications of vitamin B15 or pangamic acid]. |
| PubMed:[The supposed methylating action of pangamic acid (so-called vitamin B15)]. |
| PubMed:[Pangamic acid or vitamin B15; physiological and therapeutic properties]. |
| PubMed:[Comparative clinical evaluation of the effects of the hypothetical octamethyl pangamic acid & dichloroethanoate of diisopropylammonium in dermatological pathology]. |
| PubMed:[Vitamin B15 (pangamic acid)]. |
| PubMed:[Analysis of commercial samples of vitamin B15]. |
| PubMed:[Clinical research on pangamic acid]. |
| PubMed:[Effects of pangamic acid in persons with cerebral sclerotic vascular disease]. |
| PubMed:[Pangamic acid in human therapy; pangamic acid and chronic liver diseases]. |
| PubMed:[Clinical evaluation of cardiotrophic effect of a new salt of pangamic acid]. |
| PubMed:[Pharmacological notes on pangamic acid]. |
| PubMed:[Pangamic acid in cerebral damages induced by sclerotic vasculopathy]. |
| PubMed:[Adrenal stimulation by pangamic acid and salicylic acid administered in association]. |
| PubMed:[Effect of pangamic acid on various tests of antirheumatic activity]. |
| PubMed:[Pharmacology and therapeutic role of a new biocatalase; pangamic acid or vitamin B15]. |
| PubMed:Preliminary observations in the treatment of cyanide poisoning with pangametin (vitamin B15). |
| PubMed:Preliminary observations on the therapeutic effects of pangametin (vitamin B15). |
| PubMed:The effect of administration of synthetic vitamin B15 H8 upon creatine formation in the rat. |
| PubMed:Pangamic acid (Vitamin B15) in heart disease; preliminary report of ten cases. |
| PubMed:Pangamic acid sodium: a newly isolated crystalline water-soluble factor; a preliminary report. |
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Isol. from apricot kernel, also said to be present in cereals etc. Said to be a vitamin of significance in, inter alia, hypertension control
Pangamic acid is also known as vitamin B15, but it is not widely accepted as a vitamin for it has not been shown to be essential in the human diet, and a deficiency in consumption of pangamic acid is not known to be associated with any disease.; Pangamic acid is an ester derived from gluconic acid and dimethylglycine. It was first isolated by Ernst T. Krebs from apricot kernels, and has since been identified in some foods such as pulses. Also found in rice bran & apricot kernels.
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3D/inchi