EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

4,4'-dimethoxystilbene
bianisal

Supplier Sponsors

Name:1-methoxy-4-[(E)-2-(4-methoxyphenyl)ethenyl]benzene
CAS Number: 4705-34-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:225-189-9
FDA UNII: Search
Nikkaji Web:J407.926D
XlogP3-AA:4.10 (est)
Molecular Weight:240.30192000
Formula:C16 H16 O2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 2.664 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
4,4'-Dimethoxystilbene
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for 4,4'-dimethoxystilbene usage levels up to:
 not for fragrance use.
 
Recommendation for 4,4'-dimethoxystilbene flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :641296
National Institute of Allergy and Infectious Diseases:Data
1-methoxy-4-[(E)-2-(4-methoxyphenyl)ethenyl]benzene
Chemidplus:0004705344
 
References:
 1-methoxy-4-[(E)-2-(4-methoxyphenyl)ethenyl]benzene
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):641296
Pubchem (cas):4705-34-4
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
FooDB:FDB006585
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 anise seed
Search Trop Picture
 
Synonyms:
 bianisal
 bianisylidene
para,para'-dimethoxystilbene
1,1'-(1,2-ethene diyl) bis(4-methoxybenzene)
1-methoxy-4-[(E)-2-(4-methoxyphenyl)ethenyl]benzene
 photoanethole
 

Articles:

PubMed:Chemical constituents and biological studies of the leaves of Grevillea robusta.
PubMed:[The effect of oxidized glutathione and its pharmacological analogue, glutoxim, on intracellular Ca2+ concentration in macrophages].
PubMed:Tyrosine phosphorylation / dephosphorylation balance is involved in thrombin-evoked microtubular reorganisation in human platelets.
PubMed:Effect of protein kinase inhibitors on protein phosphorylation and germination of aerial spores from Streptomyces coelicolor.
PubMed:Tyrosine kinase inhibitor, methyl 2,5-dihydromethylcinnimate, induces PML nuclear body formation and apoptosis in tumor cells.
PubMed:Dual effect of hydrogen peroxide on store-mediated calcium entry in human platelets.
PubMed:Regulation of K-Cl cotransport by Syk and Src protein tyrosine kinases in deoxygenated sickle cells.
PubMed:Synthesis and cytotoxicity of some rigid derivatives of methyl 2,5-dihydroxycinnamate.
PubMed:Endothelin-induced myoplasmic Ca2+ responses and tyrosine phosphorylation in coronary smooth muscle.
PubMed:Renal proximal tubular cell growth and differentiation are differentially modulated by renotropic growth factors and tyrosine kinase inhibitors.
PubMed:ATP-induced histamine release is in part related to phospholipase A2-mediated arachidonic acid metabolism in rat peritoneal mast cells.
PubMed:Influence of hepatocyte growth factor, epidermal growth factor, and mycophenolic acid on endothelin-1 synthesis in human endothelial cells.
PubMed:Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors.
PubMed:Tyrosine kinases activate store-mediated Ca2+ entry in human platelets through the reorganization of the actin cytoskeleton.
PubMed:Tyrosine kinase-regulated small GTPase translocation and the activation of phospholipase D in HL60 granulocytes.
PubMed:The role of tyrosine kinases in capacitative calcium influx-mediated aldosterone production in bovine adrenal zona glomerulosa cells.
PubMed:Differential effects of tyrosine kinase inhibitors on contraction and relaxation of the aortas of normotensive and hypertensive rats.
PubMed:Activation of mitogen activated protein kinase in human platelets by genistein.
PubMed:The adhesion of anti-CD3-activated mouse T cells to syngeneic colon adenocarcinoma cells is differentially regulated by protein tyrosine kinase-, protein kinase C-, and cAMP-dependent pathways in the effector cell.
PubMed:Adhesion of tumoricidal eosinophils to MCA-38 colon adenocarcinoma cells involves protein tyrosine kinase activation and is diminished by elevated cyclic AMP in the effector cell.
PubMed:Regulation of the renal Na-HCO3 cotransporter: IX. Modulation by insulin, epidermal growth factor and carbachol.
PubMed:Pleiotropic effects of hepatocyte growth factor in proximal tubule involve different signaling pathways.
PubMed:Signal pathways that transduce growth factor-stimulated mitogenesis in bone cells.
PubMed:Involvement of deoxygenation-induced increase in tyrosine kinase activity in sickle cell dehydration.
PubMed:Differentiating and proliferative effects of HGF in renal proximal tubular cells are mediated via different signalling pathways.
PubMed:Regulation of renal Na-HCO3 cotransporter: VIII. Mechanism Of stimulatory effect of respiratory acidosis.
PubMed:Differential regulation of human neutrophil FcgammaRIIa (CD32) and FcgammaRIIIb (CD16)-induced Ca2+ transients.
PubMed:Is tyrosine kinase activation involved in basophil histamine release in asthma due to western red cedar?
PubMed:Effects of tyrosine kinase inhibitor on the motility and ATP concentrations of fowl spermatozoa.
PubMed:Stimulatory effect of growth hormone on in vitro maturation of bovine oocytes is exerted through the cyclic adenosine 3',5'-monophosphate signaling pathway.
PubMed:Granulocyte colony-stimulating factor-induced activation of protein kinase-C in myeloid cells.
PubMed:Cell differentiation and cell-cycle alterations by tyrosine kinase inhibitors in human melanoma cells.
PubMed:Human monocytes maintained in culture acquire functional responsiveness to platelet-activating factor that is independent of increases in protein tyrosine phosphorylation.
PubMed:Suppression of tyrosine kinase activity inhibits [3H]thymidine uptake in cultured human pituitary tumor cells.
PubMed:Inhibition of protein tyrosine kinases or protein kinase C prevents nonspecific killer T lymphocyte-mediated tumoricidal activity.
PubMed:Differential effects of the tyrosine kinase inhibitors on collagen type 1-induced platelet aggregation and adhesion to this protein.
PubMed:Tyrosine kinase, phosphatidylinositol 3-kinase, and protein kinase C regulate insulin-stimulated NaCl absorption in the thick ascending limb.
PubMed:Protein tyrosine kinase, mitogen-activated protein kinase and protein kinase C are involved in the mitogenic signaling of platelet-activating factor (PAF) in HEC-1A cells.
PubMed:[Phenylarsine oxide, a tyrosine phosphatase inhibitor, induces an increase in the intracellular concentration of calcium in rat peritoneal macrophages and human fibroblasts].
PubMed:[Effect of tyrosine kinase and tyrosine phosphatase inhibitors on ATP- and thapsigargin-induced CA2+ entry in rat peritoneal macrophages].
PubMed:Epidermal growth factor-stimulated production of esterified 13(S)-hydroxyoctadecadienoic acid is associated with tumor suppressor phenotype in Syrian hamster embryo fibroblasts.
PubMed:The tyrosine kinase inhibitor methyl 2,5-dihydroxycinnimate disrupts changes in the actin cytoskeleton required for neurite formation.
PubMed:Basic fibroblast growth factor stimulates phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like cells.
PubMed:Mechanism of topoisomerase II inhibition by staurosporine and other protein kinase inhibitors.
PubMed:Inhibition of the G2/M transition of the cell cycle by methyl-2,5-dihydroxycinnamate in human lymphoid cells.
PubMed:Thapsigargin-induced calcium influx in the absence of detectable tyrosine phosphorylation in human platelets.
PubMed:Cell protein cross-linking by erbstatin and related compounds.
PubMed:Molecular insights into the anticoagulant-induced spontaneous activation of platelets in whole blood-various anticoagulants are not equal.
PubMed:Inhibition of cytokine-inducible nitric oxide synthase in rat microglia and murine macrophages by methyl-2,5-dihydroxycinnamate.
PubMed:Inhibition of invasion and intraerythrocytic development of Plasmodium falciparum by kinase inhibitors.
PubMed:Protein tyrosine kinase inhibitors promote amylase secretion and inhibit ornithine decarboxylase induction in sialagogue-stimulated rat parotid explants.
PubMed:Attenuation of endothelin-1-induced calcium response by tyrosine kinase inhibitors in vascular smooth muscle cells.
PubMed:Regulation of 13(S)-hydroxyoctadecadienoic acid biosynthesis in Syrian hamster embryo fibroblasts by the epidermal growth factor receptor tyrosine kinase.
PubMed:Tyrosine kinase-dependent release of an adenovirus preterminal protein complex from the nuclear matrix.
PubMed:Protein tyrosine kinase inhibitors prevent didemnin B-induced apoptosis in HL-60 cells.
PubMed:Induction of interleukin-6 after stimulation of human B-cell CD21 by Epstein-Barr virus glycoproteins gp350 and gp220.
PubMed:Protein tyrosine phosphorylation in equine platelets: the effect of stimulation by thrombin and platelet-activating factor (PAF)
PubMed:The erbstatin analogue methyl 2,5-dihydroxycinnamate cross-links proteins and is cytotoxic to normal and neoplastic epithelial cells by a mechanism independent of tyrosine kinase inhibition.
PubMed:Possible role of protein kinase C in the regulation of intracellular stability of focal adhesion kinase in mouse 3T3 cells.
PubMed:Capacitative Ca2+ influx and a Ca2+-dependent nonselective cation pathway are discriminated by genistein in mouse pancreatic acinar cells.
PubMed:bFGF promotes functional expression of transient outward currents in cultured neonatal rat ventricular cells.
PubMed:Effect of platelet-derived growth factor on phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like cells.
PubMed:Tyrosine kinase inhibitors inhibit multiple steps of the cell cycle of vascular smooth muscle cells.
PubMed:Ligation of endothelial alpha v beta 3 integrin increases capillary hydraulic conductivity of rat lung.
PubMed:Changes associated with tyrosine phosphorylation during short-term hypoxia in retinal microvascular endothelial cells in vitro.
PubMed:EGF and TPA stimulate de novo synthesis of PGHS-1 and PGHS-2 through different signal transduction pathways.
PubMed:Effects of protein tyrosine kinase inhibitors with different modes of action on topoisomerase activity and death of IL-2-dependent CTLL-2 cells.
PubMed:Tyrosine kinase inhibitors regulate serotonin uptake in platelets.
PubMed:Characterization of the swelling-induced alkalinization of endocytotic vesicles in fluorescein isothiocyanate-dextran-loaded rat hepatocytes.
PubMed:Modulation of T cell morphology and induction of homotypic adhesion by a protein tyrosine kinase inhibitor.
PubMed:The effect of tyrosine kinase inhibition on phorbol 12,13-dibutyrate- and ionomycin-induced LH and GH release.
PubMed:Alpha 2-adrenoceptor-mediated vasoconstriction requires a tyrosine kinase.
PubMed:Effect of tyrosine kinase inhibitors on luteinizing hormone-releasing hormone (LHRH)-induced gonadotropin release from the anterior pituitary.
PubMed:The Ca2+ signaling capacity of the beta 2-integrin on HL60-granulocytic cells is abrogated following phosphorylation of its CD18-chain: relation to impaired protein tyrosine phosphorylation.
PubMed:Differential release of histamine and prostaglandin D2 in rat peritoneal mast cells: roles of cytosolic calcium and protein tyrosine kinases.
PubMed:Cell spreading in Colo 201 by staurosporin is alpha 3 beta 1 integrin-mediated with tyrosine phosphorylation of Src and tensin.
PubMed:Phospholipase C-dependent activation of tyrosine kinases by LHRH in alpha T3-1 cells, and its role in LHRH priming of inositol phosphate production.
PubMed:Tyrosine kinase may participate in Ca2+ entry for endothelial nitric oxide production.
PubMed:Role for tyrosine kinases in carbachol-regulated Ca entry into colonic epithelial cells.
PubMed:The tyrosine kinase inhibitors, genistein and methyl 2,5-dihydroxycinnamate, inhibit the release of (3H)arachidonate from human platelets stimulated by thrombin or collagen.
PubMed:Induction of 12-lipoxygenase expression by epidermal growth factor is mediated by protein kinase C in A431 cells.
PubMed:Effect of tyrosine kinase inhibition on basal and epidermal growth factor-stimulated human Caco-2 enterocyte sheet migration and proliferation.
PubMed:Tyrosine kinase inhibitors attenuate "capacitative" Ca2+ influx in rat pancreatic acinar cells.
PubMed:Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors.
PubMed:Protein tyrosine kinase inhibitors inhibit chemotaxis of vascular smooth muscle cells.
PubMed:Tyrphostins inhibit secretagogue-induced 1,4,5-IP3 production and amylase release in pancreatic acini.
PubMed:Tyrosine kinase inhibitors impair fibroblast growth factor signaling in coronary endothelial cells.
PubMed:A sensitive colorimetric assay for the release of tryptase from human lung mast cells in vitro.
PubMed:Induction of mouse thymocyte apoptosis by inhibitors of tyrosine kinases is associated with dephosphorylation of nuclear proteins.
PubMed:Depression of neuronal protein synthesis initiation by protein tyrosine kinase inhibitors.
PubMed:Association of insulin-like growth-factor-I-induced DNA synthesis with phosphorylation and nuclear exclusion of p53 in human breast cancer MCF-7 cells.
PubMed:Benzoquinoid tyrosine kinase inhibitors are potent blockers of cardiac muscarinic receptor function.
PubMed:ADP- and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human platelets.
PubMed:Inhibition of bradykinin- and thapsigargin-induced Ca2+ entry by tyrosine kinase inhibitors.
PubMed:The tyrosine kinase inhibitors methyl 2,5-dihydroxycinnamate and genistein reduce thrombin-evoked tyrosine phosphorylation and Ca2+ entry in human platelets.
PubMed:Crystal-induced protein tyrosine phosphorylation in neutrophils and the effect of a tyrosine kinase inhibitor on neutrophil responses.
PubMed:Inhibition of Abelson oncogene function by erbstatin analogues.
PubMed:Inhibition of epidermal growth factor receptor functions by tyrosine kinase inhibitors in NIH3T3 cells.
PubMed:Role of tyrosine kinases in IgE-mediated signal transduction in human lung mast cells and basophils.
PubMed:Involvement of tyrosine kinase and protein kinase C in platelet-activating-factor-induced c-fos gene expression in A-431 cells.
PubMed:Synergistic induction of erythroid differentiation of mouse erythroleukemia (MEL) cells by inhibitors of topoisomerases and protein tyrosine kinases.
PubMed:Induction of morphological change by tyrosine kinase inhibitors in Rous sarcoma virus-transformed rat kidney cells.
PubMed:Effects of inhibitors of protein tyrosine kinase activity and/or phosphatidylinositol turnover on differentiation of some human myelomonocytic leukemia cells.
PubMed:Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors.
 
Notes:
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