astacin, 514-76-1

Articles:

PubMed:Global Transcriptome Analysis of the Tentacle of the Jellyfish Cyanea capillata Using Deep Sequencing and Expressed Sequence Tags: Insight into the Toxin- and Degenerative Disease-Related Transcripts.

PubMed:Sturgeon hatching enzyme and the mechanism of egg envelope digestion: Insight into changes in the mechanism of egg envelope digestion during the evolution of ray-finned fish.

PubMed:Brown spider (Loxosceles genus) venom toxins: Evaluation of biological conservation by immune cross-reactivity.

PubMed:Membrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors.

PubMed:Origin and Diversification of Meprin Proteases.

PubMed:Expression, purification and initial characterization of human meprin β from Pichia pastoris.

PubMed:Proteomics of ionomycin-induced ascidian sperm reaction: Released and exposed sperm proteins in the ascidian Ciona intestinalis.

PubMed:The venomous cocktail of the vampire snail Colubraria reticulata (Mollusca, Gastropoda).

PubMed:Metalloproteinases: A parade of functions in matrix biology and an outlook for the future.

PubMed:Draft genome of neurotropic nematode parasite Angiostrongylus cantonensis, causative agent of human eosinophilic meningitis.

PubMed:Biochemical, transcriptomic and proteomic analyses of digestion in the scorpion Tityus serrulatus: insights into function and evolution of digestion in an ancient arthropod.

PubMed:Identification of the Mamestra configurata (Lepidoptera: Noctuidae) peritrophic matrix proteins and enzymes involved in peritrophic matrix chitin metabolism.

PubMed:A highly conserved, inhibitable astacin metalloprotease from Teladorsagia circumcincta is required for cuticle formation and nematode development.

PubMed:A novel mechanism of latency in matrix metalloproteinases.

PubMed:Plectreurys tristis venome: A proteomic and transcriptomic analysis.

PubMed:Xhe2 is a member of the astacin family of metalloproteases that promotes Xenopus hatching.

PubMed:Comparison of hatching mode in pelagic and demersal eggs of two closely related species in the order pleuronectiformes.

PubMed:Biochemical and proteomic characterisation of haemolymph serum reveals the origin of the alkali-labile phosphate (ALP) in mussel (Mytilus galloprovincialis).

PubMed:Secreted proteomes of different developmental stages of the gastrointestinal nematode Nippostrongylus brasiliensis.

PubMed:Characterization and neutralization of Nemopilema nomurai (Scyphozoa: Rhizostomeae) jellyfish venom using polyclonal antibody.

PubMed:Recent advances in the understanding of brown spider venoms: From the biology of spiders to the molecular mechanisms of toxins.

PubMed:A Drosophila protease cascade member, seminal metalloprotease-1, is activated stepwise by male factors and requires female factors for full activity.

PubMed:Structure and mechanism of a type III secretion protease, NleC.

PubMed:Physicochemical properties of the modeled structure of astacin metalloprotease moulting enzyme NAS-36 and mapping the druggable allosteric space of Heamonchus contortus, Brugia malayi and Ceanorhabditis elegans via molecular dynamics simulation.

PubMed:Functional similarity and molecular divergence of a novel reproductive transcriptome in two male-pregnant Syngnathus pipefish species.

PubMed:Spit and venom from scytodes spiders: a diverse and distinct cocktail.

PubMed:Comparative analysis of binding sites of human meprins with hydroxamic acid derivative by molecular dynamics simulation study.

PubMed:Meprin-β regulates production of pro-inflammatory factors via a disintegrin and metalloproteinase-10 (ADAM-10) dependent pathway in macrophages.

PubMed:SAS1B protein [ovastacin] shows temporal and spatial restriction to oocytes in several eutherian orders and initiates translation at the primary to secondary follicle transition.

PubMed:Differential metalloprotease content and activity of three Loxosceles spider venoms revealed using two-dimensional electrophoresis approaches.

PubMed:[Structural properties and functional importance of metzincin metalloproteinases].

PubMed:Potential tumor biomarkers identified in ovarian cyst fluid by quantitative proteomic analysis, iTRAQ.

PubMed:Meprin A metalloproteinase and its role in acute kidney injury.

PubMed:Molecular cloning and characterisation of in vitro immune response against astacin-like metalloprotease Ace-MTP-2 from Ancylostoma ceylanicum.

PubMed:Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3.

PubMed:Functional and structural insights into astacin metallopeptidases.

PubMed:An oocyte-specific astacin family protease, alveolin, is released from cortical granules to trigger egg envelope hardening during fertilization in medaka (Oryzias latipes).

PubMed:Meprinα transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration.

PubMed:Theoretical investigation of astacin proteolysis.

PubMed:Attenuated BMP1 function compromises osteogenesis, leading to bone fragility in humans and zebrafish.

PubMed:Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy.

PubMed:Molecular cloning and characterization of hatching enzyme-like geneII (BmHELII) in the silkworm, Bombyx mori.

PubMed:Differential expression profiling of orange-spotted grouper larvae, Epinephelus coioides (Hamilton), that survived a betanodavirus outbreak.

PubMed:Metal preferences of zinc-binding motif on metalloproteases.

PubMed:Astacin-like metallo-endopeptidase is dynamically expressed in embryonic stem cells and embryonic epithelium during morphogenesis.

PubMed:The Drosophila melanogaster seminal fluid protease "seminase" regulates proteolytic and post-mating reproductive processes.

PubMed:Expression profiling, gene silencing and transcriptional networking of metzincin metalloproteases in the cattle tick, Rhipicephalus (Boophilus) microplus.

PubMed:Identification of a mutation causing deficient BMP1/mTLD proteolytic activity in autosomal recessive osteogenesis imperfecta.

PubMed:Life cycle stage-resolved proteomic analysis of the excretome/secretome from Strongyloides ratti--identification of stage-specific proteases.

PubMed:First transcriptome of the testis-vas deferens-male accessory gland and proteome of the spermatophore from Dermacentor variabilis (Acari: Ixodidae).

PubMed:Spinning gland transcriptomics from two main clades of spiders (order: Araneae)--insights on their molecular, anatomical and behavioral evolution.

PubMed:Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates.

PubMed:Bone morphogenetic protein (BMP)1-3 enhances bone repair.

PubMed:Strongyloides stercoralis excretory/secretory protein strongylastacin specifically recognized by IgE antibodies in infected human sera.

PubMed:Transcripts analysis of infective larvae of an intestinal nematode, Strongyloides venezuelensis.

PubMed:Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases.

PubMed:The astacin metalloprotease moulting enzyme NAS-36 is required for normal cuticle ecdysis in free-living and parasitic nematodes.

PubMed:Intron-loss evolution of hatching enzyme genes in Teleostei.

PubMed:Crystal structure of zebrafish hatching enzyme 1 from the zebrafish Danio rerio.

PubMed:Astacin proteases cleave dentin sialophosphoprotein (Dspp) to generate dentin phosphoprotein (Dpp).

PubMed:Cloning, characterisation and heterologous expression of an astacin metalloprotease, Sc-AST, from the entomoparasitic nematode Steinernema carpocapsae.

PubMed:A novel expression profile of the Loxosceles intermedia spider venomous gland revealed by transcriptome analysis.

PubMed:Processing of procollagen III by meprins: new players in extracellular matrix assembly?

PubMed:First evidence of bone morphogenetic protein 1 expression and activity in sheep ovarian follicles.

PubMed:Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity.

PubMed:Proenzyme structure and activation of astacin metallopeptidase.

PubMed:Hatching mechanism of the Chinese soft-shelled turtle Pelodiscus sinensis.

PubMed:Characterization of the astacin family of metalloproteases in C. elegans.

PubMed:Collagen processing and cuticle formation is catalysed by the astacin metalloprotease DPY-31 in free-living and parasitic nematodes.

PubMed:Astacin-like metalloproteases are a gene family of toxins present in the venom of different species of the brown spider (genus Loxosceles).

PubMed:Activation of mammalian Tolloid-like 1 expression by hypoxia in human neuroblastoma SH-SY5Y cells.

PubMed:A meprin inhibitor suppresses atherosclerotic plaque formation in ApoE-/- mice.

PubMed:Acclimatory responses of the Daphnia pulex proteome to environmental changes. II. Chronic exposure to different temperatures (10 and 20 degrees C) mainly affects protein metabolism.

PubMed:Ecological function of myroilysin, a novel bacterial M12 metalloprotease with elastinolytic activity and a synergistic role in collagen hydrolysis, in biodegradation of deep-sea high-molecular-weight organic nitrogen.

PubMed:Tolliod-like gene in Crassostrea ariakensis: Molecular cloning, structural characterization and expression by RLO stimulation.

PubMed:[The astacin family of metalloproteinases].

PubMed:News from an ancient world: two novel astacin metalloproteases from the horseshoe crab.

PubMed:Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.

PubMed:Special issue: metzincin metalloproteinases.

PubMed:Meprins, membrane-bound and secreted astacin metalloproteinases.

PubMed:A novel 2D-based approach to the discovery of candidate substrates for the metalloendopeptidase meprin.

PubMed:Analysis of genes isolated from plated hemocytes of the Pacific oyster, Crassostreas gigas.

PubMed:The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion.

PubMed:Identification of softness syndrome-associated candidate genes and DNA sequence variation in the sea squirt, Halocynthia roretzi.

PubMed:Comparative expression and tissue distribution analyses of astacin-like squid metalloprotease in squid and cuttlefish.

PubMed:cDNA microarray analyses reveal candidate marker genes for the detection of ascidian disease in Korea.

PubMed:Biotechnological applications of brown spider (Loxosceles genus) venom toxins.

PubMed:The midgut transcriptome of Lutzomyia longipalpis: comparative analysis of cDNA libraries from sugar-fed, blood-fed, post-digested and Leishmania infantum chagasi-infected sand flies.

PubMed:Identifying common metalloprotease inhibitors by protein fold types using Fourier transform mass spectrometry.

PubMed:Identification of midgut microvillar proteins from Tenebrio molitor and Spodoptera frugiperda by cDNA library screenings with antibodies.

PubMed:Identification, cloning, expression and functional characterization of an astacin-like metalloprotease toxin from Loxosceles intermedia (brown spider) venom.

PubMed:Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio.

PubMed:The protease domain of procollagen C-proteinase (BMP1) lacks substrate selectivity, which is conferred by non-proteolytic domains.

PubMed:Microarray analyses of newborn mouse ovaries lacking Nobox.

PubMed:Identification and characterization of onchoastacin, an astacin-like metalloproteinase from the filaria Onchocerca volvulus.

PubMed:Compartmentalised expression of meprin in small intestinal mucosa: enhanced expression in lamina propria in coeliac disease.

PubMed:Molecular cloning and characterization of Ac-MTP-2, an astacin-like metalloprotease released by adult Ancylostoma caninum.

PubMed:Pf-ALMP, a novel astacin-like metalloproteinase with cysteine arrays, is abundant in hemocytes of pearl oyster Pinctada fucata.

PubMed:Gene cooption without duplication during the evolution of a male-pregnancy gene in pipefish.

PubMed:Predicted seminal astacin-like protease is required for processing of reproductive proteins in Drosophila melanogaster.

PubMed:Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin.

PubMed:Protease domain glycans affect oligomerization, disulfide bond formation, and stability of the meprin A metalloprotease homo-oligomer.

PubMed:Evolution of teleostean hatching enzyme genes and their paralogous genes.

PubMed:cDNA cloning, purification and properties of Paralithodes camtschatica metalloprotease.

PubMed:The interaction of recombinant subdomains of the procollagen C-proteinase with procollagen I provides a quantitative explanation for functional differences between the two splice variants, mammalian tolloid and bone morphogenetic protein 1.

PubMed:Developmental roles of the BMP1/TLD metalloproteinases.

PubMed:Characterization of astaxanthin esters in Haematococcus pluvialis by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.

PubMed:A survey of the intestinal transcriptomes of the hookworms, Necator americanus and Ancylostoma caninum, using tissues isolated by laser microdissection microscopy.

PubMed:Evolution of astacin-like metalloproteases in animals and their function in development.

PubMed:Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains.

PubMed:Overexpression and mechanistic characterization of blastula protease 10, a metalloprotease involved in sea urchin embryogenesis and development.

PubMed:Astacin family metallopeptidases and serine peptidase inhibitors in spider digestive fluid.

PubMed:Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration.

PubMed:Biomimetic zinc funnel complexes based on calix[6]N3ArO ligands: an acid-base switch for guest binding.

PubMed:Expression and tissue distribution of astacin-like squid metalloprotease (ALSM).

PubMed:Cloning of a quail homologue of hatching enzyme: its conserved function and additional function in egg envelope digestion.

PubMed:Identification of an astacin-like metallo-proteinase transcript from the infective larvae of Strongyloides stercoralis.

PubMed:cimp1, a novel astacin family metalloproteinase gene from East African cichlids, is differentially expressed between species during growth.

PubMed:Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1).

PubMed:Molecular analysis of astacin-like metalloproteases of Ostertagia ostertagi.

PubMed:Gene interactions in Caenorhabditis elegans define DPY-31 as a candidate procollagen C-proteinase and SQT-3/ROL-4 as its predicted major target.

PubMed:Metalloproteases with EGF, CUB, and thrombospondin-1 domains function in molting of Caenorhabditis elegans.

PubMed:Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish.

PubMed:Structure and developmental expression of hatching enzyme genes of the Japanese eel Anguilla japonica: an aspect of the evolution of fish hatching enzyme gene.

PubMed:Solubility properties of a 65-kDa peptide prepared by restricted digestion of myosin with astacin-like squid metalloprotease.

PubMed:Purification and cloning of an endogenous protein inhibitor of carp nephrosin, an astacin metalloproteinase.

PubMed:The astacin protein family in Caenorhabditis elegans.

PubMed:The role of the matrix metalloproteinases in human endometrial and ovarian cycles.

PubMed:Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors.

PubMed:Meprin proteolytic complexes at the cell surface and in extracellular spaces.

PubMed:Phorbol 12-myristate 13-acetate-induced ectodomain shedding and phosphorylation of the human meprinbeta metalloprotease.

PubMed:Critical amino acids in the active site of meprin metalloproteinases for substrate and peptide bond specificity.

PubMed:Differences in the activation mechanism between the alpha and beta subunits of human meprin.

PubMed:Characterization and cloning of metallo-proteinase in the excretory/secretory products of the infective-stage larva of Trichinella spiralis.

PubMed:Expression of meprins in health and disease.

PubMed:The Cu(II) acetate complex of the heteroscorpionate ligand (2-hydroxy-3-t-butyl-methylphenyl)bis(3,5-dimethylpyrazolyl)methane: a structural model for copper-substituted serralysin and astacin.

PubMed:Mammalian tolloid metalloproteinase, and not matrix metalloprotease 2 or membrane type 1 metalloprotease, processes laminin-5 in keratinocytes and skin.

PubMed:Activation mechanism of pro-astacin: role of the pro-peptide, tryptic and autoproteolytic cleavage and importance of precise amino-terminal processing.

PubMed:Zinc ligands in an astacin family metalloprotease meprin A.

PubMed:Cloning and biochemical characterization of astacin-like squid metalloprotease.

PubMed:Human meprin beta: O-linked glycans in the intervening region of the type I membrane protein protect the C-terminal region from proteolytic cleavage and diminish its secretion.

PubMed:Structure, expression, and developmental function of early divergent forms of metalloproteinases in hydra.

PubMed:Activation of human meprin-alpha in a cell culture model of colorectal cancer is triggered by the plasminogen-activating system.

PubMed:Purification and Biochemical Characterization of the Hatching Enzyme from Xenopus laevis.

PubMed:The 1.35 A structure of cadmium-substituted TM-3, a snake-venom metalloproteinase from Taiwan habu: elucidation of a TNFalpha-converting enzyme-like active-site structure with a distorted octahedral geometry of cadmium.

PubMed:Mechanistic studies of the astacin-like Serratia metalloendopeptidase serralysin: highly active (>2000%) Co(II) and Cu(II) derivatives for further corroboration of a "metallotriad" mechanism.

PubMed:Arylamidase activity of neutral proteinase from Saccharomonospora canescens. Comparison with other Zn-proteinases that exhibit the same activity.

PubMed:Characterization of the proteolytic enzymes in the midgut of the European Cockchafer, Melolontha melolontha (Coleoptera: Scarabaeidae).

PubMed:Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen.

PubMed:Expression cloning in ascidians: isolation of a novel member of the asctacin protease family.

PubMed:A developmentally regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of proteases.

PubMed:Properties of the hatching enzyme from Xenopus laevis.

PubMed:Simultaneous immunoblotting analysis with activity gel electrophoresis in a single polyacrylamide gel.

PubMed:Comparing protein structures: a Gaussian-based approach to the three-dimensional structural similarity of proteins.

PubMed:Activation of pro-astacin. Immunological and model peptide studies on the processing of immature astacin, a zinc-endopeptidase from the crayfish Astacus astacus.

PubMed:Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity.

PubMed:Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity.

PubMed:The roles of Glu93 and Tyr149 in astacin-like zinc peptidases.

PubMed:Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues.

PubMed:Structure and function of procollagen C-proteinase (mTolloid) domains determined by protease digestion, circular dichroism, binding to procollagen type I, and computer modeling.

PubMed:Identification and cDNA cloning of alveolin, an extracellular metalloproteinase, which induces chorion hardening of medaka (Oryzias latipes) eggs upon fertilization.

PubMed:Hydra metalloproteinase 1: a secreted astacin metalloproteinase whose apical axis expression is differentially regulated during head regeneration.

PubMed:Human N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin): genomic structure of the alpha and beta subunits.

PubMed:Identification and characterization of hydra metalloproteinase 2 (HMP2): a meprin-like astacin metalloproteinase that functions in foot morphogenesis.

PubMed:Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro.

PubMed:cDNA cloning, bacterial expression, in vitro renaturation and affinity purification of the zinc endopeptidase astacin.

PubMed:Identification of an astacin matrix metalloprotease as target gene for Hydra foot activator peptides.

PubMed:Purification and characterization of a novel isoform of myosinase from spear squid liver.

PubMed:The NTR module: domains of netrins, secreted frizzled related proteins, and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases.

PubMed:Identification and localization of MEP1A-like sequences (MEP1AL1-4) in the human genome.

PubMed:The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart.

PubMed:N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase beta (human meprinbeta). A 13-amino-acid sequence is required for proteolyticprocessing and subsequent secretion.

PubMed:A three-dimensional construction of the active site (region 507-749) of human neutral endopeptidase (EC.3.4.24.11).

PubMed:Nonpolarized secretion of human meprin alpha in colorectal cancer generates an increased proteolytic potential in the stroma.

PubMed:Regulation of BMP signaling by the BMP1/TLD-related metalloprotease, SpAN.

PubMed:Secretion of human meprin from intestinal epithelial cells depends on differential expression of the alpha and beta subunits.

PubMed:The active site structure of tetanus neurotoxin resolved by multiple scattering analysis in X-Ray absorption spectroscopy.

PubMed:A toxin homology domain in an astacin-like metalloproteinase of the jellyfish Podocoryne carnea with a dual role in digestion and development.

PubMed:Cloning and characterization of a cDNA coding for Astacus embryonic astacin, a member of the astacin family of metalloproteases from the crayfish Astacus astacus.

PubMed:Phosphinic peptides, the first potent inhibitors of astacin, behave as extremely slow-binding inhibitors.

PubMed:Reprolysins and astacins...alive, alive-o.

PubMed:Activation mechanism of meprins, members of the astacin metalloendopeptidase family.

PubMed:C-cytosolic and transmembrane domains of the N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase alpha subunit (human meprin alpha) are essential for its retention in the endoplasmic reticulum and C-terminal processing.

PubMed:Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells.

PubMed:Purification and cloning of carp nephrosin, a secreted zinc endopeptidase of the astacin family.

PubMed:Kinetic characterization of the serralysins: a divergent catalytic mechanism pertaining to astacin-type metalloproteases.

PubMed:Correlation of the exon/intron organization to the secondary structures of the protease domain of mouse meprin alpha subunit.

PubMed:Species-dependent migration of fish hatching gland cells that express astacin-like proteases in common [corrected].

PubMed:Molecular cloning of Xenopus hatching enzyme and its specific expression in hatching gland cells.

PubMed:Genomic organization of the zinc-endopeptidase astacin.

PubMed:Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid.

PubMed:Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface.

PubMed:A HhaI polymorphism in the human MEP1A gene encoding the alpha subunit of the metalloendopeptidase meprin.

PubMed:hch-1, a gene required for normal hatching and normal migration of a neuroblast in C. elegans, encodes a protein related to TOLLOID and BMP-1.

PubMed:Structure of astacin with a transition-state analogue inhibitor.

PubMed:Structure of the gene encoding the sea urchin blastula protease 10 (BP10), a member of the astacin family of Zn2+-metalloproteases.

PubMed:BMP-1 and the astacin family of metalloproteinases: a potential link between the extracellular matrix, growth factors and pattern formation.

PubMed:Characterization of a SpAN promoter sufficient to mediate correct spatial regulation along the animal-vegetal axis of the sea urchin embryo.

PubMed:The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1.

PubMed:Different exon-intron organizations of the genes for two astacin-like proteases, high choriolytic enzyme (choriolysin H) and low choriolytic enzyme (choriolysin L), the constituents of the fish hatching enzyme.

PubMed:X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily.

PubMed:Designing inhibitors of the metalloproteinase superfamily: comparative analysis of representative structures.

PubMed:X-ray absorption spectroscopy study of zinc coordination in tetanus neurotoxin, astacin, alkaline protease and thermolysin.

PubMed:A novel meprin beta' mRNA in mouse embryonal and human colon carcinoma cells.

PubMed:Mapping of the active site zinc ligands of peptide deformylase.

PubMed:Matrilysin: expression, purification, and characterization.

PubMed:Proteolytic processing of the alpha-subunit of rat endopeptidase-24.18 by furin.

PubMed:The astacin family of metalloendopeptidases.

PubMed:A 25.7 x 10(3) M(r) hydra metalloproteinase (HMP1), a member of the astacin family, localizes to the extracellular matrix of Hydra vulgaris in a head-specific manner and has a developmental function.

PubMed:Molecular cloning and sequence analysis of flavastacin: an O-glycosylated prokaryotic zinc metalloendopeptidase.

PubMed:The metzincins--topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases.

PubMed:cDNA cloning and deduced amino acid sequence of prothrombin activator (ecarin) from Kenyan Echis carinatus venom.

PubMed:Astacin.

PubMed:Characterization of tolloid-related-1: a BMP-1-like product that is required during larval and pupal stages of Drosophila development.

PubMed:The univin gene encodes a member of the transforming growth factor-beta superfamily with restricted expression in the sea urchin embryo.

PubMed:Families of zinc metalloproteases.

PubMed:The cleavage of the bait region of alpha 2-macroglobulin by human immunodeficiency virus proteinases and by astacin.

PubMed:Characterization of a membrane-bound metalloendoprotease of rat C6 glioblastoma cells.

PubMed:The crystal structure of adamalysin II, a zinc-endopeptidase from the snake venom of the eastern diamondback rattlesnake Crotalus adamanteus.

PubMed:Crystal structures of recombinant 19-kDa human fibroblast collagenase complexed to itself.

PubMed:Crystal structures, spectroscopic features, and catalytic properties of cobalt(II), copper(II), nickel(II), and mercury(II) derivatives of the zinc endopeptidase astacin. A correlation of structure and proteolytic activity.

PubMed:Refined 2.0 A X-ray crystal structure of the snake venom zinc-endopeptidase adamalysin II. Primary and tertiary structure determination, refinement, molecular structure and comparison with astacin, collagenase and thermolysin.

PubMed:Zinc content of promatrilysin, matrilysin and the stromelysin catalytic domain.

PubMed:Retrospective analysis of a secondary structure prediction: the catalytic domain of matrix metalloproteinases.

PubMed:Membrane association and oligomeric organization of the alpha and beta subunits of mouse meprin A.

PubMed:Expression of rat endopeptidase-24.18 in COS-1 cells: membrane topology and activity.

PubMed:Embryonic expression of mouse bone morphogenetic protein-1 (BMP-1), which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase.

PubMed:A kinetic comparison of the homologous proteases astacin and meprin A.

PubMed:Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation.

PubMed:Characterization of a homolog of human bone morphogenetic protein 1 in the embryo of the sea urchin, Strongylocentrotus purpuratus.

PubMed:Two domains of the tolloid protein contribute to its unusual genetic interaction with decapentaplegic.

PubMed:Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor.

PubMed:Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor.

PubMed:A new member to the astacin family of metalloendopeptidases: a novel 1,25-dihydroxyvitamin D-3-stimulated mRNA from chorioallantoic membrane of quail.

PubMed:Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells.

PubMed:Rat endopeptidase-24.18 alpha subunit is secreted into the culture medium as a zymogen when expressed by COS-1 cells.

PubMed:Assignments for the main-chain nuclear magnetic resonances and delineation of the secondary structure of the catalytic domain of human stromelysin-1 as obtained from triple-resonance 3D NMR experiments.

PubMed:The precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: structural, functional, and evolutionary implications.

PubMed:First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases.

PubMed:Cloning, expression, and chromosomal localization of the mouse meprin beta subunit.

PubMed:Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the 'metzincins'.

PubMed:Three-dimensional structure of the alkaline protease of Pseudomonas aeruginosa: a two-domain protein with a calcium binding parallel beta roll motif.

PubMed:Implications of the three-dimensional structure of astacin for the structure and function of the astacin family of zinc-endopeptidases.

PubMed:Refined 1.8 A X-ray crystal structure of astacin, a zinc-endopeptidase from the crayfish Astacus astacus L. Structure determination, refinement, molecular structure and comparison with thermolysin.

PubMed:Families of metalloendopeptidases and their relationships.

PubMed:Isolation of cDNAs for LCE and HCE, two constituent proteases of the hatching enzyme of Oryzias latipes, and concurrent expression of their mRNAs during development.

PubMed:Structure of astacin and implications for activation of astacins and zinc-ligation of collagenases.

PubMed:The alpha subunit of meprin A. Molecular cloning and sequencing, differential expression in inbred mouse strains, and evidence for divergent evolution of the alpha and beta subunits.

PubMed:The astacin family of metalloendopeptidases.

PubMed:Kinetics of nitroanilide cleavage by astacin.

PubMed:[Incidence of astacin in neonfish].

astacin

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