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butylated hydroxymethyl phenol
benzenemethanol, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-

Supplier Sponsors

Name:2,6-di-tert-butyl-4-(hydroxymethyl)phenol
CAS Number: 88-26-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:201-815-6
FDA UNII: 46ND6GQI48
Nikkaji Web:J12.804J
Beilstein Number:2052291
MDL:MFCD00017254
XlogP3-AA:4.00 (est)
Molecular Weight:236.35468000
Formula:C15 H24 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:antioxidants and stabilizers
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (SATF):88-26-6 ; 4-HYDROXYMETHYL-2,6-DI-TERTBUTYLPHENOL
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart B--Food Preservatives
Sec. 172.150 4-Hydroxymethyl-2,6-di-tert-butylphenol.


FDA PART 178 -- INDIRECT FOOD ADDITIVES: ADJUVANTS, PRODUCTION AIDS, AND SANITIZERS
Subpart C--Antioxidants and Stabilizers
Sec. 178.2550 4-Hydroxymethyl-2,6-di-tert-butylphenol.
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 306.00 to 307.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000330 mmHg @ 25.00 °C. (est)
Flash Point: 268.00 °F. TCC ( 131.20 °C. ) (est)
logP (o/w): 3.504 (est)
Soluble in:
 water, 312.6 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
3,5-Di-tert-butyl-4-hydroxybenzyl alcohol 98%
Frinton Laboratories
For experimental / research use only.
4-Hydroxymethyl-2,6-di-tert-butylphenol
Santa Cruz Biotechnology
For experimental / research use only.
butylated Hydroxymethyl Phenol
Sigma-Aldrich: Aldrich
For experimental / research use only.
3,5-Di-tert-butyl-4-hydroxybenzyl alcohol 97%
sds
TCI AMERICA
For experimental / research use only.
2,6-Di-tert-butyl-4-hydroxymethylphenol >97.0%(GC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LDLo 7000 mg/kg
Toxicology and Applied Pharmacology. Vol. 17, Pg. 669, 1970.

oral-rat LDLo 7000 mg/kg
Toxicology and Applied Pharmacology. Vol. 17, Pg. 669, 1970.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
antioxidants and stabilizers
Recommendation for butylated hydroxymethyl phenol usage levels up to:
 not for fragrance use.
 
Recommendation for butylated hydroxymethyl phenol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):88-26-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6929
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2,6-di-tert-butyl-4-(hydroxymethyl)phenol
Chemidplus:0000088266
RTECS:DO0750000 for cas# 88-26-6
 
References:
 2,6-di-tert-butyl-4-(hydroxymethyl)phenol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:88-26-6
Pubchem (cid):6929
Pubchem (sid):134972179
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB32048
FooDB:FDB008752
Export Tariff Code:2907.29.0500
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 antioxidant 754
 benzenemethanol, 3,5-bis (1,1-dimethylethyl)-4-hydroxy-
 benzenemethanol, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-
 benzyl alcohol, 3,5-di-t-butyl-4-hydroxy-
 benzyl alcohol, 3,5-di-tert-butyl-4-hydroxy-
 BHT alcohol
2,6-bis(tert-butyl)-4-(hydroxymethyl)phenol
3,5-di-t-butyl-4-hydroxybenzyl alcohol
2,6-di-t-butyl-4-hydroxymethylphenol
2,6-di-tert-butyl-4-(hydroxymethyl)benzolol
2,6-di-tert-butyl-4-(hydroxymethyl)phenol
3,5-di-tert-butyl-4-hydroxybenzyl alcohol
3,5-di-tert-butyl-4-hydroxybenzylalcohol
 di-tert-butyl-4-hydroxymethyl phenol
2,6-di-tert-butyl-4-hydroxymethyl phenol
2,6-di-tert-butyl-4-hydroxymethylphenol
3,5-bis(1,1-dimethyl ethyl)-4-hydroxybenzene methanol
2,6-bis(1,1-dimethylethyl)-4-(hydroxymethyl)phenol
3,5-bis(1,1-dimethylethyl)-4-hydroxybenzene methanol
3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenemethanol
alpha-hydroxy-2,6-di-tert-butyl-p-cresol
alpha-hydroxy-2,6-di-tert-butyl-para-cresol
4-hydroxymethyl-2,6-di-tert-butylphenol
4-hydroxymethyl-2,6-di-tertbutylphenol
4-(hydroxymethyl)-2,6-bis(2-methyl-2-propanyl)phenol
butylated hydroxymethylphenol
 ionox 100 antioxidant
 

Articles:

PubMed:Oxidation of synthetic phenolic antioxidants during water chlorination.
PubMed:Identification of phenolic dermal sensitizers in a wound closure tape.
PubMed:Comparative study on the antioxidant and biological activities of carvacrol, thymol, and eugenol derivatives.
PubMed:Simultaneous determination of five synthetic antioxidants in edible vegetable oil by GC-MS.
PubMed:The relationship between the physicochemical properties of antioxidants and their ability to inhibit lipid oxidation in bulk oil and oil-in-water emulsions.
PubMed:Antioxidants reversibly inhibit the spontaneous resumption of meiosis.
PubMed:Selective induction of apoptosis in mouse and human lung epithelial cell lines by the tert-butyl hydroxylated metabolite of butylated hydroxytoluene: a proposed role in tumor promotion.
PubMed:Contact allergy to 2-hydroxy-5-tert-butyl benzylalcohol and 2,6-bis(hydroxymethyl)-4-tert-butylphenol, components of a phenolic resin used in marking pens.
PubMed:DNA cleavage by metabolites of butylated hydroxytoluene.
PubMed:Butylated hydroxyanisole specifically inhibits tumor necrosis factor-induced cytotoxicity and growth enhancement.
PubMed:A metabolite of butylated hydroxytoluene with potent tumor-promoting activity in mouse lung.
PubMed:Oxidative metabolism of butylated hydroxytoluene by hepatic and pulmonary microsomes from rats and mice.
PubMed:Bisulfite induced lipid oxidation.
 
Notes:
Antioxidant used in foods
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