Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Assay: | 95.00 to 100.00
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Food Chemicals Codex Listed: | No |
Boiling Point: | 413.60 °C. @ 760.00 mm Hg (est)
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Flash Point: | 348.00 °F. TCC ( 175.60 °C. ) (est)
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logP (o/w): | 1.950 (est) |
Soluble in: |
| water, 1154 mg/L @ 25 °C (est) |
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
intraperitoneal-cat LD50 > 250 mg/kg GASTROINTESTINAL: NAUSEA OR VOMITING
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
BEHAVIORAL: MUSCLE WEAKNESS Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962.
intraperitoneal-dog LD50 > 200 mg/kg BEHAVIORAL: MUSCLE WEAKNESS
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
GASTROINTESTINAL: NAUSEA OR VOMITING Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962.
intraperitoneal-mouse LD50 325 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
BEHAVIORAL: ATAXIA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962.
intravenous-mouse LD50 53 mg/kg BEHAVIORAL: ANTICONVULSANT Archives Internationales de Pharmacodynamie et de Therapie. Vol. 177, Pg. 261, 1969.
oral-mouse LD50 920 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962.
intraperitoneal-rabbit LD50 350 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962.
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | natural substances and extractives |
Recommendation for dihydrokawain usage levels up to: | | not for fragrance use.
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Recommendation for dihydrokawain flavor usage levels up to: |
| not for flavor use.
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Safety References:
References:
| 4-methoxy-2-(2-phenylethyl)-2,3-dihydropyran-6-one |
NIST Chemistry WebBook: | Search Inchi |
Pubchem (cid): | 98356 |
Pubchem (sid): | 135057035 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
(S)-5,6- | dihydro-4-methoxy-6-(2-phenyl ethyl)-2H-pyran-2-one | 5,6- | dihydro-4-methoxy-6-(2-phenylethyl)-2H-pyran-2-one | | dihydrokavain | 7,8- | dihydrokawain | | kavain, dihydro- | | kawain, dihydro- | | marindinin | 4- | methoxy-2-(2-phenylethyl)-2,3-dihydropyran-6-one | 4- | methoxy-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-one | 2H- | pyran-2-one, 5,6-dihydro-4-methoxy-6-(2-phenylethyl)- | 2H- | pyran-2-one, 5,6-dihydro-4-methoxy-6-phenethyl- |
Articles:
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