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Category:stabilizing agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 97.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 309.60 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.000057 mmHg @ 25.00 °C. (est) |
| Flash Point: | 311.00 °F. TCC ( 155.20 °C. ) (est)
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| logP (o/w): | -1.721 (est) |
| Soluble in: |
| | water, 333000 mg/L @ 25 °C (exp) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-rat LD50 1724 mg/kg
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
intravenous-rabbit LD50 418 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
intravenous-mouse LD50 71 mg/kg
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
intraperitoneal-mouse LD50 1771 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
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| Dermal Toxicity: |
subcutaneous-mouse LD50 2580 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 852, 1965.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | stabilizing agents |
| Recommendation for disodium citrate usage levels up to: | | | not for fragrance use.
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| Recommendation for disodium citrate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | alkacitron | | | citralka | | | citric acid disodium salt | | | citric acid, disodium salt | | | disodium 2-(carboxymethyl)-2-hydroxysuccinate | | | disodium 2-hydroxy-1,2,3-propane tricarboxylate | | | disodium 2-hydroxy-1,2,3-propanetricarboxylate | | | disodium 3-carboxy-3-hydroxypentanedioate | | | disodium hydrogen citrate | | | disodium monohydrogen citrate | | | hydrogen sodium 2-hydroxypropane-1,2,3-tricarboxylate (1:2:1) | | 2- | hydroxy-1,2,3-propanetricarboxylic acid disodium salt | | 1,2,3- | propanetricarboxylate, 2-hydroxy-, hydrogen sodium salt (1:1:2) | | 1,2,3- | propanetricarboxylic acid, 2-hydroxy-, disodium salt | | 1,2,3- | propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:2) |
Articles:
| PubMed:Multiple long-term, experimentally-evolved populations of Escherichia coli acquire dependence upon citrate as an iron chelator for optimal growth on glucose. |
| PubMed:Chiroptical spectroscopy of natural products: avoiding the aggregation effects of chiral carboxylic acids. |
| PubMed:Production of microbial cellulose by a bacterium isolated from fruit. |
| PubMed:Influence of mixtures of calcium-chelating salts on the physicochemical properties of casein micelles. |
| PubMed:Analysis of pesticides residues in fresh produce using buffered acetonitrile extraction and aminopropyl cleanup with gas chromatography/triple quadrupole mass spectrometry, liquid chromatography/triple quadrupole mass spectrometry, gas chromatography/ion trap detector mass spectrometry, and GC with a halogen-specific detector. |
| PubMed:Extraction, partial characterization, and storage stability of β-glucosidase from propolis. |
| PubMed:Toward an understanding of the salting-out effects in aqueous ionic liquid solutions: vapor-liquid equilibria, liquid-liquid equilibria, volumetric, compressibility, and conductivity behavior. |
| PubMed:Microfluidic formation of ionically cross-linked polyamine gels. |
| PubMed:Preparation of icariside II from icariin by enzymatic hydrolysis method. |
| PubMed:Effects of pH on the textural properties and meltability of pasteurized process cheese made with different types of emulsifying salts. |
| PubMed:Extractive spectrophotometric determination of TRODAT-1 hydrochloride in lyophilized kit. |
| PubMed:Off-line HPLC method combined to LC-MS for the determination of sildenafil and its active metabolite in post-mortem human blood according to confirmation criteria. |
| PubMed:Effects of phosphates and citrates on sediment formation in UHT goats' milk. |
| PubMed:Synthesis of tetracalcium phosphate from mechanochemically activated reactants and assessment as a component of bone cements. |
| PubMed:An improved HPLC assay with fluorescence detection for the determination of domperidone and three major metabolites for application to in vitro drug metabolism studies. |
| PubMed:Desorption of copper and cadmium from soils enhanced by organic acids. |
| PubMed:Effects of additives on the rheological properties and injectability of a calcium phosphate bone substitute material. |
| PubMed:Effects of emulsifying salts on the turbidity and calcium-phosphate-protein interactions in casein micelles. |
| PubMed:[Determination of trace cobalt in water samples by graphite furnace atomic absorption spectrometry after cloud point]. |
| PubMed:Extraction behavior of metallic contaminants and soil constituents from contaminated soils. |
| PubMed:Identification of factors involved in recovery of heat-injured Salmonella Enteritidis. |
| PubMed:Influences of osmotic agents in diffusion layer on drug release from multilayer coated pellets. |
| PubMed:Regional citrate anticoagulation in continuous venovenous haemodiafiltration using commercial solutions. |
| PubMed:Influence of EDTA and citrate on physicochemical properties of whey protein-stabilized oil-in-water emulsions containing CaCl2. |
| PubMed:Alkaline CPD and the preservation of RBC 2,3-DPG. |
| PubMed:Intravenous tolerability of an acid vehicle in Sprague Dawley rats and beagle dogs after daily slow bolus injection and infusion for one hour during 14 days. |
| PubMed:Effect of salt form on chemical stability of an ester prodrug of a glycoprotein IIb/IIIa receptor antagonist in solid dosage forms. |
| PubMed:Heat resistance of Bacillus cereus spores: effects of milk constituents and stabilizing additives. |
| PubMed:Chemical stability of an ester prodrug of a glycoprotein IIb/IIIa receptor antagonist in solid dosage forms. |
| PubMed:Determination of heterocyclic amines in flame-grilled fish patty by capillary electrophoresis. |
| PubMed:In vivo viability studies of two additive solutions in the postthaw preservation of red cells held for 3 weeks at 4 degrees C. |
| PubMed:Quantification of human amniotic fluid constituents by high resolution proton nuclear magnetic resonance (NMR) spectroscopy. |
| PubMed:Importance of extracellular divalent cations to polarisation of polymorphonuclear leukocytes induced by plasma. |
| PubMed:Residues in fish exposed to sublethal doses of endosulfan and fish collected from cotton growing area. |
| PubMed:One-step extraction and cleanup procedure for determination of p,p'-DDT, p,p'-DDD, and p,p'-DDE in fish. |
| PubMed:Effects of different anticoagulants on human platelet size distribution and serotonin (5-HT) induced shape change and uptake kinetics. |
| PubMed:High-performance liquid chromatography with amperometric detection of plasma L-3,4-dihydroxyphenylalanine in Parkinsonian patients. |
| PubMed:In vivo study of the influence of adenine and guanosine on the erythrocytes of ACD (pH 5.0 and 5.6) preserved blood. |
| PubMed:Effects of sodium picosulfate and other laxatives in cultured Chang cells. |
| PubMed:Zinc-iodide-osmium procedures as markers of subcellular structures. I. Standardization of staining of transmitter containing vesicles. |
| PubMed:Aggregation of calcium oxalate crystals: effect of urine and various inhibitors. |
| PubMed:Some properties of p-coumarate decarboxylase from Cladosporium phlei. |
| PubMed:The effect of citric acid and its sodium salts in test meals on the gastric outputs of acid and of chloride. |
| PubMed:Inhibition of Rh agglutination by disodium hydrogen citrate. |
| PubMed:Disodium-Citrate-Glucose Mixture as a Blood Preservative. |
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Preservative
Disodium citrate, or disodium hydrogen citrate, is a sodium acid salt of citric acid (sodium citrate) with the chemical formula Na2HC6H5O7, or Na2H(C3H5O(COO)3). It is one of the 3 citric acid salts. It is used as an antioxidant in food as well as to improve the effects of other antioxidants. It is also used as an acidity regulator and sequestrant. Typical products include gelatin, jam, sweets, ice cream, carbonated beverages, milk powder, wine, and processed cheeses. (Wikipedia)
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3D/inchi