EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

disodium citrate
1,2,3-propanetricarboxylate, 2-hydroxy-, hydrogen sodium salt (1:1:2)

Supplier Sponsors

Name:disodium 3-carboxy-3-hydroxypentanedioate
CAS Number: 144-33-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:205-623-3
FDA UNII:6FO62KCQ7A
Nikkaji Web:J2.344.233G
MDL:MFCD00036367
Molecular Weight:236.08775856
Formula:C6 H6 Na2 O7
NMR Predictor:Predict (works with chrome or firefox)
Category:stabilizing agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (SATF):144-33-2 ; DISODIUM CITRATE
FDA Regulation:
FDA PART 181 -- PRIOR-SANCTIONED FOOD INGREDIENTS
Subpart B--Specific Prior-Sanctioned Food Ingredients
Sec. 181.29 Stabilizers.
 
Physical Properties:
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 309.60 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000057 mmHg @ 25.00 °C. (est)
Flash Point: 311.00 °F. TCC ( 155.20 °C. ) (est)
logP (o/w): -1.721 (est)
Soluble in:
 water, 333000 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Disodium citrate ≥98%
Santa Cruz Biotechnology
For experimental / research use only.
Disodium Citrate ≥98%
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50 1724 mg/kg
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.

intravenous-rabbit LD50 418 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.

intravenous-mouse LD50 71 mg/kg
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.

intraperitoneal-mouse LD50 1771 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.

Dermal Toxicity:
subcutaneous-mouse LD50 2580 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 852, 1965.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: stabilizing agents
Recommendation for disodium citrate usage levels up to:
 not for fragrance use.
 
Recommendation for disodium citrate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NLM Hazardous Substances Data Bank:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):144-33-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8950
National Institute of Allergy and Infectious Diseases:Data
disodium 3-carboxy-3-hydroxypentanedioate
Chemidplus:0000144332
RTECS:GE7580000 for cas# 144-33-2
 
References:
 disodium 3-carboxy-3-hydroxypentanedioate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:144-33-2
Pubchem (cid):8950
Pubchem (sid):134974252
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):Search
FooDB:FDB020549
FDA Listing of Food Additive Status:View
Haz-Map:View
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 alkacitron
 citralka
 citric acid disodium salt
 citric acid, disodium salt
 disodium 2-(carboxymethyl)-2-hydroxysuccinate
 disodium 2-hydroxy-1,2,3-propane tricarboxylate
 disodium 2-hydroxy-1,2,3-propanetricarboxylate
 disodium 3-carboxy-3-hydroxypentanedioate
 disodium hydrogen citrate
 disodium monohydrogen citrate
 hydrogen sodium 2-hydroxypropane-1,2,3-tricarboxylate (1:2:1)
2-hydroxy-1,2,3-propanetricarboxylic acid disodium salt
1,2,3-propanetricarboxylate, 2-hydroxy-, hydrogen sodium salt (1:1:2)
1,2,3-propanetricarboxylic acid, 2-hydroxy-, disodium salt
1,2,3-propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:2)
 

Articles:

PubMed:Multiple long-term, experimentally-evolved populations of Escherichia coli acquire dependence upon citrate as an iron chelator for optimal growth on glucose.
PubMed:Chiroptical spectroscopy of natural products: avoiding the aggregation effects of chiral carboxylic acids.
PubMed:Production of microbial cellulose by a bacterium isolated from fruit.
PubMed:Influence of mixtures of calcium-chelating salts on the physicochemical properties of casein micelles.
PubMed:Analysis of pesticides residues in fresh produce using buffered acetonitrile extraction and aminopropyl cleanup with gas chromatography/triple quadrupole mass spectrometry, liquid chromatography/triple quadrupole mass spectrometry, gas chromatography/ion trap detector mass spectrometry, and GC with a halogen-specific detector.
PubMed:Extraction, partial characterization, and storage stability of β-glucosidase from propolis.
PubMed:Toward an understanding of the salting-out effects in aqueous ionic liquid solutions: vapor-liquid equilibria, liquid-liquid equilibria, volumetric, compressibility, and conductivity behavior.
PubMed:Microfluidic formation of ionically cross-linked polyamine gels.
PubMed:Preparation of icariside II from icariin by enzymatic hydrolysis method.
PubMed:Effects of pH on the textural properties and meltability of pasteurized process cheese made with different types of emulsifying salts.
PubMed:Extractive spectrophotometric determination of TRODAT-1 hydrochloride in lyophilized kit.
PubMed:Off-line HPLC method combined to LC-MS for the determination of sildenafil and its active metabolite in post-mortem human blood according to confirmation criteria.
PubMed:Effects of phosphates and citrates on sediment formation in UHT goats' milk.
PubMed:Synthesis of tetracalcium phosphate from mechanochemically activated reactants and assessment as a component of bone cements.
PubMed:An improved HPLC assay with fluorescence detection for the determination of domperidone and three major metabolites for application to in vitro drug metabolism studies.
PubMed:Desorption of copper and cadmium from soils enhanced by organic acids.
PubMed:Effects of additives on the rheological properties and injectability of a calcium phosphate bone substitute material.
PubMed:Effects of emulsifying salts on the turbidity and calcium-phosphate-protein interactions in casein micelles.
PubMed:[Determination of trace cobalt in water samples by graphite furnace atomic absorption spectrometry after cloud point].
PubMed:Extraction behavior of metallic contaminants and soil constituents from contaminated soils.
PubMed:Identification of factors involved in recovery of heat-injured Salmonella Enteritidis.
PubMed:Influences of osmotic agents in diffusion layer on drug release from multilayer coated pellets.
PubMed:Regional citrate anticoagulation in continuous venovenous haemodiafiltration using commercial solutions.
PubMed:Influence of EDTA and citrate on physicochemical properties of whey protein-stabilized oil-in-water emulsions containing CaCl2.
PubMed:Alkaline CPD and the preservation of RBC 2,3-DPG.
PubMed:Intravenous tolerability of an acid vehicle in Sprague Dawley rats and beagle dogs after daily slow bolus injection and infusion for one hour during 14 days.
PubMed:Effect of salt form on chemical stability of an ester prodrug of a glycoprotein IIb/IIIa receptor antagonist in solid dosage forms.
PubMed:Heat resistance of Bacillus cereus spores: effects of milk constituents and stabilizing additives.
PubMed:Chemical stability of an ester prodrug of a glycoprotein IIb/IIIa receptor antagonist in solid dosage forms.
PubMed:Determination of heterocyclic amines in flame-grilled fish patty by capillary electrophoresis.
PubMed:In vivo viability studies of two additive solutions in the postthaw preservation of red cells held for 3 weeks at 4 degrees C.
PubMed:Quantification of human amniotic fluid constituents by high resolution proton nuclear magnetic resonance (NMR) spectroscopy.
PubMed:Importance of extracellular divalent cations to polarisation of polymorphonuclear leukocytes induced by plasma.
PubMed:Residues in fish exposed to sublethal doses of endosulfan and fish collected from cotton growing area.
PubMed:One-step extraction and cleanup procedure for determination of p,p'-DDT, p,p'-DDD, and p,p'-DDE in fish.
PubMed:Effects of different anticoagulants on human platelet size distribution and serotonin (5-HT) induced shape change and uptake kinetics.
PubMed:High-performance liquid chromatography with amperometric detection of plasma L-3,4-dihydroxyphenylalanine in Parkinsonian patients.
PubMed:In vivo study of the influence of adenine and guanosine on the erythrocytes of ACD (pH 5.0 and 5.6) preserved blood.
PubMed:Effects of sodium picosulfate and other laxatives in cultured Chang cells.
PubMed:Zinc-iodide-osmium procedures as markers of subcellular structures. I. Standardization of staining of transmitter containing vesicles.
PubMed:Aggregation of calcium oxalate crystals: effect of urine and various inhibitors.
PubMed:Some properties of p-coumarate decarboxylase from Cladosporium phlei.
PubMed:The effect of citric acid and its sodium salts in test meals on the gastric outputs of acid and of chloride.
PubMed:Inhibition of Rh agglutination by disodium hydrogen citrate.
PubMed:Disodium-Citrate-Glucose Mixture as a Blood Preservative.
 
Notes:
Preservative Disodium citrate, or disodium hydrogen citrate, is a sodium acid salt of citric acid (sodium citrate) with the chemical formula Na2HC6H5O7, or Na2H(C3H5O(COO)3). It is one of the 3 citric acid salts. It is used as an antioxidant in food as well as to improve the effects of other antioxidants. It is also used as an acidity regulator and sequestrant. Typical products include gelatin, jam, sweets, ice cream, carbonated beverages, milk powder, wine, and processed cheeses. (Wikipedia)
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