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thiamine
vitamin B1

Supplier Sponsors

Name:2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol chloride
CAS Number: 59-43-8Picture of molecule3D/inchi
Other(deleted CASRN):100660-17-1
ECHA EINECS - REACH Pre-Reg:200-425-3
FDA UNII: X66NSO3N35
Molecular Weight:300.81169000
Formula:C12 H17 Cl N4 O S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (SATF):59-43-8 ; THIAMINE
FDA Regulation:
FDA PART 101 -- FOOD LABELING
Subpart A--General Provisions
Sec. 101.9 Nutrition labeling of food.


FDA PART 107 -- INFANT FORMULA
Subpart D--Nutrient Requirements
Sec. 107.100 Nutrient specifications.


FDA PART 136 -- BAKERY PRODUCTS
Subpart B--Requirements for Specific Standardized Bakery Products
Sec. 136.115 Enriched bread, rolls, and buns.


FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products
Sec. 137.165 Enriched flour.


FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products
Sec. 137.185 Enriched self-rising flour.


FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products
Sec. 137.260 Enriched corn meals.


FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products
Sec. 137.305 Enriched farina.


FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products
Sec. 137.350 Enriched rice.


FDA PART 139 -- MACARONI AND NOODLE PRODUCTS
Subpart B--Requirements for Specific Standardized Macaroni and Noodle Products
Sec. 139.115 Enriched macaroni products.


FDA PART 139 -- MACARONI AND NOODLE PRODUCTS
Subpart B--Requirements for Specific Standardized Macaroni and Noodle Products
Sec. 139.117 Enriched macaroni products with fortified protein.


FDA PART 139 -- MACARONI AND NOODLE PRODUCTS
Subpart B--Requirements for Specific Standardized Macaroni and Noodle Products
Sec. 139.122 Enriched nonfat milk macaroni products.


FDA PART 139 -- MACARONI AND NOODLE PRODUCTS
Subpart B--Requirements for Specific Standardized Macaroni and Noodle Products
Sec. 139.155 Enriched noodle products.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
 
Physical Properties:
Appearance:white to off-white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 248.00 °C. @ 760.00 mm Hg
logP (o/w): -3.930 (est)
Soluble in:
 water, 500000 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Vitamin B1 98%
American International Chemical, LLC.
Vitamin B1
Atlantic Chemicals
Thiamine (Vitamin B1)
BOC Sciences
For experimental / research use only.
thiamine 98%
DSM Nutritional
Vitamin B1 (thiamin)
Foodchem International
Vitamin B1
George Uhe Company
Thiamine
Graham Chemical
Vitamin B1
Jiangyin Healthway
Vitamin B1
New functional food ingredients
Kraft Chemical
Vitamin B1
OQEMA
Vitamin B1
Prinova
Vitamin B1 USP; FCC
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
subcutaneous-mouse LD50 301 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 119, Pg. 444, 1957.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
special dietary and nutritional additives
Recommendation for thiamine usage levels up to:
 not for fragrance use.
 
Recommendation for thiamine flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Benfotiamine, thiamine monophosphate chloride and thiamine pyrophosphate chloride, as sources of vitamin B1 added for nutritional purposes to food supplements - Scientific Opinion of the Panel on Food Additives and Nutrient Sources added to Food (ANS)
View page or View pdf

Scientific Opinion on the substantiation of a health claim related to a combination of thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, D-biotin and pumpkin seed oil and maintenance of normal hair pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf

Literature search and review related to specific preparatory work in the establishment of Dietary References Values for Thiamin, Pantothenic Acid and Choline
View page or View pdf

Dietary reference values for thiamin
View page or View pdf

Outcome of a public consultation on the draft scientific opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on dietary reference values for thiamin
View page or View pdf

Safety and efficacy of feed additives consisting of Vitamin B (98%) and Vitamin B (80%) as riboflavin produced by Bacillus subtilis KCCM 10445 for all animal species (Hubei Guangji Pharmaceutical Co. Ltd.)
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):59-43-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6042
National Institute of Allergy and Infectious Diseases:Data
2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol chloride
Chemidplus:0000059438
 
References:
 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol chloride
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:59-43-8
Pubchem (cid):6042
Pubchem (sid):135104368
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):D08580
HMDB (The Human Metabolome Database):HMDB00235
FooDB:FDB008425
YMDB (Yeast Metabolome Database):YMDB00220
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
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 cardamom seed
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 cashew fruit
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 cashew leaf
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 cashew nut
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 cassava leaf
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 celery fruit
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 celery plant
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 chamomile garden chamomile flower
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 chamomile sweet false chamomile plant
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 chayote plant
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 chayote shoot
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 cherimoya fruit
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 cherry brazilian cherry fruit
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 cherry sour cherry fruit
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 chestnut water chestnut tuber
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 chickpea seed
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 chicory leaf
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 chicory root
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 chive leaf
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 chrysanthemum edible chrysanthemum bud
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 chrysanthemum edible chrysanthemum leaf
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 cinnamon ceylon cinnamon bark
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 clove fruit
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 coconut seed
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 coffee bean
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 coriander fruit
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 coriander leaf
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 corn fruit
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 corn silk
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 cotton seed
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 cranberry fruit
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 cress garden cress leaf
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 cucumber fruit
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 cumin seed
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 currant black currant fruit
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 currant red currant fruit
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 dandelion leaf
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 dandelion plant
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 dandelion root
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 date palm fruit
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 dill plant
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 dill seed
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 durian fruit
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 eggplant fruit
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 elder black elder plant
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 endive leaf
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 fennel plant
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 fennel seed
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 fenugreek seed
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 fig fruit
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 flax seed
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 garlic bulb
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 garlic flower
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 garlic leaf
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 garlic root
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 garlic shoot
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 ginger root
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 ginkgo biloba leaf
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 ginkgo biloba seed
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 gooseberry fruit
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 goosefoot leaf
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 goosefoot seed
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 gourd calabash gourd fruit
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 gourd white gourd fruit
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 grape fruit
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 grape stem
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 guava fruit
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 guava strawberry guava fruit
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 hazelnut nut
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 horseradish root
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 irish moss plant
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 jackfruit fruit
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 jambul fruit
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 kiwi fruit
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 kohlrabi stem
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 leek wild leek flower
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 leek wild leek leaf
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 leek wild leek root
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 lemon fruit
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 lentil seed
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 lentil sprout
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 lettuce leaf
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 lime fruit
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 loquat fruit
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 lotus indian lotus rhizome
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 luffa fruit
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 luffa leaf
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 lupine white lupine seed
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 macadamia nut
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 mallow jew's mallow leaf
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 mamey fruit
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 mandarin fruit
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 mango fruit
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 mango leaf
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 mangosteen fruit
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 marango fruit
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 marango shoot
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 marjoram plant
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 melon bitter melon fruit
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 melon bitter melon leaf
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 mugwort leaf
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 mustard white mustard seed
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 nance fruit
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 nutmeg aril
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 nutmeg seed
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 oat plant
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 oat seed
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 okra fruit
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 okra seed
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 onion bulb
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 onion leaf
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 orange fruit
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 oregano plant
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 papaya fruit
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 papaya leaf
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 parsley plant
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 parsley shoot
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 parsnip root
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 passion fruit fruit
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 pea black-eyed pea seed
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 pea black-eyed pea shoot
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 pea fruit
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 pea pigeon pea fruit
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 pea pigeon pea seed
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 pea seed
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 peach fruit
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 peanut leaf
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 peanut nut
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 pear fruit
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 pepper bell pepper fruit
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 pepper black pepper fruit
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 peppermint leaf
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 pigweed leaf
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 pine pinyon pine seed
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 pineapple fruit
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 plum fruit
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 plum malabar plum fruit
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 pokeweed shoot
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 pomegranate fruit
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 poppy opium poppy seed
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 potato sweet potato leaf
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 potato sweet potato root
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 potato tuber
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 purslane herb
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 quince fruit
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 radish fruit
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 radish leaf
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 radish root
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 raspberry red raspberry fruit
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 raspberry red raspberry leaf
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 rhubarb leaf
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 rhubarb plant
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 rice seed
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 roselle flower
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 roselle leaf
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 rosemary leaf
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 rye seed
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 safflower flower
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 safflower seed
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 saffron stigma
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 sage leaf
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 salsify root
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 sapodilla fruit
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 savory summer savory plant
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 sesame seed
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 shea tree seed
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 sorrel garden sorrel leaf
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 soursop fruit
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 soybean fruit
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 soybean seed
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 soybean sprout
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 spearmint leaf
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 spinach indian spinach leaf
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 spinach plant
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 spinach sea spinach leaf
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 spinach water spinach leaf
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 spirulina plant
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 squash summer squash fruit
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 star fruit fruit
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 sunflower seed
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 tamarind flower
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 tamarind fruit
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 tamarind leaf
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 taro leaf
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 taro root
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 tarragon plant
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 tea leaf
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 thyme leaf
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 thyme plant
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 tomatillo fruit
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 tomato fruit
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 turmeric plant
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 turmeric rhizome
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 walnut black walnut nut
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 walnut black walnut pericarp
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 walnut english walnut nut
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 watercress herb
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 watermelon fruit
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 wheat plant
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 wheat seed
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 yam mountain yam root
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 yam wild yam root
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Synonyms:
3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl thiazolium chloride
 aneurine
S-[2-[3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (3S)-3-hydroxybutanethioate
 oryzanine
 thiamine monochloride
 thiaminum
 vitamin B1
 vitamin B1 USP; FCC
 

Articles:

PubMed:Analysis of thiamine concentrations in commercial canned foods formulated for cats.
J-Stage:Production Potency of Folate, Vitamin B12, and Thiamine by Lactic Acid Bacteria Isolated from Japanese Pickles
PubMed:Substrate specificity of thiamine pyrophosphate-dependent 2-oxo-acid decarboxylases in Saccharomyces cerevisiae.
PubMed:Response surface methodology for meat-like odorants from Maillard reaction with glutathione I: the optimization analysis and the general pathway exploration.
PubMed:Response surface methodology for meat-like odorants from the Maillard reaction with glutathione II: the tendencies analysis of meat-like donors.
PubMed:Quality and sensory characteristics of hard red wheat after residential storage for up to 32 y.
PubMed:Sensory and nutritional quality of split peas (Pisum sativum) stored up to 34 y in residential storage.
PubMed:The aroma side of the Maillard reaction.
PubMed:Precursors of chicken flavor. I. Determination of some flavor precursors in chicken muscle.
PubMed:[Composition analysis and dominance test of three kinds of raw variety of Gynostemma pentaphyllum].
PubMed:Optimizing conditions for thermal processes of soy milk.
PubMed:[Current aroma research].
PubMed:Hard-to-cook phenomenon in common beans--a review.
 
Notes:
3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride. Essential vitamin. Present in yeast, eggs, liver, milk, green vegetables, roots, tubers and cereals, esp. rice husks. Dietary supplement esp. in baked goods and grain products Nutrient supplement
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