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(6)-gingerol
(S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone

Supplier Sponsors

Name:(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one
CAS Number: 23513-14-6Picture of molecule3D/inchi
FDA UNII:925QK2Z900
MDL:MFCD00210507
XlogP3-AA:3.10 (est)
Molecular Weight:294.39102000
Formula:C17 H26 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:yellow clear oily liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 31.00 °C. @ 760.00 mm Hg
Boiling Point: 452.00 to 454.00 °C. @ 760.00 mm Hg
Flash Point: 318.00 °F. TCC ( 158.89 °C. )
logP (o/w): 2.485 (est)
Soluble in:
 alcohol
 water, 204.9 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Gingerol > 95%
Odor: characteristic
Use: Gingerol is the active constituent of fresh ginger. It is bioactive compound found in ginger (Zingiber officinale) with antioxidant activity, which functions as an anti-inflammatory and antitumor agent. It has been shown to inhibit COX-2 expression
Dalton Pharma Services
For experimental / research use only.
6-Gingerol >95%
EMD Millipore
For experimental / research use only.
(6)-Gingerol, Zingiber officinale
ExtraSynthese
For experimental / research use only.
6-Gingerol (HPLC) ≥90%
Glentham Life Sciences
[6]-Gingerol
Santa Cruz Biotechnology
For experimental / research use only.
(6)-Gingerol ≥98%
Sigma-Aldrich
For experimental / research use only.
[6]-Gingerol
analytical standard
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 250 mg/kg
Journal of Pharmacobio-Dynamics. Vol. 7, Pg. 836, 1984.

intraperitoneal-mouse LD50 58100 ug/kg
Journal of Pharmacobio-Dynamics. Vol. 7, Pg. 836, 1984.

intravenous-mouse LD50 25500 ug/kg
Journal of Pharmacobio-Dynamics. Vol. 7, Pg. 836, 1984.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for (6)-gingerol usage levels up to:
 not for fragrance use.
 
Recommendation for (6)-gingerol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :90942
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one
Chemidplus:0023513146
 
References:
 (5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):90942
Pubchem (sid):135049126
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10462
HMDB (The Human Metabolome Database):HMDB05783
FooDB:FDB001108
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 ginger oil
Search Trop Picture
 ginger rhizome
Search Trop Picture
 ginger rhizome oil
Search Trop Picture
 ginger root
Search Trop Picture
 ginger root oil
Search Trop Picture
 
Synonyms:
3-decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-
3-decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-
3-decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-(+)-
[6]-gingerol
6-gingerol
(5S)-5-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)decan-3-one
(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone
(S)-(+)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone
(S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone
5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone
(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one
(S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one
5-hydroxy-1-(4'-hydroxy-3'-methoxyphenyl)-3-decanone
 

Articles:

PubMed:Assay of 6-gingerol in CO2 supercritical fluid extracts of ginger and evaluation of its sustained release from a transdermal delivery system across rat skin.
PubMed:Cestocidal activities of ginger (Zingiber officinale) against Hymenolepis nana.
PubMed:Influence of side chain structure changes on antioxidant potency of the [6]-gingerol related compounds.
PubMed:Gingerol-derivatives: emerging new therapy against human drug-resistant MCF-7.
PubMed:6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways.
PubMed:Optimized microwave-assisted extraction of 6-gingerol from Zingiber officinale Roscoeand evaluation of antioxidant activity in vitro.
PubMed:Mechanisms for antidiabetic effect of gingerol in cultured cells and obese diabetic model mice.
PubMed:Synthesis and quorum sensing inhibitory activity of key phenolic compounds of ginger and their derivatives.
PubMed:Ginger and its pungent constituents non-competitively inhibit serotonin currents on visceral afferent neurons.
PubMed:Crystallization and preliminary X-ray crystallographic analysis of α-glucosidase HaG from Halomonas sp. strain H11.
PubMed:6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling.
PubMed:Cytochrome P450 inhibitory potential and RP-HPLC standardization of trikatu--a Rasayana from Indian Ayurveda.
PubMed:Variations in the contents of gingerols and chromatographic fingerprints of ginger root extracts prepared by different preparation methods.
PubMed:Simultaneous determination of 13 chemical marker compounds in Gwakhyangjeonggi-san, a herbal formula, with validated analytical methods.
PubMed:[Inhibition effect of 6-gingerol on hair growth].
PubMed:[6]-gingerol as a cancer chemopreventive agent: a review of its activity on different steps of the metastatic process.
PubMed:Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents.
PubMed:Multitargeted effects of hangeshashinto for treatment of chemotherapy-induced oral mucositis on inducible prostaglandin e2 production in human oral keratinocytes.
PubMed:Enterohepatic recirculation of bioactive ginger phytochemicals is associated with enhanced tumor growth-inhibitory activity of ginger extract.
PubMed:Preventative Effect of Zingiber officinale on Insulin Resistance in a High-Fat High-Carbohydrate Diet-Fed Rat Model and its Mechanism of Action.
PubMed:Simultaneous quantification and inhibitory effect on LDL oxidation of the traditional Korean medicine, Leejung-tang.
PubMed:Modulation of multidrug resistance P-glycoprotein activity by antiemetic compounds in human doxorubicin-resistant sarcoma cells (MES-SA/Dx-5): implications on cancer therapy.
PubMed:(6)-Gingerolinduced myeloid leukemia cell death is initiated by reactive oxygen species and activation of miR-27b expression.
PubMed:Molecular approaches toward targeted cancer prevention with some food plants and their products: inflammatory and other signal pathways.
PubMed:The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESK.
PubMed:[6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2.
PubMed:[6]-Gingerol Prevents Disassembly of Cell Junctions and Activities of MMPs in Invasive Human Pancreas Cancer Cells through ERK/NF- κ B/Snail Signal Transduction Pathway.
PubMed:Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins.
PubMed:(S)-[6]-Gingerol enhances glucose uptake in L6 myotubes by activation of AMPK in response to [Ca2+]i.
PubMed:Identification of a Calcium Signalling Pathway of S-[6]-Gingerol in HuH-7 Cells.
PubMed:Qualitative and quantitative analysis of nine major compounds in the Bozhougyiqi-Tang using a high-performance liquid chromatography coupled with a diode array detector and electrospray ionization mass spectrometer.
PubMed:Anti-neuroinflammatory capacity of fresh ginger is attributed mainly to 10-gingerol.
PubMed:Higenamine Combined with [6]-Gingerol Suppresses Doxorubicin-Triggered Oxidative Stress and Apoptosis in Cardiomyocytes via Upregulation of PI3K/Akt Pathway.
PubMed:Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROS/NF-Kappa B/COX2 Activation in HuH7 Cells.
PubMed:Role of 6-gingerol in reduction of cholera toxin activity in vitro and in vivo.
PubMed:Pungent ginger components modulates human cytochrome P450 enzymes in vitro.
PubMed:Simultaneous determination of 11 major components in Palmul-tang by HPLC-DAD and LC-MS-MS.
PubMed:(S)-[6]-Gingerol inhibits TGF-β-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells.
PubMed:Glutathione conjugation attenuates biological activities of 6-dehydroshogaol from ginger.
PubMed:Influence of cultivar and maturity at harvest on the essential oil composition, oleoresin and [6]-gingerol contents in fresh ginger from northeast India.
PubMed:Enzyme-assisted extraction of bioactive compounds from ginger (Zingiber officinale Roscoe).
PubMed:6-gingerol inhibits rosiglitazone-induced adipogenesis in 3T3-L1 adipocytes.
PubMed:Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3 receptors of enteric neurons.
PubMed:[6]-gingerol: a novel AT₁ antagonist for the treatment of cardiovascular disease.
PubMed:Highly efficient sample preparation and quantification of constituents from traditional Chinese herbal medicines using matrix solid-phase dispersion extraction and UPLC-MS/MS.
PubMed:Ginger phytochemicals exhibit synergy to inhibit prostate cancer cell proliferation.
PubMed:6-Gingerol inhibits hair shaft growth in cultured human hair follicles and modulates hair growth in mice.
PubMed:Efficient preparation of Hangekobokuto (Banxia-Houpo-Tang) decoction by adding perilla herb before decoction is finished.
PubMed:6-gingerol prevents adipogenesis and the accumulation of cytoplasmic lipid droplets in 3T3-L1 cells.
PubMed:Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men.
PubMed:Terpenoids from Zingiber officinale (Ginger) induce apoptosis in endometrial cancer cells through the activation of p53.
PubMed:A note on the relevance of [6]-Gingerol for the prevention and/or treatment of Alzheimer's disease.
PubMed:Qualitative and quantitative simultaneous determination of six marker compounds in Soshiho-tang by HPLC-DAD-ESI-MS.
PubMed:[Effect of Zingiber offiicinale and Aconitum cainichaeli before and after compatibility on contents of four gingerols].
PubMed:Response to comment: "A note on the relevance of [6]-gingerol for the prevention and/or treatment of Alzheimer's disease".
PubMed:6-gingerdiols as the major metabolites of 6-gingerol in cancer cells and in mice and their cytotoxic effects on human cancer cells.
PubMed:Effects of ginger and its constituents on airway smooth muscle relaxation and calcium regulation.
PubMed:Dietary agonists of TRPV1 inhibit gastric acid secretion in mice.
PubMed:Ovariectomized mouse uterotrophic assay of 36 chemicals.
PubMed:[6]-Gingerol induces bone loss in ovary intact adult mice and augments osteoclast function via the transient receptor potential vanilloid 1 channel.
PubMed:6-gingerol ameliorated doxorubicin-induced cardiotoxicity: role of nuclear factor kappa B and protein glycation.
PubMed:Intrathecal [6]-gingerol administration alleviates peripherally induced neuropathic pain in male Sprague-Dawley rats.
PubMed:[6]-Gingerol induces caspase 3 dependent apoptosis and autophagy in cancer cells: drug-DNA interaction and expression of certain signal genes in HeLa cells.
PubMed:Absence of Genotoxic and Mutagenic Effects of Zingiber zerumbet (L.) Smith (Zingiberaceae) Extract.
PubMed:Anti-platelet aggregation and vasorelaxing effects of the constituents of the rhizomes of Zingiber officinale.
PubMed:Gingerols of Zingiber officinale enhance glucose uptake by increasing cell surface GLUT4 in cultured L6 myotubes.
PubMed:Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta.
PubMed:6-shogaol-rich extract from ginger up-regulates the antioxidant defense systems in cells and mice.
PubMed:6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest.
PubMed:[Antioxidant constituents from Smilax riparia].
PubMed:[Simultaneous determination of four components in sini tang by HPLC].
PubMed:Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol.
PubMed:Optimization of Extraction Conditions for the 6-Shogaol-rich Extract from Ginger (Zingiber officinale Roscoe).
PubMed:Protein tyrosine phosphatase 1B inhibitory activity of Indonesian herbal medicines and constituents of Cinnamomum burmannii and Zingiber aromaticum.
PubMed:An impression on current developments in the technology, chemistry, and biological activities of ginger (Zingiber officinale Roscoe).
PubMed:Zingiber officinale (ginger) as an anti-emetic in cancer chemotherapy: a review.
PubMed:α-Glucosylated 6-gingerol: chemoenzymatic synthesis using α-glucosidase from Halomonas sp. H11, and its physical properties.
PubMed:Effect of [6]-gingerol on myofibroblast differentiation in transforming growth factor beta 1-induced nasal polyp-derived fibroblasts.
PubMed:Anti-Candida and radical scavenging activities of essential oils and oleoresins of Zingiber officinale Roscoe and essential oils of other plants belonging to the family Zingiberaceae.
PubMed:6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection.
PubMed:6-Gingerol induces apoptosis through lysosomal-mitochondrial axis in human hepatoma G2 cells.
PubMed:Phenylpropanoid ester from Zingiber officinale and their inhibitory effects on the production of nitric oxide.
PubMed:Simultaneous determination of six active components in traditional herbal medicine 'Oyaksungisan' by HPLC-DAD.
PubMed:Protective effect of [6]-gingerol on the ethanol-induced teratogenesis of cultured mouse embryos.
PubMed:[6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signaling in mice.
PubMed:Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators.
PubMed:[Phenolic and amide constituents from Lycianthes marlipoensis].
PubMed:Using 6-gingerol content and gene mapping for identification of two types of ginger used in Thai traditional medicine.
PubMed:In vitro cytotoxic activity of Benjakul herbal preparation and its active compounds against human lung, cervical and liver cancer cells.
PubMed:Determination and pharmacokinetics of [6]-gingerol in mouse plasma by liquid chromatography-tandem mass spectrometry.
PubMed:6-gingerol, an active ingredient of ginger, protects acetaminophen-induced hepatotoxicity in mice.
PubMed:Simultaneous determination of eight marker compounds in the traditional herbal medicine, Sipjundaebo-tang by HPLC-DAD.
PubMed:Ginger phytochemicals mitigate the obesogenic effects of a high-fat diet in mice: a proteomic and biomarker network analysis.
PubMed:6-gingerol prevents patulin-induced genotoxicity in HepG2 cells.
PubMed:Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet.
PubMed:Orosensory stimulation effects on human saliva proteome.
PubMed:Administration of 6-gingerol greatly enhances the number of tumor-infiltrating lymphocytes in murine tumors.
PubMed:Antiinflammatory effects of ginger and some of its components in human bronchial epithelial (BEAS-2B) cells.
PubMed:Inhibitory effect of [6]-gingerol on melanogenesis in B16F10 melanoma cells and a possible mechanism of action.
PubMed:Examination of the pharmacokinetics of active ingredients of ginger in humans.
PubMed:Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: phenolic acids, monophenol, polyphenol, and their derivatives.
PubMed:A HPLC-DAD method for the simultaneous determination of five marker components in the traditional herbal medicine Bangpungtongsung-san.
PubMed:[6]-Gingerol attenuates β-amyloid-induced oxidative cell death via fortifying cellular antioxidant defense system.
PubMed:Emodin and [6]-gingerol lessen hypoxia-induced embryotoxicities in cultured mouse whole embryos via upregulation of hypoxia-inducible factor 1α and intracellular superoxide dismutases.
PubMed:Ginger suppresses phthalate ester-induced airway remodeling.
PubMed:Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats.
PubMed:Characterization of [6]-gingerol metabolism in rat by liquid chromatography electrospray tandem mass spectrometry.
PubMed:Effects of ginger constituents on the gastrointestinal tract: role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptors.
PubMed:Preparation of the monomers of gingerols and 6-shogaol by flash high speed counter-current chromatography.
PubMed:Simultaneous quantification of marker components in Ojeok-san by HPLC-DAD.
PubMed:[Comparative protein analysis of K562 cell apoptosis induced by 6-gingerol].
PubMed:[Reactive oxygen species and mitochondrial membrane potential changes in leukemia cells during 6-gingerol induced apoptosis].
PubMed:[Everted intestinal sac method for quick finding absorption ingredients of Wuzhuyu decoction].
PubMed:Simultaneous determination of five marker constituents in Ssanghwa tang by HPLC/DAD.
PubMed:Zingiber officinale (ginger) compounds have tetracycline-resistance modifying effects against clinical extensively drug-resistant Acinetobacter baumannii.
PubMed:Larvicidal constituents of Zingiber officinale (ginger) against Anisakis simplex.
PubMed:Anti-invasion effects of 6-shogaol and 6-gingerol, two active components in ginger, on human hepatocarcinoma cells.
PubMed:[Chemical constituents of rhizomes of Zingiber officinale].
PubMed:Dietary polyphenols affect MUC5AC expression and ciliary movement in respiratory cells and nasal mucosa.
PubMed:6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice.
PubMed:Molecular targets of [6]-gingerol: Its potential roles in cancer chemoprevention.
PubMed:Genotoxic effect of 6-gingerol on human hepatoma G2 cells.
PubMed:RP-thin layer chromatographic method for the quantification of three gingerol homologs of ultrasonic-assisted fresh rhizome extracts of Zingiber officinale collected from North Western Himalayas.
PubMed:Larvicidal activities of ginger (Zingiber officinale) against Angiostrongylus cantonensis.
PubMed:Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols.
PubMed:Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol.
PubMed:Identification and quantification of gingerols and related compounds in ginger dietary supplements using high-performance liquid chromatography-tandem mass spectrometry.
PubMed:Visualization of volatile substances in different organelles with an atmospheric-pressure mass microscope.
PubMed:[6]-Gingerol suppresses interleukin-1 beta-induced MUC5AC gene expression in human airway epithelial cells.
PubMed:Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis.
PubMed:[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase.
PubMed:[Quality analysis of processing products of dried ginger].
PubMed:[6]-Gingerol induces reactive oxygen species regulated mitochondrial cell death pathway in human epidermoid carcinoma A431 cells.
PubMed:Cytometric analysis of cytotoxicity of polyphenols and related phenolics to rat thymocytes: potent cytotoxicity of resveratrol to normal cells.
PubMed:6-Gingerol inhibits ROS and iNOS through the suppression of PKC-alpha and NF-kappaB pathways in lipopolysaccharide-stimulated mouse macrophages.
PubMed:[Analysis of volatile and non-volatile compositions in ginger oleoresin by gas chromatography-mass spectrometry].
PubMed:Plasma pharmacokinetics, tissue distribution and excretion study of 6-gingerol in rat by liquid chromatography-electrospray ionization time-of-flight mass spectrometry.
PubMed:Simultaneous determination of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma by liquid chromatography-mass spectrometry: Application to pharmacokinetics.
PubMed:Ginger's (Zingiber officinale Roscoe) inhibition of rat colonic adenocarcinoma cells proliferation and angiogenesis in vitro.
PubMed:Plasma pharmacokinetics and tissue distribution of [6]-gingerol in rats.
PubMed:Inhibitory effect of gingerol on the proliferation and invasion of hepatoma cells in culture.
PubMed:Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria.
PubMed:Muscarinic, Ca(++) antagonist and specific butyrylcholinesterase inhibitory activity of dried ginger extract might explain its use in dementia.
PubMed:Specific reaction of alpha,beta-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damage.
PubMed:Goshuyuto, a traditional Japanese medicine for migraine, inhibits platelet aggregation in guinea-pig whole blood.
PubMed:Analysis of anti-platelet aggregation components of Rhizoma Zingiberis using chicken thrombocyte extract and high performance liquid chromatography.
PubMed:Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects.
PubMed:Ginger prevents Th2-mediated immune responses in a mouse model of airway inflammation.
PubMed:6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages.
PubMed:[RP-HPLC fingerprint evaluating different ginger juice as processing material].
PubMed:6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes.
PubMed:Changes in the contents of oleoresin and pungent bioactive principles of Jamaican ginger (Zingiber officinale Roscoe.) during maturation.
PubMed:Effects of spice constituents on P-glycoprotein-mediated transport and CYP3A4-mediated metabolism in vitro.
PubMed:6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression.
PubMed:Systemic administration of [6]-gingerol, a pungent constituent of ginger, induces hypothermia in rats via an inhibitory effect on metabolic rate.
PubMed:Selective isolation of in vitro phase II conjugates using a lipophilic anionic exchange solid phase extraction method.
PubMed:[6]-gingerol induces Ca2+ mobilization in Madin-Darby canine kidney cells.
PubMed:Induction of adiponectin by natural and synthetic phenolamides in mouse and human preadipocytes and its enhancement by docosahexaenoic acid.
PubMed:Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells.
PubMed:Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells.
PubMed:Evaluation of the topical anti-inflammatory activity of ginger dry extracts from solutions and plasters.
PubMed:In vitro and in vivo modulation of testosterone mediated alterations in apoptosis related proteins by [6]-gingerol.
PubMed:Stability of [6]-gingerol and [6]-shogaol in simulated gastric and intestinal fluids.
PubMed:Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms.
PubMed:[6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells.
PubMed:Antioxidant actions of phenolic compounds found in dietary plants on low-density lipoprotein and erythrocytes in vitro.
PubMed:High-performance liquid chromatographic analysis of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol in ginger-containing dietary supplements, spices, teas, and beverages.
PubMed:[6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo.
PubMed:Effect of 6-gingerol on pro-inflammatory cytokine production and costimulatory molecule expression in murine peritoneal macrophages.
PubMed:Cancer preventive properties of ginger: a brief review.
PubMed:Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells.
PubMed:Determination of 6-gingerol in ginger (Zingiber officinale) using high-performance thin-layer chromatography.
PubMed:Microsomal hydroxylation and glucuronidation of [6]-gingerol.
PubMed:[6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells.
PubMed:6-Gingerol prevents cisplatin-induced acute renal failure in rats.
PubMed:Species differences in the prokinetic effects of ginger.
PubMed:Variation in concentration and labeling of ginger root dietary supplements.
PubMed:Gingerol metabolite and a synthetic analogue Capsarol inhibit macrophage NF-kappaB-mediated iNOS gene expression and enzyme activity.
PubMed:Molecular targets of dietary agents for prevention and therapy of cancer.
PubMed:Curcumin: getting back to the roots.
PubMed:Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum.
PubMed:Beneficial effects of Zingiber officinale Roscoe on fructose induced hyperlipidemia and hyperinsulinemia in rats.
PubMed:Suppressive effects of mioga ginger and ginger constituents on reactive oxygen and nitrogen species generation, and the expression of inducible pro-inflammatory genes in macrophages.
PubMed:Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles.
PubMed:[6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo.
PubMed:[Study on quality standard of extracts from Rhizoma Zingiberis by supercritical fluid extraction].
PubMed:5-HT3 receptor blocking activity of arylalkanes isolated from the rhizome of Zingiber officinale.
PubMed:Gingerol content of diploid and tetraploid clones of ginger (Zingiber officinale Roscoe).
PubMed:Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-stimulated PGE2 production.
PubMed:Mechanism of inhibition of peroxynitrite-induced oxidation and nitration by [6]-gingerol.
PubMed:Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta1 involves MAPK, Smad and AP-1 signalling pathways.
PubMed:[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin.
PubMed:Effects of dietary chemopreventive phytochemicals on P-glycoprotein function.
PubMed:Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin.
PubMed:Analgesic and anti-inflammatory activities of [6]-gingerol.
PubMed:Separation and isolation methods for analysis of the active principles of Sho-saiko-to (SST) oriental medicine.
PubMed:Role of chemopreventive agents in cancer therapy.
PubMed:From chemoprevention to chemotherapy: common targets and common goals.
PubMed:Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger.
PubMed:Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production.
PubMed:Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats.
PubMed:Effects of 6-gingerol, an antioxidant from ginger, on inducing apoptosis in human leukemic HL-60 cells.
PubMed:[6]-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions.
PubMed:Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in Human T lymphoma Jurkat cells.
PubMed:Modifications of capsaicin-sensitive neurons in isolated guinea pig ileum by [6]-gingerol and lafutidine.
PubMed:[HPLC determination of 6-gingerol in Rhizoma Zingiberis Recens].
PubMed:Gingerols: a novel class of vanilloid receptor (VR1) agonists.
PubMed:Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review.
PubMed:Metabolism of [6]-gingerol in rats.
PubMed:The stability of gingerol and shogaol in aqueous solutions.
PubMed:Insect growth inhibition, antifeedant and antifungal activity of compounds isolated/derived from Zingiber officinale Roscoe (ginger) rhizomes.
PubMed:Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol.
PubMed:Assessment of oleoresin and gingerol contents in gamma irradiated ginger rhizomes.
PubMed:Effect of different combinations of MGK-264 or piperonyl butoxide with plant-derived molluscicides on snail reproduction.
PubMed:Effect of active molluscicidal component of spices on different enzyme activities and biogenic amine levels in the nervous tissue of Lymnaea acuminata.
PubMed:Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances.
PubMed:Interactions of 6-gingerol and ellagic acid with the cardiac sarcoplasmic reticulum Ca2+-ATPase.
PubMed:Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol.
PubMed:Endothelium-dependent potentiation of prostaglandin F2alpha-induced contractions by (+/-)-[6]-gingerol is inhibited by cyclooxygenase- but not lipoxygenase-inhibitors in mouse mesenteric veins.
PubMed:Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice.
PubMed:Keishi-ka-kei-to, a traditional Chinese herbal medicine, inhibits pulmonary metastasis of B16 melanoma.
PubMed:[A simultaneous determination of various main components in oriental pharmaceutical decoction "heii-san" by ion-pair high-performance liquid chromatography].
PubMed:Stimulation of sarcoplasmic reticulum Ca(2+)-ATPase by gingerol analogues.
PubMed:Stomachic principles in ginger. III. An anti-ulcer principle, 6-gingesulfonic acid, and three monoacyldigalactosylglycerols, gingerglycolipids A, B, and C, from Zingiberis Rhizoma originating in Taiwan.
PubMed:Inhibitory effects of phenolics on xanthine oxidase.
PubMed:Enzymic reduction of [6]-gingerol, a major pungent principle of ginger, in the cell-free preparation of rat liver.
PubMed:Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol.
PubMed:[Qualitative and quantitative analysis of bioactive principles in Zingiberis Rhizoma by means of high performance liquid chromatography and gas liquid chromatography. On the evaluation of Zingiberis Rhizoma and chemical change of constituents during Zingiberis Rhizoma processing].
PubMed:Pungent principles of ginger (Zingiber officinale) are thermogenic in the perfused rat hindlimb.
PubMed:6-Gingesulfonic acid, a new anti-ulcer principle, and gingerglycolipids A, B, and C, three new monoacyldigalactosylglycerols, from zingiberis rhizoma originating in Taiwan.
PubMed:Pharmacokinetics of [6]-gingerol after intravenous administration in rats with acute renal or hepatic failure.
PubMed:[The study of Chinese herbal medicinal prescription with enzyme inhibitory activity. V. The study of hange-shashin-to, kanzo-shashin-to, shokyo-shashin-to with adenosine 3',5'-cyclic monophosphate phosphodiesterase].
PubMed:Pharmacokinetics of [6]-gingerol after intravenous administration in rats.
PubMed:[Quality evaluation of oriental medicines. I. Quantitative analysis of marker substances in the ethical extract preparation of Hangekouboku-to].
PubMed:Increasing 5-lipoxygenase inhibitory activities by oxidative conversion of o-methoxyphenols to catechols using a Cu2(+)-ascorbic acid-O2 system.
PubMed:Lethal efficacy of extract from Zingiber officinale (traditional Chinese medicine) or [6]-shogaol and [6]-gingerol in Anisakis larvae in vitro.
PubMed:Modulation of eicosanoid-induced contraction of mouse and rat blood vessels by gingerols.
PubMed:Reversed effects between crude and processed ginger extracts on PGF2 alpha-induced contraction in mouse mesenteric veins.
PubMed:Chemical structural requirement in gingerol derivatives for potentiation of prostaglandin F2 alpha-induced contraction in isolated mesenteric veins of mice.
PubMed:Suppression of spontaneous calcium spikes and contraction in isolated portal veins of mice by gingerols and chemically related compounds.
PubMed:The anti-ulcer effect in rats of ginger constituents.
PubMed:Cholagogic effect of ginger and its active constituents.
PubMed:Pharmacological studies on ginger. I. Pharmacological actions of pungent constitutents, (6)-gingerol and (6)-shogaol.
PubMed:The active part of the [6]-gingerol molecule in mutagenesis.
PubMed:Mutagen and anti-mutagen in ginger, Zingiber officinale.
 
Notes:
active ingredient in ginger; a nonvolatile methoxy phenyl decanone. Constit. of ginger Zingiber officinale
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