demeclocycline hydrochloride
7-chloro-6-demethyltetracycline hydrochloride

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  CODE138012 CODE138012
  Product(s):
  64-73-3 Demeclocycline hydrochloride >98%
  Demeclocycline HCl is a tetracycline antibiotic via inhibition of protein synthesis by bacteria, used for the treatment of bacterial infections.

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  CODE138012 CODE138012
  Product(s):
  GA7186 Demeclocycline hydrochloride

Name: (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride CAS Number: 64-73-3 3D/inchi ECHA EINECS - REACH Pre-Reg: 200-592-2 FDA UNII: 29O079NTYT MDL: MFCD00082371 Molecular Weight: 501.31794000 Formula: C21 H22 Cl2 N2 O8 BioActivity Summary: listing NMR Predictor: Predict (works with chrome, Edge or firefox) Category:pharmaceuticals / chemical synthisis   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Boiling Point: 684.50 °C. @ 760.00 mm Hg (est) Flash Point: 815.00 °F. TCC ( 435.20 °C. ) (est) Soluble in:   water, 8.493e+004 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: BOC Sciences For experimental / research use only. Demeclocycline hydrochloride >98% Odor: characteristic Use: Demeclocycline HCl is a tetracycline antibiotic via inhibition of protein synthesis by bacteria, used for the treatment of bacterial infections. George Uhe Company Demeclocycline HCL Glentham Life Sciences Demeclocycline hydrochloride Matrix Scientific For experimental / research use only. Demeclocycline hydrochloride, 95+% sds Santa Cruz Biotechnology For experimental / research use only. Demeclocycline Hydrochloride ≥93% Sigma-Aldrich: Sigma For experimental / research use only. Demeclocycline hydrochloride ≥90% (HPLC), powder sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: oral-man TDLo 69 mg/kg/4D-I KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION American Journal of Kidney Diseases. Vol. 5, Pg. 270, 1985. intravenous-mouse LD50 275 mg/kg Archivio Italiano di Scienze Mediche Tropical e di Parassitologia. Italian Archives of the Science of Tropical Medicine and Parasitology. Vol. 43, Pg. 143, 1962. oral-mouse LD50 2150 mg/kg Drugs in Japan Vol. -, Pg. 704, 1990. intravenous-rat LD50 94 mg/kg Drugs in Japan Vol. -, Pg. 704, 1990. oral-rat LD50 2372 mg/kg Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. Dermal Toxicity: Not determined Inhalation Toxicity: Not determined   Safety in Use Information: Category: pharmaceuticals / chemical synthisis Recommendation for demeclocycline hydrochloride usage levels up to:   not for fragrance use.   Recommendation for demeclocycline hydrochloride flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View ClinicalTrials.gov:search Daily Med:search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :54686764 National Institute of Allergy and Infectious Diseases:Data WGK Germany:2 (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride Chemidplus:0000064733   References:   (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride NIST Chemistry WebBook: Search Inchi Pubchem (cid): 54686764 Pubchem (sid): 135017847   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View CHEMBL: View KEGG (GenomeNet): D00290 HMDB (The Human Metabolome Database): Search MedlinePlusSupp: View ChemSpider: View   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   not found in nature   Synonyms: 7- chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride (4S,4aS,5aS,6S,12aR)-7- chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride 7- chloro-6-demethyltetracycline hydrochloride   declomycin hydrochloride   demethylchlorotetracycline hydrochloride   ledermycin hydrochloride   Articles:   None found yet. Try the PubMed Search.

Notes: a tetracycline analog having a 7-chloro and a 6-methyl. because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.