tryptophan-P-1, 62450-06-0

Articles:

PubMed:Metabolism of Foodborne Heterocyclic Aromatic Amines by Lactobacillus reuteri DSM 20016.

PubMed:Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells.

PubMed:Screening of molecular cell targets for carcinogenic heterocyclic aromatic amines by using CALUX® reporter gene assays.

PubMed:Aryl hydrocarbon receptor activation and CYP1A induction by cooked food-derived carcinogenic heterocyclic amines in human HepG2 cell lines.

PubMed:Inhibitory Effect of Rosa rugosa Tea Extract on the Formation of Heterocyclic Amines in Meat Patties at Different Temperatures.

PubMed:Ion-molecule adduct formation in tandem mass spectrometry.

PubMed:Determination of Heterocyclic Amines and Acrylamide in Agricultural Products with Liquid Chromatography-Tandem Mass Spectrometry.

PubMed:Influence of beer marinades on the reduction of carcinogenic heterocyclic aromatic amines in charcoal-grilled pork meat.

PubMed:Influence of food condiments on the formation of carcinogenic heterocyclic amines in cooked chicken and determination by LC-MS/MS.

PubMed:Effects of frying and boiling on the formation of heterocyclic amines in braised chicken.

PubMed:Chemical state of heterocyclic aromatic amines in grilled beef: evaluation by in vitro digestion model and comparison of alkaline hydrolysis and organic solvent for extraction.

PubMed:Caffeine and other methylxanthines as interceptors of food-borne aromatic mutagens: inhibition of Trp-P-1 and Trp-P-2 mutagenic activity.

PubMed:Determination of heterocyclic amines in braised sauce beef.

PubMed:[Interaction of mutagens in binary mixtures using the alkaline comet assay in human lymphocytes].

PubMed:Physicochemical characterisation of dietary fibre components and their ability to bind some process-induced mutagenic heterocyclic amines, Trp-P-1, Trp-P-2, AαC and MeAαC.

PubMed:Photodegradation of environmental mutagens by visible irradiation in the presence of xanthene dyes as photosensitizers.

PubMed:[Simultaneous determination of 9 heterocyclic aromatic amine in poultry products by solid-phase extraction-high performance liquid chromatography].

PubMed:[Sex- and species-differences on xenobiotic-induced toxicity: differences in constitutive and xenobiotic-mediated expression of cytochrome P450 1A subfamily enzymes (CYP1As)].

PubMed:Screening of non-polar heterocyclic amines in urine by microextraction in packed sorbent-fluorimetric detection and confirmation by capillary liquid chromatography.

PubMed:Trp-P-1, a carcinogenic heterocyclic amine, inhibits lipopolysaccharide-induced maturation and activation of human dendritic cells.

PubMed:Bioactivation of Aromatic Amines by Human CYP2W1, An Orphan Cytochrome P450 Enzyme.

PubMed:Simultaneous determination of six non-polar heterocyclic amines in meat samples by supercritical fluid extraction-capillary electrophoresis under fluorimetric detection.

PubMed:Heterocyclic aromatic amine formation in barbecued sardines (Sardina pilchardus) and Atlantic salmon (Salmo salar).

PubMed:Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract.

PubMed:Use of four new human-derived liver-cell lines for the detection of genotoxic compounds in the single-cell gel electrophoresis (SCGE) assay.

PubMed:Suppression of mutagens-induced SOS response by phytoncide solution using Salmonella typhimurium TA1535/pSK1002 umu test.

PubMed:Antimutagenic activity of a novel ascorbic derivative, disodium isostearyl 2-O-L-ascorbyl phosphate.

PubMed:3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) attenuates LPS-induced IL-8 expression by decreasing mRNA stability in THP-1 cells.

PubMed:Suppressive components in rice husk against mutagens-induced SOS response using Salmonella typhimurium TA1535/pSK1002 umu test.

PubMed:Validity of a self-administered food frequency questionnaire in the assessment of heterocyclic amine intake using 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) levels in hair.

PubMed:Heterocyclic amines in griddled beef steak analysed using a single extract clean-up procedure.

PubMed:Differential effects of heterocyclic amines on poly(ADP-ribose) polymerase-1 and mono-ADP-ribosyltransferase A.

PubMed:Lack of formation of heterocyclic amines in fumes from frying French fries.

PubMed:Antimutagenic and antioxidant properties of phenolic fractions from Andean purple corn (Zea mays L.).

PubMed:Chemical synthesis of 2'-deoxyguanosine-C8 adducts with heterocyclic amines: an application to synthesis of oligonucleotides site-specifically adducted with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

PubMed:Involvement of reactive oxygen species in the immunosuppressive effect of 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), a food-born carcinogenic heterocyclic amine.

PubMed:A hepatocarcinogenic tryptophan-pyrolyzate component, Trp-P-1, decreases serum total testosterone level and induces hepatic Cyp1a2 in male mice.

PubMed:Antimutagenicity and DT-diaphorase inducing activity of Gynostemma pentaphyllum Makino extract.

PubMed:3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), a food-born carcinogenic heterocyclic amine, promotes nitric oxide production in murine macrophages.

PubMed:Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk.

PubMed:Inhibition of DNA repair glycosylases by base analogs and tryptophan pyrolysate, Trp-P-1.

PubMed:Suppression of the SOS-inducing activity of mutagenic heterocyclic amine, Trp-P-1, by triterpenoid from Uncaria sinensis in the Salmonella typhimurium TA1535/pSK1002 Umu test.

PubMed:DNA adduct formation of 14 heterocyclic aromatic amines in mouse tissue after oral administration and characterization of the DNA adduct formed by 2-amino-9H-pyrido[2,3-b]indole (AalphaC), analysed by 32P_HPLC.

PubMed:Antimutagenicity of Japanese traditional herbs, gennoshoko, yomogi, senburi and iwa-tobacco.

PubMed:Binding effect of polychlorinated compounds and environmental carcinogens on rice bran fiber.

PubMed:Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.

PubMed:Antigenotoxic properties of Cassia tea (Cassia tora L.): mechanism of action and the influence of roasting process.

PubMed:Potent antioxidative and antigenotoxic activity in aqueous extract of Japanese rice bran--association with peroxidase activity.

PubMed:Inhibition of mutagenicity of food-derived heterocyclic amines by sulforaphane--a constituent of broccoli.

PubMed:Modulation of cytochrome P450 1A1 by food-derived heterocyclic aromatic amines.

PubMed:3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole induces apoptosis and necrosis with activation of different caspases in rat splenocytes.

PubMed:Occurrence of heterocyclic amines in several home-cooked meat dishes of the Spanish diet.

PubMed:Uptake of heterocyclic aromatic amine by insoluble dietary fiber in artificial gastric and intestinal juice.

PubMed:3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) triggers apoptosis by DNA double-strand breaks caused by inhibition of topoisomerase I.

PubMed:Antimutagenic activity of flavonoids from Chrysanthemum morifolium.

PubMed:Prenylated flavanones isolated from flowers of Azadirachta indica (the neem tree) as antimutagenic constituents against heterocyclic amines.

PubMed:Antimutagenic activity of phenylpropanoids from clove (Syzygium aromaticum).

PubMed:Suppressive effect of the SOS-inducing activity of chemical mutagen by citric acid esters from Prunus mume Sieb. Et Zucc. using the Salmonella typhimurium TA1535/pSK1002 umu test.

PubMed:Inhibitory effect of dibenzoylmethane on mutagenicity of food-derived heterocyclic amine mutagens.

PubMed:Potential chemopreventive properties of anthocyanin-rich aqueous extracts from in vitro produced tissue of sweetpotato (Ipomoea batatas L.).

PubMed:Inhibitory effect of curcumin and its natural analogues on genotoxicity of heterocyclic amines from cooked food.

PubMed:Validity of mutagenic activity as an indicator of river water pollution.

PubMed:Antimutagenic activity of 8-hydroxyisoflavones and 6-hydroxydaidzein from soybean miso.

PubMed:Antimutagenicity of mono-, di-, and tricaffeoylquinic acid derivatives isolated from sweetpotato (Ipomoea batatas L.) leaf.

PubMed:Antimutagenic effect of various honeys and sugars against Trp-p-1.

PubMed:Apoptosis in the thymus after intraperitoneal injection of rats with Trp-P-1.

PubMed:Estimation of dietary HCA intakes in a large-scale population-based prospective study in Japan.

PubMed:Antimutagenicity of some edible Thai plants, and a bioactive carbazole alkaloid, mahanine, isolated from Micromelum minutum.

PubMed:3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (trp-P-1) is incorporated into rat splenocytes, thymocytes, and hepatocytes through monoamine transporters and induces apoptosis.

PubMed:Effects of soy sauce and sugar on the formation of heterocyclic amines in marinated foods.

PubMed:Evoking cytochrome P450 1A activity interferes with apoptosis induced by 3-amino-1,4-dimethyl-5H-pyrido [4,3-b]indole (Trp-P-1) in rat hepatocytes under the ex vivo system.

PubMed:Selective in vitro binding of dietary mutagens, individually or in combination, by lactic acid bacteria.

PubMed:[Behavior of Trp-P-1 and its metabolites in rat excreta].

PubMed:Antimutagenic activity against trp-P-1 of the edible Thai plant, Oroxylum indicum vent.

PubMed:Induction of cytochrome P450 1B1 in lung, liver and kidney of rats exposed to diesel exhaust.

PubMed:Binding activity of natto (a fermented food) and Bacillus natto isolates to mutagenic-carcinogenic heterocyclic amines.

PubMed:Norharman, an indoleamine-derived beta-carboline, but not Trp-P-2, a gamma-carboline, induces apoptotic cell death in human neuroblastoma SH-SY5Y cells.

PubMed:The heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole induces apoptosis in cocultures of rat parenchymal and nonparenchymal liver cells.

PubMed:Cell transformation in vitro by food-derived heterocyclic amines Trp-P-1, Trp-P-2 and N(2)-OH-PhIP.

PubMed:Antimutagenicity of extracts of Hericium erinaceus.

PubMed:Suppression of chemical mutagen-induced SOS response by alkylphenols from clove (Syzygium aromaticum) in the Salmonella typhimurium TA1535/pSK1002 umu test.

PubMed:The unique correlation between anti-mutagenicity of human saliva and change in body weight.

PubMed:Structural analysis of a novel antimutagenic compound, 4-Hydroxypanduratin A, and the antimutagenic activity of flavonoids in a Thai spice, fingerroot (Boesenbergia pandurata Schult.) against mutagenic heterocyclic amines.

PubMed:3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) induces caspase-dependent apoptosis in mononuclear cells.

PubMed:DNA-damaging carcinogen 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) induces apoptosis via caspase-9 in primary cultured rat hepatocytes.

PubMed:Antimutagenic activity of isoflavone from Pueraria lobata.

PubMed:Identification of mutagenic heterocyclic amines (IQ, Trp-P-1 and AalphaC) in the water of the Danube river.

PubMed:3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) induces apoptosis in rat splenocytes and thymocytes by different mechanisms.

PubMed:Synthesis and biological activity of alpha-methylene-gamma-lactones as new aroma chemicals.

PubMed:Differential response of cultured human umbilical vein and artery endothelial cells to Ah receptor agonist treatment: CYP-dependent activation of food and environmental mutagens.

PubMed:Detection of biomarkers for apoptosis in rat liver after perfusion with 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1).

PubMed:Activation of genotoxins to DNA-damaging species in exfoliated breast milk cells.

PubMed:CYP1A-dependent activation of xenobiotics in endothelial linings of the chorioallantoic membrane (CAM) in birds.

PubMed:Antimutagens in gaiyou (Artemisia argyi levl. et vant.).

PubMed:Synergistic effects of food colors on the toxicity of 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) in primary cultured rat hepatocytes.

PubMed:Effect of Streptococcus thermophilus on the trp-P-1 level in the blood.

PubMed:Evaluation of the single cell gel electrophoresis assay with human hepatoma (Hep G2) cells.

PubMed:Cytotoxicity and keratinocyte microsome-mediated mutagenic activation of carcinogens in cultured epidermal cells.

PubMed:Antimutagenicity of the purple pigment, hordeumin, from uncooked barley bran-fermented broth.

PubMed:Antimutagenic activity of flavonoids from Pogostemon cablin.

PubMed:Antimutagenic activity of polymethoxyflavonoids from Citrus aurantium.

PubMed:Moscatilin from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity.

PubMed:Genotoxic effects of heterocyclic aromatic amines in human derived hepatoma (HepG2) cells.

PubMed:Antimutagenic activity of isoflavones from soybean seeds (Glycine max merrill).

PubMed:Inhibitory effects of beer and other alcoholic beverages on mutagenesis and DNA adduct formation induced by several carcinogens.

PubMed:Effect of cigarette smoke on the mutagenic activation of environmental carcinogens by rodent liver.

PubMed:Carcinogenicity of heterocyclic amines for the pancreatic duct epithelium in hamsters.

PubMed:Effects of roselle (Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in F344 rats.

PubMed:Antimutagenicity of sweetpotato (Ipomoea batatas) roots.

PubMed:Heterocyclic amines in process flavours, process flavour ingredients, bouillon concentrates and a pan residue.

PubMed:The antimutagenic properties of a polysaccharide produced by Bifidobacterium longum and its cultured milk against some heterocyclic amines.

PubMed:Tryptophan pyrolysis products, Trp-P-1 and Trp-P-2 induce apoptosis in primary cultured rat hepatocytes.

PubMed:Scavenging effect of various tea extracts on superoxide derived from the metabolism of mutagens.

PubMed:Localization of cytochrome P4501A1 and covalent binding of a mutagenic heterocyclic amine in blood vessel endothelia of rodents.

PubMed:Suppression of the SOS-inducing activity of Trp-P-1 and aflatoxin B1 by meso-dihydroguaiaretic acid from Machilus thunbergii in the Salmonella typhimurium TA1535/pSK1002 umu test.

PubMed:Induction of ethoxyresorufin O-deethylase (EROD) and endothelial activation of the heterocyclic amine Trp-P-1 in bird embryo hearts.

PubMed:Effect of some cooked food mutagens on unscheduled DNA synthesis in cultured precision-cut rat, mouse and human liver slices.

PubMed:3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) sensitizes mammalian cells to UV radiation by causing the S-phase arrest, not by inhibiting the repair of DNA damage as observed in Escherichia coli.

PubMed:Analysis of nonpolar heterocyclic amines in cooked foods and meat extracts using gas chromatography-mass spectrometry.

PubMed:Mutagenic activities of exhaust gas and ash from sludge incineration plants.

PubMed:Xenobiotic tolerance of primary cultured hepatocytes in rats fed a high-fat or high-protein diet.

PubMed:Potent suppressing activity of the non-polyphenolic fraction of green tea (Camellia sinensis) against genotoxin-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002)--association with pheophytins a and b.

PubMed:Binding of heterocyclic amines by lactic acid bacteria from miso, a fermented Japanese food.

PubMed:Effects of lactic acid bacteria on binding and absorption of mutagenic heterocyclic amines.

PubMed:Prevention by antioxidants of heterocyclic amine-induced carcinogenesis in a rat medium-term liver bioassay: results of extended and combination treatment experiments.

PubMed:In vivo genotoxicity of heterocyclic amines detected by a modified alkaline single cell gel electrophoresis assay in a multiple organ study in the mouse.

PubMed:Suppression of the SOS-Inducing Activity of Trp-P-1 and Aflatoxin B1 by Meso-dihydroguaiaretic Acid from Machilus thunbergii in the Salmonella typhimurium TA1535/pSK1002 umu Test.

PubMed:Interaction of mutagenic tryptophan pyrolysate with d(CGATCG)2: intercalation model based on NMR experiments.

PubMed:Quantification of mutagenic/carcinogenic heterocyclic amines, MeIQx, Trp-P-1, Trp-P-2 and PhIP, contributing highly to genotoxicity of river water.

PubMed:Food-derived heterocyclic amines potentiate the mutagenicity of a drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX).

PubMed:Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens.

PubMed:Antimutagenic effect of resveratrol against Trp-P-1.

PubMed:Mutagenic heterocyclic aromatic amines (HAAs) in 'processed food flavour' samples.

PubMed:Analysis of synergism in hepatocarcinogenesis based on preneoplastic foci induction by 10 heterocyclic amines in the rat.

PubMed:Antimutagenic effect of methanolic extracts from peanut hulls.

PubMed:Suppressive effects of chlorophyllin on mutagen-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002) and tumor promoter-dependent ornithine decarboxylase induction in BALB/c 3T3 fibroblast cells.

PubMed:Desmutagenicity of soybean after heating.

PubMed:Suppressive effects of retinoids, carotenoids and antioxidant vitamins on heterocyclic amine-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002).

PubMed:3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) inhibits the binding activity of T4 endonuclease V to UV-damaged DNA.

PubMed:Determination of heterocyclic amines by pneumatically assisted electrospray liquid chromatography-mass spectrometry.

PubMed:Antimutagenic activity of caffeic acid and related compounds.

PubMed:Effects of beta- and gamma-carboline derivatives of DNA topoisomerase activities.

PubMed:Relationship between antimutagenic activity and major components of various teas.

PubMed:Binding specificity of mutagenic tryptophan pyrolysates for DNA conformation: spectroscopic and viscometric studies.

PubMed:2,3,7,8-Tetrachlorodibenzo-p-dioxin sensitization of cultured human epidermal cells to carcinogenic heterocyclic amine toxicity.

PubMed:The effects of a soluble-fibre polysaccharide on the adsorption of carcinogens to insoluble dietary fibres.

PubMed:Development of high sensitive umu test system: rapid detection of genotoxicity of promutagenic aromatic amines by Salmonella typhimurium strain NM2009 possessing high O-acetyltransferase activity.

PubMed:Enhancement of rat liver cell foci development by combined treatment with heterocyclic amines at low doses.

PubMed:Identification of new mutagenic heterocyclic amines and quantification of known heterocyclic amines.

PubMed:Quantitative determination of heterocyclic amines in food products.

PubMed:Effect of cigarette smoke on the mutagenic activation of various carcinogens in hamster.

PubMed:Suppressive effects of the extracts of Japanese edible seaweeds on mutagen-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002) and tumor promotor-dependent ornithine decarboxylase induction in BALB/c 3T3 fibroblast cells.

PubMed:Antimutagenicity of lemon grass (Cymbopogon citratus Stapf) to various known mutagens in salmonella mutation assay.

PubMed:Metabolism-dependent binding of the heterocyclic amine Trp-P-1 in endothelial cells of choroid plexus and in large cerebral veins of cytochrome P450-induced mice.

PubMed:Influence of chemicals commonly found in a water environment on the Salmonella mutagenicity test.

PubMed:Effect of cooking time and temperature on the heterocyclic amine content of fried beef patties.

PubMed:Inhibitory activity of cigarette-smoke condensate on the mutagenicity of heterocyclic amines.

PubMed:Metabolic activation of the food mutagen 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]indole (Trp-P-1) in endothelial cells of cytochrome P-450-induced mice.

PubMed:Synergistic enhancement of hepatic foci development by combined treatment of rats with 10 heterocyclic amines at low doses.

PubMed:Metabolic activation of the food mutagen Trp-P-1 in endothelial cells of heart and kidney in cytochrome P450-induced mice.

PubMed:Hepatic Phosphoglucomutase Activity as a Marker of Oxidative Stress Induced by Pro-oxidative Drugs.

PubMed:Desmutagenicity of Melanoidins against Various Kinds of Mutagens and Activated Mutagens.

PubMed:Food-derived heterocyclic amines, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and related amines, as inhibitors of monoamine metabolism.

PubMed:Identification of heterogenous antimutagenic activities in the extract of edible brown seaweeds, Laminaria japonica (Makonbu) and Undaria pinnatifida (Wakame) by the umu gene expression system in Salmonella typhimurium (TA1535/pSK1002).

PubMed:Microorganisms in the gastrointestinal tract of the rat prevent absorption of the mutagen-carcinogen 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole.

PubMed:Anticlastogenic and bio-antimutagenic activity of cultured broth of Saccharomyces cerevisiae 28 on mutagens.

PubMed:3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) inhibits the removal of both cyclobutane dimers and (6-4) photoproducts from the DNA of ultraviolet-irradiated E. coli.

PubMed:Suppressing effects of S phase post-treatment with carbolines on sister-chromatid exchanges induced by mitomycin C in Chinese hamster cells.

PubMed:Interaction of mutagenic tryptophan pyrolysate with DNA. CD spectral study on the binding specificity.

PubMed:Analysis of mutational specificity induced by heterocyclic amines in the lacZ gene of Escherichia coli.

PubMed:Binding of polycyclic planar mutagens to chlorophyllin resulting in inhibition of the mutagenic activity.

PubMed:The effect of a heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), on tyrosine hydroxylase mRNA in PC12h cells.

PubMed:Antimutagenicity of cell fractions of microorganisms on potent mutagenic pyrolysates.

PubMed:Enhancing Effect of Ascorbic Acid on the Mutagenicity of Trp-P-1 by Indigocarmine in the Salmonella Microsome.

PubMed:[Antimutagenic substances in the Armeniacae semen and Persicae semen].

PubMed:Enhancing effects of heterocyclic amines and beta-carbolines on the induction of chromosome aberrations in cultured mammalian cells.

PubMed:Enhancing effect of heterocyclic amines and beta-carbolines on UV or chemically induced mutagenesis in E. coli.

PubMed:Binding of mutagenic pyrolyzates to fractions of intestinal bacterial cells.

PubMed:Determination of human exposure to the dietary carcinogen 3-amino-1, 4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) from hemoglobin adduct: the relationship to DNA adducts.

PubMed:Optimization of the sensitivity of high-performance liquid chromatography in the detection of heterocyclic aromatic amine mutagens.

PubMed:Mutagenic activity of a series of synthetic and naturally occurring heterocyclic amines in Salmonella.

PubMed:Antimutagenic effect of Maillard browning products obtained from amino acids and sugars.

PubMed:Modulating effect of tanshinones on mutagenic activity of Trp-P-1 and benzo[a]pyrene in Salmonella typhimurium.

PubMed:Effects of pH on the in Vitro Sorption of Mutagens to Dietary Fibers.

PubMed:Elevation of levels of carcinogenic tryptophan pyrolysis products in plasma and red blood cells of patients with uremia.

PubMed:Mutagenicity of some heterocyclic amines in Salmonella typhimurium with metabolic activation by human red blood cell cytosol.

PubMed:Chromosome aberrations, micronuclei and sister-chromatid exchanges (SCEs) in rat liver induced in vivo by hepatocarcinogens including heterocyclic amines.

PubMed:Mutagenicity of various chemicals including nickel and cobalt compounds in cultured mouse FM3A cells.

PubMed:Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not of inpatients receiving parenteral alimentation.

PubMed:Enhancement of GST-P positive liver cell foci development by combined treatment of rats with five heterocyclic amines at low doses.

PubMed:Binding of mutagens by fractions of the cell wall skeleton of lactic acid bacteria on mutagens.

PubMed:Reduction of enzymatic activity of tyrosine hydroxylase by a heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole (Trp-P-1), was due to reduced affinity to a cofactor biopterin.

PubMed:In vitro binding of mutagenic pyrolyzates to lactic acid bacterial cells in human gastric juice.

PubMed:Carcinogenic tryptophan pyrolysis products in the environment.

PubMed:Inhibition of tryptophan hydroxylase by food-derived carcinogenic heterocyclic amines, 3-amino-1-methyl-5H-pyrido[4,3-b]indole and 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole.

PubMed:Loss of heterocyclic amine mutagens by insoluble hemicellulose fiber and high-molecular-weight soluble polyphenolics of coffee.

PubMed:The formation of heart DNA adducts in F344 rat following dietary administration of heterocyclic amines.

PubMed:Antimutagenicity and binding of lactic acid bacteria from a Chinese cheese to mutagenic pyrolyzates.

PubMed:Simple methods for quantifying mutagenic heterocyclic aromatic amines in food products.

PubMed:Inhibition of human brain aromatic L-amino acid decarboxylase by cooked food-derived 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and other heterocyclic amines.

PubMed:Enhancement of the mutagenicity of Trp-P-1, Trp-P-2 and benzo[a]pyrene by bupleuri radix extract.

PubMed:Effects of dietary and intraperitoneally administered beta-naphthoflavone on mutagenicity and tissue distribution of Trp-P-1 in the rat.

PubMed:Genotoxicity of heterocyclic amines in the hepatocyte/DNA repair assay using hepatocytes of rats or mice pretreated with 3-methylcholanthrene.

PubMed:Inhibitory effects of carcinogenic tryptophan pyrolysis products on phytohemagglutinin-induced blast transformation of human lymphocytes.

PubMed:3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and other heterocyclic amines as inhibitors of mitochondrial monoamine oxidases separated from human brain synaptosomes.

PubMed:Carcinogenic tryptophan pyrolysis products in cigarette smoke condensate and cigarette smoke-polluted indoor air.

PubMed:Identification of carcinogenic tryptophan pyrolysis products in human bile by high-performance liquid chromatography.

PubMed:Hyperketonaemia markedly modulates the metabolic activation of chemical carcinogens.

PubMed:Prostaglandin hydroperoxidase-dependent activation of heterocyclic aromatic amines.

PubMed:Improvement of carcinogen identification in BALB/3T3 cell transformation by application of a 2-stage method.

PubMed:Carcinogenic tryptophan pyrolysis products in airborne particles and rain water.

PubMed:Hepatocarcinogenic heterocyclic aromatic amines that induce cytochrome P-448 isozymes, mainly cytochrome P-448H (P-450IA2), responsible for mutagenic activation of the carcinogens in rat liver.

PubMed:Uptake of heterocyclic amines, Trp-P-1 and Trp-P-2, into clonal rat pheochromocytoma PC12h cells by dopamine uptake system.

PubMed:Carcinogenic tryptophan pyrolysis products in human lens.

PubMed:Human cDNA-expressed cytochrome P450 IA2: mutagen activation and substrate specificity.

PubMed:Exposure level monitor of 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole, a dietary carcinogen, in rabbits.

PubMed:Reduction of enzyme activity of tyrosine hydroxylase and aromatic L-aminoacid decarboxylase in clonal pheochromocytoma PC12h cells by carcinogenic heterocyclic amines.

PubMed:In vitro reaction of hydroxyamino derivatives of MeIQx, Glu-P-1 and Trp-P-1 with DNA: 32P-postlabelling analysis of DNA adducts formed in vivo by the parent amines and in vitro by their hydroxyamino derivatives.

PubMed:Analysis of human plasma as an exposure level monitor for carcinogenic tryptophan pyrolysis products.

PubMed:Effects of heterocyclic amines in food on dopamine metabolism in nigro-striatal dopaminergic neurons.

PubMed:Hepatic cytochrome P-450 isozyme(s) induced by dietary carcinogenic aromatic amines preferentially in female mice of DBA/2 and other strains.

PubMed:Adsorption of mutagens by refined corn bran.

PubMed:Species and sex differences in genotoxicity of heterocyclic amine pyrolysis and cooking products in the hepatocyte primary culture/DNA repair test using rat, mouse, and hamster hepatocytes.

PubMed:Heterocyclic amine-DNA adducts analyzed by 32P-postlabeling method.

PubMed:Streptozotocin-induced diabetes modulates the metabolic activation of chemical carcinogens.

PubMed:Species, sex and organ differences in induction of a cytochrome P-450 isozyme responsible for carcinogen activation: effects of dietary hepatocarcinogenic tryptophan pyrolysate components in mice and rats.

PubMed:Inhibition of mutagenicity by glycyrrhiza extract and glycyrrhizin.

PubMed:SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals.

PubMed:Tumor induction in mice administered neonatally with 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole or 3-amino-1-methyl-5H-pyrido[4,3-b]indole.

PubMed:Inhibitory effects of tryptophan pyrolysis products on human platelet aggregation through inhibition of prostaglandin endoperoxide synthetase.

PubMed:Carcinogenic effect of the simultaneous administration of five heterocyclic amines to F344 rats.

PubMed:Initiating activity in a two-stage mouse skin model of nine mutagenic pyrolysates of amino acids, soybean globulin and proteinaceous food.

PubMed:Mutagenicity modulating effect of quercetin on aromatic amines and acetamides.

PubMed:Counteraction of the genotoxicity of some cooked-food mutagens by biogenic amines.

PubMed:Detection of Trp-P-1 and Trp-P-2, carcinogenic tryptophan pyrolysis products, in dialysis fluid of patients with uremia.

PubMed:Thermospray liquid chromatographic-mass spectrometric analysis of mutagenic substances present in tryptophan pyrolysates.

PubMed:Desmutagenic effect of alpha-dicarbonyl and alpha-hydroxycarbonyl compounds against mutagenic heterocyclic amines.

PubMed:Activation of mutagenic and carcinogenic heterocyclic amines by S-9 from the liver of a rhesus monkey.

PubMed:Effects of plant-derived flavonoids and polyphenolic acids on the activity of mutagens from cooked food.

PubMed:Mutagen formation in a model beef supernatant fraction. IV. Properties of the system.

PubMed:Carcinogenicity in mice and rats of heterocyclic amines in cooked foods.

PubMed:Mutagenic activities of heterocyclic amines in Chinese hamster lung cells in culture.

PubMed:Metabolism of the dietary carcinogen TRP-P-1 in rats.

PubMed:In vitro binding of potent mutagenic pyrolysates to intestinal bacteria.

PubMed:Induction of unscheduled DNA synthesis in rat and hamster hepatocytes by cooked food mutagens.

PubMed:Role of the uvr gene in the SOS function inducing activity of two tryptophan pyrolysis products, Trp-P-1 and Trp-P-2, in Escherichia coli K12.

PubMed:Metabolic activation of mutagenic heterocyclic aromatic amines from protein pyrolysates.

PubMed:Use of nitrite and hypochlorite treatments in determination of the contributions of IQ-type and non-IQ-type heterocyclic amines to the mutagenicities in crude pyrolyzed materials.

PubMed:Mutagenicity of smoked, dried bonito products.

PubMed:Genotoxicity of heterocyclic amines in the Salmonella/hepatocyte system.

PubMed:Carcinogenicity in rats of a mutagenic compound, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole, from tryptophan pyrolysate.

PubMed:Early cellular effects of Trp-P-1 on adult rat hepatocytes in primary culture.

PubMed:Enhancement of hepatocellular genotoxicity of several mutagens from amino acid pyrolysates and broiled foods following ethanol pretreatment.

PubMed:Mutagenic potency of heterocyclic amines in the Drosophila wing spot test and its correlation to carcinogenic potency.

PubMed:Effect of liver S9 from 3,4,5,3',4'-pentachlorobiphenyl-pretreated rats on the mutagenic activity of the various carcinogens toward Salmonella typhimurium TA 98.

PubMed:Hypersensitivity of xeroderma pigmentosum cells to dietary carcinogens.

PubMed:Mutagenic nitropyrenes in foods.

PubMed:Sex-dependent induction of hepatic enzymes for mutagenic activation of a tryptophan pyrolysate component, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]-indole, by feeding in mice.

PubMed:A desmutagenic factor isolated from burdock (Arctium lappa Linne).

PubMed:Mutagenic activation of 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole(Trp-P-1) and 3-amino-1-methyl-5H-pyrido(4,3-b)indole (Trp-P-2) by primary cultures of adult rat hepatocytes: effect of Aroclor induction in vitro.

PubMed:Damaging effect of dietary components to colon epithelial cells in vivo: effect of mutagenic heterocyclic amines.

PubMed:Inhibition of benzodiazepine and GABA receptor binding by amino-gamma-carbolines and other amino acid pyrolysate mutagens.

PubMed:Effect of glutathione and uridine-5'-diphosphoglucuronic acid on the mutagenicity of tryptophan pyrolysis products (Trp-P-1 and Trp-P-2) by rat-liver and -intestine S9 fraction.

PubMed:Defective repair of tryptophan pyrolysate (Trp P-1 and Trp P-2) and aflatoxin B1 damage in xeroderma pigmentosum cells.

PubMed:Comparative induction of somatic eye-color mutations and sex-linked recessive lethals in Drosophila melanogaster by tryptophan pyrolysates.

PubMed:Formation of mutagens by amino-carbonyl reactions.

PubMed:Distribution of the carcinogenic tryptophan pyrolysis product Trp-P-1 in control, 9-hydroxyellipticine and beta-naphthoflavone pretreated mice.

PubMed:Aroclor 1254 pretreatment enhances the DNA repair response to amino acid pyrolysate mutagens in primary cultures of rat hepatocytes.

PubMed:Ultimate forms of mutagenic and carcinogenic heterocyclic amines produced by pyrolysis.

PubMed:Trp-P-1(3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole) and its acetate.

PubMed:Mutagenic activity of heterocyclic amines in Chinese hamster lung cells with diphtheria toxin resistance as a marker.

PubMed:Mutagenesis of amino acid pyrolysis products in Chinese hamster V79 cells.

PubMed:Induction of sister-chromatid exchanges in human lymphocytes by indirect carcinogens with and without metabolic activation.

PubMed:N-hydroxylation of carcinogenic and mutagenic aromatic amines.

PubMed:Actions of amino-beta-carbolines on induction of sister-chromatid exchanges.

PubMed:Ultrastructural and biochemical alterations induced by tryptophan pyrolysis products on rat hepatocytes in primary culture. I. Action on the transcriptional process.

PubMed:Induction of bladder cancer in mice by implanting pellets containing tryptophan pyrolysis products.

PubMed:Inhibition of protein pyrolysate mutagenicity by retinol (vitamin A).

PubMed:A solvent effect on the mutagenicity of tryptophan-pyrolysate mutagens in the Salmonella/mammalian microsome assay.

PubMed:Antimutagenic action of cobaltous chloride on Trp-P-1-induced mutations in Salmonella typhimurium TA98 and TA1538.

PubMed:Activation of Trp-P-1 and Trp-P-2 in vitro and in vivo.

PubMed:Human saliva inactivates mutagenicity of carcinogens.

PubMed:Induction of gamma-glutamyl transpeptidase positive foci in rat liver by pyrolysis products of amino acids.

PubMed:Inhibitory effect of the ether extract of human feces on activities of mutagens: inhibition by oleic and linoleic acids.

PubMed:Detection of chemical carcinogens by assay of unscheduled DNA synthesis in rat tracheal epithelium in short-term organ culture.

PubMed:Inactivation of mutagens from pyrolysates of tryptophan and glutamic acid by nitrite in acidic solution.

PubMed:Metabolic activation of mutagenic tryptophan pyrolysis products by rat liver microsomes.

PubMed:Metabolic activation of mutagenic tryptophan pyrolysis products (Trp-P-1 and Trp-P-2) by a purified cytochrome P-450-dependent monooxygenase system.

PubMed:Detection of potent mutagens, Trp-P-1 and Trp-P-2, in broiled fish.

PubMed:Induction of sister-chromatid exchanges by mutagens from amino acid and protein pyrolysates.

PubMed:The enhancing effect of cysteine and its derivatives on the mutagenic activities of the tryptophan-pyrolysis products, Trp-P-1 and Trp-P-2.

PubMed:Oxidation of tryptophan-P-1 and P-2 by beef liver catalase-H2O2 intermediate: comparison with horseradish peroxidase.

PubMed:Induction of enzyme-altered islands in rat liver by tryptophan pyrolysis products.

tryptophan-P-1
trp-P-1

Supplier Sponsors

Articles:

tryptophan-P-1 trp-P-1

Supplier Sponsors

Articles:

tryptophan-P-1
trp-P-1