cycasin, 14901-08-7

Articles:

PubMed:Toxic phytochemicals and their potential risks for human cancer.

PubMed:Relative seed and fruit toxicity of the Australian cycads Macrozamia miquelii and Cycas ophiolitica: further evidence for a megafaunal seed dispersal syndrome in cycads, and its possible antiquity.

PubMed:Effect of methanolic extract of Vernonia amygdalina (common bitter leaf) on lipid peroxidation and antioxidant enzymes in rats exposed to cycasin.

PubMed:Animal models of brain maldevelopment induced by cycad plant genotoxins.

PubMed:Cycads and their association with certain neurodegenerative diseases.

PubMed:Unraveling 50-Year-Old Clues Linking Neurodegeneration and Cancer to Cycad Toxins: Are microRNAs Common Mediators?

PubMed:Does the cycad genotoxin MAM implicated in Guam ALS-PDC induce disease-relevant changes in mouse brain that includes olfaction?

PubMed:Is neurodegenerative disease a long-latency response to early-life genotoxin exposure?

PubMed:Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants.

PubMed:The cycad genotoxin MAM modulates brain cellular pathways involved in neurodegenerative disease and cancer in a DNA damage-linked manner.

PubMed:Two genera of Aulacoscelinae beetles reflexively bleed azoxyglycosides found in their host cycads.

PubMed:A survey of phytotoxic microbial and plant metabolites as potential natural products for pest management.

PubMed:[Studies on the chemical constituents of the roots of Anemone altaica].

PubMed:Return of the cycad hypothesis - does the amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) of Guam have new implications for global health?

PubMed:Molecular networks perturbed in a developmental animal model of brain injury.

PubMed:Azoxyglycoside content and beta-glycosidase activities in leaves of various cycads.

PubMed:Acute Cycas seed poisoning in Taiwan.

PubMed:Western Pacific ALS/PDC and flying foxes: What's next?

PubMed:Cycads: their evolution, toxins, herbivores and insect pollinators.

PubMed:Behavioral and neurological correlates of ALS-parkinsonism dementia complex in adult mice fed washed cycad flour.

PubMed:Toxicology. Fruit bats linked to mystery disease.

PubMed:Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam.

PubMed:Effects of single injection of methylazoxymethanol at postnatal day one on cell proliferation in different brain regions of male rats.

PubMed:SOS induction of selected naturally occurring substances in Escherichia coli (SOS chromotest).

PubMed:Damage and repair of nerve cell DNA in toxic stress.

PubMed:The Guam cycad toxin methylazoxymethanol damages neuronal DNA and modulates tau mRNA expression and excitotoxicity.

PubMed:Cycad poisoning in cattle in Japan--studies on spontaneous and experimental cases.

PubMed:Are age-related neurodegenerative diseases linked with various types of magnesium depletion?

PubMed:Na+-dependent and phlorizin-inhibitable transport of glucose and cycasin in brain endothelial cells.

PubMed:ApoE and CYP2D6 polymorphism with and without parkinsonism-dementia complex in the people of Chamorro, guam.

PubMed:Neuroepidemiology of amyotrophic lateral sclerosis: clues to aetiology and pathogenesis.

PubMed:Motor neuron disease on Guam: geographic and familial occurrence, 1956-85.

PubMed:Potential role of environmental genotoxic agents in diabetes mellitus and neurodegenerative diseases.

PubMed:Substrate specificity and transglucosylation catalyzed by cycad beta-glucosidase.

PubMed:A partially purified beta-glucosidase from Bifidobacterium adolescentis converts cycasin to a mutagenic compound.

PubMed:Cycad toxin-induced damage of rodent and human pancreatic beta-cells.

PubMed:Genotoxic activity in vivo of the naturally occurring glucoside, cycasin, in the Drosophila wing spot test.

PubMed:Early biochemical events in mice exposed to cycas and fed a Nigerian-like diet.

PubMed:Transport of cycasin by the intestinal Na+/glucose cotransporter.

PubMed:The magical and medicinal usage of Stangeria eriopus in South Africa.

PubMed:Tumor incidence in a chemical carcinogenesis study of nonhuman primates.

PubMed:Seeds of discovery: a new look at one environmental factor in Alzheimer's disease.

PubMed:Guam ALS-PDC: possible causes.

PubMed:Content of the neurotoxins cycasin (methylazoxymethanol beta-D-glucoside) and BMAA (beta-N-methylamino-L-alanine) in cycad flour prepared by Guam Chamorros.

PubMed:Long-latency neurodegenerative disease in the western Pacific.

PubMed:Slow toxins, biologic markers, and long-latency neurodegenerative disease in the western Pacific region.

PubMed:Dietary protein and chronic toxicity of 1,2-dimethylhydrazine fed to mice.

PubMed:Mutagenicity of methylazoxymethanol acetate in the presence of alcohol dehydrogenase, aldehyde dehydrogenase, and rat liver microsomes in Salmonella typhimurium His G46.

PubMed:Intestinal microflora: metabolism of drugs and carcinogens.

PubMed:Etiology of Alzheimer's disease: a western pacific view.

PubMed:Acquired chemical defense in the lycaenid butterfly,Eumaeus atala.

PubMed:Mutagenic activity of promutagens in plants: indirect evidence of their activation.

PubMed:A poison tree.

PubMed:Statistical analysis of a carcinogen mixture experiment. I. Liver carcinogens.

PubMed:Hepatic and spinal lesions in goats chronically intoxicated with cycasin.

PubMed:On the distribution of genotoxic factors in various organs of mice treated with cycasin.

PubMed:Induction of tumors with cycasin in newborn and preweanling rats.

PubMed:Animal model for colorectal cancer.

PubMed:Diet and nutrition as risk factors for cancer.

PubMed:[Experimental multiple primary malignant tumors induced by chemical carcinogen].

PubMed:Review: putative mutagens and carcinogens in foods. V. Cycad azoxyglycosides.

PubMed:Potentiation of large intestinal tumorigenicity of cycasin derivative by high-fat diet and Lactobacillus in germfree mice.

PubMed:Activation of cycasin to a mutagen for Saccharomyces cerevisiae by rat intestinal flora.

PubMed:Bacterial mutagenicity of natural materials, pyrolysis products and additives in foodstuffs and their association with genotoxic effects in mammals.

PubMed:Cycasin and its mutagenic metabolites.

PubMed:Genetic damage caused by methylazoxymethanol acetate, the aglycone of cycasin. Analysis of sister-chromatid exchange frequency under in vivo conditions and in cell cultures.

PubMed:Comparison of the carcinogenicity of methylazoxymethanol-beta-D-glucosiduronic acid in conventional and germfree Sprague-Dawley rats.

PubMed:Determination of the carcinogen methylazoxymethyl-beta-D-glucosiduronic acid in rat bile and urine.

PubMed:Natural carcinogenic products of plant origin.

PubMed:[Occurrence of neoplasms in the large intestine and role of intestinal bacteria].

PubMed:Genotoxicity of cycasin in the hepatocyte primary culture/DNA repair test supplemented with beta-glucosidase.

PubMed:Rapid hepatoma induction in rats by dipentylnitrosamine and its modification by other carcinogens.

PubMed:Effect of phenobarbital on the development of neoplastic lesions in the liver of cycasin-treated rats.

PubMed:[Classification, histochemistry and ultrastructure of experimental renal tumors (author's transl)].

PubMed:Carcinogenicity and hepatotoxicity of cycasin and its aglycone methylazoxymethanol acetate in nonhuman primates.

PubMed:Role of bacteria in human carcinogenesis.

PubMed:Mutagenicity of the naturally occurring carcinogen cycasin and synthetic methylazoxymethanol conjugates in Salmonella typhimurium.

PubMed:Synthesis of the glucuronic acid conjugate of methylazoxymethanol.

PubMed:DNA fragmentation in some organs of rats and mice treated with cycasin.

PubMed:Mutagenicity of alkaloids in the Salmonella/microsome system.

PubMed:Contributions of gnotobiology to nutrition science.

PubMed:Toxins and carcinogens in the environment: an observation in the tropics.

PubMed:A practical procedure for testing DNA damage in vivo, proposed for a pre-screening of chemical carcinogens.

PubMed:[Histology, fine structure and differentiation of experimental Wilms tumors (author's transl)].

PubMed:Naturally occurring compounds Containing a nitrogen-nitrogen bond.

PubMed:Cancer and the environment.

PubMed:Effect of coffee on carcinogenicity of cycasin.

PubMed:PHA response and methylazoxymethanol acetate.

PubMed:Pathogenesis of methylazoxymethanol-induced lesions in the postnatal mouse cerebellum.

PubMed:Carcinogens occurring naturally in foods.

PubMed:Leiomyomas and leiomyosarcomas of the kidney in 4-day-old BUF rats given methylazoxymethanol acetate intraperitoneally.

PubMed:Naturally occuring mutagens.

PubMed:Cycasin.

PubMed:Experimental carcinogenesis in small aquarium fishes.

PubMed:[Microorganisms as indicators of the mutagenic activity of chemical compounds and their metabolites].

PubMed:Intestinal tumors of rats by gastric or intestinal administration of cycad extract and cycasin.

PubMed:Hepatic tumors of rabbits induced by cycad extract.

PubMed:Dendritic growth in vitro.

PubMed:[Ultrastructure of cycasin-induced adenomas of kidney (author's transl)].

PubMed:Renal carcinogenesis.

PubMed:The alkylation of nucleic acids of rat and mouse in vivo by the carcinogen 1,2-dimethylhydrazine.

PubMed:Morphological and biochemical effects of 1,2-dimethylhydrazine and 1-methylhydrazine in rats and mice.

PubMed:[Cycasin carcinogenesis. (5). Carcinogenic properties of cycasin, methylazoxymethanol and methylazoxymethyl benzoate].

PubMed:Acute hepatic lesions induced by cycasin.

PubMed:Induction of a retinal disorder with cycasin in newborn mice and rats.

PubMed:Relations between postnatal days of mice and carcinogenic effect of cycasin.

PubMed:High yield of hepatic tumors in rats by cycasin.

PubMed:Cycasin-induced central nervous system lesions in postnatal mice.

PubMed:Fine structure of cycasin-induced cerebellar alterations.

PubMed:Cycasin in cycad materials used in Japan.

PubMed:Lipid composition of the cerebellum and spinal cord in postnatal cycasin-treated Swiss albino mice: preliminary observations.

PubMed:Carcinogenicity and neurotoxicity of cycasin with sepcial reference to species differences.

PubMed:-Glucosidase modulation in preweanling rats and its association with tumor induction by cycasin.

PubMed:[Natural carcinogens: target organs and species specificity in induction of cancer by single administration of cycasin].

PubMed:[Natural carcinogens: aglycon-methylazoxymethanol in cycasin].

PubMed:[Natural carcinogens: isolation of cycasin].

PubMed:[Natural carcinogens: toxicity and carcinogenicity of cyasin: induction of tumors by cycasin in the seeds of Cycas revoluta].

PubMed:[Natural carcinogens: hepatic disorders in the rat caused by cycasin, with special reference to the induction of hepatic tumors].

PubMed:Decomposition of methylazoxymethanol, the aglycone of cycasin, in D 2 O.

PubMed:An electron microscopic study of cycasin-induced cerebellar alterations.

PubMed:Shift of target organs in cycasin carcinogenesis.

PubMed:Dose related effects of cycasin induced renal and hepatic tumors.

PubMed:Carcinogenic effects of cycasin in Syrian golden hamsters and the transplantability of induced tumors.

PubMed:High incidence of pulmonary tumors in dd mice by a single injection of cycasin.

PubMed:[Carcinogenesis by cycasin, with special reference to the target organs].

PubMed:Tumor induction in C57BL-6 mice by a single administration of cycasin.

PubMed:Induction of a cerebellar disorder with cycasin in newborn mice and hamsters.

PubMed:Cycling of cycasin from newborn rats to their mother and back to the newborn.

PubMed:Cycasin: detection of associated mutagenic activity in vivo.

PubMed:[Cycasin-induced renal tumors in the Wistar rat with special consideration of the adenoma].

PubMed:Toxicology of cycasin.

PubMed:Effect of cycasin on protein synthesis.

PubMed:Induction of mammary cancer in rats with cycasin: a preliminary report.

PubMed:Tumor induction in Fischer and Osborne-Mendel rats by a single administration of cycasin.

PubMed:Transplantability of cycasin-induced tumors in rats, with emphasis on nephroblastomas.

PubMed:Evidence for transplacental passage of the natural carcinogen cycasin and its aglycone.

PubMed:Induction of a neurological disorder by cycasin in mice.

PubMed:Similarities between the biochemical actions of cycasin and dimethylnitrosamine.

PubMed:Tumor induction in germfree rats with methylazoxymethanol (MAM) and synthetic MAM acetate.

PubMed:Mutation in Drosophila by methylazoxymethanol, the aglycone of cycasin.

PubMed:Cycasin synthesis in Seirarctia echo (Lepidoptera) larvae fed methylazoxymethanol.

PubMed:Role of intestinal microorganisms in determining cycasin toxicity.

PubMed:[Histological-histochemical studies on the "interstitial cycasin tumor" of rat kidneys].

PubMed:Mutagenicity of cycasin aglycone (methylazoxymethanol), a naturally occurring carcinogen.

PubMed:Effect of boiling and storing on cycasin content of Cycas circinalis L.

PubMed:Studies on methylazoxymethanol, the aglycone of cycasin: methylation of nucleic acids in vitro.

PubMed:Cycasin excretion in conventional and germfree rats.

PubMed:Naturally occurring toxicants in foods.

PubMed:The induction of intestinal neoplasms in rats with the glycoside cycasin and its aglycone.

PubMed:CYCASIN: RADIOMIMETIC EFFECT.

PubMed:Cycasin content of Cycas circinalis.

PubMed:STUDIES ON METHYLAZOXYMETHANOL, THE AGLYCONE OF CYCASIN. ISOLATION, BIOLOGICAL, AND CHEMICAL PROPERTIES.

PubMed:STUDIES ON METHYLAZOXYMETHANOL, THE AGLYCONE OF CYCASIN: A SYNTHESIS OF METHYLAZOXYMETHYL ACETATE.

PubMed:RESPONSE OF LIVER NUCLEIC ACIDS AND LIPIDS IN RATS FED CYCAS CIRCINALIS L. ENDOSPERM OR CYCASIN.

PubMed:EFFECT OF INGESTED CYCASIN ON RAT BLOOD PLASMA CHOLINESTERASE.

PubMed:CARCINOGENIC EFFECTS OF CYCAD MEAL AND CYCASIN, METHYLAZOXYMETHANOL GLYCOSIDE, IN RATS AND EFFECTS OF CYCASIN IN GERMFREE RATS.

PubMed:EFFECTS OF CYCAD MEAL AND CYCASIN ON HISTOCHEMICALLY DEMONSTRABLE LIVER PHOSPHATASES AND NON SPECIFIC ESTERASES.

PubMed:RATES AND KINETICS OF CATALASE SYNTHESIS AND DESTRUCTION IN RATS FED CYCAD AND CYCASIN IN VIVO.

PubMed:EFFECT OF CYCAD AND CYCASIN FEEDING ON LIVER RNA, DNA, SUCCINIC OXIDASE, AND LIPIDS IN THE RAT.

PubMed:EFFECTS OF CYCASIN AND CYCAD MEAL.

PubMed:METHYLAZOXYMETHANOL, THE AGLYCONE OF CYCASIN.

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