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cyclamate
cyclamic acid

Supplier Sponsors

CAS Number: 100-88-9Picture of molecule3D/inchi
Other:45951-45-9
ECHA EINECS - REACH Pre-Reg:202-898-1
FDA UNII:HN3OFO5036
Nikkaji Web:J4.986G
Beilstein Number:2208885
MDL:MFCD00065234
XlogP3-AA:0.60 (est)
Molecular Weight:179.23921000
Formula:C6 H13 N O3 S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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JECFA Food Additive: Cyclohexylsulfamic Acid
GSFA Codex: Cyclamic acid (952(i))
DG SANTE Food Additives:cyclamic acid
FDA Mainterm (SATF):977016-96-8 ; CYCLAMATE--PROHIBITED
FDA Regulation:
FDA PART 189 -- SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD
Subpart C--Substances Generally Prohibited From Direct Addition or Use as Human Food
Sec. 189.135 Cyclamate and its derivatives.
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 169.00 to 170.00 °C. @ 760.00 mm Hg
logP (o/w): -1.610 (est)
Soluble in:
 water, 1000000 mg/L @ 25 °C (exp)
 alcohol
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Cyclamic acid >98%
Odor: characteristic
Use: Cyclamic acid in the form of its sodium or calcium salt is one of the most widely used artificial sweeteners.
Carbosynth
For experimental / research use only.
Cyclamic acid
Sigma-Aldrich: Aldrich
For experimental / research use only.
N-Cyclohexylsulfamic acid ≥98.0% (T)
The Ingredient House
RightSweet Cyclamate
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 12000 mg/kg
American Journal of the Medical Sciences. Vol. 225, Pg. 551, 1953.

intravenous-rat LD50 4000 mg/kg
American Journal of the Medical Sciences. Vol. 225, Pg. 551, 1953.

oral-mouse LD50 680 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
National Technical Information Service. Vol. OTS0540890

intravenous-mouse LD50 180 mg/kg
U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01774

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: information only not used for fragrances or flavors
Recommendation for cyclamate usage levels up to:
 not for fragrance use.
 
Recommendation for cyclamate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NLM Hazardous Substances Data Bank:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):100-88-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7533
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
cyclohexylsulfamic acid
Chemidplus:0000100889
RTECS:GV6950000 for cas# 100-88-9
 
References:
 cyclohexylsulfamic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:100-88-9
Pubchem (cid):7533
Pubchem (sid):135269892
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C02824
HMDB (The Human Metabolome Database):HMDB31340
FooDB:FDB009257
Haz-Map:View
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
•sodium and calcium cyclamates were used mainly in the form of the 10:1 cyclamate:saccharin salt mixt. na & ca salt •grades: nf national formulary; fcc food chem codex, nrc. sodium salt •in the us, cyclamic acid is available with a minimum purity of 98% on an anhydrous basis •in the usa, calcium cyclamate was available commercially in 1970 as a us national formulary (nf) grade crystalline powder containing 98-101% active ingredient on an anhydrous basis, 6-9% water, a maximum of 30 mgkg selenium, 25 mgkg cyclohexylamine, 10 mgkg heavy metals and 3 mgkg arsenic. it was also available in: (1) aqueous solutions containing about 6% calcium cyclamate combined with about 0.6% calcium saccharin, and (2) tablets containing about 50 mg calcium cyclamate combined with about 5 mg calcium saccharin. calcium cyclamate •trade names: cyclan; cylan; dietil; sucaryl calcium. calcium cyclamate
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 sweetener
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 cyclamic acid
 cyclohexane sulfamic acid
 cyclohexanesulfamic acid
 cyclohexanesulphamic acid
 cyclohexyl amidosulfuric acid
 cyclohexyl amine sulfamic acid
 cyclohexyl sulfamic acid
 cyclohexylamidosulfuric acid
 cyclohexylamidosulphuric acid
 cyclohexylaminesulfonic acid
 cyclohexylaminesulphonic acid
 cyclohexylsulfamic acid
N-cyclohexylsulfamic acid
 cyclohexylsulphamic acid
N-cyclohexylsulphamic acid
 hexamic acid
 polycat 200
 sucaryl
 sucaryl acid
 sulfamic acid, cyclohexyl-
 sulfamic acid, N-cyclohexyl-
 sulfuric acid monoamide, N-cyclohexyl-
 

Articles:

PubMed:Determination of cyclamate in urine by derivatized gas chromatography-mass spectrometry.
PubMed:Rapid analysis of cyclamate in foods and beverages by gas chromatography-electron capture detector (GC-ECD).
PubMed:Stevia, cyclamate and saccharin - natural and artificial sweeteners - exert no effect on sulfane levels in tissues.
PubMed:[Determination of sodium cyclamate in liquor by high performance liquid chromatography-tandem mass spectrometry with linear trap technology].
PubMed:Structural elucidation of main ozonation products of the artificial sweeteners cyclamate and acesulfame.
PubMed:Development and single-laboratory validation of an HPLC method for the determination of cyclamate sweetener in foodstuffs.
PubMed:Simultaneous square-wave voltammetric determination of aspartame and cyclamate using a boron-doped diamond electrode.
PubMed:Determination of cyclamate in foods by ultraperformance liquid chromatography/tandem mass spectrometry.
PubMed:Suitability of artificial sweeteners as indicators of raw wastewater contamination in surface water and groundwater.
PubMed:Structures of artificial sweeteners--cyclamic acid and sodium cyclamate with other cyclamates.
PubMed:Rapid determination of cyclamate in foods by solid-phase extraction and capillary electrophoresis.
PubMed:Cyclamate intake and cyclohexylamine excretion are not related to male fertility in humans.
PubMed:The fate of cyclamate in man and other species.
PubMed:Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3.
PubMed:Caffeine enhancement of saccharin but not cyclamate flavor avoidance.
PubMed:[Influence of several weeks' treatment of male and female mice with saccharin, cyclamate or cyclohexylamine sulfate on fertility and dominant lethal effects (author's transl)].
PubMed:The role of the gut flora in the metabolism of cyclamate.
PubMed:Long-term toxicity and carcinogenicity study of cyclamate in nonhuman primates.
PubMed:Synthesis and bacterial metabolism of cis- and trans-2-alkyl analogues of sodium cyclamate.
PubMed:Bitterness suppression with zinc sulfate and na-cyclamate: a model of combined peripheral and central neural approaches to flavor modification.
PubMed:Quantification of four artificial sweeteners in Finnish surface waters with isotope-dilution mass spectrometry.
PubMed:Induction of morphological changes in the urothelium of cultured adult rat bladder by sodium saccharin and sodium cyclamate.
PubMed:Toxicological aspects of cyclamate and cyclohexylamine.
PubMed:Cyclamate consumption in Catalonia, Spain (1992): relationship with the body mass index.
PubMed:The metabolism of cyclamate to cyclohexylamine and its cardiovascular consequences in human volunteers.
PubMed:Determination of cyclamate in low-calorie foods by high-performance liquid chromatography with indirect visible photometry.
PubMed:Spectrophotometric determination of cyclamate in foods: NMKL collaborative study.
PubMed:Multistage transformation of cultured rat urothelium: the effects of N-methyl-N-nitrosourea, sodium saccharin, sodium cyclamate and 12-O-tetradecanoylphorbol-13-acetate.
PubMed:Metabolic adaptation of rat faecal microflora to cyclamate in vitro.
PubMed:Estimated intake of the artificial sweeteners acesulfame-K, aspartame, cyclamate and saccharin in a group of Swedish diabetics.
PubMed:Assessment of the genotoxicity of calcium cyclamate and cyclohexylamine.
PubMed:Effects of sodium cyclamate and sodium saccharin on focus induction in explant cultures of rat bladder.
PubMed:Evaluation of a new model to detect bladder carcinogens or co-carcinogens; results obtained with saccharin, cyclamate and cyclophosphamide.
PubMed:Synthesis, characterization and antimycobacterial activity of Ag(I)-aspartame, Ag(I)-saccharin and Ag(I)-cyclamate complexes.
PubMed:Occurrence of seven artificial sweeteners in the aquatic environment and precipitation of Tianjin, China.
PubMed:Indirect determination of cyclamate by an on-line continuous precipitation-dissolution flow system.
PubMed:Liposome aggregation in presence of the sweeteners cyclamate and saccharine.
PubMed:[Studies of the interractions of cyclamate with phenprocomon (author's transl)].
PubMed:Dietary intake of artificial sweeteners by the Belgian population.
PubMed:Intake of saccharin, aspartame, acesulfame K and cyclamate in Italian teenagers: present levels and projections.
PubMed:Quantification of cyclamate and cyclohexylamine in urine samples using high-performance liquid chromatography with trinitrobenzenesulfonic acid pre-column derivatization.
PubMed:[Sensitive and selective HPLC methods with prechromatographic derivatization for the determination of cyclamate in foods].
PubMed:[Determination of cyclamate in complex matrix using HPLC after column derivatization with 4-fluoro-7-nitrobenzofurazan].
PubMed:Saccharin and cyclamate inhibit binding of epidermal growth factor.
PubMed:Effects of cyclamate calcium on the immune response in rabbits.
PubMed:[35S]Cyclamate metabolism: incorporation of 35S into proteins of intestinal bacteria in vitro and production of volatile 35S-containing compounds.
PubMed:Orally disintegrating tablet of novel salt of antiepileptic drug: formulation strategy and evaluation.
PubMed:The metabolism of cyclamate to cyclohexylamine in humans during long-term administration.
PubMed:[A rapid separation and quantitation of sodium cyclamate in food by ion-pair reversed-phase high performance liquid chromatography].
PubMed:[Sweetness potency of saccharin and cyclamate in hot drinks].
PubMed:Bladder tumors in rats fed cyclohexylamine or high doses of a mixture of cyclamate and saccharin.
PubMed:Production of mouse urinary bladder carcinomas by sodium cyclamate.
PubMed:Flow-injection determination of amine contaminants in cyclamate samples based on temperature for controlling selectivity.
PubMed:Metabolism of cyclamate and its conversion to cyclohexylamine.
PubMed:No evidence found for induction of dominant lethal mutations and heritable translocations in male mice by calcium cyclamate.
PubMed:Investigations on the carcinogenicity of the artificial sweeteners sodium cyclamate and sodium saccharin in rats in a two-generation experiment.
PubMed:Determination of cyclamate by high-performance liquid chromatography with indirect photometry.
PubMed:Method for testing mutagenic effects of chemicals on spermatogonia of the Chinese hamster: results obtained with cyclophosphamide, saccharin, and cyclamate.
PubMed:Studies on synthetic sweetening agents. XVI. Metabolism of sodium cyclamate. 5. The metabolism of sodium cyclamate in rabbits and rats after prolonged administration of sodium cyclamate.
PubMed:Measurement of the relative sweetness of stevia extract, aspartame and cyclamate/saccharin blend as compared to sucrose at different concentrations.
PubMed:Intake of saccharin and cyclamate from Finnish foods between 1979 and 1985.
PubMed:Carcinogenicity prediction and battery selection procedure: an in-depth analysis of cyclamate and its major metabolite cyclohexylamine.
PubMed:Effect of the suspected tumor promoters saccharin, cyclamate, and phenol on nerve growth factor binding and response in cultured embryonic chick ganglia.
PubMed:Saccharin, cyclamate, and human bladder cancer. No evidence of an association.
PubMed:Three cases of human bladder cancer following high dose cyclamate ingestion.
PubMed:[Subchronic toxicologic studies using cyclamate-Na in dogs].
PubMed:Protective effects of cholestyramine in rats fed a low-fiber diet containing toxic doses of sodium cyclamate or amaranth.
PubMed:NEW and nonofficial remedies: cyclamate sodium.
PubMed:Evaluating the environmental impact of artificial sweeteners: a study of their distributions, photodegradation and toxicities.
PubMed:Studies on cyclamate sodium (sucaryl sodium); a new noncaloric sweetening agent.
PubMed:Selective continuous monitoring and analysis of mixtures of acesulfame-K, cyclamate, and saccharin in artificial sweetener tablets, diet soft drinks, yogurts, and wines using filter-supported bilayer lipid membranes.
PubMed:[The psychophysics of sweet taste. 7. New determination of sweet taste parameters of acesulfame, aspartame, cyclamate, saccharin, glucose and sorbitol].
PubMed:Assessment of the carcinogenicity of the nonnutritive sweetener cyclamate.
PubMed:Myocardial effects of calcium cyclamate in the BIO F1D Alexander Syrian golden hamster.
PubMed:Acesulfame K, cyclamate and saccharin inhibit the anaerobic fermentation of glucose by intestinal bacteria.
PubMed:Studies on synthetic sweetening agents. XVIII. Metabolism of sodium cyclamate. (7). Dicyclohexylamine, a metabolite of sodium cyclamate in rabbits and rats.
PubMed:Chronic toxicity study of cyclamate: saccharin (10: 1) in rats.
PubMed:Quantitative conversion of cyclamate to N,N-dichlorocyclohexylamine, and ultraviolet spectrophotometric assay of cyclamate in food.
PubMed:Studies on synthetic sweetening agents. XV. Metabolism of sodium cyclamate. Influences of phenylbutaone, phenobarbital, and tolbutamide on metabolism of sodium cyclamate in rabbits.
PubMed:Cytogenetic studies with cyclamate and related compounds.
PubMed:Determination of dicyclohexylamine in sodium cyclamate.
PubMed:A case for safety of cyclamate and cyclamate-saccharin combinations.
PubMed:Effects of artificial sweeteners on the AhR- and GR-dependent CYP1A1 expression in primary human hepatocytes and human cancer cells.
PubMed:Effects of a saccharin and cyclamate mixture on rat embryos.
PubMed:Spectrophotometric determination of cyclamate in soft drinks and desserts: complementary collaborative study.
PubMed:[A new HPLC procedure for cyclamate in food with pre-chromatographic derivatization].
PubMed:Fatty-acid conjugation with cyclamate metabolites as a possible mechanism for ultimate retention.
PubMed:Inhibition of iodinated nerve growth factor binding by the suspected tumor promoters saccharin and cyclamate.
PubMed:Absence of carcinogenic response to cyclamate and saccharin in Sprague-Dawley rats after transplacental application.
PubMed:Correlation of chemical structure and taste in the cyclamate series and the steric nature of the chemoreceptor site.
PubMed:Studies on synthetic sweetening agents. XVII. Metabolism of sodium cyclamate. (6). Influences of neomycin and sulfaguanidine on metabolism of sodium cyclamate.
PubMed:Studies on synthetic sweetening agents. XIV. Metabolism of sodium cyclamate. 3. On metabolites of sodium cyclamate in human.
PubMed:Cytogenetic studies in rats of cyclohexylamine, a metabolite of cyclamate.
PubMed:Studies on synthetic sweetening agents. 13. Metabolism of sodium cyclamate. (2). Detection of metabolites of sodium cyclamate in the rabbit and rat by gas-liquid chromatography.
PubMed:Determination of artificial sweeteners by capillary electrophoresis with contactless conductivity detection optimized by hydrodynamic pumping.
PubMed:Re: Long-term toxicity and carcinogenicity study of cyclamate in nonhuman primates (Takayama et al., Toxicol. Sci. 53, 33-39)
PubMed:[Synthesis of cyclohexanone and 2-cyclohexenone from sodium cyclamate].
PubMed:Synthetic sweetener cyclamate as a potential source of false-positive amphetamine results in the TDx system.
PubMed:Analysis of saccharin, acesulfame-K and sodium cyclamate by high-performance ion chromatography.
PubMed:Concern about cyclamate as toothpaste sweetener.
PubMed:Use of post-column ion-pair extraction with absorbance detection for the liquid chromatographic determination of cyclamate and other artificial sweeteners in diet beverages.
PubMed:Spectrophotometric determination of sodium cyclamate and saccharin sodium with Astrazone pink FG.
PubMed:Effects on oral health of mouthrinses containing xylitol, sodium cyclamate and sucrose sweeteners in the absence of oral hygiene. V. Response of hamster cheek pouch microcirculation to dental plaque.
PubMed:Effects on oral health of mouthrinses containing xylitol, sodium cyclamate and sucrose sweeteners in the absence of oral hygiene. IV. Analysis of whole saliva.
PubMed:Effects on oral health of mouthrinses containing xylitol, sodium cyclamate and sucrose sweeteners in the absence of oral hygiene. II. Relative composition of free amino acids in human crevicular fluid.
PubMed:The science and politics of cyclamate.
PubMed:Effects in the mammalian spot test: cyclamate versus saccharin.
PubMed:Syncarcinogenic action of saccharin or sodium cyclamate in the induction of bladder tumours in MNU-pretreated rats.
PubMed:Effect of cyclamate sodium, saccharin sodium and stevioside on arginine-induced insulin and glucagon secretion in the isolated perfused rat pancreas.
PubMed:[Effect of sodium saccharin and sodium cyclamate on water-soluble vitamins and essential amino acids].
PubMed:Saccharin and cyclamate.
PubMed:[The reaction of cyclohexylsulphamic acid (Cyclamate) with nitrous acid in aqueous HCl-solution, isolated human gastric juice and urine (author's transl)].
PubMed:Histological examination of perinatal eye development in the rat after ingestion of sodium cyclamate and sodium saccharin during pregnancy.
PubMed:[Detection and determination of artificial sweeteners in foodstuffs. I. Detection of saccharin, cyclamate and dulcin].
PubMed:Cyclamate sweeteners.
PubMed:Editorial: The cyclamate ban.
PubMed:Proceedings: Syncarcinogenesis with n-methyl N-nitrosourea (MNU) and cyclamate in rat urinary bladder.
PubMed:Cyclamate and cyclohexylamine: lack of effect on the chromosomes of man and rats in vivo.
PubMed:Inhibitory effect of sodium cyclamate and sodium saccharin on tumor induction by 2-acetylaminofluorene in rats.
PubMed:Partial purification and some properties of cyclamate sulfamatase.
PubMed:Lack of mutagenicity of the cyclamate metabolites in Drosophila.
PubMed:Determination of cyclamate in soft drinks by reaction with nitrous acid. 3. Manual and semi-automated methods: determination of excess of nitrous acid with safranine.
PubMed:[Investigation of cyclamate for mutagenic effects by use of the dominant lethal assay in mouse].
PubMed:Comparative effects of a purified diet and stock ration on sodium cyclamate toxicity in rats.
PubMed:Determination of cyclamate in soft drinks by reaction with nitrous acid. Gas-liquid chromatographic determination of cyclohexene and of cyclohexyl nitrite.
PubMed:Colorimetric determination of cyclamate in soft drinks, using picryl chloride.
PubMed:[Lack of a syncarcinogenic effect of cyclamate in inducing bladder neoplasms by butyl-butanol-nitrosamine in rats].
PubMed:[In vitro effect of sodium cyclamate on human chromosomes].
PubMed:Conversion of cyclamate to cyclohexylamine in guinea pig.
PubMed:Characterization of some lincomycin and cyclamate salts by thermal analysis and infrared spectroscopy.
PubMed:Whole-body autoradiography of 14 C sodium cyclamate in pregnant and fetal rats.
PubMed:Cytogenetic studies on calcium cyclamate in Meriones unguiculatus (gerbil) in vivo.
PubMed:[Noxious effects of various drugs and medicaments on the genetic material. 3. The case of sodium cyclamate].
PubMed:Cyclohexylamine production and physiological measurements in subjects ingesting sodium cyclamate.
PubMed:Excretion of cyclohexylamine, a metabolite of cyclamate, in human urine.
PubMed:The cyclamate story--what kind of lesson do we get out of it as regards problems of food additive control in general?
PubMed:[Intestinal dialysis with sodium cyclamate--a new method for chronic uremia treatment].
PubMed:[Cytogenetic effects of cyclamate on human peripheral lymphocytes in vivo].
PubMed:Sodium cyclamate and bladder carcinoma.
PubMed:Detection and estimation of cyclamate by thin-layer chromatography.
PubMed:Cyclamate brouhaha.
PubMed:[Clinical experimentation of the thiabendazole and tetramizole cyclamate combination in the treatment of human enteroparasitosis].
PubMed:Dietary cyclamate and cyclohexylamine excretion in man.
PubMed:Cyclamate and cyclohexylamine.
PubMed:Feeding studies on sodium cyclamate, saccharin and sucrose for carcinogenic and tumour-promoting activity.
PubMed:[The discussion on cyclamate continues].
PubMed:The metabolism of tolbutamide and cyclamate.
PubMed:[New histologic findings and further experimental data to the problem of cyclamate tolerance of the guinea pig].
PubMed:Editorial. The cyclamate story till now.
PubMed:Cyclamate and cyclohexylamine: transfer across the hemochorial placenta.
PubMed:[How dangerous is cyclamate?].
PubMed:[Therapeutic test using a single dose of tetramizole cyclamate in ascariasis].
PubMed:[The pharmacological study of the effect of alpha-(isopropyl) -alpha- (beta-dimethyl aminopropyl) phenylacetonitril cyclamate (Perocan) on the central nervous system].
PubMed:Studies of the possible therapeutic interaction between cyclamate and warfarin.
PubMed:Pharmacological characteristics of cyclohexylamine, one of metabolites of cyclamate.
PubMed:[On the toxicity of cyclamate for mouse embryos].
PubMed:[Continued clinical studies on the question of toxicity of prolonged administrations of cyclamate in the patients with liver and kidney diseases].
PubMed:Studies of the renal secretion of PAH and cyclamate in rats.
PubMed:[Sodium cyclamate in the "in vitro test". Macomolecular syntheses and oxygen consumption].
PubMed:[Noticeable therapeutical effect of tetramisol cyclamate-new synthetic antihelminthic in ascariasis].
PubMed:Conversion of cyclamate to cyclohexylamine in rats.
PubMed:Toxicological studies with sodium cyclamate and saccharin.
PubMed:Studies on synthetic sweetening agents. XII. The binding of sodium cyclamate with bovine serum albumin.
PubMed:Observations on the instability of cyclamate in hydroalcoholic solution.
PubMed:[Effects on rat's intestinal mucosa of prolonged calcium cyclamate administration].
PubMed:A new colorimetric method of sodium cyclamate by solvent extraction with tris(1,10-phenanthroline)iron+2 chelate.
PubMed:[Therapy of ascariasis and other human intestinal parasites, with tetramisole cyclamate].
PubMed:[Studies on the analytical methods of artificial sweeteners. I. Determination of sodium cyclamate. (1)].
PubMed:Studies on synthetic sweetening agents. VI. Absorption and excretion of sodium cyclamate.
PubMed:Studies on synthetic sweetening agents. VII. Absorption and excretion of sodium cyclamate.
PubMed:The determination of cyclamate in soft drinks by titration with sodium nitrate.
PubMed:Feeding and reproduction of rats fed calcium cyclamate.
PubMed:[STUDIES ON SYNTHETIC SWEETENING AGENTS. IV. ON THE COLORING MATTER IN COLORIMETRIC DETERMINATION OF SODIUM CYCLAMATE].
PubMed:[STUDIES ON SYNTHETIC SWEETENING AGENTS. II. COLORIMETRIC DETERMINATION OF SODIUM CYCLAMATE. (1)].
PubMed:A taste panel study of cyclamate-saccharin mixture and of its components.
PubMed:Excretion and distribution of radioactive S35-cyclamate sodium (sucaryl sodium) in animals.
PubMed:Reversible malabsorption caused by high doses of cyclamate.
PubMed:Detection of saccharin, cyclamate and dulcine in soft drinks.
PubMed:Effects on oral health of mouthrinses containing xylitol, sodium cyclamate and sucrose sweeteners in the absence of oral hygiene. I. Clinical findings and analysis of gingival exudate.
PubMed:Effects on oral health of mouthrinses containing xylitol, sodium cyclamate and sucrose sweeteners in the absence of oral hygiene. III. Composition and bone resorbing potential of dental plaque.
PubMed:Nyctotheroides puytoraci as a new protozoan test animal for detecting the carcinogenicity of saccharin, cyclamate, or bracken fern (Pteridium aquilinum).
PubMed:Structure-reactivity relationships in the sweetening cyclamate series: different N-cyclohexyl sulfamic acid derivatives (esters and amides) as a probe for the conformational requirements of the target sweet-taste receptor.
PubMed:Inhibition of epidermal growth factor binding by phorbol esters, saccharin, and cyclamate and its implications in the mechanism of tumor promotion.
PubMed:Stability of sodium cyclamate in simulated gastric and intestinal media.
PubMed:Urticaria induced by cyclamate.
PubMed:[Sweetening agents: saccharin--cyclamate and its metabolites--aspartame].
PubMed:Comparison of responses to bans on cyclamate (1969) and saccharin (1977).
PubMed:Long term toxicity and reproduction study (including a teratogenicity study) with cyclamate, saccharin and cyclohexylamine.
PubMed:[Determination of sodium cyclamate by isotope dilution analysis (author's transl)].
PubMed:Cyclamate sweeteners.
PubMed:Effects of dietary carbohydrate on sodium cyclamate toxicity in rats feds a purified, low-fiber diet.
PubMed:Cyclamate decision criticized.
PubMed:[Letter: No carcinogenic effect of cyclamate].
PubMed:Entero-bacterial formation of cyclohexylamine in rats ingesting cyclamate.
PubMed:Mutagenicity testing of cyclamate and some pesticides in Drosophila melanogaster.
PubMed:Proceedings: The conversion of cyclamate to cyclohexylamine in 255 diabetic and obese patients.
PubMed:The inhibition by saccharin and cyclamate of phosphotransferase and phosphohydrolase activities of glucose-6-phosphatase.
PubMed:[Lack of carcinogenic effects of cyclamate, cyclohexylamine, and saccharine in rats].
PubMed:Long-term toxicity of sodium cyclamate in mice.
PubMed:Determination of cyclamate in soft drinks by reaction with nitrous acid. II. Manual and semi-automated methods: determination of cyclohexyl nitrite by diazotisation and coupling with Bratton--Marshall reagent.
PubMed:[Effect of sodium cyclamate on adolescent rats].
PubMed:[The toxicity of cyclohexylamine, cyclohexanone and cyclohexanol, metabolites of cyclamate].
PubMed:Blood constituents and hepatic lipids in rats fed sucrose or starch with or without cyclamate.
PubMed:Effects of simultaneous administration of drugs on absorption and excretion. I. Effect of phenylbutazone on absorption and excretion of sodium cyclamate in rabbits.
PubMed:A toxicity method with calcium cyclamate for chronic carcinogenesis experiments.
PubMed:Cyclamate still to the fore.
PubMed:Effects of cyclamate and food restriction on various metabolites in the rat.
PubMed:[Teratogenic effect of cyclamate].
PubMed:The effect of cyclamate and saccharin on the chromosomes of a Chinese hamster cell line.
PubMed:Distribution of 14 C-cyclamate in the lactating rat.
PubMed:[Cytogenetic effect of sodium cyclamate, cyclohexanone and cyclohexanol].
PubMed:In vivo conversion of 14 C-labeled cyclamate to cyclohexylamine.
PubMed:[Cyclamate and cyclohexylamine--sweet and bitter].
PubMed:How can metabolic processes influence the action of orally administered drugs (cardia glycosides, sympathomimetic amines, cyclamate).
PubMed:The conversion of cyclamate into cyclohexylamine by gut bacteria.
PubMed:Influence of extra sucrose, fats, protein and of cyclamate in the daily food on the life-span of rats.
PubMed:[Cytogenetic and teratogenic action of cyclamate and its metabolites].
PubMed:Preparation and characterization of lincomycin cyclamate.
PubMed:[Concluding report of a 3-year clinical study on cyclamate].
PubMed:[Influence of cyclamate on blood sugar in normal and diabetic children].
PubMed:In vitro cytogenetic investigation of calcium cyclamate, cyclohexylamine and triflupromazine.
PubMed:Placental transmission and fetal distribution of cyclamate in early human pregnancy.
PubMed:The cyclamate story unfolds.
PubMed:Effects of sodium cyclamate on Haworthia callus cultured in vitro.
PubMed:[Influence of sodium cyclamate on the fertility and pre and post-natal development of the rat].
PubMed:Cyclamate acceptance.
PubMed:Effect of maternal calcium cyclamate intake on cellular development in the young rat.
PubMed:[Cyclamate sweetening agents again on the market].
PubMed:[Cyclamate].
PubMed:[The use of cyclamate and its problems].
PubMed:Irresponsibility of cyclamate ban.
PubMed:Man and his cyclamate.
PubMed:Calcium cyclamate and renal tubular acidosis.
PubMed:[On the test methods of sodium cyclamate in dentifrices].
PubMed:Wisdom of cyclamate ban.
PubMed:Photosensitive dermatitis and renal tubular acidosis after ingestion of calcium cyclamate.
PubMed:[Carcinogenic effect of cyclamate?].
PubMed:Cyclamate ban has interesting local angle.
PubMed:Letters to the editor: effect of sodium cyclamate on protein-bound iodine.
PubMed:Cyclamate ban.
PubMed:The effect of cyclamate on the hypoglycaemic response of tolbutamide and chlorpropamide in rats.
PubMed:Ban on cyclamate sweeteners.
PubMed:The cyclamate bandwagon.
PubMed:The safety of cyclamate--an artificial sweetener.
PubMed:Gut bacteria and the metabolism of cyclamate in the rat.
PubMed:Sodium cyclamate, saccharin and food efficiency.
PubMed:Sugar substitute, sodium and calcium cyclamate.
PubMed:Growth inhibitory action of saccharin and cyclamate on rats receiving a poor rice diet.
PubMed:[Therapeutic activity of the combination thiabendazole and tetramisol cyclamate in human intestinal parasitosis].
PubMed:Myocardial lesions: a reassessment of the toxicology of calcium cyclamate.
PubMed:Excretion of cyclohexylamine in subjects ingesting sodium cyclamate.
PubMed:[On the question of the teratogenic and embryotoxic effects of cyclamate, saccharin and saccharose].
PubMed:[Studies of cyclamate and saccharin on the embryo-toxic and teratogenic effect in the moust].
PubMed:[Saccharin and sodium cyclamate toxicity for the offspring of pregnant mice].
PubMed:Effects of sodium cyclamate on the growth of rats compared with other variations in the diet.
PubMed:[Therapeutic effect of Tetramisol cyclamate, a new synthetic anthelmintic in ascariasis].
PubMed:[Colorimetric determination of cyclohexylamine in commerical sodium cyclamate].
PubMed:Prenatal development in the rat following administration of cyclamate, saccharin and sucrose.
PubMed:Cyclamate sweeteners.
PubMed:Study of the sympathomimetic action of cyclohexylamine, a possible metabolite of cyclamate.
PubMed:[On the effect of the sweetening agent cyclamate on the liver parenchyma, corresponding enzymes and coagulation factors of the blood].
PubMed:[Study of the possible activity of sodium cyclamate in the rat within the span of 3 generations].
PubMed:[Clinical studies on the question of toxicity of prolonged administration of cyclamate in patients with liver and kidney diseases].
PubMed:Cyclohexylamine excretors among human volunteers given cyclamate.
PubMed:A new photosensitizer. The artificial sweetener cyclamate.
PubMed:[Analyses of drugs and chemicals by infrared absorption spectroscopy. XI. Determination of saccharin sodium, dulcin, and sodium cyclamate in their mixture by use of methanol and water as solvents].
PubMed:[The sweetening power of cyclamate].
PubMed:Distribution and excretion of 14C-cyclamate sodium in animals.
PubMed:Studies on synthetic sweetening agents. 8. Cyclohexylamine, a metabolite of sodium cyclamate.
PubMed:Determination of cyclamate in soft drinks by gas chromatography.
PubMed:Separation and identification of dulcin, cyclamate sodium and saccharin sodium with the aid of thin-layer chromatography.
PubMed:[STUDIES ON SYNTHETIC SWEETENING AGENTS. III. COLORIMETRIC DETERMINATION OF SODIUM CYCLAMATE. (2)].
PubMed:[Studies on synthetic sweetening agents. I. Paper chromatography of cyclamate sodium, dulcin, and saccharin sodium].
PubMed:NEW and nonofficial remedies: cyclamate calcium.
PubMed:Artificial sweeteners in a large Canadian river reflect human consumption in the watershed.
PubMed:Role of nitrification in the biodegradation of selected artificial sweetening agents in biological wastewater treatment process.
PubMed:Distribution of artificial sweeteners in dust and soil in China and their seasonal variations in the environment of Tianjin.
PubMed:Interlaboratory testing of Insent e-tongues.
PubMed:Artificial sweeteners - a review.
PubMed:Biosensor analysis of natural and artificial sweeteners in intact taste epithelium.
PubMed:Artificial sweeteners as potential tracers of municipal landfill leachate.
PubMed:[Simultaneous determination of five synthetic sweeteners in food by solid phase extraction-high performance liquid chromatography-evaporative light scattering detection].
PubMed:High-performance ion mobility spectrometry with direct electrospray ionization (ESI-HPIMS) for the detection of additives and contaminants in food.
PubMed:Determination of artificial sweeteners in sewage sludge samples using pressurised liquid extraction and liquid chromatography-tandem mass spectrometry.
PubMed:The content of high-intensity sweeteners in different categories of foods available on the Polish market.
PubMed:Ecotoxicity of artificial sweeteners and stevioside.
PubMed:Analysis and occurrence of seven artificial sweeteners in German waste water and surface water and in soil aquifer treatment (SAT).
PubMed:Determination of artificial sweeteners in beverages and special nutritional products using high performance liquid chromatography.
PubMed:Estimated intake of intense sweeteners from non-alcoholic beverages in Denmark, 2005.
PubMed:Application of dispersive solid-phase extraction and ultra-fast liquid chromatography-tandem quadrupole mass spectrometry in food additive residue analysis of red wine.
PubMed:Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins.
PubMed:[Study on optimization of formulation of Danggui Liuhuang effervescent granules].
PubMed:Stability considerations of aspartame in the direct analysis of artificial sweeteners in water samples using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).
PubMed:Determination of artificial sweeteners in water samples by solid-phase extraction and liquid chromatography-tandem mass spectrometry.
PubMed:Anticonvulsant activity of artificial sweeteners: a structural link between sweet-taste receptor T1R3 and brain glutamate receptors.
PubMed:Artificial sweeteners--a recently recognized class of emerging environmental contaminants: a review.
PubMed:Retention behaviour of some high-intensity sweeteners on different SPE sorbents.
PubMed:Saccharin/cyclamates: epidemiological evidence.
PubMed:Cytogenetic effects of cyclamates.
PubMed:Qualitative and quantitative control of carbonated cola beverages using ¹H NMR spectroscopy.
PubMed:Reaction of cyclohexylamine with hypochlorite and enhancement of oxidation of plasma sulfhydryl groups by hypochlorite in vitro.
PubMed:Intake of intense sweeteners in Germany.
PubMed:[Determination of five synthetic sweeteners in wines using high performance liquid chromatography-tandem mass spectrometry].
PubMed:Sensory quality of functional beverages: bitterness perception and bitter masking of olive leaf extract fortified fruit smoothies.
PubMed:Performance of conventional multi-barrier drinking water treatment plants for the removal of four artificial sweeteners.
PubMed:Simultaneous determination of nonnutritive sweeteners in foods by HPLC/ESI-MS.
PubMed:Relationships among taste qualities assessed with response-context effects.
PubMed:Anionic leak currents through the Na+/monocarboxylate cotransporter SMCT1.
PubMed:Estimated intake of intense sweeteners from non-alcoholic beverages in Denmark.
PubMed:[Use of diet sweeteners by adults in Pelotas, Rio Grande do Sul State, Brazil: a population-based study].
PubMed:[Determination of three sweeteners in vinegars by solid phase extraction-high performance liquid chromatography/tandem mass spectrometry].
PubMed:Determination of nine high-intensity sweeteners in various foods by high-performance liquid chromatography with mass spectrometric detection.
PubMed:The capsaicin receptor participates in artificial sweetener aversion.
PubMed:Saccharin and other artificial sweeteners in soils: estimated inputs from agriculture and households, degradation, and leaching to groundwater.
PubMed:Effects of artificial sweeteners on body weight, food and drink intake.
PubMed:[Simultaneous determination of six synthetic sweeteners in food by high performance liquid chromatography-tandem mass spectrometry].
PubMed:Effects of treatment with N-methyl-N-nitrosourea, artificial sweeteners, and cyclophosphamide on adult rat urinary bladder in vitro.
PubMed:The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.
PubMed:Stevia and saccharin preferences in rats and mice.
PubMed:Responses of single chorda tympani taste fibers of the calf (Bos taurus).
PubMed:Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor.
PubMed:Positive allosteric modulators of the human sweet taste receptor enhance sweet taste.
PubMed:An attempt to use sweeteners as a material for accident dosimetry.
PubMed:Mechanism of iodide transport in the rabbit cortical collecting duct.
PubMed:Anion dependence of Ca2+ transport and (Ca2+ + K+)-stimulated Mg2+-dependent transport ATPase in rat pancreatic endoplasmic reticulum.
PubMed:Carcinogen-induced chromosomal breakage decreased by antioxidants.
PubMed:Influence of artificial sweeteners on the kinetic and metabolic behavior of Lactobacillus delbrueckii subsp. bulgaricus.
PubMed:[Restless legs due to ingestion of 'light' beverages containing saccharine. Results of an N-of-1 trial].
PubMed:[Restless legs due to ingestion of 'light' beverages containing saccharine; results of an N-of-1 trial].
PubMed:Different functional roles of T1R subunits in the heteromeric taste receptors.
PubMed:Oral zinc sulfate solutions inhibit sweet taste perception.
PubMed:Determination of seven artificial sweeteners in diet food preparations by reverse-phase liquid chromatography with absorbance detection.
PubMed:Moderate intake of sucrose does not impair metabolic control in pump-treated diabetic out-patients.
PubMed:Asymmetric organocatalytic Michael addition of ketones to vinyl sulfone.
PubMed:The intake of intense sweeteners - an update review.
PubMed:Taste qualities of solutions preferred by hamsters.
PubMed:Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions.
PubMed:Potential intake of intense sweeteners in Brazil.
PubMed:Uptake of saccharin and related intense sweeteners by Streptococcus mutans NCTC 10449.
PubMed:In vivo and in vitro studies with sulfamate sweeteners.
PubMed:Direct NMR detection of the binding of functional ligands to the human sweet receptor, a heterodimeric family 3 GPCR.
PubMed:[Compound preservative and cyclamat determinated by gas chromatography].
PubMed:Development of a new oat-based probiotic drink.
PubMed:Sweetener preference of C57BL/6ByJ and 129P3/J mice.
PubMed:Improved water solubility of neohesperidin dihydrochalcone in sweetener blends.
PubMed:Inhibition of P-glycoprotein-mediated transport by a hydrophobic contaminant in commercial gluconate salts.
PubMed:Experimental study of the internal signal of alliesthesia induced by sweet molecules in rats.
PubMed:Interaction of Cl- and other halogens with Cl- transport systems in rabbit cortical collecting duct.
PubMed:Membrane effects of chloride substitutes in guinea pig gallbladder epithelial cells.
PubMed:Developmental toxicity testing with FETAX: evaluation of five compounds.
PubMed:Studies to evaluate artificial sweeteners, especially Remsen--Fahlberg saccharin, and their possible impurities, for potential mutagenicity by the Salmonella/mammalian liver microsome test.
PubMed:The determination of mixtures of some artificial sweeteners.
PubMed:The importance of synergy between weak carcinogens in the induction of bladder cancer in experimental animals and humans.
PubMed:Sugar binding to purified fractions from bovine taste buds and epithelial tissue. Relationships to bioactivity.
PubMed:Relationship between tubular net sodium reabsorption and peritubular potassium uptake in the perfused Necturus kidney.
PubMed:Chemical carcinogenesis studies in nonhuman primates.
PubMed:[Optimization of preparative technique for banxia-houpu effervescent tablets by orthogonal design].
PubMed:Separation and simultaneous determination of four artificial sweeteners in food and beverages by ion chromatography.
PubMed:Artificial sweeteners--do they bear a carcinogenic risk?
PubMed:Behavioral study in the gray mouse lemur (Microcebus murinus) using compounds considered sweet by humans.
PubMed:Liquid chromatographic determination of aniline in table-top sweeteners based on pre-column derivatization with 1,2-naphthoquinone-4-sulfonate.
PubMed:Evolution of the sweetness receptor in primates. II. Gustatory responses of non-human primates to nine compounds known to be sweet in man.
PubMed:Tumor incidence in a chemical carcinogenesis study of nonhuman primates.
PubMed:Pseudo-streaming potentials in Necturus gallbladder epithelium. I. Paracellular origin of the transepithelial voltage changes.
PubMed:The role of sucrose-sensitive neurons in ingestion of sweet stimuli by hamsters.
PubMed:Aspartame: effect on lunch-time food intake, appetite and hedonic response in children.
PubMed:The metabolism of intense sweeteners.
PubMed:Effect on hepatic ornithine decarboxylase of some food additives and synthetic elastomers.
PubMed:Influence of phosphate, sulfonic, and sulfamic acids on sulfoconjugate release in the vascularly perfused mouse small intestine.
PubMed:Sensory evaluation of soft drinks with various sweeteners.
PubMed:Electrogenic calcium transport in plasma membrane of rat pancreatic acinar cells.
PubMed:Effects of solute concentration on vasopressin stimulated cyclic AMP generation in the rat medullary thick ascending limbs of Henle's loop.
PubMed:Water absorption in the proximal tubule: effect of bicarbonate, chloride gradient, and organic solutes.
PubMed:Long-term and multigeneration toxicity studies with cyclohexylamine hydrochloride.
PubMed:Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors.
PubMed:The heterodimeric sweet taste receptor has multiple potential ligand binding sites.
PubMed:Riboflavin-binding protein exhibits selective sweet suppression toward protein sweeteners.
PubMed:Direct simultaneous determination of eight sweeteners in foods by capillary isotachophoresis.
PubMed:Dietary estimated intake of intense sweeteners by Italian teenagers. Present levels and projections derived from the INRAN-RM-2001 food survey.
PubMed:Probabilistic modelling of human exposure to intense sweeteners in Italian teenagers: validation and sensitivity analysis of a probabilistic model including indicators of market share and brand loyalty.
PubMed:Sense of taste in a new world monkey, the common marmoset: recordings from the chorda tympani and glossopharyngeal nerves.
PubMed:pH changes in dental plaque after using sugar-free pediatric medicine.
PubMed:Artificial sweetener reduces nociceptive reaction in term newborn infants.
PubMed:Similarity of A(3)-adenosine and swelling-activated Cl(-) channels in nonpigmented ciliary epithelial cells.
PubMed:Selective inhibition of sweetness by the sodium salt of +/-2-(4-methoxyphenoxy)propanoic acid.
PubMed:Angiotensin II stimulates macula densa basolateral sodium/hydrogen exchange via type 1 angiotensin II receptors.
PubMed:Effects of artificial sweeteners on insulin release and cationic fluxes in rat pancreatic islets.
PubMed:Gustatory responses of the hamster Mesocricetus auratus to various compounds considered sweet by humans.
PubMed:Capillary electrophoretic determination of different classes of organic ions by potentiometric detection with coated-wire ion-selective electrodes.
PubMed:Characterization of an inwardly rectifying chloride conductance expressed by cultured rat cortical astrocytes.
PubMed:Expression of human pICln and ClC-6 in Xenopus oocytes induces an identical endogenous chloride conductance.
PubMed:Use of artificial sweeteners to promote alcohol consumption by rats.
PubMed:The use of chlorophenol red for the selective determination of chlorine dioxide in drinking water.
PubMed:Evidence for apical sodium proton exchange in macula densa cells.
PubMed:Apical membrane sodium and chloride entry during osmotic swelling of renal (A6) epithelial cells.
PubMed:Laparoscopy as a means of monitoring liver tumor induction in nonhuman primates.
PubMed:[Changes in cytomembrane and surface cells of the large intestine resulting from the action of sweetening agents].
PubMed:Investigation of synergism in binary mixtures of sweeteners.
PubMed:Vasopressin activates a chloride conductance in cultured cortical collecting duct cells.
PubMed:Two isoforms of a chloride channel predominantly expressed in thick ascending limb of Henle's loop and collecting ducts of rat kidney.
PubMed:cAMP-activated apical membrane chloride channels in Necturus gallbladder epithelium. Conductance, selectivity, and block.
PubMed:Electrophysiological identification of cell types in cortical collecting duct monolayers.
PubMed:Use of fetal mouse salivary glands in culture to detect embryotoxicity: evaluation of eight additional chemicals.
PubMed:The effects of energy content and sweet taste on food consumption in restrained and non-restrained eaters.
PubMed:Taste as a highly discriminative system: a hamster intrapapillar single unit study with 18 compounds.
PubMed:Intestinal microflora: metabolism of drugs and carcinogens.
PubMed:Single chloride channels in endosomal vesicle preparations from rat kidney cortex.
PubMed:Effects of serosal anion composition on the permeability properties of rabbit urinary bladder.
PubMed:Electrical membrane properties of a cell clone derived from human nonpigmented ciliary epithelium.
PubMed:Characterization of Cl-/HCO3- exchange in cultured bovine pigmented ciliary epithelium.
PubMed:Reverse-phase liquid chromatographic determination of benzoic and sorbic acids in foods.
PubMed:Amine N-sulfotransferase.
PubMed:The role of non-nutritive dietary constituents in carcinogenesis.
PubMed:Synthesis of some derivatives of 6-amino-1,5-anhydro-6-deoxy-D-glucitol and 2-amino-1,5-anhydro-2-deoxy-D-glucitol.
PubMed:Ion transport in rat proximal colon in vivo.
PubMed:The use of continuous flow systems for studying the metabolic activity of the hindgut microflora in vitro.
PubMed:[Contribution of stereochemistry to the study of the spatial organization of pharmacological receptors].
PubMed:Intracellular messengers in stimulus-secretion coupling of pancreatic acinar cells.
PubMed:Correlation of results of agglutination assays with concanavalin A and carcinogenesis experiments on promoters of bladder cancer.
PubMed:Gustatory reaction time to various sweeteners in human adults.
PubMed:Contraluminal sulfate transport in the proximal tubule of the rat kidney. II. Specificity: sulfate-ester, sulfonates and amino sulfonates.
PubMed:Transforming growth factors induce markers of neoplasia in cultured adult rat bladder.
PubMed:Luminal and peritubular ionic substitutions and intracellular potential of the rabbit proximal convoluted tubule.
PubMed:[Failure to activate Epstein-Barr virus genome in a latently-infected human lymphoblastoid cell line with urine containing a bladder carcinogenesis promoter].
PubMed:Characterization of calcium uptake into rough endoplasmic reticulum of rat pancreas.
PubMed:Preference for sugars and nonnutritive sweeteners in young beagles.
PubMed:Vagotomy abolishes the differential palatability of food.
PubMed:Tumor promoter receptors regulating neurite formation in cultured human neuroblastoma cells.
PubMed:Promotion in urinary bladder carcinogenesis.
PubMed:Effect of promoters on incidence of bladder cancer in experimental animal models.
PubMed:Anion permeabilities of the isolated perfused rabbit proximal tubule.
PubMed:Effect of partial cystectomy on the induction of pre-neoplastic lesions in rat bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine followed by bladder carcinogens and promoters.
PubMed:Urinary bladder carcinogenesis with N-substituted aryl compounds: initiation and promotion.
PubMed:Characteristics of volume reabsorption in rabbit superficial and juxtamedullary proximal convoluted tubules.
PubMed:Bladder calculi in rats treated with nitrosomethylurea and fed artificial sweeteners.
PubMed:Regulation of carcinogenic food additives and drugs in the US.
PubMed:Toxins and carcinogens in the environment: an observation in the tropics.
PubMed:Food additives.
PubMed:Modification by fiber of toxic dietary effects.
PubMed:Gas chromatographic determination of micro-amounts of cyclamates.
PubMed:Cyclamates: a review of the current position.
PubMed:Cytogenetic effects of cyclamates on human cells in vitro.
PubMed:A conductive pathway generated from fragments of the human red cell anion exchanger AE1.
PubMed:Swelling-activated Cl- channels support Cl- secretion by bovine ciliary epithelium.
PubMed:High-performance liquid chromatography-electronspray ionization mass spectrometry for determination of tiopronin in human plasma.
PubMed:[Analysis of nine kinds of sweeteners in foods by LC/MS].
PubMed:Catabolism of sulfamate by Mycobacterium sp. CF1.
PubMed:[Controversies with aspartame].
PubMed:Is the negative charge on RNHSO3-M+ an essential requirement for sulfamate sweetness?
PubMed:[Simultaneous determination of various food additives by high performance liquid chromatography].
PubMed:[Infrared spectroscopy of the dry residue of liquor crystallograms in various diseases].
PubMed:The comet assay with 8 mouse organs: results with 39 currently used food additives.
PubMed:Application of the U and gamma' models in binary sweet taste mixtures.
PubMed:Enhancement of sucrose sweetness with soluble starch in humans.
PubMed:Inhalation toxicity studies of the alpha,beta-unsaturated ketones: 2-cyclohexene-1-one.
PubMed:Chloride channel expression in cultured human fetal RPE cells: response to oxidative stress.
PubMed:Activation of volume-regulated Cl(-) channels by ACh and ATP in Xenopus follicles.
PubMed:Susceptibility of nonhuman primates to carcinogens of human relevance.
PubMed:Lack of DNA-damaging activity of five non-nutritive sweeteners in the rat hepatocyte/DNA repair assay.
PubMed:Effect of temperature, pH, and ions on sweet taste.
PubMed:Solution properties and sweetness response of selected bulk and intense sweeteners.
PubMed:Cytosolic [Ca2+] signaling pathway in macula densa cells.
PubMed:Role of nonallergic hypersensitivity reactions in children with chronic urticaria.
PubMed:Characterization of the hyperpolarization-activated chloride current in dissociated rat sympathetic neurons.
PubMed:Isolation and culture of bovine pancreatic duct epithelial cells.
PubMed:Primate sense of taste: behavioral and single chorda tympani and glossopharyngeal nerve fiber recordings in the rhesus monkey, Macaca mulatta.
PubMed:Sulfadiazine-induced sialadenitis.
PubMed:The chloride current induced by expression of the protein pICln in Xenopus oocytes differs from the endogenous volume-sensitive chloride current.
PubMed:[Clastogenic activity of dietary sugar substitutes].
PubMed:Cyclohexylamine inhibits the adhesion of lymphocytic cells to human syncytiotrophoblast.
PubMed:Bitterness of sweeteners as a function of concentration.
PubMed:Effects of liquid preloads with different fructose/fibre concentrations on subsequent food intake and ratings of hunger in women.
PubMed:[Does the diabetic patient need special diabetic food?].
PubMed:Flow injection potentiometric determination of saccharin in dietary products with relocation of filtration unit.
PubMed:Adaptation of sweeteners in water and in tannic acid solutions.
PubMed:Potentiometric determination of saccharin in dietary products using mercurous nitrate as titrant.
PubMed:Gustatory neural coding in the monkey cortex: the quality of sweetness.
PubMed:Fetal mouse salivary glands and applications for determining teratogenic mechanisms in vitro.
PubMed:Pedagogical patronizing of the pharmacodynamic promises of illicit drugs.
PubMed:ACTH secretion from mouse pituitary tumor cells is inhibited by loop diuretic drugs.
PubMed:Interactive effects of aldrin, cyclohexylamine, 2,4-diaminotoluene and two phorbol esters on metabolic cooperation between V79 cells.
PubMed:Basolateral ionic permeabilities of macula densa cells.
PubMed:Effects of changes in mucosal solution Cl- or K+ concentration on cell water volume of Necturus gallbladder epithelium.
PubMed:Safety evaluation of substances consumed as technical ingredients (food additives).
PubMed:Basolateral transport pathways for K+ and Cl- in rabbit proximal tubule: effects on cell volume.
PubMed:Review of present and future use of nonnutritive sweeteners.
PubMed:Acceptable daily intake and the regulation of intense sweeteners.
PubMed:Aspartame: effects on learning, behavior, and mood.
PubMed:Ionic and osmotic dependence of secretion from permeabilised acini of the rat pancreas.
PubMed:[Ion pair-HPLC of a pharmaceutical multicomponent system].
PubMed:Factors affecting metabolic activity of the intestinal microflora.
PubMed:Inactivation of antiadherence effect of bladder surface glycosaminoglycans as possible mechanism for carcinogenesis.
PubMed:Food additives and contaminants. An update.
PubMed:Caffeine intensifies taste of certain sweeteners: role of adenosine receptor.
PubMed:Anion dependence of electrical effects of bicarbonate and sodium on cultured bovine corneal endothelial cells.
PubMed:[Prophylaxis of dental caries using sugar substitutes].
PubMed:Using epidemiology to regulate food additives: saccharin case-control studies.
PubMed:Cl-/HCO3- exchange at the apical membrane of Necturus gallbladder.
PubMed:Reduced trisialoganglioside synthesis in chemically but not mos-transformed mouse epidermal cells.
PubMed:Determination of short-circuit current in the in vivo perfused rat colon.
PubMed:Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis.
PubMed:[Glycine uptake in brush border vesicles isolated from the rat intestinal cells].
PubMed:Artificial sweeteners and absence of bladder cancer risk in Copenhagen.
PubMed:Trihalogenated benzamides--a new class of artificial sweeteners.
PubMed:Chloride transport by intact rat liver and cultured rat hepatocytes.
PubMed:Effect of tumor promoters on soft-agar growth of Swiss 3T3 cells infected with SV40 tsA mutants.
PubMed:Possible mutagenic activity of saccharin.
PubMed:The mutagenic activity of 61 agents as determined by the micronucleus, Salmonella, and sperm abnormality assays.
PubMed:[Critical test of the activity of tetramisole phosphate on gastrointestinal helminths of sheep].
PubMed:Qualitative differences among sweeteners.
PubMed:Ionic requirements of proximal tubular sodium transport. III. Selective luminal anion substitution.
PubMed:Metabolic studies with nonnutritive sweeteners cyclooctylsulfamate and 4-methylcyclohexylsulfamate.
PubMed:[Reaction kinetic studies on the formation of n-nitrosoephedrine in vitro and in vivo (author's transl)].
PubMed:Purification and some properties of cyclohexylamine oxidase from a Pseudomonas sp.
PubMed:Function of the thin ascending limb of Henle of rats and hamsters perfused in vitro.
PubMed:Mechanism of NaCl and water reabsorption in the proximal convoluted tubule of rat kidney.
PubMed:Non-nutritive sweeteners and human bladder cancer: preliminary findings.
PubMed:Chemical induction of sperm abnormalities in mice.
PubMed:Taste rejection of nonnutritive sweeteners in cats.
PubMed:Experiences with the dominant lethal test in female mice: effects of alkylating agents and artificial sweeteners on pre-ovulatory oocyte stages.
PubMed:Characteristics of salt and water transport in superficial and juxtamedullary straight segments of proximal tubules.
 
Notes:
Artificial sweetening agent, usually employed as Na or Ca salt (cyclamate). Use suspended in some countries, including USA, because of possible weak carcinogenic activity (disputed). Permitted in EU at levels of 250-1600 ppm in food products Cyclamic acid is a compound with formula C6H11NHSO2OH. Used as a food additive, prohibited [EAFUS]
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