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2-ethyl-5(or 6)-methoxypyrazine
mixture of 85% 2-methoxy-3-ethylpyrzine and 15% (2-methoxy-3-methylpyrazine and 2-methoxy-5-methylpyrazine)

Supplier Sponsors

Name:2-ethyl-5-methoxypyrazine
CAS Number: 68739-00-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:272-125-0
FDA UNII: SAM61DOI2G
Nikkaji Web:J429.719I
CoE Number:11329
XlogP3-AA:0.90 (est)
Molecular Weight:138.16990000
Formula:C7 H10 N2 O
NMR Predictor:Predict (works with chrome, Edge or firefox)
EFSA/JECFA Comments:
AV 7), BP 8), ID 9), MP 10), PF 11), RI 12), SG 13), SE 14), SW 15) Registername to be changed to mixture of 2-, 5- or 6-methoxy-3-ethylpyrazine
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
JECFA Food Flavoring:789 2-, 5- or 6-methoxy-3-ethylpyrazine
FEMA Number:3280 2-, 5- or 6-methoxy-3-ethylpyrazine
FDA:No longer provide for the use of these seven synthetic flavoring substances
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 187.00 to 188.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.854000 mmHg @ 25.00 °C. (est)
Flash Point: 153.00 °F. TCC ( 67.22 °C. )
logP (o/w): 1.703 (est)
Soluble in:
 alcohol
 water, 1824 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
2-ethyl-5(or6)-methoxypyrazine
Penta International
2-METHYL-3 (5 or 6) METHOXY PYRAZINE
R C Treatt & Co Ltd
6-Methoxy-3-Ethyl Pyrazine
Synerzine
Mixture of 85% 2-Methoxy-3-Ethylpyrzine and 15% (2-Methoxy-3-Methylpyrazine and 2-Methoxy-5-Methylpyrazine)
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
flavoring agents
Recommendation for 2-ethyl-5(or 6)-methoxypyrazine usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 5
Click here to view publication 5
 average usual ppmaverage maximum ppm
baked goods: -5.00000
beverages(nonalcoholic): -5.00000
beverages(alcoholic): --
breakfast cereal: -5.00000
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -5.00000
fruit ices: -5.00000
gelatins / puddings: -5.00000
granulated sugar: --
gravies: -5.00000
hard candy: -5.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -5.00000
milk products: -5.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -5.00000
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 17, Revision 3 (FGE.17Rev3): Pyrazine derivatives from chemical group 24
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):68739-00-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :106443
National Institute of Allergy and Infectious Diseases:Data
2-ethyl-5-methoxypyrazine
Chemidplus:0068739004
 
References:
 2-ethyl-5-methoxypyrazine
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):106443
Pubchem (sid):135064573
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
2-ethyl-(or methyl)-(3,5 or 6)-methoxypyrazine
2-ethyl-5(6)-methoxypyrazine
2-ethyl-5(or6)-methoxypyrazine
2,5 or 6-methoxy-3-ethyl pyrazine
2-, 5- or 6-methoxy-3-ethylpyrazine
2,5 or 6-methoxy-3-ethylpyrazine
2-methyl-3 (5 or 6) methoxy pyrazine
 mixture of 85% 2-methoxy-3-ethylpyrzine and 15% (2-methoxy-3-methylpyrazine and 2-methoxy-5-methylpyrazine)
 pyrazine, 2-ethyl-5(or 6)-methoxy-
 

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