EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

lutein
all-trans-(+)-xanthophyll

Supplier Sponsors

Name:(1R)-4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1R)-4-hydroxy-2,6,6-trimethylcyclohex-2-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-3,5
CAS Number: 127-40-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:204-840-0
FDA UNII:X72A60C9MT
Beilstein Number:2068547
MDL:MFCD08435941
XlogP3-AA:11.00 (est)
Molecular Weight:568.88472000
Formula:C40 H56 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:color agents, nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 390 Suspended lutein View - notice PDF
GRN 385 Lutein View - notice PDF
GRN 291 Crystalline lutein View - notice PDF
GRN 140 Crystalline lutein View - notice PDF
GRN 221 Suspended lutein View - notice PDF
EU SANCO Lutein View - review
GRN 542 Lutein View - notice PDF
JECFA Food Additive: Lutein from Tagetes erecta

Mixed Carotenoids
GSFA Codex: Lutein from Tagetes erecta (161b(i))
DG SANTE Food Additives:lutein
FDA Mainterm (SATF):127-40-2 ; XANTHOPHYLL
FDA Regulation:
FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.275 Dried algae meal.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.295 Tagetes (Aztec marigold) meal and extract.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.315 Corn endosperm oil.
 
Physical Properties:
Appearance:orange red powder (est)
Assay: 80.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 196.00 °C. @ 760.00 mm Hg
Boiling Point: 702.27 °C. @ 760.00 mm Hg (est)
Flash Point: 516.00 °F. TCC ( 269.10 °C. ) (est)
logP (o/w): 11.524 (est)
Soluble in:
 hexane
 water, 5.631e-011 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
AIDP
Lutein 5% Beadlets 5%
Allied Biotech
Lutene 10% TG
Flavor: characteristic
is a Tablet Grade version of lutein being used in multivitamins and other dietary supplements.
Allied Biotech
Lutene 10% WSC
Flavor: characteristic
is a powder formulation of lutein developed for water based applications to impart a yellow color.
Allied Biotech
Lutene 15% EM
Flavor: characteristic
is an oil in water emulsion system which will provide a yellow shade for water based applications.
American International Chemical, LLC.
LUTEIN MC 10% Plus 1% ZEAXANTHIN
Atlantic Chemicals
Lutein
BASF
Lutein™
BOC Sciences
For experimental / research use only.
Xanthophyll 0.95
Odor: characteristic
Use: Xanthophyll is a widespread carotenoid alcohols and could be obtained from some natural plants. anti-tumor; anti-cancer; antimutagenic; antibacterial; antimicrobial;
Changsha Organic Herb
Marigold Extract Lutein
Chr. Hansen A/S
Luteins
Flavor: characteristic
Lutein is obtained from marigold flowers, Tagetes erecta, found abundantly throughout Mexico. Lutein is a warm, yellow color and is used in products such as juices and cakes. The color displays good light, heat and pH stability. The pigment is also used in functional foods, being favored for its antioxidant properties.
Coompo
For experimental / research use only.
Lutein from Plants ≥96%
DSM Nutritional
FloraGLO® Lutein
ExtraSynthese
For experimental / research use only.
Lutein UV ≥95%
Farbest-Tallman Foods
ZMC Natural Lutein 20% Oil Dispersion
Flavor: bland
This product is used in dietary supplement applications including soft gel capsules for eye health.
Farbest-Tallman Foods
ZMC Natural Lutein 5% CWS-S
Flavor: bland
It is used as a nutrient supplement for baking, beverages, confectionary and dairy products.
Farbest-Tallman Foods
ZMC Natural Lutein 5% TAB
Flavor: bland
It is used as a nutrient for tablet or hard-shell eye health capsule preparations.
Maypro Industries
Lutein
Pangaea Sciences
Lutein (Marigold extract)
Qingdao Dacon Trading
Lutein
Risun Ingredients
Lutein 10%,20% HPLC
Rung International
Lutein
Odor: characteristic
Use: A type of carotenoid found in most green vegetables which positively contributes to maintenance of eye vision. Its major source is the marigold. It is classified as xanthophyll.
Sigma-Aldrich: Sigma
For experimental / research use only.
Xanthophyll from marigold
Sinoway Industrial
For experimental / research use only.
Lutein
Synthite Industries
Lutein 75% crystalline/ Pure Lutein
E-books and Brochures
Synthite Industries
Lutein oil soluble
Synthite Industries
Lutein Powder
Vevy Europe
FITOESTESINA ETH-F
Odor: characteristic
Use: coadjuvant in the topical treatment of cellulitis
Vevy Europe
FITOXANTINA
Odor: characteristic
Use: xantophyll-rich extract, emollient, natural dye
WILD Flavors
Lutein Ester Emulsions
Flavor: taste
Lutein is a member of the carotenoid family, a group of chemicals related to vitamin A that give color to certain fruits and vegetables. Lutein is found in nature as a fatty acid ester and is an antioxidant that is beneficial for skin and eye health.
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: color agents, nutrient supplements
Recommendation for lutein usage levels up to:
 not for fragrance use.
 
Recommendation for lutein flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the re-evaluation of lutein (E 161b) as a food additive
View page or View pdf

Scientific Opinion on the re-evaluation of lutein preparations other than lutein with high concentrations of total saponified carotenoids at levels of at least 80%
View page or View pdf

Statement on the safety assessment of the exposure to lutein preparations based on new data on the use levels of lutein
View page or View pdf

Scientific Opinion on the substantiation of a health claim related to a combination of lutein and zeaxanthin and improved vision under bright light conditions pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf

NWT-02, a fixed combination of lutein, zeaxanthin and docosahexaenoic acid in egg yolk and reduction of the loss of vision: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf

Safety and efficacy of lutein and lutein/zeaxanthin extracts from Tagetes erecta for poultry for fattening and laying (except turkeys)
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):127-40-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6433159
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(1R)-4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1R)-4-hydroxy-2,6,6-trimethylcyclohex-2-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-3,5
Chemidplus:0000127402
 
References:
 (1R)-4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1R)-4-hydroxy-2,6,6-trimethylcyclohex-2-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-3,5
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6433159
Pubchem (sid):134974058
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
KEGG (GenomeNet):C08601
HMDB (The Human Metabolome Database):HMDB03233
FooDB:FDB015471
YMDB (Yeast Metabolome Database):YMDB01519
FDA Listing of Food Additive Status:View
FDA Color Additive Status ListView
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
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Synonyms:
beta,(E)-carotene-3,3'-diol
 fitoestesina eth-F (Vevy)
 fitoxantina (Vevy)
 lutein
floraglo lutein
 lutein (marigold extract)
ZMC natural lutein 20% Oil Dispersion
ZMC natural lutein 5% CWS-S
ZMC natural lutein 5% TAB
 lutein from Tagetes erecta
 vegetable llutein
 vegetable luteol
 xanthophyll
all-trans-(+)-xanthophyll
 xanthophyll from marigold
 

Articles:

Info:Lutein and Zeaxanthin
PubMed:Oxidative stability of yogurt with added lutein dye.
PubMed:Increase in β-ionone, a carotenoid-derived volatile in zeaxanthin-biofortified sweet corn.
PubMed:UV-B radiation impacts shoot tissue pigment composition in Allium fistulosum L. cultigens.
PubMed:Identifying carotenoids and phenolic compounds in naranjilla (Solanum quitoense Lam. var. Puyo hybrid), an Andean fruit.
PubMed:Bioconversion of lutein using a microbial mixture--maximizing the production of tobacco aroma compounds by manipulation of culture medium.
PubMed:Kale carotenoids remain stable while flavor compounds respond to changes in sulfur fertility.
PubMed:Enhanced levels of the aroma and flavor compound S-linalool by metabolic engineering of the terpenoid pathway in tomato fruits.
 
Notes:
a carotenoid alcohol widespread in nature. it is present in egg yolk, algae, and petals of yellow flowers, among other sources. Pigment from egg yolk and leaves. Found in all higher plants. Nutriceutical with anticancer and antioxidation props. Potentially useful for the treatment of age-related macular degeneration (AMD) of the eye Lutein is a xanthophyll and one of 600 known naturally-occurring carotenoids. The principal natural stereoisomer of lutein is (3R,3?R,6?R)-beta,epsilon-carotene-3,3?-diol. (Wikipedia)
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