ichthammol
 
Notes:
tsca definition 2008: a complex product obtained by the sulfonation and ammoniation of the distillation product from bituminous schists. it may contain saturated and unsaturated hydrocarbons, nitrogen bases and thiophene derivatives.
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CAS Number: 8029-68-3 
Other: 1394-96-3
ECHA EC Number: 232-439-0
FDA UNII: NQ14646378
Category: antimicrobial agents
 
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Physical Properties:
Appearance: pale yellow or brownish-black very viscous liquid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antimicrobial agents
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Suppliers:
Santa Cruz Biotechnology
For experimental / research use only.
Ichthammol
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50  700 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 199, 1956.

intravenous-rabbit LDLo  1000 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 199, 1956.

oral-rat LD  > 10000 mg/kg
BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 44, Pg. 844, 1994.

Dermal Toxicity:
skin-rat LD > 21500 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 44, Pg. 844, 1994.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antimicrobial agents
Recommendation for ichthammol usage levels up to:
 not for fragrance use.
 
Recommendation for ichthammol flavor usage levels up to:
 not for flavor use.
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Safety References:
Daily Med: search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 8029-68-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
Chemidplus: 0008029683
EPA/NOAA CAMEO: hazardous materials
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References:
Pubchem (sid): 135305546
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Other Information:
HMDB (The Human Metabolome Database): Search
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 antimicrobial agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 ichthammol
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Articles:
PubMed: Better living through chemistry.
PubMed: Comparison of steroid antibiotic pack and 10% ichthammol glycerine pack in relieving pain of acute otitis externa in children.
PubMed: Effective treatment of acute otitis externa: a comparison of steroid antibiotic versus 10% ichthammol glycerine pack.
PubMed: Tea tree oil attenuates experimental contact dermatitis.
PubMed: Ichthammol revisited.
PubMed: Efficacy and tolerability of pale sulfonated shale oil cream 4% in the treatment of mild to moderate atopic eczema in children: a multicentre, randomized vehicle-controlled trial.
PubMed: Incorporation of bovine serum albumin into biomimetic coatings on titanium with high loading efficacy and its release behavior.
PubMed: Expansile properties of otowicks: an in vitro study.
PubMed: A randomised controlled trial comparing Triadcortyl with 10% glycerine-ichthammol in the initial treatment of severe acute otitis externa.
PubMed: The 'Ic and Glic Pope Wick'.
PubMed: Facial Sweet's syndrome mimicking rosacea fulminans.
PubMed: Efficacy of topical pale sulfonated shale oil in the treatment of venous leg ulcers: a randomized, controlled, multicenter study.
PubMed: Phototoxicity of bituminous tars-correspondence between results of 3T3 NRU PT, 3D skin model and experimental human data.
PubMed: [Influence of manufacturing procedure on stability of Unguentum contra perniones preparations].
PubMed: [Anti-inflammatory, antibacterial and antimycotic effects of dark sulfonated shale oil (ichthammol)].
PubMed: Examining the range of medicated and paste-impregnated bandages.
PubMed: Anti-inflammatory action of pale sulfonated shale oil (ICHTHYOL pale) in UVB erythema test.
PubMed: Glycerol and ichthammol: medicinal solution or mythical potion?
PubMed: Antimicrobial activity of glycerine-ichthammol in otitis externa.
PubMed: Tropical ear treatment.
PubMed: [The adverse effects of dark sulfonated shale oil following local and systemic administration].
PubMed: Soluble interleukin 2 receptor in atopic eczema.
PubMed: Inhibitory effect of sulfonated shale oils (ammonium bituminosulfonate) on the stimulation of neutrophilic granulocytes by the chemotactic tripeptide f-Met-Leu-Phe.
PubMed: [Postmenopausal bleeding following the application of an estrogen-containing hair lotion--concomitant endocrine changes].
PubMed: Ichthammol sensitivity.
PubMed: [KNEIPP'S HYDROTHERAPY IN RHEUMATIC DISEASES WITH REFERENCE TO THE ICHTHO-BATH].
PubMed: ULCERATION OF THE LEGS.
PubMed: HAND ECZEMA.
PubMed: [PROBLEMS OF PUERPERAL MASTITIS].
PubMed: ON THE LENGTH AND MOLECULAR WEIGHT OF TROPOCOLLAGEN FROM CALF SKIN.
PubMed: [ICHTHYOL, A FACTOR IN COSMETICS].
PubMed: [FURUNCLE AND FURUNCULOSIS].
PubMed: [IODOCHLORIMETRIC METHOD FOR THE QUANTITATIVE ANALYSIS OF ICHTHYOL IN VARIOUS PREPARATIONS, SOLUTIONS AND OINTMENTS].
PubMed: [THE FLASK COMBUSTION METHOD IN THE CONTROL OF DRUGS. II. DETERMINATION OF TOTAL SULFUR IN ICHTHAMMOL AND SOME OF ITS GALENICAL PREPARATIONS].
PubMed: THE NATURE, QUANTITY, AND MODE OF ATTACHMENT OF HEXOSES IN ICHTHYOCOL.
PubMed: [CONTRIBUTION ON THE BALNEOTHERAPY OF DERMATOLOGICAL VASCULAR DISEASES].
PubMed: [CLINICAL EXPERIENCES WITH AN ICHTHYOL-HYDROCORTISONE SOLUTION].
PubMed: [THE TREATMENT OF ECZEMA].
PubMed: [HISTOCHEMICAL STUDY ON REACTIVE EPIDERMATOSES].
PubMed: [Nilnocere'. A contribution to the treatment of inflammatory diseases of the genitalia. 10 years of Ichthophen therapy].
PubMed: [Clinical trial of Adnexol in ambulant practice].
PubMed: [QUALITATIVE DETERMINATION OF THIOPHENE SODIUM IN ICHTHYOL].
PubMed: [CLINICAL EVALUATION OF NONROENTGENOLOGICAL METHODS OF TREATING TRICHOMYCOSIS].
PubMed: [Experiences with a new light ichthyol ointment].
PubMed: [On the therapy of localized intertriginous skin disease].
PubMed: [Determination of sulfur in ichthammol and some preparations containing ichthammol].
PubMed: [On the problem of prostatitis and its treatment, especially as a focal infection].
PubMed: [Iodo-chlorometric method for quantitative determination of ichthyol in pure preparations, solutions andointments].
PubMed: [On a new principle in the conservative treatment of adnexitis].
PubMed: [The treatment of otitis externa in private practice].
PubMed: [On the therapy of vaginal mycoses].
PubMed: [On the local therapy of juvenile acne].
PubMed: [On the treatment of ulcer and gastritis with an oral ichthyol preparation].
PubMed: [Clinical and experimental studies on the cardiovascular effect of organic, intravenous administration of sulfur combinations (ichthophen)].
PubMed: [Therapy of arthrosis of the knee joint with intra-articular decortin-H crystalline suspension & ichtholan-permanent bandage].
PubMed: [Treatment of arthrosis deformans of the hip joint with ichthophen].
PubMed: [Contribution to intensification of antimycotic treatment].
PubMed: [Pharmacodynamics & use of ammonium sulfobituminosum].
PubMed: [Study of ichthyol derivatives in therapy of mycoses].
PubMed: [A promising method for treatment of cervical erosion].
PubMed: [Treatment of inflammatory diseases of the internal female genitalia].
PubMed: [The treatment of painful conditions in the true pelvis of the female with ichthobellol compositum].
PubMed: [Not Available].
PubMed: [New approaches in internal therapy of seborrheic skin diseases, particularly acne].
PubMed: [Effect of an organic fossilsulfur preparation (ichthophen) in peripheral vascular diseases].
PubMed: Treatment of various skin diseases; topical application of ichthyol.
PubMed: Office treatment of atopic dermatitis.
PubMed: [New ways of conservative treatment of inflammatory genital diseases].
PubMed: [A proposal to use ammonium sulfobituminosum as an entry in a further addendum to DAB. 6].
PubMed: [Experimental and clinical experiences with ichthophene for intravenous injection in various dermatoses].
PubMed: [Experience with a percutaneous remedy for rheumatism, rheum-ichthol].
PubMed: [Proposal for the product ammonium sulfobituminosum in a further supplement to DAB 6].
PubMed: [Permanent bandage with ictholan special; progress in the treatment of locomotor disorders].
PubMed: [Ichthammol; a commentary on the monograph in the Pharmacopoea Danica 19-18 addendum].
PubMed: [Clinical experiences with ichtholan T; therapeutic report].
PubMed: [Application and technic of compression bandages with ichthyol in treatment of arthritis, arthrosis and joint injuries].
PubMed: [Effect of ichthyol preparations in the view of physicochemical observations].
PubMed: [The internal treatment of various dermatoses with ichthentral, a new ichthyol preparation].
PubMed: [Experiences with ichthogel in therapy of skin diseases].
PubMed: An effective conservative treatment for chronic sinusitis.
PubMed: [Cytological test for determination of ichthyol-estrogen effect].
PubMed: [Ichthammol estrin therapy of cicatricial vaginal stenosis].
PubMed: [Water soluble shale oil preparations in therapy of dermatoses].
PubMed: [A new form of ichthyol for use in general dermatologic practice].
PubMed: [Experimental therapy with iodoichthyol (preparation of iodate and ichthyol)].
PubMed: [Not Available].
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