EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

benzenecarboximidamide, 4,4'-(1,6-hexanediylbis(oxy))bis-

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CAS Number: 3811-75-4Picture of molecule3D/inchi
FDA UNII: 3483C2H13H
Nikkaji Web:J238.611I
XlogP3-AA:2.90 (est)
Molecular Weight:354.45362000
Formula:C20 H26 N4 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 548.60 °C. @ 760.00 mm Hg (est)
Flash Point: 546.00 °F. TCC ( 285.60 °C. ) (est)
logP (o/w): 3.000 (est)
Soluble in:
 water, 9.136 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: preservatives
BOC Sciences
For experimental / research use only.
Hexamidine > 95%
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
Recommendation for hexamidine usage levels up to:
 not for fragrance use.
Recommendation for hexamidine flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :65130
National Institute of Allergy and Infectious Diseases:Data
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):65130
Pubchem (sid):135022761
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):D07206
HMDB (The Human Metabolome Database):Search
Potential Blenders and core components note
None Found
Potential Uses:
Occurrence (nature, food, other):note
 not found in nature
4,4'-(1,6-hexane diyl bis(oxy)) bisbenzene carboximidamide
 benzenecarboximidamide, 4,4'-(1,6-hexanediylbis(oxy))bis-


PubMed:[Acanthamoeba keratitis.]
PubMed:Development of a practical complete-kill assay to evaluate anti-Acanthamoeba drugs.
PubMed:Prognostic factors associated with the need for surgical treatments in acanthamoeba keratitis.
PubMed:Application of genomics to breakthroughs in the cosmetic treatment of skin ageing and discoloration.
PubMed:Double-biguanide therapy for resistant acanthamoeba keratitis.
PubMed:A double-blind randomized controlled comparison of APDDR-0901, a novel cosmeceutical formulation, and 0.1% adapalene gel in the treatment of mild-to-moderate acne vulgaris.
PubMed:Microsporidial keratoconjunctivitis in the tropics: a case series.
PubMed:[Effect of psychotropic drugs on activity of anticonvulsants in maximal electroshock test].
PubMed:Antiseptic properties of two calix[4]arenes derivatives on the human coronavirus 229E.
PubMed:Action potential-enhanced ATP release from taste cells through hemichannels.
PubMed:[Acanthamoeba keratitis. Report of 3 cases diagnosed in central Tunisia].
PubMed:[Infectious keratitis and cosmetic lenses: a five-case retrospective study].
PubMed:Treatment with voriconazole in 3 eyes with resistant Acanthamoeba keratitis.
PubMed:Painless Acanthamoeba keratitis in a soft contact lens wearer--case report.
PubMed:Understanding metabolic pathways for skin anti-aging.
PubMed:p-Guanidinoethyl calixarene and parent phenol derivatives exhibiting antibacterial activities. Synthesis and biological evaluation.
PubMed:A new Sephadex-based method for removing microbicidal and cytotoxic residues when testing antiseptics against viruses: Experiments with a human coronavirus as a model.
PubMed:Cationic compounds with activity against multidrug-resistant bacteria: interest of a new compound compared with two older antiseptics, hexamidine and chlorhexidine.
PubMed:Prevalence and risk factors for allergic contact dermatitis to topical treatment in atopic dermatitis: a study in 641 children.
PubMed:Rapidly progressive cataract and iris atrophy during treatment of Acanthamoeba keratitis.
PubMed:Final report on the safety assessment of Hexamidine and Hexamidine Diisethionate.
PubMed:Bilateral acanthamoeba keratitis.
PubMed:Visual outcome and rehabilitation in a case of bilateral acanthamoeba sclerokeratitis.
PubMed:In vitro activity of para-guanidinoethylcalix[4]arene against susceptible and antibiotic-resistant Gram-negative and Gram-positive bacteria.
PubMed:Antistaphylococcal activities of CG400549, a new bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor.
PubMed:[Acanthamoeba keratitis: about the first two Tunisian cases].
PubMed:[Clinical tolerance of cutaneous antiseptics in 3,403 patients in France].
PubMed:[Towards new antibacterial drugs. Interest of para-guanidinoethylcalix[4]arene].
PubMed:Systemic allergy to topical hexamidine.
PubMed:A keratitis rat model for evaluation of anti-Acanthamoeba polyphaga agents.
PubMed:Acanthamoeba keratitis in a 5-year-old boy without a history of contact lens usage.
PubMed:[Contact allergy to antiseptics: 75 cases analyzed by the dermato-allergovigilance network (Revidal)].
PubMed:Acanthamoeba keratitis during orthokeratology.
PubMed:[Treatment of Acanthamoeba keratitis: possibilities, problems, and new approaches].
PubMed:Opportunistic amoebae: challenges in prophylaxis and treatment.
PubMed:Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization.
PubMed:Persistently culture positive acanthamoeba keratitis: in vivo resistance and in vitro sensitivity.
PubMed:Bilateral Acanthamoeba keratitis with late recurrence of the infection in a corneal graft: a case report.
PubMed:NTP Toxicology and Carcinogenesis Studies of Primidone (CAS No. 125-33-7) in F344/N Rats and B6C3F1 Mice (Feed Studies).
PubMed:[A clinico-pathological case report of necrotizing ulcerating keratopathy due to topical anaesthetic abuse].
PubMed:Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase.
PubMed:Antimicrobial susceptibility of 19 Australian corneal isolates of Acanthamoeba.
PubMed:[Antiseptic treatment of the umbilical cord in newborns: survey and recommendations].
PubMed:[Contact sensitization in leg ulcers].
PubMed:[Amebicide activity of antiseptics and an antibiotic on 2 Acanthamoeba isolated from corneal ulcers].
PubMed:Plasmid-mediated resistance to antimicrobial agents among listeriae.
PubMed:Acanthamoeba keratitis in New Zealand, including two cases with in vivo resistance to polyhexamethylene biguanide.
PubMed:Amebic keratitis due to a mixed infection with Acanthamoeba and Hartmanella species.
PubMed:Sequence-selective binding to DNA of bis(amidinophenoxy)alkanes related to propamidine and pentamidine.
PubMed:Cutaneous infection caused by Tsukamurella paurometabolum.
PubMed:[A clinico-pharmacological basis for optimizing the treatment of therapy-resistant forms of epilepsy].
PubMed:Contact sensitivity to 5 different ingredients of a topical medicament (Imacort cream).
PubMed:Amoebicidal efficiencies of various diamidines against two strains of Acanthamoeba polyphaga.
PubMed:Contact photosensitivity to nonoxynol used in antiseptic preparations.
PubMed:Successful treatment of Acanthamoeba keratitis by hexamidine.
PubMed:[The spectrum of the anticonvulsant action of morfolid ].
PubMed:Examination of the activities of 43 chemotherapeutic agents against Neospora caninum tachyzoites in cultured cells.
PubMed:[Relationship between the level of minimal inhibitory concentrations of five antiseptics and the presence of qacA gene in Staphylococcus aureus].
PubMed:High-performance liquid chromatographic determination of pentamidine in plasma.
PubMed:Photoallergy to hexamidine.
PubMed:[Study of combinations of antimicrobial agents. Development of the method].
PubMed:Comparative study on the antimicrobial effects of Hexomedine and Betadine on the human skin flora.
PubMed:[A foaming antiseptic solution for handwashing. Study in dentists].
PubMed:[Allergy survey in genital contact dermatitis].
PubMed:[Therapeutic and pharmacological monitoring of individual monotherapy of epilepsy with hexamidine].
PubMed:[The effect of antidepressants on the experimental anticonvulsant activity and acute toxicity of anticonvulsants].
PubMed:[Treatment of patients with psychomotor epileptic attacks resistant to conventional anticonvulsant therapy].
PubMed:[The in vitro activity of veterinary antiseptics].
PubMed:Hexamidine isethionate: a sensitizer in topical pharmaceutical products and cosmetics.
PubMed:Ring-shaped positive allergic patch test reactions to allergens in liquid vehicles.
PubMed:[Hexamidine content of the blood plasma and cerebrospinal fluid in patients with epilepsy].
PubMed:[Experimental and clinical study of the effectiveness of the combined use of anticonvulsants and tranquilizers in epilepsy].
PubMed:[Effect of anticonvulsants on the psychotropic activity of tranquilizers in their joint use in an experiment].
PubMed:Susceptibility of Torulopsis glabrata in the presence of six antifungal agents determined by comparison of growth at several pHs.
PubMed:[Folic acid treatment of epileptics].
PubMed:Gas chromatographic determination of nitrogen-containing anticonvulsant drugs and opium alkaloids using a thermoaerosol detector.
PubMed:Comparison of in vivo antibacterial activity of hydro-alcoholic solutions of hexamidine and of chlorhexidine.
PubMed:[Concentration of benzonal in the blood of epileptic patients at different daily doses and with other anticonvulsants].
PubMed:[Synergistic effect of clotrimazole and hexamidinediisethionate against Candida albicans].
PubMed:[Anticonvulsive activity of anticonvulsants and tranquilizers when used together].
PubMed:Analysis of hexamidine, dibromohexamidine, dibromopropamidine and chlorhexidine in cosmetic products by high-performance liquid chromatography.
PubMed:[Effect of phenobarbital, hexamidine and benzonal on the toxicity of dioxidine].
PubMed:[Contact dermatitis from hexamidine].
PubMed:Quantitative determination of hexamidine isethionate in pharmaceutical preparations by high-performance liquid chromatography.
PubMed:[Radioimmunologic study of the plasma concentrations of folic acid and various antiepileptic preparations during the treatment of epileptic patients].
PubMed:[Antimutagenic properties of a series of drug compounds].
PubMed:[Bone marrow hematopoiesis in epileptics].
PubMed:[Mechanism of action of antiepileptic drugs].
PubMed:[Antimutagenic activity of the anticonvulsant preparation hexamidine. Effect of hexamidine on spontaneous mutation levels of a number of subjects].
PubMed:Contact dermatitis to hexamidine.
PubMed:[Study of metabolic activation of chemical compounds by using microorganisms. I. Effect of inducers of microsomal systems].
PubMed:[Interferometric determination of hexamidine, barbamyl and theobromine in preparations and various dosage forms].
PubMed:[Use of di-isethionate of hexamidine for prevention of bedsores].
PubMed:[A rare case of severe poisoning with benzonal, hexamidine and luminal].
PubMed:[Qualitative reaction for hexamidine].
PubMed:[Spectrophotometric determination of tabletted allacil, methylthiouracil and hexamidine].
PubMed:[New insight into the use of aromatic diamidines, especially of hexamidine, in the treatment of skin diseases].
PubMed:[Changes of electrical potentials of the cortex and subcortical formations of the brain in rabbits under the influence of hexamidine during electrical convulsions].
PubMed:[Results of clinical testing of a new antispasmodic hexamidine].
PubMed:[Generalized eczema from sensitivity to hexomedine].
None found
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