EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

heparin
semuloparin

Supplier Sponsors

CAS Number: 9005-49-6
Other(deleted CASRN):104521-37-1
ECHA EC Number:232-681-7
FDA UNII: 7UQ7X4Y489
Category:cosmetic ingredient for skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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US Patents:Search
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
BOC Sciences
For experimental / research use only.
Heparin
George Uhe Company
Dermatan Sulphate
Pangaea Sciences
Heparin
Sigma-Aldrich
For experimental / research use only.
Heparin for physico-chemical analysis European Pharmacopoeia (EP) Reference Standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-man TDLo 3536 units/kg/
Southern Medical Journal. Vol. 80, Pg. 1450, 1987.

intraperitoneal-mouse LD50 1900 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 60, Pg. 507, 1964.

intravenous-mouse LD50 500 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1366, 1986.

oral-rat LD50 1950 mg/kg
German Offenlegungsschrift Patent Document. Vol. #2636091

intraperitoneal-rat LDLo 420 mg/kg
Toxicology and Applied Pharmacology. Vol. 1, Pg. 156, 1959.

Dermal Toxicity:
subcutaneous-man TDLo 1857 units/kg/
CARDIAC: OTHER CHANGES
Southern Medical Journal. Vol. 80, Pg. 1450, 1987.

subcutaneous-mouse LD50 500 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS
Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1366, 1986.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic ingredient for skin conditioning
Recommendation for heparin usage levels up to:
 not for fragrance use.
 
Recommendation for heparin flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):9005-49-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
Chemidplus:0009005496
 
References:
Pubchem (sid):135346864
 
Other Information:
KEGG (GenomeNet):C00374
HMDB (The Human Metabolome Database):HMDB01394
FooDB:FDB022599
VCF-Online:VCF Volatile Compounds in Food
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 biological additives
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 adomiparin
 bemiparin
 certoparin
 dermatan sulfate
 dermatan sulphate
 parnaparin
 reviparin
 sandoparin
 semuloparin
 
 
Notes:
a highly acidic mucopolysaccharide formed of equal parts of sulfated d-glucosamine and d-glucuronic acid with sulfaminic bridges. the molecular weight ranges from six to twenty thousand. heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts. A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts. [HMDB]
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