HC blue no. 2, 33229-34-4

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CODE137015 CODE137015
Product(s):
33229-34-4 2,2'-(4-(2-hydroxyethylamino)-3-nitro-phenylimino ≥98%

CAS Number:	33229-34-4	3D/inchi
ECHA EINECS - REACH Pre-Reg:	251-410-3
FDA UNII:	6C0EL1931V
Nikkaji Web:	J78.133I
Beilstein Number:	2148848
MDL:	MFCD00071762
XlogP3-AA:	0.40 (est)
Molecular Weight:	285.30043000
Formula:	C12 H19 N3 O5
BioActivity Summary:	listing
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:hair dyeing agents

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Appearance:	dark blue to dark brown microcrystalline powder (est)
Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Melting Point:	93.00 °C. @ 760.00 mm Hg
Boiling Point:	582.70 °C. @ 760.00 mm Hg (est)
Flash Point:	583.00 °F. TCC ( 306.20 °C. ) (est)
logP (o/w):	1.700
Soluble in:
	water, 527.8 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:	hair dyeing agents

Suppliers:

BOC Sciences

For experimental / research use only.

2,2'-(4-(2-hydroxyethylamino)-3-nitro-phenylimino ≥98%

Sigma-Aldrich: Aldrich

For experimental / research use only.

2,2'-[4-(2-Hydroxyethylamino)-3-nitrophenylimino]diethanol 98%

sds

Safety Information:

Preferred SDS: View

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD > 1000 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION National Toxicology Program Technical Report Series. Vol. NTP-TR-293, Pg. 1985 oral-rat LD > 500 mg/kg National Toxicology Program Technical Report Series. Vol. NTP-TR-293, Pg. 1985
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
hair dyeing agents
Recommendation for HC blue no. 2 usage levels up to:
	not for fragrance use.

Recommendation for HC blue no. 2 flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

Chemical Carcinogenesis Research Information System:Search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

Carcinogenic Potency Database:Search

EPA Substance Registry Services (TSCA):33229-34-4

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :36383

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:1

2-[4-[bis(2-hydroxyethyl)amino]-2-nitroanilino]ethanol

Chemidplus:0033229344

EPA/NOAA CAMEO:hazardous materials

RTECS:KL2880000 for cas# 33229-34-4

References:

	2-[4-[bis(2-hydroxyethyl)amino]-2-nitroanilino]ethanol
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	33229-34-4
Pubchem (cid):	36383
Pubchem (sid):	134999387

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
CHEMBL:	View
KEGG (GenomeNet):	C19429
HMDB (The Human Metabolome Database):	Search
ChemSpider:	View

Potential Blenders and core components note

None Found

Potential Uses:

hair dyeing agents

Occurrence (nature, food, other):note

not found in nature

Synonyms:

	ethanol, 2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino)bis-
	ethanol, 2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino)di-
	HC blue 2
2,2'-((4-((2-	hydroxyethyl)amino)-3-nitrophenyl)imino) bisethanol
2,2'-((4-((2-	hydroxyethyl)amino)-3-nitrophenyl)imino)bis(ethanol)
2-[4-[bis(2-	hydroxyethyl)amino]-2-nitroanilino]ethanol
2,2'-({4-[(2-	hydroxyethyl)amino]-3-nitrophenyl}imino)diethanol
3-	nitro-N(sup 1),N(sup 1),N(sup 4)-tris(2-hydroxyethyl)-
p-	phenylenediamine, 3-nitro-N(sup 1),N(sup 1),N(sup 4)-tris(2-hydroxyethyl)-

Articles:

PubMed:Assessing the predictiveness of the Syrian hamster embryo cell transformation assay for determining the rodent carcinogenic potential of single ring aromatic/nitroaromatic amine compounds.

PubMed:HC Blue No. 2.

PubMed:Mutagenicity evaluation of HC Blue No. 1 and HC Blue No. 2, II. Effect on the in vitro induction of unscheduled DNA synthesis in rat, mouse, rabbit, hamster, and monkey primary hepatocytes.

PubMed:Mutagenicity evaluation of HC Blue No. 1 and HC Blue No. 2, I. Effect on the induction of micronuclei in mouse bone marrow cells.

PubMed:Mutagenicity evaluation of HC Blue No. 1 and HC Blue No. 2. III. Effects in the Salmonella typhimurium/Escherichia coli reversion assay and the mouse lymphoma L5178Y TK+/- forward mutation assay.

PubMed:Comparative metabolism and genotoxicity of the structurally similar nitrophenylenediamine dyes, HC Blue 1 and HC Blue 2, in mouse hepatocytes.

PubMed:Species comparisons regarding comparative metabolism of two structurally similar phenylenediamines (HC Blue 1 and HC Blue 2).

PubMed:Comparative carcinogenicity of two structurally similar phenylenediamine dyes (HC blue no. 1 and HC blue no. 2) in F344/N rats and B6C3F1 mice.

PubMed:NTP Toxicology and Carcinogenesis Studies of C.I. Acid Orange 3 (CAS No. 6373-74-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).

PubMed:Failure of short-term in vitro mutagenicity tests to predict the animal carcinogenicity of hair dyes.

PubMed:NTP Toxicology and Carcinogenesis Studies of HC Blue No. 2 [2,2'-((4-((2-Hydroxyethyl)amino)-3-nitrophenyl)imino)bis(ethanol)] (CAS No. 33229-34-4) in F344/N Rats and B6C3F 1 Mice (Feed Studies).

Notes:

None found

HC blue no. 2 p-phenylenediamine, 3-nitro-N(sup 1),N(sup 1),N(sup 4)-tris(2-hydroxyethyl)-

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Articles:

HC blue no. 2
p-phenylenediamine, 3-nitro-N(sup 1),N(sup 1),N(sup 4)-tris(2-hydroxyethyl)-