EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

HC blue no. 2
p-phenylenediamine, 3-nitro-N(sup 1),N(sup 1),N(sup 4)-tris(2-hydroxyethyl)-

Supplier Sponsors

CAS Number: 33229-34-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:251-410-3
FDA UNII: 6C0EL1931V
Nikkaji Web:J78.133I
Beilstein Number:2148848
MDL:MFCD00071762
XlogP3-AA:0.40 (est)
Molecular Weight:285.30043000
Formula:C12 H19 N3 O5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:hair dyeing agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:dark blue to dark brown microcrystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 93.00 °C. @ 760.00 mm Hg
Boiling Point: 582.70 °C. @ 760.00 mm Hg (est)
Flash Point: 583.00 °F. TCC ( 306.20 °C. ) (est)
logP (o/w): 1.700
Soluble in:
 water, 527.8 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair dyeing agents
 
Suppliers:
BOC Sciences
For experimental / research use only.
2,2'-(4-(2-hydroxyethylamino)-3-nitro-phenylimino ≥98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
2,2'-[4-(2-Hydroxyethylamino)-3-nitrophenylimino]diethanol 98%
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD > 1000 mg/kg
KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
National Toxicology Program Technical Report Series. Vol. NTP-TR-293, Pg. 1985

oral-rat LD > 500 mg/kg
National Toxicology Program Technical Report Series. Vol. NTP-TR-293, Pg. 1985

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
hair dyeing agents
Recommendation for HC blue no. 2 usage levels up to:
 not for fragrance use.
 
Recommendation for HC blue no. 2 flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):33229-34-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :36383
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
2-[4-[bis(2-hydroxyethyl)amino]-2-nitroanilino]ethanol
Chemidplus:0033229344
EPA/NOAA CAMEO:hazardous materials
RTECS:KL2880000 for cas# 33229-34-4
 
References:
 2-[4-[bis(2-hydroxyethyl)amino]-2-nitroanilino]ethanol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:33229-34-4
Pubchem (cid):36383
Pubchem (sid):134999387
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C19429
HMDB (The Human Metabolome Database):Search
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 hair dyeing agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 ethanol, 2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino)bis-
 ethanol, 2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino)di-
 HC blue 2
2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino) bisethanol
2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino)bis(ethanol)
2-[4-[bis(2-hydroxyethyl)amino]-2-nitroanilino]ethanol
2,2'-({4-[(2-hydroxyethyl)amino]-3-nitrophenyl}imino)diethanol
3-nitro-N(sup 1),N(sup 1),N(sup 4)-tris(2-hydroxyethyl)-
p-phenylenediamine, 3-nitro-N(sup 1),N(sup 1),N(sup 4)-tris(2-hydroxyethyl)-
 

Articles:

PubMed:Assessing the predictiveness of the Syrian hamster embryo cell transformation assay for determining the rodent carcinogenic potential of single ring aromatic/nitroaromatic amine compounds.
PubMed:HC Blue No. 2.
PubMed:Mutagenicity evaluation of HC Blue No. 1 and HC Blue No. 2, II. Effect on the in vitro induction of unscheduled DNA synthesis in rat, mouse, rabbit, hamster, and monkey primary hepatocytes.
PubMed:Mutagenicity evaluation of HC Blue No. 1 and HC Blue No. 2, I. Effect on the induction of micronuclei in mouse bone marrow cells.
PubMed:Mutagenicity evaluation of HC Blue No. 1 and HC Blue No. 2. III. Effects in the Salmonella typhimurium/Escherichia coli reversion assay and the mouse lymphoma L5178Y TK+/- forward mutation assay.
PubMed:Comparative metabolism and genotoxicity of the structurally similar nitrophenylenediamine dyes, HC Blue 1 and HC Blue 2, in mouse hepatocytes.
PubMed:Species comparisons regarding comparative metabolism of two structurally similar phenylenediamines (HC Blue 1 and HC Blue 2).
PubMed:Comparative carcinogenicity of two structurally similar phenylenediamine dyes (HC blue no. 1 and HC blue no. 2) in F344/N rats and B6C3F1 mice.
PubMed:NTP Toxicology and Carcinogenesis Studies of C.I. Acid Orange 3 (CAS No. 6373-74-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
PubMed:Failure of short-term in vitro mutagenicity tests to predict the animal carcinogenicity of hair dyes.
PubMed:NTP Toxicology and Carcinogenesis Studies of HC Blue No. 2 [2,2'-((4-((2-Hydroxyethyl)amino)-3-nitrophenyl)imino)bis(ethanol)] (CAS No. 33229-34-4) in F344/N Rats and B6C3F 1 Mice (Feed Studies).
 
Notes:
None found
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