dextran sulfate
sulfuric acid dextran ester
 
Notes:
long-chain polymer of glucose containing 17-20% sulfur. it has been used as an anticoagulant and also has been shown to inhibit the binding of hiv-1 to cd4-positive t-lymphocytes. it is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.
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CAS Number: 9042-14-2 
Other: 191288-77-4
FDA UNII: NXV22KT7NQ
Category: cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: binding agents
skin conditioning
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
unreported-mammal (species unspecified) LD50  2500 mg/kg
Journal of Medicinal Chemistry. Vol. 30, Pg. 810, 1987.

intraperitoneal-mouse LD50  341 mg/kg
Drug Delivery System. Vol. 14, Pg. 407, 1999.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for dextran sulfate usage levels up to:
 not for fragrance use.
 
Recommendation for dextran sulfate flavor usage levels up to:
 not for flavor use.
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Safety References:
ClinicalTrials.gov: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 9042-14-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
Chemidplus: 0009042142
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References:
Pubchem (sid): 135346937
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Other Information:
HMDB (The Human Metabolome Database): Search
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 binding agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 sulfuric acid dextran ester
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