zinc citrate
1,2,3-propanetricarboxylic acid, 2-hydroxy-, zinc salt (2:3)
 
Notes:
None found
  • American International Chemical, LLC.
    • American International Chemical, Inc.
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      ZCTGIP ZINC CITRATE TRIHYDRATE USP FCC
       
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trizinc 2-hydroxypropane-1,2,3-tricarboxylate (Click)
CAS Number: 546-46-3Picture of molecule
Other: 12405-10-6
ECHA EINECS - REACH Pre-Reg: 208-901-2
FDA UNII: K72I3DEX9B
Molecular Weight: 574.34050000
Formula: C12 H10 O14 Zn3
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic agents, dietary supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Appearance: white powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 309.00 to  310.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000057 mm/Hg @ 25.00 °C. (est)
Flash Point: 311.00 °F. TCC ( 155.20 °C. ) (est)
logP (o/w): -1.721 (est)
Soluble in:
 water
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antiplaque agents
oral care agents
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Suppliers:
American International Chemical, LLC.
ZINC CITRATE TRIHYDRATE USP FCC
Global Calcium
Zinc Citrate
Jost Chemical
Zinc Citrate Dihydrate USP Fine Granular
Jost Chemical
Zinc Citrate Dihydrate USP Low HM Fine Granular
Jost Chemical
Zinc Citrate Dihydrate USP Low HM Powder
Jost Chemical
Zinc Citrate Dihydrate USP Powder
Jungbunzlauer Suisse
Zinc Citrate
Flavor: characteristic
Zinc citrate is a trihydrate and is produced by complete neutralization of citric acid with a high purity zinc source, subsequent precipitation and dehydration. Zinc citrate is mainly used in dental care products such as toothpastes, mouthwashes and chewing gums due to its antimicrobial and anti-inflammatory effects and its ability to reduce or inhibit the formation of dental plaque and tartar. In pharmaceuticals, zinc citrate fights common colds. Since adequate zinc levels are difficult to reach via the diet, zinc is increasingly used in food supplements, functional foods and beverages. As an organic mineral source it is preferred in many applications over inorganic sources because of its superior bioavailability and physiological compatibility. Among the organic zinc salts zinc citrate has one of the highest zinc content (31%).
Qingdao Dacon Trading
Zinc Citrate
Sabinsa Corporation
Zinc Citrate
Tate & Lyle
Zinc Citrate
Universal Preserv-A-Chem Inc.
ZINC CITRATE TH 31% ZN POWDER
Odor: characteristic
Use: Zinc Citrate can be used as a dietary supplement and as a nutrient. This product is known to be used in oral care products. Zinc is an important antioxidant nutrient. It is necessary for protein synthesis, wound healing, for blood stability, normal tissue function, and aids in the digestion and metabolism of phosphorus. It also governs the contractility of muscles and maintains the body-s alkaline balance.
Universal Preserv-A-Chem Inc.
ZINC CITRATE TRIHYD PURIFIED
Odor: characteristic
Use: Zinc Citrate can be used as a dietary supplement and as a nutrient. This product is known to be used in oral care products. Zinc is an important antioxidant nutrient. It is necessary for protein synthesis, wound healing, for blood stability, normal tissue function, and aids in the digestion and metabolism of phosphorus. It also governs the contractility of muscles and maintains the body-s alkaline balance.
Zhong Ya Chemical
Zinc Citrate
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents, dietary supplements
Recommendation for zinc citrate usage levels up to:
 not for fragrance use.
 
Recommendation for zinc citrate flavor usage levels up to:
 not for flavor use.
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Safety References:
ClinicalTrials.gov: search
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 546-46-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 11023
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 trizinc 2-hydroxypropane-1,2,3-tricarboxylate
Chemidplus: 0000546463
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References:
 trizinc 2-hydroxypropane-1,2,3-tricarboxylate
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 11023
Pubchem (sid): 134977229
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
Household Products: Search
ChemSpider: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 biological additives 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 citric acid zinc salt
2-hydroxy-1,2,3-propanetricarboxylic acid, zinc salt
1,2,3-propanetricarboxylic acid, 2-hydroxy-, zinc salt (2:3)
 trizinc 2-hydroxypropane-1,2,3-tricarboxylate
 trizinc dicitrate
 zinc 2-hydroxypropane-1,2,3-tricarboxylate (3:2)
 zinccitrate
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Articles:
PubMed: The bioavailability of different zinc compounds used as human dietary supplements in rat prostate: a comparative study.
PubMed: Facile preparation of well-dispersed CeO2-ZnO composite hollow microspheres with enhanced catalytic activity for CO oxidation.
PubMed: Zinc absorption by young adults from supplemental zinc citrate is comparable with that from zinc gluconate and higher than from zinc oxide.
PubMed: Zinc induced damage to kidney proximal tubular cells: studies on chemical speciation leading to a mechanism of damage.
PubMed: Antiproliferative effects of zinc-citrate compound on hormone refractory prostate cancer.
PubMed: Induction of apoptosis of bladder cancer cells by zinc-citrate compound.
PubMed: Effect of dietary zinc and phytase supplementation on botulinum toxin treatments.
PubMed: Human prostate cancer ZIP1/zinc/citrate genetic/metabolic relationship in the TRAMP prostate cancer animal model.
PubMed: A pilot study to investigate the treatment of cervical human papillomavirus infection with zinc-citrate compound (CIZARĀ®).
PubMed: Formation of amorphous zinc citrate spheres and their conversion to crystalline ZnO nanostructures.
PubMed: Efficacy of two commercially available dentifrices in reducing dentinal hypersensitivity.
PubMed: The effects of a zinc citrate dentifrice on bacteria found on oral surfaces.
PubMed: Evaluation of different fluoridated dentifrice formulations using an in situ erosion remineralization model.
PubMed: Effect of chewing gums on the production of volatile sulfur compounds (VSC) in vivo.
PubMed: Comparative in vitro toxicity of seven zinc-salts towards neuronal PC12 cells.
PubMed: Clinical anti-microbial efficacy of a new zinc citrate dentifrice.
PubMed: Comparison of a stabilized stannous fluoride/sodium hexametaphosphate dentifrice and a zinc citrate dentifrice on plaque formation measured by digital plaque imaging (DPIA) with white light illumination.
PubMed: Zinc distribution and speciation within rocket plants (Eruca vesicaria L. Cavalieri) grown on a polluted soil amended with compost as determined by XRF microtomography and micro-XANES.
PubMed: Zinc bioavailability is improved by the micronised dispersion of zinc oxide with the addition of L-histidine in zinc-deficient rats.
PubMed: Extracellular zinc and zinc-citrate, acting through a putative zinc-sensing receptor, regulate growth and survival of prostate cancer cells.
PubMed: Dental plaque control effect of a zinc citrate dentifrice.
PubMed: Effects of various forms of calcium added to chewing gum on initial enamel carious lesions in situ.
PubMed: A meta-analysis of six-month studies of antiplaque and antigingivitis agents.
PubMed: Rational design, synthesis, and application of a new receptor for the molecular recognition of tricarboxylate salts in aqueous media.
PubMed: Antiproliferative and apoptotic effects of zinc-citrate compound (CIZAR(R)) on human epithelial ovarian cancer cell line, OVCAR-3.
PubMed: Cytotoxic effect of zinc-citrate compound on choriocarcinoma cell lines.
PubMed: The effectiveness of self-performed mechanical plaque control with triclosan containing dentifrices.
PubMed: A study into the plaque-inhibitory activity of experimental toothpaste formulations containing antimicrobial agents.
PubMed: The effect of exogenous zinc ions on the pattern of oxygen consumption of the hepatic mitochondria of albino rats.
PubMed: Reducing variability and choosing ideal subjects for experimental gingivitis studies.
PubMed: A comparison of a reformulated potassium citrate desensitising toothpaste with the original proprietary product.
PubMed: The role of Triclosan in dentifrice formulations, with particular reference to a new 0.3% Triclosan calcium carbonate-based system.
PubMed: The effect of a toothpaste containing 2% zinc citrate and 0.3% Triclosan on bacterial viability and plaque growth in vivo compared to a toothpaste containing 0.3% Triclosan and 2% copolymer.
PubMed: The effect of a toothpaste containing 2% zinc citrate/0.3% Triclosan on the glycolysis of plaque bacteria ex vivo after food intake.
PubMed: The effect of a 2% zinc citrate, 0.3% Triclosan dentifrice on plaque acid production following consumption of a snackfood.
PubMed: Plaque antibacterial levels following controlled food intake and use of a toothpaste containing 2% zinc citrate and 0.3% Triclosan.
PubMed: Antimicrobial effects of a novel Triclosan/zinc citrate dentifrice against mixed culture oral biofilms.
PubMed: Anti-microbial efficacy and mode of action studies on a new zinc/ Triclosan formulation.
PubMed: Physiologic actions of zinc related to inhibition of acid and alkali production by oral streptococci in suspensions and biofilms.
PubMed: The antibacterial properties of solid supported liposomes on Streptococcus oralis biofilms.
PubMed: Zinc as a potential enteroprotector in oral rehydration solutions: its role in nitric oxide metabolism.
PubMed: Effects of triclosan/copolymer dentifrice on dental plaque and gingivitis in a 3-month randomized controlled clinical trial: influence of baseline gingivitis on observed efficacy.
PubMed: Experimental gingivitis studies: effects of triclosan and triclosan-containing dentifrices on dental plaque and gingivitis in three-week randomized controlled clinical trials.
PubMed: The significance of the source of zinc and its anti-VSC effect.
PubMed: Anticalculus effect of two zinc citrate/essential oil-containing dentifrices.
PubMed: A study to assess the plaque inhibitory action of a new zinc citrate toothpaste formulation.
PubMed: Metal complexes of lactoferrin and their effect on the intracellular multiplication of Legionella pneumophila.
PubMed: The influence of specific foods and oral hygiene on the microflora of fissures and smooth surfaces of molar teeth: A 5-day study.
PubMed: Clinical efficacy of a dentifrice containing zinc citrate: a 12-week calculus clinical study in adults.
PubMed: Efficacy of a dentifrice containing zinc citrate for the control of plaque and gingivitis: a 6-month clinical study in adults.
PubMed: Anti-calculus activity of a toothpaste with microgranules.
PubMed: Is the chemical prevention of gingivitis necessary to prevent severe periodontitis?
PubMed: Triclosan: cytotoxicity, mode of action, and induction of apoptosis in human gingival cells in vitro.
PubMed: The influence of triclosan, zinc or propylene glycol on oral mucosa exposed to sodium lauryl sulphate.
PubMed: An 18-week home-use study comparing the oral hygiene and gingival health benefits of triclosan and fluoride toothpastes.
PubMed: The effect of some metal ions on volatile sulfur-containing compounds originating from the oral cavity.
PubMed: Skin reactions and irritation potential of four commercial toothpastes.
PubMed: A comparison of triclosan and stannous fluoride toothpastes for inhibition of plaque regrowth. A crossover study designed to assess carry over.
PubMed: The comparative clinical efficacy of pyrophosphate/triclosan, copolymer/triclosan and zinc citrate/triclosan dentifrices for the reduction of supragingival calculus formation.
PubMed: Relative effectiveness coefficient: a quality characteristic of toothpastes containing active components.
PubMed: Antiplaque, antibacterial, and anti-inflammatory properties of triclosan mouthrinses in combination with zinc citrate or polyvinylmethylether maleic acid (PVM-MA) copolymer.
PubMed: Modulation of nitrate-nitrite conversion in the oral cavity.
PubMed: Anticalculus efficacy of three dentifrices.
PubMed: Comparison between 3 triclosan dentifrices on plaque, gingivitis and salivary microflora.
PubMed: The effect of three commercially available dentifrices containing triclosan on supragingival plaque formation and gingivitis: a six month clinical study.
PubMed: The effects of three silica dentifrices containing Triclosan on supragingival plaque and calculus formation and on gingivitis.
PubMed: The effects of a silica dentifrice containing Triclosan and zinc citrate on supragingival plaque and calculus formation and the control of gingivitis.
PubMed: The effect of dentifrices containing Triclosan on the development of gingivitis in a 21-day experimental gingivitis study.
PubMed: The caries preventive effect of a fluoride dentifrice containing Triclosan and zinc citrate, a compilation of in vitro and in situ studies.
PubMed: Microbiological effects of new agents in dentifrices for plaque control.
PubMed: Oral delivery and clearance of antiplaque agents from Triclosan-containing dentifrices.
PubMed: The effects of triclosan and zinc citrate, alone and in combination, on a community of oral bacteria grown in vitro.
PubMed: Technical advances in intra-oral model systems used to assess cariogenicity: experimental design and analysis (reactor paper).
PubMed: Antibacterial activity of some triclosan-containing toothpastes and their ingredients.
PubMed: Interaction of zinc with dental mineral.
PubMed: Concentration of antimicrobial proteins in human saliva. The effect of six months use of an antiplaque dentifrice on levels of antimicrobial proteins in unstimulated saliva from 102 adults.
PubMed: Antibacterial dentifrices. Clinical data and relevance with emphasis on zinc/triclosan.
PubMed: Dentifrices containing new agents for the control of plaque and gingivitis: microbiological aspects.
PubMed: Zinc citrate/Triclosan: a new anti-plaque system for the control of plaque and the prevention of gingivitis: short-term clinical and mode of action studies.
PubMed: Anticalculus effect of a dentifrice containing 0.5% zinc citrate trihydrate.
PubMed: Inhibition of acid production by Streptococcus mutans NCTC 10449 by zinc and the effect of metal speciation.
PubMed: Clinical comparison of anticalculus dentifrices: a three-month study of Thai children and teenagers.
PubMed: Clinical evaluation of seven anticalculus dentifrice formulations.
PubMed: Control of gingivitis and calculus by a dentifrice containing a zinc salt and triclosan.
PubMed: Microbiological and clinical effects of a dentifrice containing zinc citrate and Triclosan in the human experimental gingivitis model.
PubMed: Six-month study of the effect of a dentifrice containing zinc citrate and triclosan on plaque, gingival health, and calculus.
PubMed: Clinical evaluation of anticalculus dentifrices.
PubMed: An evaluation of 6 dentifrice formulations for supragingival anticalculus and antiplaque activity.
PubMed: Studies on the effect of toothpaste rinses on plaque regrowth. (II). Triclosan with and without zinc citrate formulations.
PubMed: Studies on the effect of toothpaste rinses on plaque regrowth. (I). Influence of surfactants on chlorhexidine efficacy.
PubMed: Effects of cadmium, copper, magnesium, and zinc on the decomposition of citrate by a Klebsiella sp.
PubMed: Efficacy of zinc citrate ascorbate for treatment of canine cataracts.
PubMed: One-year study of the efficacy of a dentifrice containing zinc citrate and triclosan to maintain gingival health.
PubMed: Comparison of the effect of toothpastes containing enzymes or antimicrobial compounds with a conventional fluoride toothpaste on the development of plaque and gingivitis.
PubMed: A 1-year study on the maintenance of gingival health by a dentifrice containing a zinc salt and non-anionic antimicrobial agent.
PubMed: Plaque inhibition by a combination of zinc citrate and sodium lauryl sulfate.
PubMed: [Dental calculus-inhibiting tooth pastes and mouthwashes. A review of the literature of clinical trials].
PubMed: The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis.
PubMed: A 3-year oral health dose-response study of sodium monofluorophosphate dentifrices with and without zinc citrate: anti-caries results.
PubMed: Antiplaque effects and mode of action of a combination of zinc citrate and a nonionic antimicrobial agent.
PubMed: The oral disposition of zinc following the use of an anticalculus toothpaste containing 0.5% zinc citrate.
PubMed: The effect of long-term use of a dentifrice containing zinc citrate and a non-ionic agent on the oral flora.
PubMed: [Experimental studies of male infertility and zinc].
PubMed: Long-term exposure of plaque to zinc citrate.
PubMed: The influence of a dentifrice containing a zinc salt and a nonionic antimicrobial agent on the maintenance of gingival health.
PubMed: Retention of selenium (75Se), Zinc (65Zn) and manganese (54Mn) in humans after intake of a labelled vitamin and mineral supplement.
PubMed: Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans.
PubMed: The effects of a dentifrice containing a zinc salt and a non-cationic antimicrobial agent on plaque and gingivitis.
PubMed: In vivo anticalculus effect of a dentifrice containing 0.5% zinc citrate trihydrate.
PubMed: The effects of a dentifrice containing zinc citrate and 2,4,4' trichloro-2'-hydroxydiphenyl ether.
PubMed: The effect of dentifrices containing zinc citrate on plaque growth and oral zinc levels.
PubMed: Utilization of zinc from picolinic or citric acid complexes in relation to dietary protein source in rats.
PubMed: Sodium, potassium, calcium, magnesium, zinc, citrate and chloride content of human prostatic and seminal fluid.
PubMed: Accumulation of zinc and Organic Acids in Roots of Zinc Tolerant and Non-tolerant Ecotypes of Deschampsia caespitosa.
PubMed: Identification of a low molecular weight ligand for zinc in the human hyperplastic prostate.
PubMed: Chemical factors affecting the intestinal absorption of zinc in vitro and in vivo.
PubMed: Zinc binding in cow's milk and human milk.
PubMed: Effect of zinc citrate on fluoride uptake by artificial caries lesions.
PubMed: Zinc and zinc ligands in human seminal plasma. III. The principal low molecular weight zinc ligand in prostatic secretion and seminal plasma.
PubMed: Effects of a zinc citrate mouthwash on dental plaque and salivary bacteria.
PubMed: Isolation of a low molecular weight zinc binding ligand from human milk.
PubMed: Zinc citrate, human milk, and acrodermatitis enteropathica.
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