EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

copper gluconate
gluconic acid, copper(2+) salt (2:1), D-

Supplier Sponsors

CAS Number: 527-09-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:208-408-2
Nikkaji Web:J6.667B
Molecular Weight:453.84214000
Formula:C12 H22 Cu O14
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:nutrient supplements
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1260 Copper (cupric) gluconate View - review
FDA Mainterm (SATF):527-09-3 ; COPPER GLUCONATE
FDA Regulation:
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1260 Copper gluconate.

Subpart A--General Provisions
Sec. 582.80 Trace minerals added to animal feeds.
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 673.00 to 674.00 °C. @ 760.00 mm Hg (est)
Flash Point: 707.00 °F. TCC ( 375.20 °C. ) (est)
logP (o/w): -3.175 (est)
Soluble in:
 water, 300000 mg/L @ 25 °C (exp)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
skin protecting agents
American Elements
Copper(II) D-gluconate 99%
Odor: characteristic
Use: Copper(II) D-gluconate is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical, LLC.
Copper Gluconate
American International Chemical, LLC.
Copper Gluconate
Flavor: characteristic
Vitashure is an extensive line of microencapsulated vitamins, minerals, amino acids, and bioactive substances, specifically designed for the supplementation and fortification industries.
BOC Sciences
For experimental / research use only.
D-Gluconic acid copper (II) salt
For experimental / research use only.
Gluconic acid copper (II) salt
Glentham Life Sciences
Copper(II) D-gluconate
Global Calcium
Copper Gluconate USP
Jost Chemical
Copper Gluconate USP Low HM Powder
Jost Chemical
Copper Gluconate USP Powder
Jost Chemical
Microencapsulated Copper Gluconate 20%
For experimental / research use only.
Copper Gluconate 99%
Qingdao Dacon Trading
Copper Gluconate
Sigma-Aldrich: Aldrich
For experimental / research use only.
Copper(II) D-gluconate 98%
United International
Copper Gluconate
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
nutrient supplements
Recommendation for copper gluconate usage levels up to:
 not for fragrance use.
Recommendation for copper gluconate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):527-09-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10692
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
copper (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
 copper (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:527-09-3
Pubchem (cid):10692
Pubchem (sid):134978408
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
KEGG (GenomeNet):C12278
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 copper (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
 copper D-gluconate
 copper D-gluconate (1:2)
 copper di-D-gluconate
 copper di-dextro-gluconate
microencapsulated copper gluconate 20%
 copper gluconate anhydrous FCC powder
 copper gluconate powder
 copper gluconate USP low HM powder
 copper gluconate USP powder
 copper glycinate anhydrous
 copper, bis(D-gluconato-kappaO1,kappaO2)-
 copper, bis(D-gluconato-O1,O2)-
 copper, bis(D-gluconato)-
 copper(2+) D-gluconate, (1:2)
 copper(II) D-gluconate
 copper(II) Gluconate
 cupric gluconate
 cupric gluconate monohydrate
 gluconic acid copper (II) salt
 gluconic acid copper(2+) salt
D-gluconic acid copper(II) salt
D-gluconic acid, copper(2+) salt (2:1)
 gluconic acid, copper(2+) salt (2:1) D-
 gluconic acid, copper(2+) salt (2:1), D-


PubMed:A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care.
PubMed:Effects of zinc gluconate and 2 other divalent cationic compounds on olfactory function in mice.
PubMed:Neurologic dysfunction and pancytopenia secondary to acquired copper deficiency following duodenal switch: case report and review of the literature.
PubMed:[Effect of copper intake and copper-zinc ratio on rat lipid peroxidation in copper deficiency].
PubMed:Photochemical synthesis of submicron- and nano-scale Cu2O particles.
PubMed:Carcinogenic risk of copper gluconate evaluated by a rat medium-term liver carcinogenicity bioassay protocol.
PubMed:Intra and inter-molecular interactions dictate the aggregation state of irinotecan co-encapsulated with floxuridine inside liposomes.
PubMed:Possible carcinogenic risks of copper gluconate and their prevention by co-administered green tea catechins evaluated by a rat medium-term multi-organ carcinogenicity bioassay protocol.
PubMed:Role of copper gluconate/triethanolamine in irinotecan encapsulation inside the liposomes.
PubMed:Copper deficiency causes reversible myelodysplasia.
PubMed:Coencapsulation of irinotecan and floxuridine into low cholesterol-containing liposomes that coordinate drug release in vivo.
PubMed:Anemia and neutropenia associated with copper deficiency of unclear etiology.
PubMed:Multiple exposures to chlorhexidine and xylitol: adhesion and biofilm formation by Streptococcus mutans.
PubMed:[Pancytopenia, arthralgia and myeloneuropathy due to copper deficiency].
PubMed:Zinc and copper: proposed fortification levels and recommended zinc compounds.
PubMed:Solubility and relative absorption of copper, iron, and zinc in two milk-based liquid infant formulae.
PubMed:In vitro modulation of keratinocyte wound healing integrins by zinc, copper and manganese.
PubMed:Anti-inflammatory properties of copper, gold and silver, individually and as mixtures.
PubMed:Anti-inflammatory properties of a preparation containing low doses of copper, gold and silver.
PubMed:Lack of effects of copper gluconate supplementation.
PubMed:Excessive intake of copper: influence on longevity and cadmium accumulation in mice.
PubMed:Influence of dietary copper on the survival of Drosophila.
PubMed:Changes with age in cadmium and copper levels in C57BL/6J mice.
PubMed:Changes with age in copper and superoxide dismutase levels in brains of C57BL/6J mice.
PubMed:[Behavior of the blood copper curve after intravenous loading with copper gluconate in rheumatic diseases].
PubMed:[Variations in cupremia following intravenous injections of copper gluconate in hepatic diseases].
PubMed:[Cupremia in normal subjects and its variations following intravenous injections of copper gluconate].
Used as a food additive [EAFUS]
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