EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

coenzyme A

Supplier Sponsors

CAS Number: 85-61-0Picture of molecule3D/inchi
Other(deleted CASRN):153-46-8
ECHA EINECS - REACH Pre-Reg:201-619-0
FDA UNII: SAA04E81UX
Nikkaji Web:J264.889J
XlogP3:-5.80 (est)
Molecular Weight:767.54040600
Formula:C21 H36 N7 O16 P3 S
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic ingredient for skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -4.358 (est)
Soluble in:
 water, 2.192e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
BOC Sciences
For experimental / research use only.
Coenzyme A Purity >85%
George Uhe Company
Coenzyme A, Free Acid
Glentham Life Sciences
Coenzyme A hydrate
Santa Cruz Biotechnology
For experimental / research use only.
Coenzyme A ≥93%
Sigma-Aldrich: Sigma
For experimental / research use only.
Coenzyme A hydrate ≥85% (UV, HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic ingredient for skin conditioning
Recommendation for coenzyme A usage levels up to:
 not for fragrance use.
 
Recommendation for coenzyme A flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):85-61-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6816
National Institute of Allergy and Infectious Diseases:Data
[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl][3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylam
Chemidplus:0000085610
 
References:
 [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl][3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylam
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:85-61-0
Pubchem (cid):6816
Pubchem (sid):134972978
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C00010
HMDB (The Human Metabolome Database):HMDB01423
FooDB:FDB022614
YMDB (Yeast Metabolome Database):YMDB00045
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 emollients
 solvents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 CoA-SH
 coenzyme A-SH
 coenzyme ASH
 depot-zeel
 propionyl CoA
 propionyl coenzyme A
 S-propanoate CoA
 S-propanoate coenzyme A
 S-propionate CoA
 S-propionate coenzyme A
 

Articles:

PubMed:Characterization of two Streptomyces enzymes that convert ferulic acid to vanillin.
PubMed:Association of DGAT1 genotype, fatty acid composition, and concentration of copper in milk with spontaneous oxidized flavor.
PubMed:Association of an ACSL1 gene variant with polyunsaturated fatty acids in bovine skeletal muscle.
PubMed:Engineering of bacterial methyl ketone synthesis for biofuels.
PubMed:Microbial formation of esters.
PubMed:Aerobic production of isoamyl acetate by overexpression of the yeast alcohol acetyl-transferases AFT1 and AFT2 in Escherichia coli and using low-cost fermentation ingredients.
PubMed:The biosynthesis and regulation of biosynthesis of Concord grape fruit esters, including 'foxy' methylanthranilate.
PubMed:An alcohol acyl transferase from apple (cv. Royal Gala), MpAAT1, produces esters involved in apple fruit flavor.
PubMed:Applicability of CoA/acetyl-CoA manipulation system to enhance isoamyl acetate production in Escherichia coli.
PubMed:4-coumarate:CoA ligase gene family in Rubus idaeus: cDNA structures, evolution, and expression.
PubMed:The phenylalanine ammonia-lyase gene family in raspberry. Structure, expression, and evolution.
PubMed:Rerouting the plant phenylpropanoid pathway by expression of a novel bacterial enoyl-CoA hydratase/lyase enzyme function.
PubMed:Acetyl-CoA:benzylalcohol acetyltransferase--an enzyme involved in floral scent production in Clarkia breweri.
 
Notes:
Adenosine 5'-(Trihydrogen Diphosphate), 3'-(Dihydrogen Phosphate), P'-(3-Hydroxy-4-((3-((2-Mercaptoethyl)Amino)-3-Oxopropyl)Amino)-2,2-Di methyl-4-Oxobutyl) Ester, (R)- Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, notable for its role in the synthesis and oxidization of fatty acids, and the oxidation of pyruvate in the citric acid cycle. It is adapted from beta-mercaptoethylamine, panthothenate and adenosine triphosphate. Acetyl-CoA is an important molecule itself. It is the precursor to HMG CoA, which is a vital component in cholesterol and ketone synthesis. Furthermore, it contributes an acetyl group to choline to produce acetylcholine, in a reaction catalysed by choline acetyltransferase. Its main task is conveying the carbon atoms within the acetyl group to the citric acid cycle to be oxidized for energy production. -- Wikipedia [HMDB]
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