methyl aspartic acid
D-aspartic acid, N-methyl-
an amino acid that, as the d-isomer, is the defining agonist for the nmda receptor subtype of glutamate receptors (receptors, nmda). N-Methyl-D-aspartic acid is an amino acid derivative acting as a specific agonist at the NMDA receptor, and therefore mimics the action of the neurotransmitter glutamate on that receptor. In contrast to glutamate, NMDA binds to and regulates the above receptor only, but not other glutamate receptors. NMDA is a water-soluble synthetic substance that is not normally found in biological tissue. It was first synthesized in the 1960's. NMDA is an excitotoxin; this trait has applications in behavioral neuroscience research. The body of work utilizing this technique falls under the term "lesion studies." Researchers apply NMDA to specific regions of an (animal) subject's brain or spinal cord and subsequently test for the behavior of interest, such as operant behavior. If the behavior is compromised, it suggests the destroyed tissue was part of a brain region that made an important contribution to the normal expression of that behavior. Examples of antagonists of the NMDA receptor are APV, dextromethorphan, ketamine, phencyclidine (PCP), riluzole, and memantine. They are commonly referred to as NMDA receptor antagonists. (Wikipedia) [HMDB]
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co.
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
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      HLCFD-149 N-Methyl-D-aspartic acid
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      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 60 years of synthesis experience and multi-purpose plants enable TCI to offer more than 27,000 products as well as custom synthesis. TCI established overseas facilities in North America, Europe, China and India to serve customers worldwide.
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      M1360 N-Methyl-D-aspartic Acid >98.0%(T)
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(2R)-2-(methylamino)butanedioic acid (Click)
CAS Number: 6384-92-5Picture of molecule
Nikkaji Web: J246.192G
Beilstein Number: 1724431
MDL: MFCD00004226
XlogP3-AA: -3.40 (est)
Molecular Weight: 147.13053000
Formula: C5 H9 N O4
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antistatic, hair conditioning, skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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US Patents: Search
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PubMed: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 258.24 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.004000 mm/Hg @ 25.00 °C. (est)
Flash Point: 230.00 °F. TCC ( 110.00 °C. ) (est)
logP (o/w): 1.390 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
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Organoleptic Properties:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antistatic agents
hair conditioning
skin conditioning
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Anhui Haibei
N-Methyl-D-aspartic Acid
EMD Millipore
For experimental / research use only.
N-Methyl-D-aspartic Acid, Hydrate
Glentham Life Sciences
N-Methyl-D-aspartic acid
Jiangyin Healthway
N-Methyl-D-aspartic acid
New functional food ingredients
Santa Cruz Biotechnology
For experimental / research use only.
N-Methyl-D-Aspartic acid ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
N-Methyl-D-aspartic acid ≥98% (TLC), solid
For experimental / research use only.
N-Methyl-D-aspartic Acid >98.0%(T)
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Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  137 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 269, Pg. 573, 1994.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antistatic, hair conditioning, skin conditioning
Recommendation for methyl aspartic acid usage levels up to:
 not for fragrance use.
Recommendation for methyl aspartic acid flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 22880
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 (2R)-2-(methylamino)butanedioic acid
Chemidplus: 0006384925
RTECS: CI9457000 for cas# 6384-92-5
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 (2R)-2-(methylamino)butanedioic acid
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 22880
Pubchem (sid): 134986917
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
KEGG (GenomeNet): C12269
HMDB (The Human Metabolome Database): HMDB02393
FooDB: FDB022992
Export Tariff Code: 2922.49.4050
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
None Found
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Potential Uses:
 antistatic agents 
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Occurrence (nature, food, other): note
 not found in nature
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D-aspartic acid, N-methyl-
N-methyl aspartic acid
N-methyl-D-aspartic acid
N-methyl-D-aspartic acid hydrate
(2R)-2-(methylamino)butanedioic acid
(R)-2-(methylamino)succinic acid
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