methyl aspartic acid
D-aspartic acid, N-methyl-
 
Notes:
an amino acid that, as the d-isomer, is the defining agonist for the nmda receptor subtype of glutamate receptors (receptors, nmda). N-Methyl-D-aspartic acid is an amino acid derivative acting as a specific agonist at the NMDA receptor, and therefore mimics the action of the neurotransmitter glutamate on that receptor. In contrast to glutamate, NMDA binds to and regulates the above receptor only, but not other glutamate receptors. NMDA is a water-soluble synthetic substance that is not normally found in biological tissue. It was first synthesized in the 1960's. NMDA is an excitotoxin; this trait has applications in behavioral neuroscience research. The body of work utilizing this technique falls under the term "lesion studies." Researchers apply NMDA to specific regions of an (animal) subject's brain or spinal cord and subsequently test for the behavior of interest, such as operant behavior. If the behavior is compromised, it suggests the destroyed tissue was part of a brain region that made an important contribution to the normal expression of that behavior. Examples of antagonists of the NMDA receptor are APV, dextromethorphan, ketamine, phencyclidine (PCP), riluzole, and memantine. They are commonly referred to as NMDA receptor antagonists. (Wikipedia) [HMDB]
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(2R)-2-(methylamino)butanedioic acid (Click)
CAS Number: 6384-92-5Picture of molecule
FDA UNII: 1903B9Q6PI
Nikkaji Web: J246.192G
Beilstein Number: 1724431
MDL: MFCD00004226
XlogP3-AA: -3.40 (est)
Molecular Weight: 147.13053000
Formula: C5 H9 N O4
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antistatic, hair conditioning, skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
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Google Patents: Search
US Patents: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 258.24 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.004000 mm/Hg @ 25.00 °C. (est)
Flash Point: 230.00 °F. TCC ( 110.00 °C. ) (est)
logP (o/w): 1.390 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antistatic agents
hair conditioning
skin conditioning
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Suppliers:
Anhui Haibei
N-Methyl-D-aspartic Acid
EMD Millipore
For experimental / research use only.
N-Methyl-D-aspartic Acid, Hydrate
Glentham Life Sciences
N-Methyl-D-aspartic acid
Jiangyin Healthway
N-Methyl-D-aspartic acid
New functional food ingredients
Santa Cruz Biotechnology
For experimental / research use only.
N-Methyl-D-Aspartic acid ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
N-Methyl-D-aspartic acid ≥98% (TLC), solid
TCI AMERICA
For experimental / research use only.
N-Methyl-D-aspartic Acid >98.0%(T)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  137 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 269, Pg. 573, 1994.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antistatic, hair conditioning, skin conditioning
Recommendation for methyl aspartic acid usage levels up to:
 not for fragrance use.
 
Recommendation for methyl aspartic acid flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 22880
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 (2R)-2-(methylamino)butanedioic acid
Chemidplus: 0006384925
RTECS: CI9457000 for cas# 6384-92-5
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References:
 (2R)-2-(methylamino)butanedioic acid
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 22880
Pubchem (sid): 134986917
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C12269
HMDB (The Human Metabolome Database): HMDB02393
FooDB: FDB022992
Export Tariff Code: 2922.49.4050
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 antistatic agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
D-aspartic acid, N-methyl-
N-methyl aspartic acid
N-methyl-D-aspartic acid
N-methyl-D-aspartic acid hydrate
N-methyl-D-asparticacid
(2R)-2-(methylamino)butanedioic acid
(R)-2-(methylamino)succinic acid
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